Association between reduced plasma 25-hydroxyvitamin D and increased risk of cancer in patients with inflammatory bowel disease.

Related Articles Association between reduced plasma 25-hydroxyvitamin D and increased risk of cancer in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2015 Apr;13(4):813-4 Authors: Kitson MT, Garg M, Roberts SK PMID: 24813176 [PubMed – indexed for MEDLINE] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/24813176?dopt=Abstract

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Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum.

Related Articles Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum. J Gastroenterol Hepatol. 1999 Nov;14(11):1132-4 Authors: Barwood N, Platell C Abstract Patients with Crohn’s disease affecting the small intestine appear to have an increased risk of developing adenocarcinoma. However, it remains an uncommon complication of an uncommon disease. The diagnosis is difficult to make both pre- and intra-operatively, and is most commonly made postoperatively on histopathology. Hence, at laparotomy, consideration should be given to performing a frozen section on all small bowel strictures due to Crohn’s disease…

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The impact of surgeon volume on postoperative outcomes after surgery for Crohn’s disease.

Related Articles The impact of surgeon volume on postoperative outcomes after surgery for Crohn’s disease. Inflamm Bowel Dis. 2014 Feb;20(2):301-6 Authors: Nguyen GC, Steinhart AH Abstract BACKGROUND: High hospital procedural volume has been associated with better postoperative inflammatory bowel disease outcomes. We assessed the independent contribution of surgeon volume to health outcomes after surgery for Crohn’s disease. METHODS: We identified 2842 individuals with Crohn’s disease who underwent first inflammatory bowel disease-related surgery between 1996 and 2009. We assessed the association between surgeon volume, hospital volume, comorbidity and demographic variables, and…

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The ileum is the major site of absorption of vitamin B12 analogues.

Related Articles The ileum is the major site of absorption of vitamin B12 analogues. Am J Gastroenterol. 1989 Jan;84(1):22-6 Authors: Shaw S, Jayatilleke E, Meyers S, Colman N, Herzlich B, Herbert V Abstract Non-cobalamin vitamin B12 analogues constitute a significant percentage of total corrinoids in human serum. The source and means of absorption of analogues and their significance are largely unknown. We studied the sites of production and absorption of B12 analogues by measuring serum vitamin B12 and analogues in 93 patients with various gastrointestinal diseases: pernicious anemia (PA), ileal…

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Complete remission of severe scleritis and psoriasis in a patient with active Crohn’s disease using Modulen IBD as an exclusive immunomodulating diet.

Related Articles Complete remission of severe scleritis and psoriasis in a patient with active Crohn’s disease using Modulen IBD as an exclusive immunomodulating diet. J Clin Gastroenterol. 2008 May-Jun;42(5):550-1 Authors: Triantafillidis JK, Mantzaris G, Stamataki A, Asvestis K, Malgarinos G, Gikas A PMID: 18344883 [PubMed – indexed for MEDLINE] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/18344883?dopt=Abstract

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Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn’s disease: an open-label pilot study.

Related Articles Prevention of postoperative recurrence with azathioprine or infliximab in patients with Crohn’s disease: an open-label pilot study. J Crohns Colitis. 2013 Dec;7(12):e623-9 Authors: Armuzzi A, Felice C, Papa A, Marzo M, Pugliese D, Andrisani G, Federico F, De Vitis I, Rapaccini GL, Guidi L Abstract BACKGROUND AND AIMS: Patients with Crohn’s disease (CD) often require surgery over their clinical course. However, endoscopic and clinical recurrence of disease appear respectively in up to 80% and 30% of patients after one year. Thus, a prophylactic treatment is needed to reduce…

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Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naïve ulcerative colitis during active and quiescent disease.

Related Articles Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naïve ulcerative colitis during active and quiescent disease. Inflamm Bowel Dis. 2009 Mar;15(3):328-34 Authors: Matsuda R, Koide T, Tokoro C, Yamamoto T, Godai T, Morohashi T, Fujita Y, Takahashi D, Kawana I, Suzuki S, Umemura S Abstract BACKGROUND: Cytokines have validated roles in the immunopathogenesis of inflammatory bowel disease (IBD). This study was to investigate the expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10 mRNAs in the colonic mucosa of patients with…

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Review article: evolutionary advances in the delivery of aminosalicylates for the treatment of ulcerative colitis.

Related Articles Review article: evolutionary advances in the delivery of aminosalicylates for the treatment of ulcerative colitis. Aliment Pharmacol Ther. 2006 Aug 1;24(3):465-74 Authors: Cohen RD Abstract Ulcerative colitis is a chronic and debilitating disease that involves inflammation of the colonic mucosa. Current therapies aim to reduce the symptom burden of ulcerative colitis and maintain disease quiescence. The standard first-line treatment for mild-to-moderate ulcerative colitis is 5-aminosalicylate therapy, which is available in oral and rectal (topical) formulations. While current 5-aminosalicylate formulations are effective in the majority of patients, they are…

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