CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn’s Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide.

Related Articles CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn’s Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide. J Crohns Colitis. 2016 Oct 25;: Authors: Marafini I, Monteleone I, Dinallo V, Di Fusco D, De Simone V, Laudisi F, Fantini MC, Di Sabatino A, Pallone F, Monteleone G Abstract BACKGROUND AND AIM: The chemokine CCL20 is over-produced in epithelium of Crohn’s disease [CD] patients and contributes to recruiting immune cells to inflamed gut. Tumour necrosis factor-α [TNF-α] is a powerful…

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Novel plasma microRNA biomarkers for the identification of colitis-associated carcinoma.

Related Articles Novel plasma microRNA biomarkers for the identification of colitis-associated carcinoma. Lancet. 2015 Feb 26;385 Suppl 1:S78 Authors: Patel M, Verma A, Aslam I, Pringle H, Singh B Abstract BACKGROUND: Ulcerative colitis is an established risk factor for colorectal cancer, also known as colitis-associated cancer. Existing colonoscopic-based surveillance has many disadvantages, so a new accurate, efficient, cost-effective screening test is needed. MicroRNAs (miRNAs) regulate gene expression and are dysregulated in a range of diseases, including ulcerative colitis and colorectal cancer. This study aimed to establish the miRNAs associated with…

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Femoral neck osteopenia in patients with inflammatory bowel disease.

Related Articles Femoral neck osteopenia in patients with inflammatory bowel disease. Am J Gastroenterol. 1998 Sep;93(9):1483-90 Authors: Pollak RD, Karmeli F, Eliakim R, Ackerman Z, Tabb K, Rachmilewitz D Abstract OBJECTIVE: The mechanism of bone loss in patients with inflammatory bowel disease (IBD) is not completely understood. The aim of this study was to assess indices of bone turnover and bone mineral density (BMD) in the lumbar spine and femoral neck in IBD patients. METHODS: Sixty-three patients with Crohn’s disease and 41 with ulcerative colitis were studied. Serum bone-specific alkaline…

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A pooled analysis of infections, malignancy, and mortality in infliximab- and immunomodulator-treated adult patients with inflammatory bowel disease.

Related Articles A pooled analysis of infections, malignancy, and mortality in infliximab- and immunomodulator-treated adult patients with inflammatory bowel disease. Am J Gastroenterol. 2012 Jul;107(7):1051-63 Authors: Lichtenstein GR, Rutgeerts P, Sandborn WJ, Sands BE, Diamond RH, Blank M, Montello J, Tang L, Cornillie F, Colombel JF Abstract OBJECTIVES: The objective of this study was to analyze the safety of long-term infliximab treatment, with/without concomitant immunomodulators, across Crohn’s disease (CD) and ulcerative colitis (UC) clinical trials. METHODS: To maximize sample size, we pooled primary safety data across 10 CD or UC…

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Oral BCG vaccine in Crohn’s disease.

Related Articles Oral BCG vaccine in Crohn’s disease. Gut. 1979 Mar;20(3):229-33 Authors: Burnham WR, Lennard-Jones JE, Hecketsweiler P, Colin R, Geffroy Y Abstract In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn’s disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking…

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Sexual and reproductive issues for men with inflammatory bowel disease.

Related Articles Sexual and reproductive issues for men with inflammatory bowel disease. Am J Gastroenterol. 2009 Mar;104(3):768-73 Authors: Feagins LA, Kane SV Abstract Relatively little attention has been focused on the reproductive and sexual function issues faced by men with inflammatory bowel disease (IBD). Infertility in men with IBD can be caused by medications used to treat the disease (most notably sulfasalazine), by active inflammation, and by the poor nutritional status that can result from IBD. Sexual function can be adversely affected by some medications used to treat IBD, by…

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Study of sexual, urinary, and fecal function in females following restorative proctocolectomy.

Related Articles Study of sexual, urinary, and fecal function in females following restorative proctocolectomy. Inflamm Bowel Dis. 2012 Sep;18(9):1601-7 Authors: Cornish J, Wooding K, Tan E, Nicholls RJ, Clark SK, Tekkis PP Abstract BACKGROUND: The aim was to investigate quality of life, sexual, fecal, and urinary function in females undergoing restorative proctocolectomy (RPC). METHODS: A prospective case-control study was performed in two tertiary centers. Controls were females with ulcerative colitis, without a stoma or RPC. Validated questionnaires (SF-36, Female sexual function index, King’s questionnaire, and the Wexner scale) were administered…

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