Functional gastrointestinal symptoms in patients with inflammatory bowel disease: A clinical challenge.

Related Articles Functional gastrointestinal symptoms in patients with inflammatory bowel disease: A clinical challenge. Clin Gastroenterol Hepatol. 2018 Aug 09;: Authors: Colombel JF, Shin A, Gibson PR Abstract DESCRIPTION: The purpose of this clinical practice update review is to describe key principles in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients with inflammatory bowel disease (IBD). METHODS: The evidence and best practices summarized in this manuscript are based on relevant scientific publications, systematic reviews, and expert opinion where applicable. BEST PRACTICE ADVICE 1: A stepwise approach to…

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Enteral nutrition for maintenance of remission in Crohn’s disease.

Related Articles Enteral nutrition for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2018 Aug 11;8:CD005984 Authors: Akobeng AK, Zhang D, Gordon M, MacDonald JK Abstract BACKGROUND: Prevention of relapse is a major issue in the management of quiescent Crohn’s disease (CD). Current therapies (e.g. methotrexate, biologics, 6-mercaptopurine and azathioprine) may be effective for maintaining remission in CD, but these drugs may cause significant adverse events. Interventions that are effective and safe for maintenance of remission in CD are desirable. OBJECTIVES: The primary objectives were to evaluate the…

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IL-17A Promotes Initiation and Development of Intestinal Fibrosis Through EMT.

Related Articles IL-17A Promotes Initiation and Development of Intestinal Fibrosis Through EMT. Dig Dis Sci. 2018 Aug 10;: Authors: Zhang HJ, Zhang YN, Zhou H, Guan L, Li Y, Sun MJ Abstract BACKGROUND: Intestinal fibrosis is a common complication of Crohn’s disease (CD). Its exact mechanism is still unclear, and effective treatments to control or reverse the fibrosis process are unavailable. Epithelial-mesenchymal transition (EMT) may promote intestinal fibrosis by increasing deposition of extracellular matrix protein. IL-17A is a pro-inflammatory cytokine, and it has been shown as a profibrotic factor as…

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Narrow Band Imaging for Surveillance in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Narrow Band Imaging for Surveillance in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2018 Aug 09;: Authors: Lv XH, Wang BL, Cao GW Abstract BACKGROUND: The role of narrow band imaging (NBI) for surveillance colonoscopy in patients with inflammatory bowel disease (IBD) is debatable. We aim to compare NBI versus other endoscopic techniques in surveillance of IBD basing on current evidences. METHODS: A systematic search of PubMed, Embase, and the Cochrane Library databases was conducted for relevant studies. To assess the detection efficacy, we estimated risk…

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Impact of Epstein-Barr virus serological status on clinical outcomes in adult patients with inflammatory bowel disease.

Impact of Epstein-Barr virus serological status on clinical outcomes in adult patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2018 Aug 10;: Authors: de Francisco R, Castaño-García A, Martínez-González S, Pérez-Martínez I, González-Huerta AJ, Morais LR, Fernández-García MS, Jiménez S, Díaz-Coto S, Flórez-Díez P, Suárez A, Riestra S Abstract BACKGROUND: Little is known about the impact of Epstein-Barr virus (EBV) infection on clinical outcomes in adults with inflammatory bowel disease (IBD). AIM: To evaluate seroprevalence, seroconversion rate and complications associated with EBV infection in an adult IBD cohort attending a…

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