Family history of IBD linked to younger diagnosis, complications

CHICAGO — Researchers associated close-relative family history of Crohn’s disease with earlier diagnosis of Crohn’s disease in patients and increased risk of related complications while, overall, family history of inflammatory bowel disease predicted a younger age of diagnosis, according to data presented at Digestive Disease Week.“As we know IBD, which combines Crohn’s disease and ulcerative colitis, is a chronic, progressive disease and the incidence of IBD is still growing worldwide,” Nynke Z. Borren, MD, from the Massachusetts General Hospital, said in a presentation. “Genetic factors play an important role in the pathogenesis of UC and CD, with over 200 distinct risk polymorphisms identified. Previous studies have shown that family history is one of the strongest risk factors for developing Crohn’s disease or UC.”