Increased Risk of Idiopathic Pulmonary Fibrosis in Inflammatory Bowel Disease: A Nationwide Study.
J Gastroenterol Hepatol. 2019 Aug 16;:
Authors: Kim J, Chun J, Lee C, Han K, Choi S, Lee J, Soh H, Choi K, Park S, Kang EA, Lee HJ, Im JP, Kim JS
BACKGROUND AND AIM: The relationship between inflammatory bowel disease (IBD) and idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the risk for developing IPF in patients with IBD using a nationwide, population-based study.
METHODS: Using claims data from the National Health Insurance service in Korea, patients with IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), were identified through both ICD-10 and rare and intractable diseases (RID) program codes from January 2010 to December 2013. We compared 38,921 IBD patients with age- and sex-matched individuals without IBD in a ratio of 1:3. Patients with newly diagnosed IPF were identified by both ICD-10 and RID registration codes.
RESULTS: During a mean 4.9-year follow-up, the incidence of IPF in patients with IBD was 33.21 per 100,000 person-years. The overall risk of IPF was significantly higher in IBD patients than in non-IBD controls (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.20-2.20; P = 0.003). In patients with CD, the incidence (per 100,000 person-years) of IPF was 26.04; in controls, the incidence was 9.15 (HR, 2.89; 95% CI, 1.46-5.72; P = 0.002). The incidence of IPF in patients with UC tended to be higher than in controls (36.66 vs. 26.54 per 100,000 person-years; 95% CI, 0.99-1.99; HR, 1.41; P = 0.066). The risk of developing IPF in patients with IBD was higher in males than in females (P = 0.093 in CD; P = 0.147 in UC by interaction analysis).
CONCLUSIONS: Patients with IBD, especially CD, have an increased risk of developing IPF.
PMID: 31420894 [PubMed – as supplied by publisher]