Fecal immunochemical test for predicting mucosal healing in ulcerative colitis patients: A systematic review and meta-analysis.
J Gastroenterol Hepatol. 2018 Feb 10;:
Authors: Dai C, Jiang M, Sun MJ, Cao Q
OBJECTIVE: Fecal immunochemical test (FIT) is a promising marker for assessment of inflammatory bowel disease (IBD) activity. However, the utility of FIT for predicting mucosal healing (MH) of Ulcerative Colitis (UC) patients has yet to be clearly demonstrated. The objective of our study was to perform a diagnostic test accuracy test meta-analysis evaluating the diagnostic accuracy of FIT in predicting MH of UC patients.
METHODS: We systematically searched the databases from inception to November 2017 that evaluated MH in UC. The methodological quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies checklist. The extracted data were pooled using a summary receiver operating characteristic curve model. Random-effects model was used to summarize the diagnostic odds ratio, sensitivity, specificity, positive likelihood ratio and negative likelihood ratio.
RESULTS: Six studies comprising 625 UC patients were included in the meta-analysis. The pooled sensitivity and specificity values for predicting MH in UC were 0.77 (95% CI, 0.72-0.81) and 0.81 (95% CI, 0.76-0.85), respectively. The FIT level had a high rule-in value (PLR, 3.79; 95% CI, 2.85-5.03) and a moderate rule-out value (NLR, 0.26; 95% CI, 0.16-0.43) for predicting MH in UC. The results of the ROC curve analysis (area under the curve, 0.88, SEM, 0.02) and DOR (18.08, 95% CI, 9.57-34.13) also revealed improved discrimination for identifying MH in UC with FIT concentration.
CONCLUSION: Our meta-analysis has found that FIT is a simple, reliable non-invasive marker for predicting MH in UC patients.
PMID: 29427297 [PubMed – as supplied by publisher]