DUBLIN (Degree of Ulcerative colitis Burden of Luminal INflammation) score, a simple method to quantify inflammatory burden in Ulcerative Colitis.
J Crohns Colitis. 2019 Mar 26;:
Authors: Rowan CR, Cullen G, Mulcahy HE, Sheridan J, Moss AC, Ryan EJ, Doherty GA
BACKGROUND & AIMS: Endoscopic scores of local severity do not reflect disease extent, or disease burden. The DUBLIN score is a simple bedside clinical score that estimates inflammatory burden using both disease severity and extent. As the need to personalise therapy for UC patients increases, a score to accurately assess disease burden will be of great relevance. The aim of this study was to assess the clinical utility of the DUBLIN score by comparing its performance with objective biomarkers.
METHODS: DUBLIN score was calculated as a product of Mayo Endoscopic Score (0-3) and disease extent (E1-E3). Correlation with objective biomarkers was performed in a retrospective ‘discovery cohort’. A ‘validation cohort was recruited from a single centre,where clinical outcomes, colectomy rate and biochemical data were collected prospectively.
RESULTS: The discovery cohort included 70 patients with UC. DUBLIN score correlated significantly with faecal calprotectin levels. (r= 0.394; p<0.01). ROC analysis using FCP>50μg/g showed a higher AUC with DUBLIN score (AUC=0.76) than Mayo Score (AUC 0.73). The validation cohort included 41 patients. Patients with high inflammatory burden (DUBLIN >3) had higher C-reactive protein and faecal calprotectin, and lower albumin than low inflammtory burden patients. High DUBLIN score was associated with an increased risk of treatment failure. (HR 2.98 95% CI 1.002-8.87; p=0.049).
CONCLUSION: The DUBLIN score is a simple measure of inflammatory burden which correlates with objective inflammatory markers and is associated with clinical outcomes such treatment failure. DUBLIN score has the potential to assist in personalising therapy for patients with UC.
PMID: 30911757 [PubMed – as supplied by publisher]