Vedolizumab Treatment in Extra-Intestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review.

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Vedolizumab Treatment in Extra-Intestinal Manifestations in Inflammatory Bowel Disease: A Systematic Review.

J Crohns Colitis. 2019 May 10;:

Authors: Chateau T, Bonovas S, Le Berre C, Mathieu N, Danese S, Peyrin-Biroulet L

Abstract
BACKGROUND AND AAIMS: We aimed to summarize the existing data on the effectiveness of vedolizumab in extra-intestinal manifestations (EIMs) in inflammatory bowel disease (IBD).
METHODS: We conducted a systematic literature search in PubMed and Cochrane Library, through October 2018. Interventional and non-interventional studies, as well as case-series studying vedolizumab and EIMs in adult patients with IBD, were considered eligible.
RESULTS: Three interventional studies (one randomized trial, n=1032; and two open-label trials, n=3247), five non-interventional studies (n=1496), and three case series (n=17) were included. Vedolizumab did not show any effectiveness in primary sclerosing cholangitis (PSC). While no effect was seen in pre-existing manifestations regarding arthralgia and arthritis, the occurrence of new rheumatic symptoms was lower among vedolizumab users compared to placebo; still higher, however, with vedolizumab than with tumor necrosis factor inhibitors. Finally, vedolizumab appears not efficacious for the treatment of cutaneous manifestations.
CONCLUSIONS: There is no strong evidence to suggest that vedolizumab may be efficacious for the treatment of pre-existing EIMs (especially PSC, rheumatic and cutaneous manifestations); however, it may reduce the occurrence of new EIMs.

PMID: 31076751 [PubMed – as supplied by publisher]

PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31076751?dopt=Abstract