A Practical Guide to the Safety and Monitoring of New IBD Therapies.

A Practical Guide to the Safety and Monitoring of New IBD Therapies. Inflamm Bowel Dis. 2018 Oct 12;: Authors: Click B, Regueiro M Abstract The therapeutic armamentarium of inflammatory bowel disease is rapidly evolving with the development of novel treatment options including targeted monoclonal antibodies and small molecules. With these new therapies come additional safety and side effect concerns. Infections, malignancies, immunogenicity, and metabolic issues exist for each treatment. Management of these agents in the face of such complications is a challenge clinicians will encounter. In this article, we review…

Read More

GlycA, a nuclear magnetic resonance spectroscopy measure for protein glycosylation, is a viable biomarker for disease activity in IBD.

GlycA, a nuclear magnetic resonance spectroscopy measure for protein glycosylation, is a viable biomarker for disease activity in IBD. J Crohns Colitis. 2018 Oct 11;: Authors: Dierckx T, Verstockt B, Vermeire S, van Weyenbergh J Abstract Background and aims: Glycoprotein acetylation (GlycA) is a novel nuclear magnetic resonance (NMR) biomarker measured in serum or plasma, which summarizes signal originating from glycan groups of certain acute phase glycoproteins. This biomarker has been shown to be robustly associated to cardiovascular and short-term all-cause mortality, and to disease severity in several inflammatory conditions.…

Read More

Incidence and Management of Infusion Reactions to Infliximab in an Alternate Care Setting.

Related Articles Incidence and Management of Infusion Reactions to Infliximab in an Alternate Care Setting. Dig Dis Sci. 2018 Oct 11;: Authors: Checkley LA, Kristofek L, Kile S, Bolgar W Abstract BACKGROUND: Infliximab is a chimeric anti-tumor necrosis factor alpha (TNF-α) monoclonal antibody that ameliorates inflammation when it binds to and neutralizes TNF-α. It is often used in patients with Crohn’s disease and ulcerative colitis to reduce the severity of disease symptoms and induce disease remission. Infusions are generally administered in the hospital setting due to concerns over patient safety,…

Read More

A Systematic Review of Self-Management Interventions for Children and Adolescents With Inflammatory Bowel Disease.

A Systematic Review of Self-Management Interventions for Children and Adolescents With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Oct 05;: Authors: Tran L, Mulligan K Abstract Background: Self-management of inflammatory bowel disease is complex. Children and adolescents (CA) with inflammatory bowel disease (IBD) often have difficulty with managing aspects of their condition, resulting in treatment nonadherence and impaired psychosocial function. Self-management interventions are developed to help support patients and their parents/carers to effectively self-manage. The aim of this systematic review was to evaluate the efficacy of self-management interventions in children…

Read More

Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1.

Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1. Inflamm Bowel Dis. 2018 Oct 05;: Authors: Reinisch W, Bressler B, Curtis R, Parikh A, Yang H, Rosario M, Røseth A, Danese S, Feagan B, Sands BE, Ginsburg P, Dassopoulos T, Lewis J, Xu J, Wyant T Abstract Background: In patients with ulcerative colitis (UC), fecal calprotectin (FC) concentrations correlate with endoscopic inflammation evidence. This study investigated the effect of vedolizumab induction on FC concentrations and whether FC concentrations…

Read More

Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis.

Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis. Inflamm Bowel Dis. 2018 Oct 05;: Authors: Battat R, Dulai PS, Vande Casteele N, Evans E, Hester KD, Webster E, Jain A, Proudfoot JA, Mairalles A, Neill J, Singh S, Chang JT, Rivera-Nieves J, Sandborn WJ, Boland BS Abstract Background: Vedolizumab inhibits α4β7-mediated lymphocyte trafficking and is effective in ulcerative colitis (UC). This study evaluated drug and biomarker concentrations and patient outcomes during vedolizumab treatment in UC. Methods: Prospectively scored maintenance clinical (26.5 weeks; interquartile range…

Read More

Refocusing IBD Patient Management: Personalized, Proactive, and Patient-Centered Care.

Related Articles Refocusing IBD Patient Management: Personalized, Proactive, and Patient-Centered Care. Am J Gastroenterol. 2018 Oct 04;: Authors: Siegel CA Abstract Medications are available that can be highly effective for the treatment of inflammatory bowel disease (IBD). However, there are multiple barriers in place to offer these treatments to the right patients at the right time. In addition to obstacles created by payers, there are concerns over medication side effects by patients and providers, and the logistic challenges of navigating the maze of initiating someone on biological therapy. As a…

Read More

Psychological therapies for the management of chronic and recurrent pain in children and adolescents.

Related Articles Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2018 Sep 29;9:CD003968 Authors: Fisher E, Law E, Dudeney J, Palermo TM, Stewart G, Eccleston C Abstract BACKGROUND: This is an update of the original Cochrane review first published in Issue 1, 2003, and previously updated in 2009, 2012 and 2014. Chronic pain, defined as pain that recurs or persists for more than three months, is common in childhood. Chronic pain can affect nearly every aspect of daily life and…

Read More

Endoscopy in inflammatory bowel disease: Role in diagnosis, management, and treatment.

Related Articles Endoscopy in inflammatory bowel disease: Role in diagnosis, management, and treatment. World J Gastroenterol. 2018 Sep 21;24(35):4014-4020 Authors: Spiceland CM, Lodhia N Abstract Endoscopy plays a fundamental role in the diagnosis, management, and treatment of inflammatory bowel disease (IBD). Colonoscopy, flexible sigmoidoscopy, and esophagogastroduodenoscopy have long been used in the care of patients with IBD. As endoscopic technologies have progressed, tools such as endoscopic ultrasound, capsule endoscopy, and balloon-assisted enteroscopy have expanded the role of endoscopy in IBD. Furthermore, chromoendoscopy has enhanced our ability to detect dysplasia in…

Read More

A (glyco)biomarker that predicts failure to standard therapy in Ulcerative Colitis patients.

A (glyco)biomarker that predicts failure to standard therapy in Ulcerative Colitis patients. J Crohns Colitis. 2018 Sep 20;: Authors: Pereira MS, Maia L, Azevedo LF, Campos S, Carvalho S, Dias AM, Albergaria A, Lima J, Marcos-Pinto R, Lago P, Pinho SS Abstract Background and Aims: There is a clinical need to identify biomarkers able to select patients who are most likely to develop aggressive/complicated disease and early select them for appropriate therapy. Changes in the glycosylation profile of intestinal lymphocytic infiltrate was previously demonstrated to regulate T cell activity being…

Read More
<< Go Back