Clinical outcomes with therapeutic drug monitoring in inflammatory bowel disease: A systematic review with meta-analysis.

Clinical outcomes with therapeutic drug monitoring in inflammatory bowel disease: A systematic review with meta-analysis. J Crohns Colitis. 2018 Aug 10;: Authors: Ricciuto A, Dhaliwal J, Walters TD, Griffiths AM, Church PC Abstract Background and aims: We undertook a systematic review and meta-analysis examining the effectiveness of therapeutic drug monitoring (TDM) to improve clinical outcomes in anti-TNF-treated IBD patients. Methods: We searched MEDLINE, Epub Ahead of Print, EMBASE and Cochrane through October 2017 for randomized trials (RCTs) and cohort studies comparing proactive or reactive TDM to each other or empiric…

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Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn’s Disease: The Toronto Consensus.

Related Articles Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn’s Disease: The Toronto Consensus. Inflamm Bowel Dis. 2018 Aug 06;: Authors: Steinhart AH, Panaccione R, Targownik L, Bressler B, Khanna R, Marshall JK, Afif W, Bernstein CN, Bitton A, Borgaonkar M, Chauhan U, Halloran B, Jones J, Kennedy E, Leontiadis GI, Loftus EV, Meddings J, Moayyedi P, Murthy S, Plamondon S, Rosenfeld G, Schwartz D, Seow CH, Williams C Abstract Background: Fistulas occur in about 25% of patients with Crohn’s disease (CD) and can be difficult to…

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New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients.

Related Articles New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients. Inflamm Bowel Dis. 2018 Aug 07;: Authors: Azuara D, Aussó S, Rodriguez-Moranta F, Guardiola J, Sanjuan X, Lobaton T, Boadas J, Piqueras M, Monfort D, Guinó E, Moreno V, Capellá G, de Oca J Abstract Background: The risk of developing colorectal cancer (CRC) is increased in patients with inflammatory bowel disease (IBD) of the colon. The aim of the study was to evaluate the effectiveness of selected methylation gene panel for…

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TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn’s disease patients?

Related Articles TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn’s disease patients? Gut. 2018 Jul 14;: Authors: Verstockt B, Verstockt S, Blevi H, Cleynen I, de Bruyn M, Van Assche G, Vermeire S, Ferrante M PMID: 30007919 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30007919?dopt=Abstract

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Alterations in Polyunsaturated Fatty Acid Metabolism and Reduced Serum Eicosadienoic Acid Level in Ulcerative Colitis: Is There a Place for Metabolomic Fatty Acid Biomarkers in IBD?

Related Articles Alterations in Polyunsaturated Fatty Acid Metabolism and Reduced Serum Eicosadienoic Acid Level in Ulcerative Colitis: Is There a Place for Metabolomic Fatty Acid Biomarkers in IBD? Dig Dis Sci. 2018 Jul 09;: Authors: Sitkin S, Pokrotnieks J PMID: 29987625 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29987625?dopt=Abstract

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Potential of Fecal Calprotectin as an Objective Marker to Discriminate Hospitalized Patients with Acute Severe Colitis from Outpatients with Less Severe Disease.

Related Articles Potential of Fecal Calprotectin as an Objective Marker to Discriminate Hospitalized Patients with Acute Severe Colitis from Outpatients with Less Severe Disease. Dig Dis Sci. 2018 Jun 08;: Authors: Kedia S, Jain S, Goyal S, Bopanna S, Yadav DP, Sachdev V, Sahni P, Pal S, Dash NR, Makharia G, Travis SPL, Ahuja V Abstract BACKGROUND: Acute severe colitis (ASC) is conventionally diagnosed by Truelove and Witts’ criteria which are non-specific and can be affected by other pathologic conditions. Fecal calprotectin (FCP) is a gut-specific marker of inflammation which…

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Correction: ACG Clinical Guideline: Management of Crohn’s Disease in Adults.

Related Articles Correction: ACG Clinical Guideline: Management of Crohn’s Disease in Adults. Am J Gastroenterol. 2018 Jun 12;: Authors: Lichtenstein GR, Loftus EV, Isaacs KL, Regueiro MD, Gerson LB, Sands BE Abstract Since the publication of these Guidelines, the authors have noticed an error in the text on page 15. The incorrect statement is. PMID: 29895986 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29895986?dopt=Abstract

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Fecal calprotectin predicts disease activity of Crohn’s disease evaluated by balloon-assisted endoscopy.

Fecal calprotectin predicts disease activity of Crohn’s disease evaluated by balloon-assisted endoscopy. J Gastroenterol Hepatol. 2018 Jun 11;: Authors: Iwamoto F, Matsuoka K, Motobayashi M, Takenaka K, Kuno T, Tanaka K, Tsukui Y, Kobayashi S, Yoshida T, Fujii T, Saito E, Yamaguchi T, Nagahori M, Sato T, Ohtsuka K, Enomoto N, Watanabe M Abstract BACKGROUND AND AIM: Fecal calprotectin (FC) is a useful marker for assessing the activity of intestinal inflammation. However, most studies have used ileocolonoscopy to evaluate the association of FC with intestinal inflammation and it is not…

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Contemporary Medical Management of Acute Severe Ulcerative Colitis.

Contemporary Medical Management of Acute Severe Ulcerative Colitis. Inflamm Bowel Dis. 2018 Jun 07;: Authors: Whaley KG, Rosen MJ Abstract Acute severe ulcerative colitis is a medical emergency that requires prompt recognition, evaluation, and intervention. Patients require hospital admission with laboratory, radiographic, and endoscopic evaluation with initiation of corticosteroid treatment. Despite early intervention, many patients require salvage medical therapy, with some progressing to colectomy. Here we review important concepts and recent advances in the evaluation and medical management of adult and pediatric patients with acute severe ulcerative colitis. PMID: 29889235…

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Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis.

Related Articles Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis. J Gastroenterol Hepatol. 2018 Jun 05;: Authors: Hamanaka S, Nakagawa T, Hiwasa T, Ohta Y, Kasamatsu S, Ishigami H, Taida T, Okimoto K, Saito K, Maruoka D, Matsumura T, Takizawa H, Kashiwado K, Kobayashi S, Matsushita K, Matsubara H, Katsuno T, Arai M, Kato N Abstract BACKGROUND: The clinical course of ulcerative colitis (UC) is characterized by repeated episodes of relapse and remission. We hypothesized that biomarkers that help distinguish refractory UC patients who…

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