DEVELOPMENT AND VALIDATION OF A TEST TO MONITOR ENDOSCOPIC ACTIVITY IN PATIENTS WITH CROHN’S DISEASE BASED ON SERUM LEVELS OF PROTEINS.

Related Articles DEVELOPMENT AND VALIDATION OF A TEST TO MONITOR ENDOSCOPIC ACTIVITY IN PATIENTS WITH CROHN’S DISEASE BASED ON SERUM LEVELS OF PROTEINS. Gastroenterology. 2019 Nov 08;: Authors: D’Haens G, Kelly O, Battat R, Silverberg MS, Laharie D, Louis E, Savarino E, Bodini G, Yarur A, Boland BS, Afif W, Li XJ, Hale M, Ho J, Kondragunta V, Huang B, Kuy C, Okada L, Hester KD, Bray KR, Mimms L, Jain A, Singh S, Collins A, Valasek MA, Sandborn WJ, Vermeire S, Dulai PS Abstract BACKGROUND & AIMS: Non-invasive tests…

Read More

Management of Inflammatory Bowel Diseases in Special Populations: Obese, Old or Obstetric.

Related Articles Management of Inflammatory Bowel Diseases in Special Populations: Obese, Old or Obstetric. Clin Gastroenterol Hepatol. 2019 Nov 08;: Authors: Singh S, Picardo S, Seow CH Abstract The epidemiology of inflammatory bowel disease (IBD) is progressively evolving impacting the type of patients with IBD we will see in clinical practice. In this review, we discuss specific challenges and solutions in the management of (a) obese, (b) older and (c) obstetric (pregnant) patients with IBD. With the global obesity epidemic, almost one in three patients with IBD are obese. Obesity…

Read More

Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial.

Related Articles Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial. World J Gastroenterol. 2019 Oct 28;25(40):6158-6171 Authors: Ankersen DV, Weimers P, Marker D, Bennedsen M, Saboori S, Paridaens K, Burisch J, Munkholm P Abstract BACKGROUND: The optimal way to home-monitor patients with inflammatory bowel disease (IBD) for disease progression or relapse remains to be found. AIM: To determine whether an electronic health (eHealth) screening procedure for disease activity in IBD should be implemented in clinical practice, scheduled…

Read More

Positioning Therapies in the Management of Crohn’s Disease.

Related Articles Positioning Therapies in the Management of Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Oct 29;: Authors: Nguyen NH, Singh S, Sandborn WJ Abstract In the last decade, several new therapies with different mechanisms of action have been approved for the management of moderate to severe Crohn’s disease (CD). However, there is limited guidance on optimal positioning of agents as first- or second-line therapies due to the absence of head-to-head trials. Furthermore, given the lack of comparative studies, treatment guidelines provide limited insight. In this review, we will discuss data…

Read More

Dining With Inflammatory Bowel Disease: A Review of the Literature on Diet in the Pathogenesis and Management of IBD.

Related Articles Dining With Inflammatory Bowel Disease: A Review of the Literature on Diet in the Pathogenesis and Management of IBD. Inflamm Bowel Dis. 2019 Oct 31;: Authors: Gu P, Feagins LA Abstract Inflammatory bowel diseases (IBDs) are chronic immune-related diseases hypothesized to be a sequela of an interplay of genetic predisposition and environmental exposures. The global incidence of IBD is increasing, and more patients are exploring diet as a means to explain and treat their IBD. In fact, many patients strongly believe diet plays a fundamental role in the…

Read More

Expert consensus: practical algorithms for management of inflammatory bowel disease patients presenting with back pain or peripheral arthropathies.

Related Articles Expert consensus: practical algorithms for management of inflammatory bowel disease patients presenting with back pain or peripheral arthropathies. Aliment Pharmacol Ther. 2019 Oct 25;: Authors: Varkas G, Ribbens C, Louis E, Van den Bosch F, Lories R, Vermeire S, Elewaut D, De Vos M Abstract BACKGROUND: Spondyloarthritis is the most frequent extra-intestinal manifestation of IBD. AIM: To present simple strategies to identify and differentiate inflammatory joint pain in IBD patients. METHODS: A panel of Belgian gastroenterologists and rheumatologists developed seven algorithms for IBD patients with joint symptoms based…

Read More

Therapeutic Drug Monitoring Increases Drug Retention of Anti-Tumor Necrosis Factor Alpha Agents in Pediatric Patients With Crohn’s Disease.

Related Articles Therapeutic Drug Monitoring Increases Drug Retention of Anti-Tumor Necrosis Factor Alpha Agents in Pediatric Patients With Crohn’s Disease. Inflamm Bowel Dis. 2019 Oct 21;: Authors: Gofin Y, Matar M, Shamir R, Assa A Abstract BACKGROUND: In recent years, therapeutic drug monitoring (TDM) of anti-tumor necrosis factor alpha (anti-TNFα) agents has been commonly utilized. We aimed to investigate its effect on long-term drug retention and clinical outcomes in pediatric patients with Crohn’s disease (CD). METHODS: The medical records of pediatric CD patients receiving anti-TNFα agents from 2007 to 2018…

Read More

Evaluating the cost-effectiveness of early compared to late or no biologic treatment to manage Crohn’s disease using real world data.

Evaluating the cost-effectiveness of early compared to late or no biologic treatment to manage Crohn’s disease using real world data. J Crohns Colitis. 2019 Oct 20;: Authors: Pillai N, Lupatsch JE, Dusheiko M, Schwenkglenks M, Maillard M, Sutherland CS, Pittet VEH, Swiss IBD Cohort study group Abstract BACKGROUND AND AIMS: We evaluated the cost-effectiveness of early (≤2 years after diagnosis) compared to late or no biologic initiation (starting biologics >2 years after diagnosis or no biologic use) for adults with Crohn’s disease in Switzerland. METHODS: We developed a Markov cohort…

Read More

Peri-operative and Post-operative Management of Patients with Crohn’s Disease and Ulcerative Colitis.

Peri-operative and Post-operative Management of Patients with Crohn’s Disease and Ulcerative Colitis. Clin Gastroenterol Hepatol. 2019 Oct 04;: Authors: Barnes EL, Lightner AL, Regueiro M Abstract Although the number of available therapies for the treatment of ulcerative colitis (UC) and Crohn’s disease (CD) continues to expand, a significant portion of patients with inflammatory bowel disease (IBD) will require surgical intervention. Surgery remains an integral part of the treatment algorithm for patients with UC and CD, and thus multidisciplinary approaches to the perioperative and postoperative management of patients with IBD are…

Read More

How, When, and For Whom Should We Perform Therapeutic Drug Monitoring?

How, When, and For Whom Should We Perform Therapeutic Drug Monitoring? Clin Gastroenterol Hepatol. 2019 Oct 04;: Authors: Vermeire S, Dreesen E, Papamichael K, Dubinsky MC Abstract The implementation of therapeutic drug monitoring (TDM) in the inflammatory bowel disease (IBD) practice has evolved during the years. In the early days, the focus was merely on the measuring and reporting of drug concentrations. Later, these concentrations were considered in light of target concentrations that are related to clinical response. This did not only allow passively predicting a patient’s future response, but…

Read More
<< Go Back