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Pseudopolyps in inflammatory bowel diseases: Have we learned enough?

Related Articles Pseudopolyps in inflammatory bowel diseases: Have we learned enough? World J Gastroenterol. 2017 Mar 07;23(9):1541-1551 Authors: Politis DS, Katsanos KH, Tsianos EV, Christodoulou DK Abstract Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration associated with excessive healing processes. Their occurrence is less common in Crohn’s disease than in ulcerative colitis, and their overall prevalence ranges from 4% to…

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Inflammatory bowel disease: An evaluation of health information on the internet.

Related Articles Inflammatory bowel disease: An evaluation of health information on the internet. World J Gastroenterol. 2017 Mar 07;23(9):1676-1696 Authors: Azer SA, AlOlayan TI, AlGhamdi MA, AlSanea MA Abstract AIM: To evaluate the quality and accuracy of websites written to the public on inflammatory bowel disease (IBD) (Crohn’s disease and ulcerative colitis) and assess their readability level. METHODS: Google™, Bing™, and Yahoo™ search engines were searched independently by three researchers in December 2014. Only English-language websites were selected on the basis of predetermined inclusion and exclusion criteria. Researchers independently evaluated…

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Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn’s disease.

Related Articles Clinical correlations of infliximab trough levels and antibodies to infliximab in South Korean patients with Crohn’s disease. World J Gastroenterol. 2017 Feb 28;23(8):1489-1496 Authors: Oh EH, Ko DH, Seo H, Chang K, Kim GU, Song EM, Seo M, Lee HS, Hwang SW, Yang DH, Ye BD, Byeon JS, Myung SJ, Yang SK, Park SH Abstract AIM: To investigate the clinical implications of infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATI) levels in Crohn’s disease (CD) patients in Asian countries. METHODS: IFX-TL and ATI level were measured using…

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Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model.

Related Articles Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model. World J Gastroenterol. 2017 Feb 28;23(8):1353-1366 Authors: de Morais Lima GR, Machado FD, Périco LL, de Faria FM, Luiz-Ferreira A, Souza Brito AR, Pellizzon CH, Hiruma-Lima CA, Tavares JF, Barbosa Filho JM, Batista LM Abstract AIM: To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS: Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in…

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Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation.

Related Articles Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation. World J Gastroenterol. 2017 Feb 21;23(7):1180-1188 Authors: Zheng L, Zhang YL, Dai YC, Chen X, Chen DL, Dai YT, Tang ZP Abstract AIM: To investigate the therapeutic effect of Jianpi Qingchang decoction (JPQCD) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: C57BL/c mice were injected intragastrically with 5% DSS instead of drinking water for 7 d, and their body weight, diarrhea severity and fecal bleeding were monitored, while the mice in the control group…

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Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation.

Related Articles Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation. World J Gastroenterol. 2017 Feb 21;23(7):1147-1162 Authors: Sarkate A, Dhaneshwar SS Abstract AIM: To develop a colon-targeting bioreversible delivery system for β-boswellic acid (BBA) and explore utility of its prodrugs in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. METHODS: Synthesis of 4 co-drugs of BBA with essential amino acids was achieved by CDI coupling, followed by their spectral characterization. In vitro kinetics were studied by…

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MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression.

Related Articles MicroRNA-155 promotes the pathogenesis of experimental colitis by repressing SHIP-1 expression. World J Gastroenterol. 2017 Feb 14;23(6):976-985 Authors: Lu ZJ, Wu JJ, Jiang WL, Xiao JH, Tao KZ, Ma L, Zheng P, Wan R, Wang XP Abstract AIM: To explore the mechanism by which microRNA-155 (miR-155) regulates the pathogenesis of experimental colitis. METHODS: A luciferase assay was performed to confirm the binding of miR-155 to the SHIP-1 3′-UTR. MiR-155 mimics, negative controls and SHIP-1 expression/knockdown vectors were established and then utilized in gain- and loss-of-function studies performed in…

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Lymphocytic esophagitis: Still an enigma a decade later.

Related Articles Lymphocytic esophagitis: Still an enigma a decade later. World J Gastroenterol. 2017 Feb 14;23(6):949-956 Authors: Rouphael C, Gordon IO, Thota PN Abstract Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as…

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Simple pain measures reveal psycho-social pathology in patients with Crohn’s disease.

Related Articles Simple pain measures reveal psycho-social pathology in patients with Crohn’s disease. World J Gastroenterol. 2017 Feb 14;23(6):1076-1089 Authors: Odes S, Friger M, Sergienko R, Schwartz D, Sarid O, Slonim-Nevo V, Singer T, Chernin E, Vardi H, Greenberg D, Israel Ibd Research Nucleus Abstract AIM: To determine whether pain has psycho-social associations in adult Crohn’s disease (CD) patients. METHODS: Patients completed demographics, disease status, Patient Harvey-Bradshaw Index (P-HBI), Short Form Health Survey (SF-36), Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and five socio-psychological questionnaires: Brief Symptom Inventory, Brief COPE Inventory,…

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Disease impact on the quality of life of children with inflammatory bowel disease.

Related Articles Disease impact on the quality of life of children with inflammatory bowel disease. World J Gastroenterol. 2017 Feb 14;23(6):1067-1075 Authors: Chouliaras G, Margoni D, Dimakou K, Fessatou S, Panayiotou I, Roma-Giannikou E Abstract AIM: To assess the impact of disease characteristics on the quality of life (QOL) in children with inflammatory bowel diseases (IBD). METHODS: This was a cross-sectional study conducted at the First Department of Pediatrics of the University of Athens at the “Aghia Sophia” Children’s Hospital. Children diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC),…

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