Application of Big Data analysis in gastrointestinal research.

Application of Big Data analysis in gastrointestinal research. World J Gastroenterol. 2019 Jun 28;25(24):2990-3008 Authors: Cheung KS, Leung WK, Seto WK Abstract Big Data, which are characterized by certain unique traits like volume, velocity and value, have revolutionized the research of multiple fields including medicine. Big Data in health care are defined as large datasets that are collected routinely or automatically, and stored electronically. With the rapidly expanding volume of health data collection, it is envisioned that the Big Data approach can improve not only individual health, but also the…

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Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis.

Related Articles Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol. 2019 Jun 21;25(23):2846-2862 Authors: Sen A, Stark H Abstract Cytochromes P450s (CYPs) are terminal enzymes in CYP dependent monooxygenases, which constitute a superfamily of enzymes catalysing the metabolism of both endogenous and exogenous substances. One of their main tasks is to facilitate the excretion of these substances and eliminate their toxicities in most phase 1 reactions. Endogenous substrates of CYPs include steroids, bile acids, eicosanoids, cholesterol, vitamin D and neurotransmitters. About 80% of…

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Increased risk of atrial fibrillation in patients with inflammatory bowel disease: A nationwide population-based study.

Related Articles Increased risk of atrial fibrillation in patients with inflammatory bowel disease: A nationwide population-based study. World J Gastroenterol. 2019 Jun 14;25(22):2788-2798 Authors: Choi YJ, Choi EK, Han KD, Park J, Moon I, Lee E, Choe WS, Lee SR, Cha MJ, Lim WH, Oh S Abstract BACKGROUND: Inflammatory bowel disease (IBD), a chronic inflammatory disease of the gastrointestinal tract, could play a role in the pathophysiology of atrial fibrillation (AF). AIM: To investigate the association between IBD and AF development. METHODS: We performed a population-based cohort study using records…

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Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics.

Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics. World J Gastroenterol. 2019 Jun 07;25(21):2539-2548 Authors: Voskuil MD, Bangma A, Weersma RK, Festen EAM Abstract Inflammatory bowel disease (IBD) is a chronic and heterogeneous intestinal inflammatory disorder. The medical management of IBD aims for long-lasting disease remission to prevent complications and disease progression. Early introduction of immunosuppression forms the mainstay of medical IBD management. Large inter-individual variability in drug responses, in terms of both efficacy and toxicity, leads to high rates of therapeutic failure in the…

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Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis.

Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis. World J Gastroenterol. 2019 Jun 07;25(21):2603-2622 Authors: Chen YL, Zheng YY, Dai YC, Zhang YL, Tang ZP Abstract BACKGROUND: Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently…

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High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis.

Related Articles High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis. World J Gastroenterol. 2019 May 21;25(19):2383-2401 Authors: Pin Vieito N, Zarraquiños S, Cubiella J Abstract BACKGROUND: The quantitative faecal immunochemical test for haemoglobin (FIT) has been revealed to be highly accurate for colorectal cancer (CRC) detection not only in a screening setting, but also in the assessment of patients presenting lower bowel symptoms. Therefore, the National Institute for Health and Care Excellence has recommended the adoption of FIT in primary care to guide referral for suspected…

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Combined evaluation of biomarkers as predictor of maintained remission in Crohn’s disease.

Related Articles Combined evaluation of biomarkers as predictor of maintained remission in Crohn’s disease. World J Gastroenterol. 2019 May 21;25(19):2354-2364 Authors: Sollelis E, Quinard RM, Bouguen G, Goutte M, Goutorbe F, Bouvier D, Pereira B, Bommelaer G, Buisson A Abstract BACKGROUND: The individual performances and the complementarity of Crohn’s disease (CD) activity index (CDAI), C-reactive protein (CRP) and faecal calprotectin (Fcal) to monitor patients with CD remain poorly investigated in the era of “tight control” and “treat to target” strategies. AIM: To assess CDAI, CRP and Fcal variation, alone or…

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Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment.

Related Articles Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment. World J Gastroenterol. 2019 May 14;25(18):2162-2176 Authors: Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T Abstract Spondyloarthropathies (SpA) include many different forms of inflammatory arthritis and can affect the spine (axial SpA) and/or peripheral joints (peripheral SpA) with Ankylosing spondylitis (AS) being the prototype of the former. Extra-articular manifestations, like uveitis, psoriasis and inflammatory bowel disease (IBD) are frequently observed in the setting of SpA and are, in fact, part of the SpA classification criteria.…

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Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease.

Related Articles Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease. World J Gastroenterol. 2019 May 14;25(18):2177-2187 Authors: Limanskiy V, Vyas A, Chaturvedi LS, Vyas D Abstract The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease (IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and…

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Characteristics of mucosa-associated gut microbiota during treatment in Crohn’s disease.

Related Articles Characteristics of mucosa-associated gut microbiota during treatment in Crohn’s disease. World J Gastroenterol. 2019 May 14;25(18):2204-2216 Authors: He C, Wang H, Liao WD, Peng C, Shu X, Zhu X, Zhu ZH Abstract BACKGROUND: The dysbiosis of the gut microbiome is evident in Crohn’s disease (CD) compared with healthy controls (HC), although the alterations from active CD to remission after treatment are unclear. AIM: To characterize the mucosa-associated gut microbiota in patients with CD before and after the induction therapy. METHODS: The basic information was collected from the subjects…

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