Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease.

Related Articles Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease. World J Gastroenterol. 2018 May 14;24(18):2036-2046 Authors: Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS Abstract AIM: To determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn’s disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants’ demographic characteristics and key variables of interest. Paired t-tests were used to compare AP-z-scores…

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Olfactomedin-4 in digestive diseases: A mini-review.

Related Articles Olfactomedin-4 in digestive diseases: A mini-review. World J Gastroenterol. 2018 May 07;24(17):1881-1887 Authors: Wang XY, Chen SH, Zhang YN, Xu CF Abstract Olfactomedin-4 (OLFM4, GW112, hGC-1) is a glycoprotein belonging to the olfactomedin family. The expression of OLFM4 is strong in the small intestine, colon and prostate, and moderate in the stomach and bone marrow. Previous studies have revealed that OLFM4 is closely associated with many digestive diseases. Up-regulation of OLFM4 has been detected in the Helicobacter pylori (H. pylori)-infected gastric mucosa, inflammatory bowel disease tissue and gastrointestinal…

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Anti-integrin therapy for inflammatory bowel disease.

Related Articles Anti-integrin therapy for inflammatory bowel disease. World J Gastroenterol. 2018 May 07;24(17):1868-1880 Authors: Park SC, Jeen YT Abstract In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the…

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Endoscopic management of Crohn’s strictures.

Related Articles Endoscopic management of Crohn’s strictures. World J Gastroenterol. 2018 May 07;24(17):1859-1867 Authors: Bessissow T, Reinglas J, Aruljothy A, Lakatos PL, Van Assche G Abstract Symptomatic intestinal strictures develop in more than one third of patients with Crohn’s disease (CD) within 10 years of disease onset. Strictures can be inflammatory, fibrotic or mixed and result in a significant decline in quality of life, frequently requiring surgery for palliation of symptoms. Patients under the age of 40 with perianal disease are more likely to suffer from disabling ileocolonic disease thus…

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Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice.

Related Articles Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice. World J Gastroenterol. 2018 Apr 28;24(16):1779-1794 Authors: Guo HX, Ye N, Yan P, Qiu MY, Zhang J, Shen ZG, He HY, Tian ZQ, Li HL, Li JT Abstract AIM: To investigate the influence of high salt on dextran sulfate sodium (DSS)-induced colitis in mice and explore the underlying mechanisms of this effect. METHODS: DSS and NaCl were used to establish the proinflammatory animal model. We evaluated the…

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Diversion colitis and pouchitis: A mini-review.

Related Articles Diversion colitis and pouchitis: A mini-review. World J Gastroenterol. 2018 Apr 28;24(16):1734-1747 Authors: Tominaga K, Kamimura K, Takahashi K, Yokoyama J, Yamagiwa S, Terai S Abstract Diversion colitis is characterized by inflammation of the mucosa in the defunctioned segment of the colon after colostomy or ileostomy. Similar to diversion colitis, diversion pouchitis is an inflammatory disorder occurring in the ileal pouch, resulting from the exclusion of the fecal stream and a subsequent lack of nutrients from luminal bacteria. Although the vast majority of patients with surgically-diverted gastrointestinal tracts…

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Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis.

Related Articles Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis. World J Gastroenterol. 2018 Apr 28;24(16):1766-1778 Authors: Gong SS, Fan YH, Wang SY, Han QQ, Lv B, Xu Y, Chen X, He YE Abstract AIM: To explore the significance of corticotropin-releasing hormone (CRH)-receptor (R)2 in mucosal healing of dextran sulfate sodium (DSS)-induced colitis and the effect of Tong-Xie-Yao-Fang (TXYF) on CRH-R2 expression and regulation. METHODS: Ulcerative colitis was induced in mice by administration of 3% (w/v) DSS for 7 d. Once the model was…

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Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease.

Related Articles Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease. World J Gastroenterol. 2018 Apr 07;24(13):1464-1477 Authors: Ma HQ, Yu TT, Zhao XJ, Zhang Y, Zhang HJ Abstract AIM: To analyze the alterations of fecal microbiota in Chinese patients with inflammatory bowel disease (IBD). METHODS: Fecal samples from 15 patients with Crohn’s disease (CD) (11 active CD, 4 inactive CD), 14 patients with active ulcerative colitis (UC) and 13 healthy individuals were collected and subjected to 16S ribosomal DNA (rDNA) gene sequencing. The V4 hypervariable regions of 16S…

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Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis.

Related Articles Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis. World J Gastroenterol. 2018 Apr 07;24(13):1398-1409 Authors: Chen YL, Zhang YL, Dai YC, Tang ZP Abstract AIM: To investigate the protective effects of Ampelopsis grossedentata (AMP) on dextran sulfate sodium (DSS)-induced colitis in mice based on systems pharmacology approach. METHODS: Systems pharmacology approach was used to predict the active ingredients, candidate targets and the efficacy of AMP on ulcerative colitis (UC) using a holistic process of active compound screening, target fishing, network construction…

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NOD2- and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn’s disease patients.

NOD2- and disease-specific gene expression profiles of peripheral blood mononuclear cells from Crohn’s disease patients. World J Gastroenterol. 2018 Mar 21;24(11):1196-1205 Authors: Schäffler H, Rohde M, Rohde S, Huth A, Gittel N, Hollborn H, Koczan D, Glass Ä, Lamprecht G, Jaster R Abstract AIM: To investigate disease-specific gene expression profiles of peripheral blood mononuclear cells (PBMCs) from Crohn’s disease (CD) patients in clinical remission. METHODS: Patients with CD in clinical remission or with very low disease activity according to the Crohn’s disease activity index were genotyped regarding nucleotide-binding oligomerization domain…

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