Postoperative changes of manometry after restorative proctocolectomy in Korean ulcerative colitis patients.

Postoperative changes of manometry after restorative proctocolectomy in Korean ulcerative colitis patients. World J Gastroenterol. 2017 Aug 21;23(31):5780-5786 Authors: Oh SH, Yoon YS, Lee JL, Kim CW, Park IJ, Lim SB, Yu CS, Kim JC Abstract AIM: To investigate the changes of postoperative anal sphincter function and bowel frequency in Korean patients with ulcerative colitis (UC). METHODS: A total of 127 patients with UC who underwent restorative proctocolectomy (RPC) during 20 years were retrospectively analyzed. The parameters of anal manometry and bowel frequency were compared according to the 6-mo intervals…

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Study to determine guidelines for pediatric colonoscopy.

Study to determine guidelines for pediatric colonoscopy. World J Gastroenterol. 2017 Aug 21;23(31):5773-5779 Authors: Yoshioka S, Takedatsu H, Fukunaga S, Kuwaki K, Yamasaki H, Yamauchi R, Mori A, Kawano H, Yanagi T, Mizuochi T, Ushijima K, Mitsuyama K, Tsuruta O, Torimura T Abstract AIM: To investigated characteristics, diagnosis, bowel-cleansing preparation, sedation, and colonoscope length and diameter in Japanese pediatric patients receiving total colonoscopy. METHODS: The present study evaluated consecutive patients aged ≤ 15 years who had undergone their first colonoscopy in Kurume University between January 2007 and February 2015. Data…

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Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress.

Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress. World J Gastroenterol. 2017 Aug 21;23(31):5700-5712 Authors: Liu Y, Ye Q, Liu YL, Kang J, Chen Y, Dong WG Abstract AIM: To elucidate the impact of Schistosoma (S.) japonicum infection on inflammatory bowel disease by studying the effects of exposure to S. japonicum cercariae on dextran sodium sulfate (DSS)-induced colitis. METHODS: Infection was percutaneously established with 20 ± 2 cercariae of S. japonicum, and colitis was induced by administration of 3% DSS at 4 wk…

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Treating children with inflammatory bowel disease: Current and new perspectives.

Related Articles Treating children with inflammatory bowel disease: Current and new perspectives. World J Gastroenterol. 2017 Aug 14;23(30):5469-5485 Authors: Guariso G, Gasparetto M Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gut characterised by alternating periods of remission and relapse. Whilst the mechanism underlying this disease is yet to be fully understood, old and newer generation treatments can only target selected pathways of this complex inflammatory process. This narrative review aims to provide an update on the most recent advances in treatment of paediatric IBD. A…

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Crohn’s disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil.

Related Articles Crohn’s disease environmental factors in the developing world: A case-control study in a statewide catchment area in Brazil. World J Gastroenterol. 2017 Aug 14;23(30):5549-5556 Authors: Salgado VCL, Luiz RR, Boechat N, Schorr BC, Leão IS, Nunes T, Zaltman C Abstract AIM: To identify environmental risk factors associated with the development of Crohn’s disease (CD) in order to re-assess the hygiene hypothesis. METHODS: A hospital-based, case-control study was carried out with CD patients (n = 145) and controls (n = 163) representing a socioeconomically diverse statewide catchment area in…

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Expression of Interleukin-26 is upregulated in inflammatory bowel disease.

Related Articles Expression of Interleukin-26 is upregulated in inflammatory bowel disease. World J Gastroenterol. 2017 Aug 14;23(30):5519-5529 Authors: Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A Abstract AIM: To investigate interleukin (IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and the function of IL-26. METHODS: Human colonic subepithelial myofibroblasts (SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The…

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Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission.

Related Articles Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission. World J Gastroenterol. 2017 Aug 07;23(29):5356-5363 Authors: Głąbska D, Guzek D, Grudzińska D, Lech G Abstract AIM: To analyse the association between isoflavone intake and ulcerative colitis motility symptoms in individuals in remission. METHODS: Cross-sectional study was conducted in a group of ulcerative colitis remission individuals, in sub-groups characterised by various intestinal motility and functioning characteristics (abdominal pain, flatulence, constipations, tenesmus). Total of 56 individuals with ulcerative colitis in remission (19 males and 37…

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MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients.

Related Articles MicroRNA exhibit altered expression in the inflamed colonic mucosa of ulcerative colitis patients. World J Gastroenterol. 2017 Aug 07;23(29):5324-5332 Authors: Valmiki S, Ahuja V, Paul J Abstract AIM: To investigate the miRNA expression in colonic mucosal biopsies from endoscopically inflamed and non inflamed regions of ulcerative colitis (UC) patients. METHODS: Colonic mucosal pinch biopsies were analyzed from the inflamed and non inflamed regions of same UC patient. Total RNA was isolated and differential miRNA profiling was done using microarray platform. Quantitative Real Time PCR was performed in colonic…

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Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease.

Related Articles Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease. World J Gastroenterol. 2017 Aug 07;23(29):5405-5411 Authors: Fu N, Jacobson K, Round A, Evans K, Qian H, Bressler B Abstract AIM: To evaluated the differences in knowledge, adherence, attitudes, and beliefs about medicine in adolescents with inflammatory bowel disease (IBD) attending transition clinics. METHODS: We prospectively enrolled patients from July 2012 to June 2013. All adolescents who attended a tertiary-centre-based dedicated IBD transition clinic were invited to participate. Adolescent controls…

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Elaboration and validation of Crohn’s disease anoperineal lesions consensual definitions.

Related Articles Elaboration and validation of Crohn’s disease anoperineal lesions consensual definitions. World J Gastroenterol. 2017 Aug 07;23(29):5371-5378 Authors: Horaist C, de Parades V, Abramowitz L, Benfredj P, Bonnaud G, Bouchard D, Fathallah N, Sénéjoux A, Siproudhis L, Staumont G, Viguier M, Marteau P Abstract AIM: To establish consensual definitions of anoperineal lesions of Crohn’s (APLOC) disease and assess interobserver agreement on their diagnosis between experts. METHODS: A database of digitally recorded pictures of APLOC was examined by a coordinating group who selected two series of 20 pictures illustrating the…

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