Ileal-anal pouches: A review of its history, indications, and complications.

Ileal-anal pouches: A review of its history, indications, and complications. World J Gastroenterol. 2019 Aug 21;25(31):4320-4342 Authors: Ng KS, Gonsalves SJ, Sagar PM Abstract The ileal pouch anal anastomosis (IPAA) has revolutionised the surgical management of ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Despite refinement in surgical technique(s) and patient selection, IPAA can be associated with significant morbidity. As the IPAA celebrated its 40th anniversary in 2018, this review provides a timely outline of its history, indications, and complications. IPAA has undergone significant modification since 1978. For both UC…

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Ustekinumab: “Real-world” outcomes and potential predictors of nonresponse in treatment-refractory Crohn’s disease.

Ustekinumab: “Real-world” outcomes and potential predictors of nonresponse in treatment-refractory Crohn’s disease. World J Gastroenterol. 2019 Aug 21;25(31):4481-4492 Authors: Hoffmann P, Krisam J, Wehling C, Kloeters-Plachky P, Leopold Y, Belling N, Gauss A Abstract BACKGROUND: Ustekinumab was approved in Europe for the treatment of adults with moderate to severe Crohn’s disease (CD) in 2016, and there is an urgent need for data on its everyday use. AIM: To obtain data on the daily use of ustekinumab. METHODS: This is a retrospective monocentric study. Patients with moderate to severe CD who…

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Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment.

Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment. World J Gastroenterol. 2019 Aug 21;25(31):4414-4426 Authors: Barros LL, Farias AQ, Rezaie A Abstract Inflammatory bowel diseases (IBD), Crohn`s disease and ulcerative colitis, are chronic conditions associated with high morbidity and healthcare costs. The natural history of IBD is variable and marked by alternating periods of flare and remission. Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing, a great proportion of IBD patients remain symptomatic despite…

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Impact of pediatric inflammatory bowel disease diagnosis on exercise and sports participation: Patient and parent perspectives.

Impact of pediatric inflammatory bowel disease diagnosis on exercise and sports participation: Patient and parent perspectives. World J Gastroenterol. 2019 Aug 21;25(31):4493-4501 Authors: Marchioni Beery RM, Li E, Fishman LN Abstract BACKGROUND: Inflammatory bowel disease (IBD) may limit physical activity due to intestinal or extraintestinal manifestations, fatigue, or exercise perception. We sought to evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population. We compared patient-reported and parent-reported perspectives. AIM: To evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric…

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Layered enhancement at magnetic resonance enterography in inflammatory bowel disease: A meta-analysis.

Layered enhancement at magnetic resonance enterography in inflammatory bowel disease: A meta-analysis. World J Gastroenterol. 2019 Aug 21;25(31):4555-4566 Authors: Bellini D, Rivosecchi F, Panvini N, Rengo M, Caruso D, Carbone I, Ferrari R, Paolantonio P, Laghi A Abstract BACKGROUND: Documentation of disease activity in patients affected by Crohn’s disease (CD) is mandatory in order to manage patients properly. Magnetic resonance imaging (MRI) is considered the reference cross-sectional technique for the assessment of CD activity. Among MRI findings, layered pattern (LP) of contrast enhancement seems to be one of the most…

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Small bowel capsule endoscopy and treat-to-target in Crohn’s disease: A systematic review.

Small bowel capsule endoscopy and treat-to-target in Crohn’s disease: A systematic review. World J Gastroenterol. 2019 Aug 21;25(31):4534-4554 Authors: Le Berre C, Trang-Poisson C, Bourreille A Abstract BACKGROUND: Crohn’s disease (CD) can affect the entire gastrointestinal tract. Proximal small bowel (SB) lesions are associated with a significant risk of stricturing disease and multiple abdominal surgeries. The assessment of SB in patients with CD is therefore necessary because it may have a significant impact on prognosis with potential therapeutic implications. Because of the weak correlation that exists between symptoms and endoscopic…

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Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases.

Related Articles Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases. World J Gastroenterol. 2019 Aug 14;25(30):4074-4091 Authors: Yeh MM, Bosch DE, Daoud SS Abstract Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine). In liver, HNF4α is best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function. Dysregulation of HNF4α expression has been associated with…

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Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases.

Related Articles Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases. World J Gastroenterol. 2019 Aug 14;25(30):4125-4147 Authors: Yoo JH, Donowitz M Abstract The introduction of biologics such as anti-tumor necrosis factor (TNF) monoclonal antibodies followed by anti-integrins has dramatically changed the therapeutic paradigm of inflammatory bowel diseases (IBD). Furthermore, a newly developed anti-p40 subunit of interleukin (IL)-12 and IL-23 (ustekinumab) has been recently approved in the United States for patients with moderate to severe Crohn’s disease who have failed treatment with anti-TNFs. However, these immunosuppressive therapeutics…

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G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis.

Related Articles G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis. World J Gastroenterol. 2019 Aug 14;25(30):4092-4104 Authors: Jacenik D, Beswick EJ, Krajewska WM, Prossnitz ER Abstract Estrogens play important roles in the development and progression of multiple tumor types. Accumulating evidence points to the significance of estrogen action not only in tumors of hormonally regulated tissues such as the breast, endometrium and ovary, but also in the development of colorectal cancer (CRC). The effects of estrogens in physiological and pathophysiological conditions are mediated by the nuclear estrogen…

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Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape.

Related Articles Elderly patients with inflammatory bowel disease: Updated review of the therapeutic landscape. World J Gastroenterol. 2019 Aug 14;25(30):4158-4171 Authors: LeBlanc JF, Wiseman D, Lakatos PL, Bessissow T Abstract High-quality data remains scarce in terms of optimal management strategies in the elderly inflammatory bowel disease (IBD) population. Indeed, available trials have been mostly retrospective, of small sample size, likely owing to under-representation of such a population in the major randomized controlled trials. However, in the last five years, there has been a steady increase in the number of published…

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