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Role of capsule endoscopy in suspected celiac disease: A European multi-centre study.

Related Articles Role of capsule endoscopy in suspected celiac disease: A European multi-centre study. World J Gastroenterol. 2017 Jan 28;23(4):703-711 Authors: Luján-Sanchis M, Pérez-Cuadrado-Robles E, García-Lledó J, Juanmartiñena Fernández JF, Elli L, Jiménez-García VA, Egea-Valenzuela J, Valle-Muñoz J, Carretero-Ribón C, Fernández-Urién-Sainz I, López-Higueras A, Alonso-Lázaro N, Sanjuan-Acosta M, Sánchez-Ceballos F, Rosa B, González-Vázquez S, Branchi F, Ruano-Díaz L, Prieto-de-Frías C, Pons-Beltrán V, Borque-Barrera P, González-Suárez B, Xavier S, Argüelles-Arias F, Herrerías-Gutiérrez JM, Pérez-Cuadrado-Martínez E, Sempere-García-Argüelles J Abstract AIM: To analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of…

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Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.

Related Articles Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective. World J Gastroenterol. 2017 Jan 28;23(4):638-645 Authors: Pallav K, Riche D, May WL, Sanchez P, Gupta NK Abstract AIM: To identify the predictors of vitamin D deficiency in patients with and without inflammatory bowel disease (IBD). METHODS: Patients with ulcerative colitis (UC) or Crohn’s disease (CD) related diagnostic codes who received medical care at University of Mississippi Medical Center between July 2012 and 2015 were identified. After thorough chart review, we identified patients with…

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α2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease.

Related Articles α2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease. World J Gastroenterol. 2017 Jan 21;23(3):437-446 Authors: Manolakis AC, Christodoulidis G, Kapsoritakis AN, Georgoulias P, Tiaka EK, Oikonomou K, Valotassiou VJ, Potamianos SP Abstract AIM: To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein (AHSG/fetuin A) and potential associations with disease and patient characteristics. METHODS: AHSG serum levels were determined in treatment-naïve newly-diagnosed patients, 96 with ulcerative colitis (UC), 84 with Crohn’s disease (CD), 62 with diarrhea-predominant or mixed irritable bowel syndrome (IBS,…

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Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease.

Related Articles Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease. World J Gastroenterol. 2017 Jan 21;23(3):414-425 Authors: Tighe D, McNamara D Abstract Despite improvement in outcomes, loss of response (LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical…

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Efficacy and safety of stellate ganglion block in chronic ulcerative colitis.

Related Articles Efficacy and safety of stellate ganglion block in chronic ulcerative colitis. World J Gastroenterol. 2017 Jan 21;23(3):533-539 Authors: Zhao HY, Yang GT, Sun NN, Kong Y, Liu YF Abstract AIM: To investigate the efficacy and safety of stellate ganglion block for the treatment of patients with chronic ulcerative colitis. METHODS: A total of 120 randomly selected patients with chronic ulcerative colitis treated in Cangzhou Central Hospital from January 2014 to January 2016 were included in this study. These patients were divided into two groups: control group (n =…

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Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease.

Related Articles Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease. World J Gastroenterol. 2017 Jan 21;23(3):472-477 Authors: Kristo I, Riss S, Argeny S, Maschke S, Chitsabesan P, Stift A Abstract AIM: To evaluate frequency and clinical course of incidental adenocarcinoma in patients with stricturing Crohn’s disease (CD). METHODS: In this study, consecutive patients, who were operated on for stricturing CD between 1997-2012, were included at an academic tertiary referral center. Demographic data and clinical course were obtained by an institutional database and individual chart review. Besides baseline characteristics,…

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IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis.

Related Articles IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis. World J Gastroenterol. 2017 Jan 21;23(3):447-454 Authors: Fischer S, Kövesdi E, Magyari L, Csöngei V, Hadzsiev K, Melegh B, Hegyi P, Sarlós P Abstract AIM: To investigate the association of seven single nucleotide polymorphisms (SNPs) of the IL23R gene with the clinical picture of ulcerative colitis (UC). METHODS: Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of…

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SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging.

Related Articles SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging. World J Gastroenterol. 2017 Jan 14;23(2):216-223 Authors: Marion-Letellier R, Bohn P, Modzelewski R, Vera P, Aziz M, Guérin C, Savoye G, Savoye-Collet C Abstract AIM: To assess the feasibility of SPECT-computed tomography (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory characteristics. METHODS: Colitis was induced in Sprague-Dawley rats by intrarectal injection of TNBS (n = 10) while controls received vehicle (n = 10). SPECT-CT with intravenous injection…

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Biosimilars in inflammatory bowel disease: A review of post-marketing experience.

Related Articles Biosimilars in inflammatory bowel disease: A review of post-marketing experience. World J Gastroenterol. 2017 Jan 14;23(2):197-203 Authors: Deiana S, Gabbani T, Annese V Abstract Biologic compounds are obtained from living organisms or cell cultures by means of biotechnology methods. A similar biologic drug, commonly called biosimilar, is a product copied by a native approved biologic drug whose license has expired. Biosimilar drugs usually are marketed at a lower price and provide important financial savings for public healthcare systems. Some differences between biosimilars and original biologic drugs might exist…

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Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice.

Related Articles Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice. World J Gastroenterol. 2017 Jan 14;23(2):242-255 Authors: Zheng XY, Lv YF, Li S, Li Q, Zhang QN, Zhang XT, Hao ZM Abstract AIM: To investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic administration. METHODS: AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons. Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS)…

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