Role of Fecal Microbiota Transplantation for Maintenance of Remission in Patients with Ulcerative Colitis: A Pilot Study.

Related Articles Role of Fecal Microbiota Transplantation for Maintenance of Remission in Patients with Ulcerative Colitis: A Pilot Study. J Crohns Colitis. 2019 Mar 11;: Authors: Sood A, Mahajan R, Singh A, Midha V, Mehta V, Narang V, Singh T, Pannu AS Abstract OBJECTIVES: To study the role of fecal microbiota transplantation (FMT) in maintenance of remission in ulcerative colitis (UC). METHODS: In this pilot study, patients with UC in clinical remission after multi-session FMT were randomly allocated to either maintenance FMT or placebo colonoscopic infusion every 8 weeks, for…

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Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis.

Related Articles Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis. Gut. 2019 Mar 14;: Authors: Liao L, Schneider KM, Galvez EJC, Frissen M, Marschall HU, Su H, Hatting M, Wahlström A, Haybaeck J, Puchas P, Mohs A, Peng J, Bergheim I, Nier A, Hennings J, Reißing J, Zimmermann HW, Longerich T, Strowig T, Liedtke C, Cubero FJ, Trautwein C Abstract OBJECTIVE: There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal…

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A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn’s Disease Flares.

Related Articles A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn’s Disease Flares. Gastroenterology. 2019 Mar 11;: Authors: Albenberg L, Brensinger CM, Wu Q, Gilroy E, Kappelman MD, Sandler RS, Lewis JD Abstract BACKGROUND & AIMS: Diet may be an important factor in progression of Crohn’s disease (CD). We performed a randomized controlled trial to determine whether reduced consumption of red and processed meats decreases the risk of symptomatic relapse of CD, analyzing results from the Food and Crohn’s Disease Exacerbation Study (FACES) trial. METHODS:…

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Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease.

Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease. Dig Dis Sci. 2019 Mar 14;: Authors: Paredes JM, Moreno N, Latorre P, Ripollés T, Martinez MJ, Vizuete J, Moreno-Osset E Abstract AIM: To assess the clinical benefits of transmural healing (TH) shown on intestinal ultrasound (IUS) after treatment with tumor necrosis factor-alpha antibodies (anti-TNF) in patients with Crohn’s disease. MATERIALS AND METHODS: This prospective study included consecutively 36 patients who underwent IUS in the week prior to start anti-TNF treatment, at 12 weeks, and 1 year…

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Risk of malignant cancers in inflammatory bowel disease.

Risk of malignant cancers in inflammatory bowel disease. J Crohns Colitis. 2019 Mar 15;: Authors: Loo SY, Vutcovici M, Bitton A, Lakatos PL, Azoulay L, Suissa S, Brassard P Abstract OBJECTIVES: To explore the trends and the predictors of incident malignant cancer among patients with inflammatory bowel disease (IBD). METHODS: We identified a cohort of all patients with incident IBD in Quebec, Canada, from 1998 to 2015, using provincial administrative healthcare databases (RAMQ and Med-Echo). Annual incidence rates (IRs) of cancer were calculated using Poisson regression and were compared to…

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Shall Patients With a History of Inflammatory Bowel Disease-Related Surgery Be Excluded in the Assessment of Sexual Function?

Shall Patients With a History of Inflammatory Bowel Disease-Related Surgery Be Excluded in the Assessment of Sexual Function? Inflamm Bowel Dis. 2019 Mar 15;: Authors: Li Y, Liu X Abstract Surgical treatment is not rare for patients with IBD. Currently, surgery seems to have a protective effect on sexual function. Thus, exclusion of those treated with IBD related surgery may affect conclusions. PMID: 30874291 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30874291?dopt=Abstract

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Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis.

Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2019 Mar 14;25(4):672-678 Authors: Jaruvongvanich V, Poonsombudlert K, Ungprasert P Abstract BACKGROUND: The association between smoking and inflammatory bowel disease has long been recognized, but its role in the development of microscopic colitis is less well defined. This systematic review and meta-analysis was conducted with the aims to identify all available studies on the association between smoking and risk of microscopic colitis and to synthesize their results. METHODS: The MEDLINE and EMBASE databases were searched from…

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Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review.

Related Articles Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review. World J Gastroenterol. 2019 Mar 07;25(9):1142-1157 Authors: Damião AOMC, de Azevedo MFC, Carlos AS, Wada MY, Silva TVM, Feitosa FC Abstract BACKGROUND: Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease (MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes. AIM: To investigate the effectiveness of conventional therapy…

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The Efficacy of Split-Dose Bowel Preparations for Polyp Detection: A Systematic Review and Meta-Analysis.

The Efficacy of Split-Dose Bowel Preparations for Polyp Detection: A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2019 Mar 11;: Authors: Zawaly K, Rumbolt C, Abou-Setta AM, Neilson C, Rabbani R, Zarychanski R, Singh H Abstract INTRODUCTION: Split-dose bowel preparation leads to superior colon cleansing for colonoscopy. However, the magnitude of benefit in detecting colonic polyps is uncertain. We performed a systematic review to synthesize the data on whether using a split-dose bowel preparation regimen improves the detection of polyps when compared with other dosing methods or regimen products. METHODS:…

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Systematic review with meta-analysis: risk of post-operative complications associated with pre-operative exposure to anti-tumour necrosis factor agents for Crohn’s disease.

Related Articles Systematic review with meta-analysis: risk of post-operative complications associated with pre-operative exposure to anti-tumour necrosis factor agents for Crohn’s disease. Aliment Pharmacol Ther. 2019 Mar 12;: Authors: Lin YS, Cheng SW, Wang YH, Chen KH, Fang CJ, Chen C Abstract BACKGROUND: Post-operative complications after anti-tumour necrosis agent treatment for Crohn’s disease (CD) have been analysed with conflicting results. AIM: To assess the effects of pre-operative anti-tumour necrosis factor (TNF) therapy on post-operative complications within 30 days post-operatively in patients with CD undergoing abdominal surgery. METHODS: Systematic review with meta-analysis…

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