Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials.

Efficacy of adjuvant curcumin therapy in ulcerative colitis: A meta-analysis of randomized controlled trials. J Gastroenterol Hepatol. 2019 Nov 07;: Authors: Zheng T, Wang X, Chen Z, He A, Zheng Z, Liu G Abstract BACKGROUND AND AIM: Aminosalicylic acids are recognized to be the first-line treatment options for ulcerative colitis. Currently, the effectiveness of curcumin as an adjuvant treatment in ulcerative colitis has been investigated, which was still controversial. This study aimed to systematically review and meta-analyze the efficacy and safety of curcumin as an adjuvant treatment in ulcerative colitis.…

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Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease.

Related Articles Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease. J Gastroenterol Hepatol. 2019 Oct 31;: Authors: Park SH, Hwang SW, Ye BD, Noh S, Park JC, Kim JY, Kim J, Ham NS, Oh EH, Yang DH, Byeon JS, Myung SJ, Yang SK Abstract BACKGROUND AND AIMS: The phenotypic concordance among familial cases of inflammatory bowel disease (IBD) has been rarely reported. Thus, the present study aimed to evaluate the concordance regarding disease type and phenotypic features in a large cohort of Korean patients…

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MAGNETIC RESONANCE ENTEROGRAPHY (MRE) FOR PREDICTING THE CLINICAL COURSE OF CROHN’S DISEASE STRICTURES.

Related Articles MAGNETIC RESONANCE ENTEROGRAPHY (MRE) FOR PREDICTING THE CLINICAL COURSE OF CROHN’S DISEASE STRICTURES. J Gastroenterol Hepatol. 2019 Oct 31;: Authors: Schulberg JD, Wright EK, Holt BA, Sutherland TR, Hume SJ, Hamilton AL, Ross AL, Connell WC, Brown SJ, Lust M, Miller AM, Bell SJ, Kamm MA Abstract Background and aims Strictures are the commonest Crohn’s disease complication but their natural history is unknown. This study aimed to characterise inflammation, predict prognosis, and understand the impact of drug therapy using Magnetic Resonance Enterography (MRE). METHODS: Patients with a stricture…

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The epidemiology of inflammatory bowel disease: East meets West.

The epidemiology of inflammatory bowel disease: East meets West. J Gastroenterol Hepatol. 2019 Oct 09;: Authors: Mak WY, Zhao M, Ng SC, Burisch J Abstract BACKGROUND: The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. Exploring East versus West differences in the epidemiology of IBD could enhance our understanding of the multifactorial nature and heterogeneity of the disease. In this narrative review, we aim to compare the epidemiology of IBD between eastern and western countries by summarizing evidence from…

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Clinical Significance of Granulomas in Crohn’s Disease: A Systematic Review and Meta-analysis.

Clinical Significance of Granulomas in Crohn’s Disease: A Systematic Review and Meta-analysis. J Gastroenterol Hepatol. 2019 Sep 14;: Authors: Hong SW, Yoon H, Shin CM, Park YS, Kim N, Lee DH, Kim JS Abstract BACKGROUND AND AIM: Epithelioid granuloma is one hallmark used to histologically diagnose Crohn’s disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas. METHODS: A literature search in PubMed, EMBASE, and Cochrane databases was performed on…

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Nationwide Validation Study of Diagnostic Algorithms for Inflammatory Bowel Disease in Korean National Health Insurance Service Database.

Nationwide Validation Study of Diagnostic Algorithms for Inflammatory Bowel Disease in Korean National Health Insurance Service Database. J Gastroenterol Hepatol. 2019 Sep 09;: Authors: Lee CK, Ha HJ, Oh SJ, Kim JW, Lee JK, Kim HS, Yoon SM, Kang SB, Kim ES, Kim TO, Na SY, Lee J, Kim SW, Koo HS, Park BK, Lee HH, Kim ES, Park JJ, Kwak MS, Cha JM, Ye BD, Choi CH, Kim HJ Abstract BACKGROUND/AIMS: We conducted a nationwide validation study of diagnostic algorithms to identify cases of inflammatory bowel disease (IBD) within…

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Increased Risk of Idiopathic Pulmonary Fibrosis in Inflammatory Bowel Disease: A Nationwide Study.

Related Articles Increased Risk of Idiopathic Pulmonary Fibrosis in Inflammatory Bowel Disease: A Nationwide Study. J Gastroenterol Hepatol. 2019 Aug 16;: Authors: Kim J, Chun J, Lee C, Han K, Choi S, Lee J, Soh H, Choi K, Park S, Kang EA, Lee HJ, Im JP, Kim JS Abstract BACKGROUND AND AIM: The relationship between inflammatory bowel disease (IBD) and idiopathic pulmonary fibrosis (IPF) remains unclear. We evaluated the risk for developing IPF in patients with IBD using a nationwide, population-based study. METHODS: Using claims data from the National Health…

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Infliximab for Very Early-Onset Inflammatory Bowel Disease: A Tertiary Center Experience in Japan.

Infliximab for Very Early-Onset Inflammatory Bowel Disease: A Tertiary Center Experience in Japan. J Gastroenterol Hepatol. 2019 Aug 19;: Authors: Takeuchi I, Kaburaki Y, Arai K, Shimizu H, Hirano Y, Nagata S, Shimizu T Abstract BACKGROUND AND AIM: Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed before six years of age, tends to be refractory to conventional treatment for IBD. However, there have been a few reports about the usage of infliximab for VEO-IBD. This study aimed to evaluate the efficacy and safety of infliximab for VEO-IBD. METHODS:…

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The Incidence and Risk Factors of Pneumocystis jirovecii Pneumonia in Korean Patients with Inflammatory Bowel Disease.

The Incidence and Risk Factors of Pneumocystis jirovecii Pneumonia in Korean Patients with Inflammatory Bowel Disease. J Gastroenterol Hepatol. 2019 Aug 14;: Authors: Nam K, Park SH, Lee J, Jo S, Kim SO, Noh S, Park JC, Kim JY, Kim J, Ham NS, Oh EH, Song EM, Hwang SW, Yang DH, Ye BD, Byeon JS, Myung SJ, Yang SK Abstract BACKGROUND AND AIM: Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We,…

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Acceptability, Tolerability and Safety of Faecal Microbiota Transplantation in patients with active Ulcerative Colitis (AT&S Study).

Acceptability, Tolerability and Safety of Faecal Microbiota Transplantation in patients with active Ulcerative Colitis (AT&S Study). J Gastroenterol Hepatol. 2019 Aug 13;: Authors: Sood A, Singh A, Mahajan R, Midha V, Mehta V, Gupta YK, Narang V, Kaur K Abstract BACKGROUND: Faecal microbiota transplantation (FMT) targets gut microbiome dysbiosis and is an emerging therapy for ulcerative colitis (UC). Though initial results with FMT in patients with active UC are encouraging, data regarding its acceptability, tolerability and safety are scant. METHODS: A retrospective analysis of patients with active UC (Mayo clinic…

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