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Influence of Age at Diagnosis on the Clinical Characteristics of Crohn’s Disease in Korea: Results from the CONNECT study.

Related Articles Influence of Age at Diagnosis on the Clinical Characteristics of Crohn’s Disease in Korea: Results from the CONNECT study. J Gastroenterol Hepatol. 2017 Mar 02;: Authors: Hwang SW, Kim JH, Im JP, Ye BD, Koo HS, Huh KC, Cheon JH, Kim YS, Kim YH, Han DS, Kim WH, Kim JS, Crohn’s disease clinical network and cohort (CONNECT) study Abstract BACKGROUND AND AIM: The present study evaluated the clinical characteristics of Korean patients with Crohn’s disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study….

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Gluten-induced cognitive impairment (“brain fog”) in coeliac disease.

Gluten-induced cognitive impairment (“brain fog”) in coeliac disease. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:90-93 Authors: Yelland GW Abstract Much is known about the serious neurological effects of gluten ingestion in coeliac disease patients, such as sporadic ataxia and peripheral neuropathy, although the causal links to gluten are still under debate. However, such disorders are observed in only a small percentage of coeliac patients. Much less is known about the transient cognitive impairments to memory, attention, executive function, and the speed of cognitive processing reported by the majority of patients…

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Use of the low-FODMAP diet in inflammatory bowel disease.

Use of the low-FODMAP diet in inflammatory bowel disease. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:40-42 Authors: Gibson PR Abstract Irritable bowel syndrome (IBS)-like symptoms are not uncommon in patients with quiescent inflammatory bowel disease (IBD). While gluten-free diet is applied by patients, there are no reported interventional studies. The low-FODMAP diet, on the other hand, has efficacy similar to that seen in patients with IBS in three unblinded or observational studies of IBD cohorts who had well-controlled inflammatory disease and in one small randomized cross-over study. FODMAP intake by…

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Using eHealth strategies in delivering dietary and other therapies in patients with irritable bowel syndrome and inflammatory bowel disease.

Using eHealth strategies in delivering dietary and other therapies in patients with irritable bowel syndrome and inflammatory bowel disease. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:27-31 Authors: Ankersen DV, Carlsen K, Marker D, Munkholm P, Burisch J Abstract Health-care systems around the world are facing increasing costs. Non-adherent, chronically ill patients are one such expense incurred by health-care providers. Web-based home-monitoring of patients-or eHealth-has been shown to increase adherence to medical therapy, facilitate contact between patients and health-care professionals, and reduce time to remission for patients with inflammatory bowel disease…

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Prebiotic inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders.

Prebiotic inulin-type fructans and galacto-oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:64-68 Authors: Wilson B, Whelan K Abstract Prebiotics are non-digestible selectively fermented dietary fibers that specifically promote the growth of one or more bacterial genera in the gastrointestinal tract and thus provide health benefit to the host. The two most investigated prebiotics being the inulin-type fructans and galacto-oligosaccharides. Prebiotic specificity is mediated through species-specific gene clusters within saccharolytic bacteria controlled by signaling sensors for various substrates. Prebiotic health benefits are attributed…

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Variations in Primary Sclerosing Cholangitis Across the Age Spectrum.

Variations in Primary Sclerosing Cholangitis Across the Age Spectrum. J Gastroenterol Hepatol. 2017 Feb 28;: Authors: Eaton JE, McCauley BM, Atkinson EJ, Juran BD, Schlicht EM, de Andrade M, Lazaridis KN Abstract BACKGROUND & AIM: Primary sclerosing cholangitis (PSC) typically develops in middle-age adults. Little is known about phenotypic differences when PSC is diagnosed at various ages. Therefore, we sought to compare the clinical characteristics of a large PSC cohort based on the age when PSC was diagnosed. METHODS: We performed a multicenter retrospective review to compare the features of…

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Evaluating clinical, dietary and psychological risk factors for relapse of ulcerative colitis in clinical, endoscopic and histological remission.

Evaluating clinical, dietary and psychological risk factors for relapse of ulcerative colitis in clinical, endoscopic and histological remission. J Gastroenterol Hepatol. 2017 Feb 21;: Authors: Dhingra R, Kedia S, Venigalla PM, Kumar S, Singh N, Bopanna S, Singla V, Choudhury BN, Verma P, Tiwari V, Datta Gupta S, Makharia G, Ahuja V Abstract BACKGROUND: The literature on possible factors that could trigger a relapse in patients with ulcerative colitis (UC) in clinical, endoscopic and histological remission on long term follow up is scarce. AIM: To determine the relapse rate in…

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ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis.

ATP-binding cassette subfamily B member 1 1236C/T polymorphism significantly affects the therapeutic outcome of tacrolimus in patients with refractory ulcerative colitis. J Gastroenterol Hepatol. 2017 Jan 30;: Authors: Onodera M, Endo K, Kakuta Y, Kuroha M, Kimura T, Hiramoto K, Kanazawa Y, Negoro K, Shiga H, Kinouchi Y, Shimosegawa T Abstract BACKGROUND AND AIM: Tacrolimus is now considered to be one of the main therapeutic options for refractory ulcerative colitis. Both cytochrome P-450 3A5 (CYP3A5) and ATP-binding cassette subfamily B member 1 (ABCB1) associated with tacrolimus metabolism are known to…

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Granulomas in mesenteric lymph nodes in Crohn’s disease patients with ileocolic resection are areassociated with younger age and transmural inflammation.

Granulomas in mesenteric lymph nodes in Crohn’s disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. J Gastroenterol Hepatol. 2017 Jan 14;: Authors: Sun X, Yuan L, Li Y, Shen B, Xie H, Liu X Abstract BACKGROUND & AIMS: Mesenteric lymph nodes were usually removed during bowel resection surgery for Crohn’s disease (CD). Mesenteric lymph node (MLN) granuloma predicted postoperative disease recurrence in patients with CD after ileocolic resection (ICR). This study was aimed to identify factors associated with MLN granulomas in a cohort of CD…

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Crosstalk Between Intestinal Epithelial Cell and Adaptive Immune Cell in Intestinal Mucosal Immunity.

Crosstalk Between Intestinal Epithelial Cell and Adaptive Immune Cell in Intestinal Mucosal Immunity. J Gastroenterol Hepatol. 2017 Jan 10;: Authors: Lu JT, Xu AT, Shen J, Ran ZH Abstract Constantly challenged by luminal bacteria, intestinal epithelium forms both a physical and biochemical defense against pathogens. Besides, intestinal epithelium senses dynamic and continuous changes in luminal environment and transmits signals to subjacent immune cells accordingly. It has been long accepted that adaptive immune cells fulfill their roles partly by modulating function of intestinal epithelial cells. Recent studies have brought up the…

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