Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress.

Related Articles Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress. J Gastroenterol Hepatol. 2018 Jun 22;: Authors: Kim DH, Kim S, Lee JH, Kim JH, Che X, Ma HW, Seo DH, Kim TI, Kim WH, Kim SW, Cheon JH Abstract BACKGROUND AND AIM: Nuclear factor kappa B (NF-κB) activation and endoplasmic reticulum (ER) stress signaling play significant roles in the pathogenesis of inflammatory bowel disease (IBD). Thus, we evaluated whether new therapeutic probiotics have anti-colitic effects and we investigated their mechanisms related to NF-κB and ER-stress pathways. METHODS:…

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Uric Acid Metabolism Was Altered In Isolated Colonic Crohn’s Disease But Not Ulcerative Colitis.

Uric Acid Metabolism Was Altered In Isolated Colonic Crohn’s Disease But Not Ulcerative Colitis. J Gastroenterol Hepatol. 2018 Jun 21;: Authors: Zhu F, Feng D, Zhang T, Gu L, Zhu W, Guo Z, Li Y, Lu N, Gong J, Li N Abstract BACKGROUND: Patients with inflammatory bowel disease (IBD) have higher incidence of developing nephrolithiasis. Increased uric acid production induced by Saccharomyces cerevisiae exacerbates colitis in mice. We aimed to evaluate the association between serum uric acid level and disease activity in IBD population. METHODS: Four hundred and thirty-five patients…

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Fecal calprotectin predicts disease activity of Crohn’s disease evaluated by balloon-assisted endoscopy.

Fecal calprotectin predicts disease activity of Crohn’s disease evaluated by balloon-assisted endoscopy. J Gastroenterol Hepatol. 2018 Jun 11;: Authors: Iwamoto F, Matsuoka K, Motobayashi M, Takenaka K, Kuno T, Tanaka K, Tsukui Y, Kobayashi S, Yoshida T, Fujii T, Saito E, Yamaguchi T, Nagahori M, Sato T, Ohtsuka K, Enomoto N, Watanabe M Abstract BACKGROUND AND AIM: Fecal calprotectin (FC) is a useful marker for assessing the activity of intestinal inflammation. However, most studies have used ileocolonoscopy to evaluate the association of FC with intestinal inflammation and it is not…

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Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis.

Related Articles Investigation of novel biomarkers for predicting the clinical course in patients with ulcerative colitis. J Gastroenterol Hepatol. 2018 Jun 05;: Authors: Hamanaka S, Nakagawa T, Hiwasa T, Ohta Y, Kasamatsu S, Ishigami H, Taida T, Okimoto K, Saito K, Maruoka D, Matsumura T, Takizawa H, Kashiwado K, Kobayashi S, Matsushita K, Matsubara H, Katsuno T, Arai M, Kato N Abstract BACKGROUND: The clinical course of ulcerative colitis (UC) is characterized by repeated episodes of relapse and remission. We hypothesized that biomarkers that help distinguish refractory UC patients who…

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Long-term course of inflammatory bowel disease after the Great East Japan Earthquake.

Related Articles Long-term course of inflammatory bowel disease after the Great East Japan Earthquake. J Gastroenterol Hepatol. 2018 May 23;: Authors: Miyazawa T, Shiga H, Kinouchi Y, Takahashi S, Tominaga G, Takahashi H, Takagi S, Obana N, Kikuchi T, Omori S, Sato Y, Takahashi S, Umemura K, Endo K, Kakuta Y, Matsuura M, Kimura T, Kuroha M, Shimosegawa T Abstract BACKGROUND AND AIM: This study analyzed inflammatory bowel disease activity for two years after the Great East Japan Earthquake. METHODS: We compared the relapse rates of patients with ulcerative colitis…

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Consensus and contentious statements on the use of probiotics in clinical practice: a South East Asian Gastro-neuro Motility Association Working Team Report.

Related Articles Consensus and contentious statements on the use of probiotics in clinical practice: a South East Asian Gastro-neuro Motility Association Working Team Report. J Gastroenterol Hepatol. 2018 Apr 26;: Authors: Gwee KA, Lee WW, Ling KL, Ooi CJ, Quak SH, Dan YY, Siah KT, Huang JG, Chua ASB, Hilmi IN, Raja Affendi RA, Ong C, Simadibrata M, Abdullah M, Sollano JD, Leelakusolvong S, Gonlachanvit S, Lee YY, Ricaforte-Campos JD, Yin YK, Chong KM, Wong CY Abstract The concept of consuming microorganisms in the treatment of a medical condition and…

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Clinical differences between elderly-onset and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan.

Clinical differences between elderly-onset and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan. J Gastroenterol Hepatol. 2018 Apr 18;: Authors: Komoto S, Higashiyama M, Watanabe C, Suzuki Y, Watanabe M, Hibi T, Takebayashi T, Asakura K, Nishiwaki Y, Miura S, Hokari R Abstract OBJECTIVE: Studies on the characteristics of elderly-onset ulcerative colitis (EOUC) and non-elderly-onset UC (NEOUC) have reported conflicting findings. The aim of this study was to compare disease characteristics of EOUC and NEOUC by analyzing the database of the Japanese nationwide inflammatory bowel disease (IBD) registry. STUDY…

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Predictors and clinical outcomes of follow-up loss in patients with inflammatory bowel disease.

Predictors and clinical outcomes of follow-up loss in patients with inflammatory bowel disease. J Gastroenterol Hepatol. 2018 Apr 17;: Authors: Woo DH, Kim KO, Kang MK, Lee SH, Jang BI, Kim TN Abstract BACKGROUND AND AIM: Nonadherence is a risk factor of disease worsening in inflammatory bowel disease (IBD). We analyzed the frequency, predictors, and clinical outcomes of patients with IBD who are lost to follow-up in outpatient clinics. METHODS: Medical records of 784 IBD patients visiting our IBD clinic between January 2010 and December 2015 were reviewed retrospectively. Overall,…

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Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease.

Related Articles Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease. J Gastroenterol Hepatol. 2018 Mar 30;: Authors: Naito T, Yokoyama N, Kakuta Y, Ueno K, Kawai Y, Onodera M, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Endo K, Nagasaki M, Masamune A, Kinouchi Y, Shimosegawa T Abstract BACKGROUND AND AIM: Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however,…

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