Increased enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn’s disease.

Increased enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn’s disease. J Gastroenterol Hepatol. 2017 Sep 05;: Authors: Li Y, Ge Y, Zhu W, Gong J, Cao L, Guo Z, Gu L, Li J Abstract BACKGROUND AND AIM: The enteric nervous system can amplify or modulate intestinal inflammation through secretion of neuropeptides, and enteric glial cells has been implicated in the pathophysiology of Crohn’s disease. The goal of the study was to search for an association between the density of neurons, neuropeptides, as well…

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Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn’s disease.

Efficacy of a concomitant elemental diet to reduce the loss of response to adalimumab in patients with intractable Crohn’s disease. J Gastroenterol Hepatol. 2017 Aug 30;: Authors: Sugita N, Watanabe K, Kamata N, Yukawa T, Otani K, Hosomi S, Nagami Y, Tanaka F, Taira K, Yamagami H, Tanigawa T, Shiba M, Watanabe T, Tominaga K, Kabata D, Shintani A, Arakawa T, Fujiwara Y Abstract BACKGROUND AND AIM: Secondary loss of response to adalimumab (ADA-LOR) commonly occurs in patients with Crohn’s disease (CD) treated with ADA. We evaluated the efficacy of…

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Thiopurines prevented surgical recurrence in patients with Crohn’s disease after intestinal resection: strategy based on risk stratification.

Related Articles Thiopurines prevented surgical recurrence in patients with Crohn’s disease after intestinal resection: strategy based on risk stratification. J Gastroenterol Hepatol. 2017 Aug 14;: Authors: Guo J, Chen BL, Chen ZH, Luo XP, Qiu Y, Zhang SH, Feng R, He Y, Zeng ZR, Song XM, Ben-Horin S, Mao R, Chen MH Abstract BACKGROUND: Thiopurines (TPs) are effective in reducing risk of clinical and endoscopic recurrence in postoperative patients with Crohn’s disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. AIM: To explore whether TPs could prevent…

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Limited uptake of ulcerative colitis ‘treat to target’ recommendations in real-world practice.

Limited uptake of ulcerative colitis ‘treat to target’ recommendations in real-world practice. J Gastroenterol Hepatol. 2017 Aug 14;: Authors: Bryant RV, Costello SP, Schoeman S, Sathananthan D, Knight E, Lau SY, Schoeman MN, Mountifield R, Tee D, Travis SPL, Andrews JM Abstract BACKGROUND & AIMS: A ‘Treat to Target’ (T2T) approach has been proposed for ulcerative colitis (UC), with a target of combined clinical and endoscopic remission. The aim of the study was evaluate the extent to which proposed targets are achieved in real-world care, along with clinician perceptions and…

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Predictors of long-term outcomes in patients with acute severe colitis: A Northern Indian cohort study.

Related Articles Predictors of long-term outcomes in patients with acute severe colitis: A Northern Indian cohort study. J Gastroenterol Hepatol. 2017 Aug 12;: Authors: Jain S, Kedia S, Sethi T, Bopanna S, Yadav DP, Goyal S, Padhan R, Venigalla PM, Sahni P, Dash NR, Pal S, Makharia G, Travis SPL, Ahuja V Abstract BACKGROUND AND AIM: Knowledge of long-term outcomes following an index episode of acute severe colitis (ASC) can help informed decision-making at a time of acute exacerbation especially when colectomy is an option. We aimed to identify long-term…

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Oral and upper gastrointestinal Crohn’s disease.

Oral and upper gastrointestinal Crohn’s disease. J Gastroenterol Hepatol. 2017 Jul 14;: Authors: Laube R, Liu K, Schifter M, Yang JL, Suen MK, Leong RW Abstract Crohn’s disease is a heterogeneous, inflammatory condition that can affect any location of the gastrointestinal tract. Proximal gastrointestinal involvement occurs in 0.5-16% of patients, and it is usually diagnosed after recognition of intestinal disease. Symptoms are often mild and non-specific, however upper gastrointestinal disease predicts a more severe Crohn’s phenotype with a greater frequency of complications such as obstruction and perforation. Gastroscopy and biopsy…

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Update on intestinal microbiota in Crohn’s disease 2017: Mechanisms, Clinical application, Adverse reactions and Outlook.

Update on intestinal microbiota in Crohn’s disease 2017: Mechanisms, Clinical application, Adverse reactions and Outlook. J Gastroenterol Hepatol. 2017 Jul 05;: Authors: Shen Z, Zhu C, Quan Y, Yuan W, Wu S, Yang Z, Luo W, Tan B, Wang X Abstract The pathogenesis of CD is complex and it is thought to be associated with the environment, immune, hereditary, microbe and other factors. If the balance between the host and the intestinal microbes in CD patients was broken, immune-inflammatory response of susceptible individuals might be triggered. Probiotics could improve the…

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Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Behçet’s disease.

Rediscover the clinical value of small intestinal bacterial overgrowth in patients with intestinal Behçet’s disease. J Gastroenterol Hepatol. 2017 Jun 30;: Authors: Jo JH, Park SJ, Cheon JH, Kim TI, Kim WH Abstract Background/Aims Many patients with intestinal Behçet’s disease (BD) still suffer from gastrointestinal symptoms despite the disease being in endoscopic or radiological remission. Previous studies report that small intestinal bacterial overgrowth (SIBO) can be associated with inflammatory bowel disease. However, there have been no reports about SIBO in patients with intestinal BD. We sought to identify the frequency…

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Examining maintenance care following infliximab salvage therapy for acute severe ulcerative colitis.

Examining maintenance care following infliximab salvage therapy for acute severe ulcerative colitis. J Gastroenterol Hepatol. 2017 Jun 15;: Authors: Seah D, Choy MC, Gorelik A, Connell WR, Sparrow MP, van Langenberg D, Hebbard G, Moore G, De Cruz P Abstract BACKGROUND AND AIMS: Data supporting the optimal maintenance drug therapy & strategy to monitor ongoing response following successful infliximab (IFX) induction, for acute severe ulcerative colitis (ASUC), are limited. We aimed to evaluate maintenance & monitoring strategies employed in patients post IFX induction therapy. METHODS: Patients in 6 Australian tertiary…

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