Impact of Aphthous Colitis at Diagnosis on Crohn’s Disease Outcomes.

Impact of Aphthous Colitis at Diagnosis on Crohn’s Disease Outcomes. J Crohns Colitis. 2019 Nov 21;: Authors: Delattre C, Lewis A, Kirchgesner J, Nion-Larmurier I, Bourrier A, Landman C, Le Gall G, Sokol H, Laurent B, Seksik P Abstract BACKGROUND: The natural history of intestinal lesions in Crohn’s disease [CD] is not fully understood. Although the extent of lesions at diagnosis usually defines the extent of the disease, some lesions seen at diagnosis, particularly aphthous ulcers [AUs], may resolve before follow-up. The aim of this study was to evaluate the…

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ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment.

ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. J Crohns Colitis. 2019 Nov 19;: Authors: Adamina M, Bonovas S, Raine T, Spinelli A, Warusavitarne J, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, Doherty G, El-Hussuna A, Ellul P, Fiorino G, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gisbert JP, Gomollon F, Lorenzo MG, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Kucharzik T, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G,…

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The Outcomes of Emergency Admissions with Ulcerative Colitis between 2007 and 2017 in England.

The Outcomes of Emergency Admissions with Ulcerative Colitis between 2007 and 2017 in England. J Crohns Colitis. 2019 Nov 12;: Authors: King D, Rees J, Mytton J, Harvey P, Thomas T, Cooney R, Patel P, Trudgill N Abstract BACKGROUND AND AIMS: Patients with Ulcerative Colitis (UC) may present as emergencies and require rapid escalation of therapy. This study aimed to assess the mortality, colectomy and readmission risk during and following a first emergency admission with UC. METHODS: Using Hospital Episode Statistics, subjects aged between 18-60 years, coded with a first…

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Autologous Exosome Transfer: A New Personalized Treatment Concept to Prevent Colitis in a Murine Model.

Autologous Exosome Transfer: A New Personalized Treatment Concept to Prevent Colitis in a Murine Model. J Crohns Colitis. 2019 Nov 09;: Authors: Yang C, Zhang M, Sung J, Wang L, Jung Y, Merlin D Abstract BACKGROUND AND AIMS: Epigenetic information delivered by intestinal exosomes can be useful for diagnosing intestinal diseases, such as ulcerative colitis, but the therapeutic effects of intestinal exosomes have not been fully exploited. We herein developed an autologous exosome therapy that could treat intestinal disease without any risk of inducing a systemic immunological reaction. METHODS: Intestinal…

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ECCO Guidelines on Therapeutics in Crohn’s Disease: medical treatment.

ECCO Guidelines on Therapeutics in Crohn’s Disease: medical treatment. J Crohns Colitis. 2019 Nov 11;: Authors: Torres J, Bonovas S, Doherty G, Kucharzik T, Gisbert JP, Raine T, Adamina M, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, El-Hussuna A, Ellul P, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gomollon F, González-Lorenzo M, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G, Rosa I, Sabino J,…

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Is Crohn’s disease a rightly used eponym?

Related Articles Is Crohn’s disease a rightly used eponym? J Crohns Colitis. 2019 Nov 08;: Authors: Van Hootegem P, Travis S Abstract In 1932 Burrill B. Crohn, a gastroenterologist at Mount Sinai Hospital in New York City described, together with two surgical colleagues, a series of 14 patients with an inflammatory condition of the terminal ileum. All patients were operated on by Dr Albert Berg, the Chief Surgeon of the hospital, whose name did not appear on the initial publication. The “new” disease was called “regional ileitis”, but was rapidly…

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Ligation of the intersphincteric fistula tract and endorectal advancement flap for high perianal fistulas in Crohn’s disease – A retrospective cohort study.

Ligation of the intersphincteric fistula tract and endorectal advancement flap for high perianal fistulas in Crohn’s disease – A retrospective cohort study. J Crohns Colitis. 2019 Nov 07;: Authors: van Praag EM, Stellingwerf ME, van der Bilt JDW, Bemelman WA, Gecse KB, Buskens CJ Abstract BACKGROUND AND AIMS: Ligation of the intersphincteric fistula tract (LIFT) and advancement flap (AF) procedures are well-established, sphincter preserving procedures, for closure of high perianal fistulas. As surgical fistula closure is not commonly offered in Crohn’s patients, long-term data is limited. This study aims to…

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Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn’s disease.

Related Articles Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn’s disease. J Crohns Colitis. 2019 Nov 06;: Authors: Robles RJ, Mukherjee S, Vuerich M, Xie A, Harshe R, Cowan PJ, Csizmadia E, Wu Y, Moss AC, Chen R, Robson SC, Longhi MS Abstract BACKGROUND AND AIMS: CD39/ENTPD1 scavenges pro-inflammatory nucleotides, to ultimately generate immunosuppressive adenosine, having a central role in immune-homeostasis. Global deletion of Cd39 increases susceptibility to experimental colitis while single-nucleotide-polymorphisms within the human CD39 promoter, and aberrant patterns of expression during experimental…

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Deletion of IL-6 exacerbates colitis and induces systemic inflammation in IL-10-deficient mice.

Related Articles Deletion of IL-6 exacerbates colitis and induces systemic inflammation in IL-10-deficient mice. J Crohns Colitis. 2019 Nov 03;: Authors: Ye M, Joosse ME, Liu L, Sun Y, Dong Y, Cai C, Song Z, Zhang J, Brant SR, Lazarev M, Li X Abstract BACKGROUND AND AIMS: Interleukin 6 (IL-6) or its receptor is currently a candidate for targeted biologic therapy of inflammatory bowel disease (IBD). Thus, a comprehensive understanding of the consequences of blocking IL-6 is imperative. We investigated these consequences by evaluating the effects of IL-6 deletion on…

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Inflammation, but Not the Underlying Disease or Its Location, Predicts Oral Iron Absorption Capacity in Patients With Inflammatory Bowel Disease.

Inflammation, but Not the Underlying Disease or Its Location, Predicts Oral Iron Absorption Capacity in Patients With Inflammatory Bowel Disease. J Crohns Colitis. 2019 Oct 28;: Authors: Aksan A, Wohlrath M, Iqbal TH, Dignass A, Stein J Abstract BACKGROUND AND AIMS: Anaemia is common in patients with inflammatory bowel disease [IBD], its two main aetiologies being iron deficiency anaemia [IDA] and anaemia of chronic inflammation [ACI]. Impaired intestinal iron absorption due to inflammatory cytokines is thought to play a role in ACI. We undertook for the first time a controlled…

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