Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition.

Related Articles Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition. J Crohns Colitis. 2018 Apr 16;: Authors: de Bruyn JR, van den Brink GR, Steenkamer J, Buskens CJ, Bemelman WA, Meisner S, Muncan V, Te Velde AA, D’Haens GR, Wildenberg ME Abstract Background and Aims: Crohn’s disease is a chronic inflammatory disorder of the intestine and often leads to fibrosis, characterized by excess extracellular matrix [ECM] deposition, increased tissue stiffness, and stricture formation. Here we evaluated the contribution of myofibroblast-ECM interactions…

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Gut barrier dysfunction – a primary defect in twins with Crohn’s disease predominantly caused by genetic predisposition.

Related Articles Gut barrier dysfunction – a primary defect in twins with Crohn’s disease predominantly caused by genetic predisposition. J Crohns Colitis. 2018 Apr 12;: Authors: Keita ÅV, Lindqvist MC, Öst Å, Magana CDL, Schoultz I, Halfvarson J Abstract Background and aims: The aetiology of Crohn’s disease is poorly understood. By investigating twin pairs discordant for Crohn’s disease we aimed to assess if the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15…

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Accelerated Clearance of Infliximab is Associated With Treatment Failure in Patients With Corticosteroid-Refractory Acute Ulcerative Colitis.

Related Articles Accelerated Clearance of Infliximab is Associated With Treatment Failure in Patients With Corticosteroid-Refractory Acute Ulcerative Colitis. J Crohns Colitis. 2018 Apr 06;: Authors: Kevans D, Murthy S, Mould DR, Silverberg MS Abstract Background and Aims: A significant proportion of patients with corticosteroid-refractory acute ulcerative colitis [UC] fail therapy. We aimed to assess the pharmacokinetics [PK] of infliximab [IFX] in patients with corticosteroid-refractory acute UC and determine the association between induction IFX PK and short- and long-term therapy outcome. Methods: A population PK model was developed using data from…

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Incidence and classification of postcolonoscopy colorectal cancers in inflammatory bowel disease: A Dutch population-based cohort study.

Incidence and classification of postcolonoscopy colorectal cancers in inflammatory bowel disease: A Dutch population-based cohort study. J Crohns Colitis. 2018 Apr 10;: Authors: Wintjens DSJ, Bogie RMM, van den Heuvel TRA, le Clercq CMC, Oostenbrug LE, Romberg-Camps MJL, Straathof JW, Stassen LPS, Masclee AAM, Jonkers DMAE, Sanduleanu-Dascalescu S, Pierik MJ Abstract Background and Aims: Patients with inflammatory bowel disease (IBD) colitis are at increased risk for colorectal cancer (CRC). We examined the proportion and most likely aetiology of potentially preventable postcolonoscopy CRCs (PCCRCs) in a population-based cohort. Furthermore, adherence to…

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Primary Intestinal Epstein-Barr Virus-associated Natural killer/T-Cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease.

Related Articles Primary Intestinal Epstein-Barr Virus-associated Natural killer/T-Cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease. J Crohns Colitis. 2018 Apr 07;: Authors: Wang Z, Zhang W, Luo C, Zhu M, Zhen Y, Mu J, Zhang Y, Hu R, Wang Y, Wen Z, Ouyang Q, Xiao S, Zhang H Abstract Background and Aims: Primary intestinal Epstein-Barr virus (EBV)-associated natural killer/T-cell lymphoproliferative disorder (PIEBV+ NK/T-LPD) is a rare clinical entity, which is difficult to differentiate from inflammatory bowel disease (IBD). We present a series of Chinese patients with PIEBV+ NK/T-LPD to…

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An examination of appetite and disordered eating in active Crohn’s disease.

An examination of appetite and disordered eating in active Crohn’s disease. J Crohns Colitis. 2018 Apr 03;: Authors: Wardle RA, Thapaliya G, Nowak A, Radford S, Dalton M, Finlayson G, Moran GW Abstract Background: Crohn’s disease (CD) patients suffer from nutritional deficiencies when in active disease. We aim to examine calorific intake, macronutrient choice and disordered eating behaviour in patients with active CD. Methods: CD patients with matched healthy volunteers (HV) were recruited. Active disease was defined by faecal calprotectin >250ug/g, C-reactive protein >5mg/dl, or active disease seen on endoscopy…

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Colectomy Rates in Ulcerative Colitis Are Low and Decreasing: 10-year-follow-up Data from the Swiss IBD Cohort Study.

Colectomy Rates in Ulcerative Colitis Are Low and Decreasing: 10-year-follow-up Data from the Swiss IBD Cohort Study. J Crohns Colitis. 2018 Mar 31;: Authors: Parragi L, Fournier N, Zeitz J, Scharl M, Greuter T, Schreiner P, Misselwitz B, Safroneeva E, Schoepfer AM, Vavricka SR, Rogler G, Biedermann L, Swiss IBD Cohort Study Group Abstract Objectives: Previous population-based studies in patients with ulcerative colitis (UC) revealed variable colectomy rates and colectomy-associated risk factors. Over the last two decades, a decrease in colectomy rates was observed. We assessed risk factors and colectomy…

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Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease.

Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease. J Crohns Colitis. 2018 Mar 28;: Authors: Koelink PJ, Wildenberg ME, Stitt LW, Feagan BG, Koldijk M, van ‘t Wout AB, Atreya R, Vieth M, Brandse JF, Duijst S, Te Velde AA, D’Haens GRAM, Levesque BG, van den Brink GR Abstract Background and Aims: Although several endoscopic and histopathologic indices are available to evaluate severity of inflammation in mouse models of colitis, the reliability of these scoring instruments is unknown. Our…

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Loss of microRNA-21 Influences the Gut Microbiota Causing Reduced Susceptibility in a Murine Model of Colitis.

Loss of microRNA-21 Influences the Gut Microbiota Causing Reduced Susceptibility in a Murine Model of Colitis. J Crohns Colitis. 2018 Mar 28;: Authors: Johnston DGW, Williams MA, Thaiss CA, Cabrera-Rubio R, Raverdeau M, McEntee C, Cotter PD, Elinav E, O’Neill LAJ, Corr SC Abstract Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated miR-21 in the pathogenesis of intestinal inflammation, as miR-21 is highly expressed in Inflammatory Bowel Disease (IBD). IBD is associated with intestinal barrier dysfunction and an altered gut…

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Proactive infliximab monitoring following reactive testing is associated with better clinical outcomes than reactive testing alone in patients with inflammatory bowel disease.

Proactive infliximab monitoring following reactive testing is associated with better clinical outcomes than reactive testing alone in patients with inflammatory bowel disease. J Crohns Colitis. 2018 Mar 24;: Authors: Papamichael K, Vajravelu RK, Vaughn BP, Osterman MT, Cheifetz AS Abstract Background and aims: Reactive testing has emerged as the new standard of care for managing loss of response to infliximab in inflammatory bowel disease (IBD). Recent data suggest that proactive infliximab monitoring is associated with better therapeutic outcomes in IBD. Nevertheless, there are no data regarding the clinical utility of…

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