The influence of microscopic inflammation at resection margins on early postoperative endoscopic recurrence after ileocaecal resection for Crohn’s disease.

Related Articles The influence of microscopic inflammation at resection margins on early postoperative endoscopic recurrence after ileocaecal resection for Crohn’s disease. J Crohns Colitis. 2019 Sep 10;: Authors: Poredska K, Kunovsky L, Marek F, Kala Z, Prochazka V, Dolina J, Zboril V, Kovalcikova P, Pavlik T, Jabandziev P, Pavlovsky Z, Vlazny J, Mitas L Abstract BACKGROUND AND AIMS: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn’s disease (CD) remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal…

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Longitudinal trajectory of fatigue with initiation of biologic therapy in inflammatory bowel diseases: A prospective cohort study.

Longitudinal trajectory of fatigue with initiation of biologic therapy in inflammatory bowel diseases: A prospective cohort study. J Crohns Colitis. 2019 Aug 26;: Authors: Borren NZ, Tan W, Colizzo FP, Luther J, Garber JJ, Khalili H, van der Woude CJ, Ananthakrishnan AN Abstract BACKGROUNDS AND AIMS: Fatigue is prevalent in patients with inflammatory bowel diseases (IBD). Biologic therapy is effective in achieving symptomatic and endoscopic remission, but its impact on fatigue is less well established. Our aim is to define the longitudinal trajectory of fatigue over 1 year in patients…

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Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease – A systematic review and meta-analysis.

Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease – A systematic review and meta-analysis. J Crohns Colitis. 2019 Aug 30;: Authors: Alinaghi F, Tekin HG, Burisch J, Wu JJ, Thyssen JP, Egeberg A Abstract BACKGROUND AND AIMS: Epidemiological studies have established an association between psoriasis and inflammatory bowel disease (IBD), i.e. ulcerative colitis (UC) and Crohn’s disease (CD) but results are inconsistent. The aim of this study was therefore to quantify the prevalence and association between IBD and psoriasis. METHODS: PubMed, Web of Science and EMBASE were…

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Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels.

Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels. J Crohns Colitis. 2019 Sep 04;: Authors: Magro F, Lopes J, Borralho P, Lopes S, Coelho R, Cotter J, Dias de Castro F, Tavares de Sousa H, Salgado M, Andrade P, Vieira AI, Figueiredo P, Caldeira P, Sousa A, Duarte MA, Ávila F, Silva J, Moleiro J, Mendes S, Giestas S, Ministro P, Sousa P, Gonçalves R, Gonçalves B, Oliveira A, Chagas C, Cravo M, Dias CC,…

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Environmental, Nutritional and Socio-Economic Determinants of IBD Incidence: A Global Ecological Study.

Environmental, Nutritional and Socio-Economic Determinants of IBD Incidence: A Global Ecological Study. J Crohns Colitis. 2019 Aug 29;: Authors: Piovani D, Danese S, Peyrin-Biroulet L, Bonovas S Abstract BACKGROUND AND AIMS: The wide variation in inflammatory bowel disease (IBD) incidence across countries entails an opportunity to recognize global disease determinants and hypothesize preventive policies. METHODS: We fitted multivariable models to identify putative environmental, nutritional and socio-economic determinants associated with the incidence of IBD [i.e. ulcerative colitis (UC) and Crohn’s disease (CD)]. We utilized the latest available country-specific incidence rates, and…

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Cadherin-11 is a Regulator of Intestinal Fibrosis.

Cadherin-11 is a Regulator of Intestinal Fibrosis. J Crohns Colitis. 2019 Aug 23;: Authors: Franzè E, Monteleone I, Laudisi F, Rizzo A, Dinallo V, Di Fusco D, Colantoni A, Ortenzi A, Giuffrida P, Di Carlo S, Sica GS, Di Sabatino A, Monteleone G Abstract BACKGROUND AND AIM: Although the mechanisms underlying the formation of intestinal fibrostrictures in Crohn’s disease (CD) are not fully understood, activation of fibroblasts and excessive collagen deposition are supposed to contribute to the development of such complications. Here, we investigated the role of cadherin-11 (CDH-11), a…

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The Safety Profile of Vedolizumab in Ulcerative Colitis and Crohn’s Disease: 4 Years of Global Post-Marketing Data.

The Safety Profile of Vedolizumab in Ulcerative Colitis and Crohn’s Disease: 4 Years of Global Post-Marketing Data. J Crohns Colitis. 2019 Aug 13;: Authors: Cohen RD, Bhayat F, Blake A, Travis S Abstract BACKGROUND AND AIMS: Vedolizumab is a gut-selective antibody to α4β7 integrin approved to treat moderate-to-severe ulcerative colitis and Crohn’s disease in adults. Clinical trial data on patients meeting protocol-specified criteria may not reflect real-world clinical practice. This is a descriptive analysis of 4 years of post-marketing safety data on vedolizumab. METHODS: The Vedolizumab Global Safety Database contains…

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Influence of drug exposure on vedolizumab-induced endoscopic remission in anti-TNF naïve and anti-TNF exposed IBD patients.

Influence of drug exposure on vedolizumab-induced endoscopic remission in anti-TNF naïve and anti-TNF exposed IBD patients. J Crohns Colitis. 2019 Aug 29;: Authors: Verstockt B, Mertens E, Dreesen E, Outtier A, Noman M, Tops S, Schops G, Van Assche G, Vermeire S, Gils A, Ferrante M Abstract BACKGROUND AND OBJECTIVES: Vedolizumab has demonstrated efficacy and safety in patients with Crohn’s disease (CD) and ulcerative colitis (UC). Endoscopic outcome data are limited, especially in anti-TNF naïve patients. The present study compared endoscopic outcome in anti-TNF naïve and exposed patients, and explored…

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IL-13 mRNA tissue content identifies two subsets of adult ulcerative colitis patients with different clinical and mucosa-associated microbiota profiles.

Related Articles IL-13 mRNA tissue content identifies two subsets of adult ulcerative colitis patients with different clinical and mucosa-associated microbiota profiles. J Crohns Colitis. 2019 Sep 10;: Authors: Butera A, Di Paola M, Vitali F, De Nitto D, Covotta F, Borrini F, Pica R, De Filippo C, Cavalieri D, Giuliani A, Pronio A, Boirivant M Abstract BACKGROUND AND AIM: A personalized approach to therapy has great promise to improve disease outcomes. To this end, the identification of different subsets of patients according with the prevalent pathogenic process might guide in…

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Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study.

Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study. J Crohns Colitis. 2019 Sep 09;: Authors: Raknes G, Simonsen P, Småbrekke L PMID: 31499520 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31499520?dopt=Abstract

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