Gene and Mirna Regulatory Networks During Different Stages of Crohn’s Disease.

Gene and Mirna Regulatory Networks During Different Stages of Crohn’s Disease. J Crohns Colitis. 2019 Jan 18;: Authors: Verstockt S, De Hertogh G, Van der Goten J, Verstockt B, Vancamelbeke M, Machiels K, Van Lommel L, Schuit F, Van Assche G, Rutgeerts P, Ferrante M, Vermeire S, Arijs I, Cleynen I Abstract Background/Aims: Early treatment of Crohn’s disease (CD) is required to optimize patient outcomes. To this end, we need to gain a better understanding of the molecular changes at the onset of CD. Methods: As a model for the…

Read More

The adipokine metrnl ameliorates chronic colitis in Il-10-/- mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis.

The adipokine metrnl ameliorates chronic colitis in Il-10-/- mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis. J Crohns Colitis. 2019 Jan 07;: Authors: Zuo L, Ge S, Ge Y, Li J, Zhu B, Zhang Z, Jiang C, Li J, Wang S, Liu M, Li S, Wu R, Hu J Abstract BACKGROUND: Crosstalk between mesenteric adipose tissue (MAT) and the intestines affects the progression of Crohn’s disease (CD). The adipokine metrnl regulates adipocyte function and has anti-inflammatory activity. We aimed to explore metrnl expression in CD MAT, investigate the…

Read More

Augmented Endoscopy for Surveillance of Colonic Inflammatory Bowel Disease: Systematic Review with Network Meta-Analysis.

Augmented Endoscopy for Surveillance of Colonic Inflammatory Bowel Disease: Systematic Review with Network Meta-Analysis. J Crohns Colitis. 2018 Dec 28;: Authors: Imperatore N, Castiglione F, Testa A, De Palma GD, Caporaso N, Cassese G, Rispo A Abstract INTRODUCTION: Considering the high risk of dysplasia and cancer in inflammatory bowel disease (IBD), surveillance is advocated. However, international guidelines do not reach a uniform recommendation on the way to perform surveillance. We performed a systematic review with a meta-analysis to assess the best endoscopic surveillance strategy in colonic IBD. METHODS: The systematic…

Read More

Transplantation of Human Intestine into the Mouse: A Novel Platform for Study of Inflammatory Enterocutaneous Fistulas.

Transplantation of Human Intestine into the Mouse: A Novel Platform for Study of Inflammatory Enterocutaneous Fistulas. J Crohns Colitis. 2018 Dec 24;: Authors: Bruckner RS, Nissim-Eliraz E, Marsiano N, Nir E, Shemesh H, Leutenegger M, Gottier C, Lang S, Spalinger MR, Leibl S, Rogler G, Yagel S, Scharl M, Shpigel NY Abstract Background and Aims: Enteric fistulas represent a severe and medically challenging co-morbidity commonly affecting Crohn’s disease [CD] patients. Gut fistulas do not develop in animal models of the disease. We have used transplantation of the human fetal gut…

Read More

Current Practices in Ileal Pouch Surveillance for Patients with Ulcerative Colitis: A Multinational, Retrospective Cohort Study.

Current Practices in Ileal Pouch Surveillance for Patients with Ulcerative Colitis: A Multinational, Retrospective Cohort Study. J Crohns Colitis. 2018 Dec 24;: Authors: Samaan MA, Forsyth K, Segal JP, de Jong D, Vleugels J, Elkady S, Kabir M, Campbell S, Kok K, Armstrong DG, Penez L, Arenaza AP, Seward E, Vega R, Mehta S, Rahman F, McCartney S, Bloom S, Patel K, Pollok R, Westcott E, Darakhshan A, Williams A, Koumoutsos I, Ray S, Mawdsley J, Anderson S, Sanderson JD, Dekker E, D’Haens GR, Hart A, Irving PM Abstract Background…

Read More

Administration of the hyper-immune bovine colostrum extract IMM-124E ameliorates experimental murine colitis.

Administration of the hyper-immune bovine colostrum extract IMM-124E ameliorates experimental murine colitis. J Crohns Colitis. 2018 Dec 12;: Authors: Spalinger MR, Atrott K, Baebler K, Schwarzfischer M, Melhem H, Peres DR, Lalazar G, Rogler G, Scharl M, Frey-Wagner I Abstract Background/Aims: Inflammatory bowel disease (IBD) is accompanied by lesions in the epithelial barrier, which allow translocation of bacterial products from the gut lumen to the host’s circulation. IMM-124E is a colostrum-based product, containing high levels of anti-E.coli-LPS IgG and might limit exposure to bacterial endotoxins. Here, we investigated whether IMM-124E…

Read More

Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease.

Related Articles Distinct histopathological features at diagnosis of very early onset inflammatory bowel disease. J Crohns Colitis. 2018 Dec 14;: Authors: Conrad MA, Carreon CK, Dawany N, Russo P, Kelsen JR Abstract Background and Aims: Children with very early onset inflammatory bowel disease represent a unique cohort, often with a severe phenotype that is refractory to conventional medications, and in some cases, have underlying primary immunodeficiencies. Prior work has identified distinct histopathological patterns in the gastrointestinal tract in patients with primary immunodeficiencies. The aim of this study is to characterize…

Read More

Intra-Cavitary Contrast-Enhanced Ultrasound: a Novel Radiation-Free Method to Detect Abscess Associated Penetrating Disease in Crohn’s Disease.

Related Articles Intra-Cavitary Contrast-Enhanced Ultrasound: a Novel Radiation-Free Method to Detect Abscess Associated Penetrating Disease in Crohn’s Disease. J Crohns Colitis. 2018 Dec 13;: Authors: Mao R, Chen YJ, Chen BL, Xie XH, He Y, Chen SL, Xu M, Li XH, Zhang J, Song XM, Zeng ZR, Rimola J, Rieder F, Ben-Horin S, Chen MH, Xie XY Abstract Background and Aim: Penetrating disease is a common condition complicating Crohn’s disease (CD). Establishing the presence of a fistula and the anatomical definition of the fistulous tracts are essential for deciding on…

Read More
<< Go Back