Clinical outcomes with therapeutic drug monitoring in inflammatory bowel disease: A systematic review with meta-analysis.

Clinical outcomes with therapeutic drug monitoring in inflammatory bowel disease: A systematic review with meta-analysis. J Crohns Colitis. 2018 Aug 10;: Authors: Ricciuto A, Dhaliwal J, Walters TD, Griffiths AM, Church PC Abstract Background and aims: We undertook a systematic review and meta-analysis examining the effectiveness of therapeutic drug monitoring (TDM) to improve clinical outcomes in anti-TNF-treated IBD patients. Methods: We searched MEDLINE, Epub Ahead of Print, EMBASE and Cochrane through October 2017 for randomized trials (RCTs) and cohort studies comparing proactive or reactive TDM to each other or empiric…

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Accuracy of Humanitas Ultrasound Criteria in assessing disease activity and severity in ulcerative colitis: a prospective study.

Accuracy of Humanitas Ultrasound Criteria in assessing disease activity and severity in ulcerative colitis: a prospective study. J Crohns Colitis. 2018 Aug 04;: Authors: Allocca M, Fiorino G, Bonovas S, Furfaro F, Gilardi D, Argollo M, Magnoni P, Peyrin-Biroulet L, Danese S Abstract Background: Colonoscopy (CS) is the standard for assessing disease activity in ulcerative colitis (UC), although invasive and poorly tolerated. Bowel ultrasound (BUS) may be a valid alternative in UC patients, however the comparative accuracy between BUS and CS is unknown. Methods: Consecutive patients with UC were prospectively…

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Serial Tuberculin Skin Tests Improves the Detection of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.

Serial Tuberculin Skin Tests Improves the Detection of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease. J Crohns Colitis. 2018 Jul 21;: Authors: Taxonera C, Ponferrada Á, Riestra S, Bermejo F, Saro C, Martín-Arranz MD, Cabriada JL, Barreiro-de Acosta M, de Castro ML, López-Serrano P, Barrio J, Suarez C, Iglesias E, Argüelles-Arias F, Ferrer I, Marín-Jiménez I, Hernández-Camba A, Bastida G, Van Domselaar M, Martínez-Montiel P, Olivares D, Rivero M, Fernandez-Salazar L, Nantes Ó, Merino O, Alba C, Gisbert JP, CONVERT study group from GETECCU Abstract Aim: To assess…

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Selective IL-23 inhibition by risankizumab modulates the molecular profile in the colon and ileum of patients with active Crohn’s disease: Results from a randomised phase II biopsy substudy.

Selective IL-23 inhibition by risankizumab modulates the molecular profile in the colon and ileum of patients with active Crohn’s disease: Results from a randomised phase II biopsy substudy. J Crohns Colitis. 2018 Jul 19;: Authors: Visvanathan S, Baum P, Salas A, Vinisko R, Schmid R, Grebe KM, Davis JW, Wallace K, Böcher WO, Padula SJ, Fine JS, Panés J Abstract Background and Aims: To investigate the underlying mechanism of action of risankizumab, a monoclonal antibody targeting the IL-23 p19 subunit, previously reported to induce clinical and endoscopic remission in a…

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Plasma Nuclear Magnetic Resonance metabolomics discriminates between high and low endoscopic activity and predicts progression in a prospective cohort of patients with ulcerative colitis.

Plasma Nuclear Magnetic Resonance metabolomics discriminates between high and low endoscopic activity and predicts progression in a prospective cohort of patients with ulcerative colitis. J Crohns Colitis. 2018 Jul 17;: Authors: Probert F, Walsh A, Jagielowicz M, Yeo T, Claridge TDW, Simmons A, Travis S, Anthony DC Abstract Background & aims: Endoscopic assessment of ulcerative colitis (UC) is one of the most accurate measures of disease activity, but frequent endoscopic investigations are disliked by patients and expensive for the health care system. A minimally-invasive test that provides a surrogate measure…

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Placebo effect on the health-related quality of life of inflammatory bowel disease patients: a systematic review with meta-analysis.

Placebo effect on the health-related quality of life of inflammatory bowel disease patients: a systematic review with meta-analysis. J Crohns Colitis. 2018 Jul 14;: Authors: Estevinho MM, Afonso J, Rosa I, Lago P, Trindade E, Correia L, Dias CC, Magro F, on behalf GEDII (Portuguese IBD Group) Abstract Background and aims: Placebo effect in health-related quality of life (HRQoL) of inflammatory bowel disease (IBD) patients has been poorly characterized. This systematic review and meta-analysis aimed to assess i) mean improvements in IBDQ (Inflammatory Bowel Disease Questionnaire) and SF-36 (36-Item Short…

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Fecal Microbiota Transplantation Reduces Susceptibility to Epithelial Injury and Modulates Tryptophan Metabolism of Microbial Community in a Piglet Model.

Fecal Microbiota Transplantation Reduces Susceptibility to Epithelial Injury and Modulates Tryptophan Metabolism of Microbial Community in a Piglet Model. J Crohns Colitis. 2018 Jul 14;: Authors: Geng S, Cheng S, Li Y, Wen Z, Ma X, Jiang X, Wang Y, Han X Abstract Background and Aims: Fecal microbiota transplantation [FMT] has shown promise as a treatment for inflammatory bowel disease [IBD]. Using a piglet model, our previous study indicated that exogenous fecal microbiota can enhance gastrointestinal health through enhancing intestinal barrier. However, specific connections between FMT-induced microbial changes and modulation…

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Accuracy of diffusion-weighted magnetic resonance imaging in detecting mucosal healing and treatment response, and in predicting surgery, in Crohn’s disease.

Accuracy of diffusion-weighted magnetic resonance imaging in detecting mucosal healing and treatment response, and in predicting surgery, in Crohn’s disease. J Crohns Colitis. 2018 Jul 09;: Authors: Thierry ML, Rousseau H, Pouillon L, Girard-Gavanier M, Baumann C, Lopez A, Danese S, Laurent V, Peyrin-Biroulet L Abstract Background and Aims: The Nancy score is a luminal Crohn’s disease (CD) activity index applied in diffusion-weighted magnetic resonance imaging (DW-MRI). We assessed the accuracy of the Nancy score in detecting mucosal healing and treatment response, and predicting surgery. Methods: Retrospective, single-centre study of…

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Comparative accuracy of bowel ultrasound versus magnetic resonance enterography in combination with colonoscopy in assessing Crohn’s disease and guiding clinical decision-making.

Related Articles Comparative accuracy of bowel ultrasound versus magnetic resonance enterography in combination with colonoscopy in assessing Crohn’s disease and guiding clinical decision-making. J Crohns Colitis. 2018 Jul 05;: Authors: Allocca M, Fiorino G, Bonifacio C, Furfaro F, Gilardi D, Argollo M, Peyrin-Biroulet L, Danese S Abstract Background: The comparative accuracy of bowel ultrasound (US) versus magnetic resonance enterography (MRE) in combination with colonoscopy (CS) in assessing Crohn’s disease (CD) and influencing the decision-making process is unknown. Methods: Ileo-colonic CD consecutive patients seen in a tertiary referral Center were prospectively…

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Corrigendum: Non-adherence to Anti-TNF Therapy is Associated with Illness Perceptions and Clinical Outcomes in Outpatients with Inflammatory Bowel Disease: Results from a Prospective Multicentre Study.

Related Articles Corrigendum: Non-adherence to Anti-TNF Therapy is Associated with Illness Perceptions and Clinical Outcomes in Outpatients with Inflammatory Bowel Disease: Results from a Prospective Multicentre Study. J Crohns Colitis. 2018 Jun 30;: Authors: van der Have M, Oldenburg B, Kaptein AA, Jansen JM, Scheffer RCH, van Tuyl BA, van der Meulen-de Jong AE, Pierik M, Siersema PD, van Oijen MGH, Fidder HH PMID: 29982408 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29982408?dopt=Abstract

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