Case-matched comparison of postoperative outcomes following surgery for inflammatory bowel disease after exposure to vedolizumab vs. other biologics.

Related Articles Case-matched comparison of postoperative outcomes following surgery for inflammatory bowel disease after exposure to vedolizumab vs. other biologics. J Crohns Colitis. 2019 Jul 20;: Authors: Novello M, Stocchi L, Steele SR, Holubar SD, Duraes LC, Kessler H, Shawki S, Hull LT Abstract BACKGROUND AND AIM: The effects of vedolizumab (VEDO) exposure on perioperative outcomes following surgery for inflammatory bowel disease (IBD) remain controversial. The aim of our study was to compare postoperative morbidity of IBD surgery following treatment with VEDO vs. other biologics or no biologics. METHODS: An…

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High-Risk Ileocolic Anastomoses for Crohn’s Disease: When Is Diversion Indicated?

High-Risk Ileocolic Anastomoses for Crohn’s Disease: When Is Diversion Indicated? J Crohns Colitis. 2019 Apr 24;: Authors: Neary PM, Aiello AC, Stocchi L, Shawki S, Hull T, Steele SR, Delaney CP, Holubar SD Abstract BACKGROUND AND AIMS: Patients with Crohn’s disease undergoing ileocolectomy and primary anastomosis are often at increased risk of anastomotic leak. We aimed to determine whether diverting ileostomy was protective against anastomotic leak after ileocolic resection for Crohn’s disease using a large international registry. METHODS: We analysed the National Surgical Quality Improvement Program Colectomy Module from 2012…

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Diagnostic Accuracy of Transabdominal Ultrasound in detecting intestinal inflammation in paediatric IBD patients- a systematic review.

Diagnostic Accuracy of Transabdominal Ultrasound in detecting intestinal inflammation in paediatric IBD patients- a systematic review. J Crohns Colitis. 2019 Apr 23;: Authors: van Wassenaer EA, de Voogd FAE, van Rijn RR, van der Lee JH, Tabbers MM, van Etten-Jamaludin FS, Gecse KB, Kindermann A, de Meij TGJ, D’Haens GR, Benninga MA, Koot BGP Abstract BACKGROUND & AIMS: Currently used non-invasive tools for monitoring children with inflammatory bowel disease (IBD), such as faecal calprotectin, do not accurately reflect the degree of intestinal inflammation and do not provide information on disease…

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Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease.

Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease. J Crohns Colitis. 2019 Jul 20;: Authors: Li T, Wang C, Liu Y, Li B, Zhang W, Wang L, Yu M, Zhao X, Du J, Zhang J, Dong Z, Jiang T, Xie R, Ma R, Fang S, Zhou J, Shi J Abstract BACKGROUND AND AIMS: Despite the presence of neutrophil extracellular traps (NETs) in inflamed colon has been confirmed, the role of NETs, especially the circulating NETs, in the progression and thrombotic tendency of inflammatory bowel disease…

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Faecal Calprotectin Predicts Endoscopic and Histological Activity in Clinically Quiescent Ulcerative Colitis.

Faecal Calprotectin Predicts Endoscopic and Histological Activity in Clinically Quiescent Ulcerative Colitis. J Crohns Colitis. 2019 Jun 10;: Authors: Hart L, Chavannes M, Kherad O, Maedler C, Mourad N, Marcus V, Afif W, Bitton A, Lakatos PL, Brassard P, Bessissow T Abstract INTRODUCTION: Faecal calprotectin [FC] is a reliable surrogate marker for disease activity in ulcerative colitis [UC]; however, there are no consensus cut-off values for remission. The study aim was to correlate FC with Mayo Endoscopic Score [MES] and histological disease activity of UC patients in clinical remission. METHODS:…

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Proteomics highlights common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease.

Related Articles Proteomics highlights common and distinct pathophysiological processes associated to ileal and colonic ulcers in Crohn’s disease. J Crohns Colitis. 2019 Jul 08;: Authors: Pierre N, Salée C, Massot C, Blétard N, Mazzucchelli G, Smargiasso N, Morsa D, Baiwir D, De Pauw E, Reenaers C, Van Kemseke C, Loly JP, Delvenne P, Meuwis MA, Louis E Abstract BACKGROUND AND AIMS: Based on genetics and natural history, Crohn’s disease can be separated in two entities, an ileal and a colonic disease. Protein based-approaches are needed to elucidate whether such subphenotypes…

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Leukocytoclastic Vasculitis Related to Ustekinumab in a Crohn’s Disease Patient: First Case Report and Literature Review.

Related Articles Leukocytoclastic Vasculitis Related to Ustekinumab in a Crohn’s Disease Patient: First Case Report and Literature Review. J Crohns Colitis. 2019 Jul 02;: Authors: Costa-Moreira P, Lopes S, Santos AL, Pedrosa AF, Andrade P, Portugal R, Macedo G Abstract Leukocytoclastic vasculitis is a single-organ, skin-isolated small vessel vasculitis. It can be a side effect of many common drugs, including biological agents. Unlike with other drugs, leukocytoclastic vasculitis induced by biological agents may have a prolonged latency period. We report the first case of a ustekinumab induced leukocytoclastic vasculitis in…

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Hypoalbuminaemia and Postoperative Outcomes in Inflammatory Bowel Disease: the NSQIP Surgical Cohort.

Related Articles Hypoalbuminaemia and Postoperative Outcomes in Inflammatory Bowel Disease: the NSQIP Surgical Cohort. J Crohns Colitis. 2019 Apr 23;: Authors: Nguyen GC, Du L, Chong RY, Jackson TD Abstract BACKGROUND: The inflammatory bowel diseases [IBD], including Crohn’s disease [CD] and ulcerative colitis [UC], frequently lead to bowel surgery. Hypoalbuminaemia has been shown to be a prognostic factor for outcomes following surgery for other indications, and we sought to determine its role in predicting IBD-related postoperative outcomes. METHODS: We included patients who underwent IBD-related major abdominal surgery in the American…

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Systemic molecular mediators of inflammation differentiate between Crohn’s disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of pro-inflammatory cytokines in therapy.

Systemic molecular mediators of inflammation differentiate between Crohn’s disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of pro-inflammatory cytokines in therapy. J Crohns Colitis. 2019 Jun 26;: Authors: Kiernan MG, Coffey JC, Sahebally SM, Tibbitts P, Lyons EM, O’Leary E, Olowabi F, Dunne CP Abstract BACKGROUND AND AIMS: Faecal diversion is associated with improvements in Crohn’s disease but not ulcerative colitis, indicating differing mechanisms mediate the diseases. This study aimed to investigate levels of systemic mediators of inflammation, including fibrocytes and cytokines, in (1) in patients…

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