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Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn’s Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study.

Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn’s Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study. J Crohns Colitis. 2017 Feb 22;: Authors: Sandborn WJ, Rutgeerts P, Colombel JF, Ghosh S, Petryka R, Sands BE, Mitra P, Luo A Abstract Background and Aims: This 11-week Phase IIa induction study evaluated the efficacy and safety of eldelumab in patients with active Crohn’s disease. Methods: Adults with Crohn’s Disease Activity Index 220-450 were randomised 1:1:1 to placebo or eldelumab 10 or 20 mg/kg intravenously on Days 1 and 8, and alternate…

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Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines.

Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines. J Crohns Colitis. 2017 Mar 14;: Authors: Waljee AK, Sauder K, Patel A, Segar S, Liu B, Zhang Y, Zhu J, Stidham RW, Balis U, Higgins PD Abstract Background and Aims: Big data analytics leverage patterns in data to harvest valuable information, but are rarely implemented in clinical care. Optimising thiopurine therapy for inflammatory bowel disease [IBD] has proved difficult. Current methods using 6-thioguanine nucleotide [6-TGN] metabolites have failed in randomized controlled trials [RCTs], and have not been used…

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Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.

Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease. J Crohns Colitis. 2017 Feb 17;: Authors: Taxonera C, Ponferrada Á, Bermejo F, Riestra S, Saro C, Martín-Arranz MD, Cabriada JL, Barreiro-de Acosta M, de Castro ML, López-Serrano P, Barrio J, Suarez C, Iglesias E, Argüelles-Arias F, Ferrer I, Marín-Jiménez I, Hernández-Camba A, Bastida G, Van Domselaar M, Martínez-Montiel P, Olivares D, Alba C, Gisbert JP, SEGURTB study group from GETECCU Abstract Background and Aim: Sensitivity of tuberculin skin test [TST] during screening…

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Assessment of endoscopic mucosal healing of ulcerative colitis using linked colour imaging, a novel endoscopic enhancement system.

Assessment of endoscopic mucosal healing of ulcerative colitis using linked colour imaging, a novel endoscopic enhancement system. J Crohns Colitis. 2017 Feb 22;: Authors: Uchiyama K, Takagi T, Kashiwagi S, Toyokawa Y, Tanaka M, Hotta Y, Dohi O, Okayama T, Yoshida N, Katada K, Kamada K, Ishikawa T, Handa O, Konishi H, Kishimoto M, Yagi N, Naito Y, Itoh Y Abstract Background and Aims: Mucosal healing and control of intestinal mucosal inflammation are important treatment goals for maintaining clinical remission in ulcerative colitis (UC) patients. Here, we investigated the efficacy…

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Risk of rectal neoplasia after colectomy and ileorectal anastomosis for ulcerative colitis.

Risk of rectal neoplasia after colectomy and ileorectal anastomosis for ulcerative colitis. J Crohns Colitis. 2017 Feb 21;: Authors: Uzzan M, Kirchgesner J, Oubaya N, Amiot A, Gornet JM, Seksik P, Nancey S, Cotte E, Allez M, Boschetti G, Laharie D, de Angelis N, Nachury M, Pelletier AL, Abitbol V, Fumery M, Brouquet A, Buisson A, Altwegg R, Cosnes J, Panis Y, Treton X Abstract Introduction-: Colectomy can be required in the management of ulcerative colitis (UC). While ileal pouch anal-anastomosis (IPAA) is the recommended reconstruction technique, ileorectal anastomosis (IRA)…

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X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans.

X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans. J Crohns Colitis. 2017 Feb 22;: Authors: Lee HS, Oh H, Baek J, Jung S, Hong M, Kim KM, Shin HD, Kim KJ, Park SH, Ye BD, Han B, Yang SK, Song K Abstract Background and Aims: Genome-wide association studies of inflammatory bowel disease identified >200 susceptibility loci only in autosomes. This study aimed to identify inflammatory bowel disease susceptibility loci on the X chromosome. Methods: We performed an X chromosome-wide association study in Korean patients…

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Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular and Prognostic Features. A Study from the Small Bowel Cancer Italian Consortium.

Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular and Prognostic Features. A Study from the Small Bowel Cancer Italian Consortium. J Crohns Colitis. 2017 Feb 24;: Authors: Vanoli A, Sabatino AD, Furlan D, Klersy C, Grillo F, Fiocca R, Mescoli C, Rugge M, Nesi G, Fociani P, Sampietro G, Ardizzone S, Luinetti O, Calabrò A, Tonelli F, Volta U, Santini D, Caio G, Giuffrida P, Elli L, Ferrero S, Latella G, Ciardi A, Caronna R, Solina G, Rizzo A, Ciacci C, D’Armiento FP, Salemme M, Villanacci V, Cannizzaro…

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