Crohn’s Disease: A Critical Approach to Publication Procedures and Citation Behavior of the Global Research Network.

Crohn’s Disease: A Critical Approach to Publication Procedures and Citation Behavior of the Global Research Network. J Clin Gastroenterol. 2018 Mar;52(3):246-254 Authors: Schöffel N, Brüggmann D, Klingelhöfer D, Bendels MHK, Groneberg DA Abstract BACKGROUND AND GOALS: Crohn’s disease (CD) is an inflammatory bowel disease, which can lead to abdominal pain, weight loss, fatigue, severe diarrhea, and malnutrition. Despite enormous efforts and progress in diagnosis and therapy, there are still many aspects of uncertainty leading to an increasing scientific interest in this topic. As it is challenging to survey all articles…

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Virtual Chromoendoscopy With FICE for the Classification of Polypoid and Nonpolypoid Raised Lesions in Ulcerative Colitis.

Virtual Chromoendoscopy With FICE for the Classification of Polypoid and Nonpolypoid Raised Lesions in Ulcerative Colitis. J Clin Gastroenterol. 2018 Feb 01;: Authors: Cassinotti A, Buffoli F, Fociani P, Staiano T, Villanacci V, Nebuloni M, Duca P, Fichera M, Grassia R, Manes G, Salemme M, Molteni P, Sampietro G, Foschi D, de Franchis R, Ardizzone S Abstract GOALS: The aim of this study was to analyze the performance of Fuji Intelligent Color Enhancement (FICE) using the classification of Kudo in the differentiation of neoplastic and non-neoplastic raised lesions in ulcerative…

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Fecal Matrix Metalloproteinase-9 Measurement for Optimizing Detection of Disease Activity in Inflammatory Bowel Disease.

Fecal Matrix Metalloproteinase-9 Measurement for Optimizing Detection of Disease Activity in Inflammatory Bowel Disease. J Clin Gastroenterol. 2017 Dec 18;: Authors: Kreijne JE, van der Giessen J, Verhaar AP, Peppelenbosch MM, de Vries AC, van der Woude JC, Fuhler GM PMID: 29256991 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29256991?dopt=Abstract

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Distinct Microbial Populations Exist in the Mucosa-associated Microbiota of Diarrhea Predominant Irritable Bowel Syndrome and Ulcerative Colitis.

Distinct Microbial Populations Exist in the Mucosa-associated Microbiota of Diarrhea Predominant Irritable Bowel Syndrome and Ulcerative Colitis. J Clin Gastroenterol. 2017 Nov 28;: Authors: Zhong W, Lu X, Shi H, Zhao G, Song Y, Wang Y, Zhang J, Jin Y, Wang S Abstract GOALS: The goal of this study was to observe the bacterial colonization in the intestinal mucosa in the patients with diarrhea predominant irritable bowel syndrome (IBS-D) and ulcerative colitis (UC), and compare the mucosa-associated microbiota among the IBS-D patients, UC patients and the healthy control, and explore…

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The Impact of Clostridium difficile Infection on Mortality in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

The Impact of Clostridium difficile Infection on Mortality in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2017 Dec 04;: Authors: Tariq R, Law CCY, Khanna S, Murthy S, McCurdy JD Abstract BACKGROUND AND AIMS: Clostridium difficile infection (CDI) has been associated with an increased mortality risk among patients with inflammatory bowel disease (IBD) in multiple observational studies. We performed a systematic review and meta-analysis to help clearly define the magnitude of risk in IBD patients with and without CDI, and to assess the risk…

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Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease.

Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease. J Clin Gastroenterol. 2017 Nov 17;: Authors: Parekh PJ, Oldfield EC, Johnson DA Abstract Sleep dysfunction is an epidemic affecting a large portion of the adult population. Recent studies have linked sleep dysfunction with an upregulation of proinflammatory cytokines (eg, tumor necrosis factor-α, interleukin-1 and interleukin-6), the implications of which can have a profound impact on a variety of gastrointestinal disease. In particular, sleep dysfunction seems to accelerate disease states characterized by inflammation (eg, gastroesophageal reflux…

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Discontinuation of Biological Treatments in Inflammatory Bowel Disease: A Concise Pragmatic Review.

Discontinuation of Biological Treatments in Inflammatory Bowel Disease: A Concise Pragmatic Review. J Clin Gastroenterol. 2017 Sep 29;: Authors: Ben-Horin S, Mao R, Qiu Y, Chen M Abstract Despite the proven efficacy of biological drugs for inflammatory bowel disease, these therapies are costly and do carry some risks, providing incentive for exploring strategies to discontinue therapy in patients with prolonged remission. We presently review multiple cohort studies indicating the overall risk of relapse after stopping an anti-tumor necrosis factor (TNF) in inflammatory bowel disease patients is roughly 40% at 12…

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Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.

Fat-soluble Vitamin Deficiencies and Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2017 Aug 30;: Authors: Fabisiak N, Fabisiak A, Watala C, Fichna J Abstract BACKGROUND: Vitamin deficiency is frequently associated with inflammatory bowel disease (IBD). Supplementation of vitamins could thus serve as an adjunctive therapy. The present meta-analysis reviews the deficiencies and alterations in serum fat-soluble vitamins (A, D, E, and K) reported in IBD patients. MATERIALS AND METHODS: PubMed database search was performed to identify all primary studies up to January 2015 that evaluated the serum…

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Risk of Cancer Recurrence Among Individuals Exposed to Antitumor Necrosis Factor Therapy: A Systematic Review and Meta-Analysis of Observational Studies.

Risk of Cancer Recurrence Among Individuals Exposed to Antitumor Necrosis Factor Therapy: A Systematic Review and Meta-Analysis of Observational Studies. J Clin Gastroenterol. 2017 Jul 21;: Authors: Micic D, Komaki Y, Alavanja A, Rubin DT, Sakuraba A Abstract BACKGROUND: Patients with immune-mediated disorders such as ankylosing spondylitis, inflammatory bowel disease, psoriasis and rheumatoid arthritis are increasingly treated with tumor necrosis factor (TNF) inhibitors. The safety of anti-TNF therapy in patients with a history of cancer requires further evaluation. We conducted a systematic review and a meta-analysis of observational studies including…

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