Financial Toxicity in Crohn’s Disease.

Financial Toxicity in Crohn’s Disease. J Clin Gastroenterol. 2018 Oct 24;: Authors: Voit A, Cross RK, Bellavance E, Bafford AC Abstract BACKGROUND: A patient-reported outcome measure called Comprehensive Score for Financial Toxicity (COST) was previously developed and validated in patients with cancer. GOALS: We sought to assess the financial toxicity associated with Crohn’s disease (CD) by administering the COST questionnaire to patients treated at a tertiary care center. STUDY: Forty-eight patients diagnosed with CD completed questionnaires, which included the COST quality of life instrument as well as questions with regard…

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Narrow Band Imaging for Surveillance in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Narrow Band Imaging for Surveillance in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis. J Clin Gastroenterol. 2018 Aug 09;: Authors: Lv XH, Wang BL, Cao GW Abstract BACKGROUND: The role of narrow band imaging (NBI) for surveillance colonoscopy in patients with inflammatory bowel disease (IBD) is debatable. We aim to compare NBI versus other endoscopic techniques in surveillance of IBD basing on current evidences. METHODS: A systematic search of PubMed, Embase, and the Cochrane Library databases was conducted for relevant studies. To assess the detection efficacy, we estimated risk…

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Hepatotoxicity of Inflammatory Bowel Disease Medications.

Hepatotoxicity of Inflammatory Bowel Disease Medications. J Clin Gastroenterol. 2018 Jul 20;: Authors: Shamberg L, Vaziri H Abstract Various medications used to treat inflammatory bowel diseases have been implicated to cause hepatotoxicity. These include sulfasalazine, 5-aminosalicylic acids, fluoroquinolones, metronidazole, thiopurines, methotrexate, anti-tumor necrosis factor agents, and alpha-4 integrin inhibitors. Various types of liver injury have been reported in association with these medications including hypersensitivity reaction, hepatocellular or cholestatic disease, nodular regenerative hyperplasia, liver fibrosis/cirrhosis, portal hypertension and autoimmune liver injury. The revised Roussel Uclaf Causality Assessment Method (RUCAM) provides a…

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Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases.

Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases. J Clin Gastroenterol. 2018 Jul 20;: Authors: Scarpato E, Russo M, Staiano A Abstract Etiology of inflammatory bowel disease (IBD) is not yet completely understood, but it is hypothesized that a disruption of the immune tolerance to gut microbiota, due to several potential factors like an abnormal gut microbiota composition and activity, may lead to IBD occurrence. Manipulation of the intestinal microbiota is an attractive target for the management of IBD, and probiotics could be useful to influence the disease’s course.…

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Oral and Otorhinolaryngological Findings in Adults Who Were Diagnosed With Pediatric Onset Crohn’s Disease: A Controlled Study.

Oral and Otorhinolaryngological Findings in Adults Who Were Diagnosed With Pediatric Onset Crohn’s Disease: A Controlled Study. J Clin Gastroenterol. 2018 Jun 16;: Authors: Haaramo A, Alapulli H, Aine L, Tuokkola J, Saarnisto U, Roine RP, Pitkäranta A, Kolho KL Abstract BACKGROUND: Up to 50% of pediatric patients with Crohn’s disease (CD) report oral manifestations, but less is known about their oral health when they become adults. GOALS: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once…

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Link Between Celiac Disease and Inflammatory Bowel Disease.

Related Articles Link Between Celiac Disease and Inflammatory Bowel Disease. J Clin Gastroenterol. 2018 May 14;: Authors: Shah A, Walker M, Burger D, Martin N, von Wulffen M, Koloski N, Jones M, Talley NJ, J Holtmann G Abstract GOAL: The aim of this analysis was to assess in patients with inflammatory bowel disease (IBD) the risk of celiac disease and in celiac disease patients the risk of IBD. BACKGROUND: Previous studies report a possible association between IBD and celiac disease; however, this link is controversial. STUDY: Using the search terms…

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Inflammatory Cytokine Profile in Crohn’s Disease Nonresponders to Optimal Antitumor Necrosis Factor Therapy.

Inflammatory Cytokine Profile in Crohn’s Disease Nonresponders to Optimal Antitumor Necrosis Factor Therapy. J Clin Gastroenterol. 2018 Mar 06;: Authors: Yarur AJ, Jain A, Quintero MA, Czul F, Deshpande AR, Kerman DH, Abreu MT Abstract BACKGROUND: A significant number of patients receiving therapy with antitumor necrosis factor (TNF) agents for Crohn’s disease experience primary or secondary nonresponse. The aim of this study was to assess whether patients with nonresponse to anti-TNF agents have increased expression of alternative cytokine pathways. METHODS: We designed a prospective, cross-sectional study that included patients with…

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Comparative Efficacy of Anti-TNF Therapies For The Prevention of Postoperative Recurrence of Crohn’s Disease: A Systematic Review and Network Meta-Analysis of Prospective Trials.

Comparative Efficacy of Anti-TNF Therapies For The Prevention of Postoperative Recurrence of Crohn’s Disease: A Systematic Review and Network Meta-Analysis of Prospective Trials. J Clin Gastroenterol. 2018 Mar 06;: Authors: Bakouny Z, Yared F, El Rassy E, Jabbour R, Hallit R, Khoury N, Honein K, Bou Jaoude J Abstract INTRODUCTION: There is a lack of studies on the optimal anti-tumor necrosis factor (anti-TNF) agent for postoperative prophylaxis of Crohn’s disease (CD) recurrence. Therefore, we conducted a network meta-analysis (NMA) of prospective trials to compare the efficacy of anti-TNF agents in…

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Crohn’s Disease: A Critical Approach to Publication Procedures and Citation Behavior of the Global Research Network.

Crohn’s Disease: A Critical Approach to Publication Procedures and Citation Behavior of the Global Research Network. J Clin Gastroenterol. 2018 Mar;52(3):246-254 Authors: Schöffel N, Brüggmann D, Klingelhöfer D, Bendels MHK, Groneberg DA Abstract BACKGROUND AND GOALS: Crohn’s disease (CD) is an inflammatory bowel disease, which can lead to abdominal pain, weight loss, fatigue, severe diarrhea, and malnutrition. Despite enormous efforts and progress in diagnosis and therapy, there are still many aspects of uncertainty leading to an increasing scientific interest in this topic. As it is challenging to survey all articles…

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