Structural Basis of Bone Fragility in Young Subjects with Inflammatory Bowel Disease: A High-resolution pQCT Study of the SWISS IBD Cohort (SIBDC).

Structural Basis of Bone Fragility in Young Subjects with Inflammatory Bowel Disease: A High-resolution pQCT Study of the SWISS IBD Cohort (SIBDC). Inflamm Bowel Dis. 2017 Aug;23(8):1410-1417 Authors: Pepe J, Zawadynski S, Herrmann FR, Juillerat P, Michetti P, Ferrari-Lacraz S, Belli D, Ratib O, Rizzoli R, Chevalley T, Ferrari SL Abstract BACKGROUND: The onset of inflammatory bowel disease (IBD) during childhood/adolescence compromises peak bone mass acquisition and predisposes to fractures later in life. However, the structural basis for bone fragility in young adults with IBD remains unknown. METHODS: One hundred…

Read More

Clinical Predictors of the Risk of Early Colectomy in Ulcerative Colitis: A Population-based Study.

Related Articles Clinical Predictors of the Risk of Early Colectomy in Ulcerative Colitis: A Population-based Study. Inflamm Bowel Dis. 2017 Aug;23(8):1272-1277 Authors: Al-Darmaki A, Hubbard J, Seow CH, Leung Y, Novak K, Shaheen AA, Panaccione R, Kaplan GG Abstract BACKGROUND: A subset of patients with ulcerative colitis (UC) will require colectomy within a few years of diagnosis. Thus, our aim was to determine the clinical predictors of early colectomy among patients with UC who are hospitalized with an acute flare. METHODS: Using population-based surveillance (1996-2009), all adults (≥18 years) hospitalized…

Read More

Inflammatory Bowel Disease Pharmacist Adherence Counseling Improves Medication Adherence in Crohn’s Disease and Ulcerative Colitis.

Related Articles Inflammatory Bowel Disease Pharmacist Adherence Counseling Improves Medication Adherence in Crohn’s Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2017 Aug;23(8):1257-1261 Authors: Tiao DK, Chan W, Jeganathan J, Chan JT, Perry J, Selinger CP, Leong RW Abstract BACKGROUND: While inflammatory bowel diseases (IBD) require long-term medication usage to maintain remission, nonadherence is common and adversely associated with poorer clinical outcomes. Personalized IBD Pharmacist Adherence Counselling, based on the Health Beliefs Model of medication perception, may increase medication adherence. METHODS: This prospective multi-center longitudinal parallel study recruited consecutive IBD subjects…

Read More

The Association Between Maternal Chronic Inflammatory Bowel Disease and Long-term Health Outcomes in Children-A Nationwide Cohort Study.

Related Articles The Association Between Maternal Chronic Inflammatory Bowel Disease and Long-term Health Outcomes in Children-A Nationwide Cohort Study. Inflamm Bowel Dis. 2017 Aug;23(8):1440-1446 Authors: Jølving LR, Nielsen J, Beck-Nielsen SS, Nielsen RG, Friedman S, Kesmodel US, Nørgård BM Abstract BACKGROUND: Very little is known about the long-term impact of maternal inflammatory bowel disease (IBD) on the offspring’s future health. We aimed to examine whether children born to mothers with IBD had an increased risk of long-term morbidities. METHODS: In this nationwide register-based cohort study, including all children born alive…

Read More

Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa.

Related Articles Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in Colonic Mucosa. Inflamm Bowel Dis. 2017 Aug;23(8):1338-1347 Authors: Sun C, Zhao Y, Gao X, Yuan Y, Wang C, Wang Y, Zhang L, Gu Y, Zhang F, Hu P, Wang Z, Li Z, Shi J, Li S, Cao K, Ren B, Yu M, Liang W, Li Z, Ye J Abstract BACKGROUND: Abnormal lipid metabolism is one of many factors that contribute to the development of ulcerative colitis (UC). As a lipid droplet-associated protein,…

Read More

Systematic Review and Meta-analysis: Adalimumab Monotherapy Versus Combination Therapy with Immunomodulators for Induction and Maintenance of Remission and Response in Patients with Crohn’s Disease.

Related Articles Systematic Review and Meta-analysis: Adalimumab Monotherapy Versus Combination Therapy with Immunomodulators for Induction and Maintenance of Remission and Response in Patients with Crohn’s Disease. Inflamm Bowel Dis. 2017 Aug;23(8):1316-1327 Authors: Chalhoub JM, Rimmani HH, Gumaste VV, Sharara AI Abstract BACKGROUND: It is unclear whether the combination of adalimumab (ADA) and immunomodulators is superior to ADA monotherapy in patients with Crohn’s disease. METHODS: PubMed, Medline, Embase, Web of Science, and other databases were searched. Randomized controlled trials, open-label, prospective cohort, and retrospective studies, and pooled analyses were included. Primary…

Read More

Hydrodynamic IL10 Gene Transfer in Human Colon: Results from an “EX VIVO” Study with Potential Clinical Application in Crohn’s Disease.

Hydrodynamic IL10 Gene Transfer in Human Colon: Results from an “EX VIVO” Study with Potential Clinical Application in Crohn’s Disease. Inflamm Bowel Dis. 2017 Jul 12;: Authors: Frasson M, Sendra L, Miguel A, Herrero MJ, Montalvá E, López-Andújar R, Martínez-Pastor J, Martí-Bonmatí L, Granero EG, Aliño S Abstract BACKGROUND: The aim of this work is to evaluate the efficacy of hydrodynamic venous IL10 gene delivery to “ex vivo” human colon segments and to determine its potential interest in Crohn’s disease treatment. METHODS: Twenty human colon segments were obtained from surgical…

Read More

Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative Colitis.

Characterization and Expansion of Autologous GMP-ready Regulatory T Cells for TREG-based Cell Therapy in Patients with Ulcerative Colitis. Inflamm Bowel Dis. 2017 Jul 12;: Authors: Voskens CJ, Fischer A, Roessner S, Lorenz C, Hirschmann S, Atreya R, Neufert C, Atreya I, Neurath MF, Schuler G Abstract BACKGROUND: A local imbalance between regulatory (Treg) and effector T cells is believed to play a major role in gut-specific inflammation, including ulcerative colitis (UC). Restoration of this balance through an adoptive Treg transfer is an attractive new treatment approach in patients who are…

Read More

Receptive Anal Intercourse in Patients with Inflammatory Bowel Disease: A Clinical Review.

Receptive Anal Intercourse in Patients with Inflammatory Bowel Disease: A Clinical Review. Inflamm Bowel Dis. 2017 Jul 12;: Authors: Martin T, Smukalla SM, Kane S, Hudesman DP, Greene R, Malter LB Abstract Receptive anal intercourse and its association with sexually transmitted infections and human papillomavirus-related anal dysplasia has been well studied in various at-risk groups including men who have sex with men. However, the relationship between receptive anal intercourse and its potential complications in patients with inflammatory bowel disease is not fully understood. This narrative review discusses sexually transmitted infections…

Read More

Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease.

Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Jul 12;: Authors: Cohn HM, Dave M, Loftus EV Abstract Ulcerative colitis and Crohn’s disease are chronic inflammatory bowel diseases for which there are no cures. These diseases are immunopathogenic, and medical treatment is centered on the temperance of a dysregulated immune response to allow mucosal healing and prevent the sequelae of fistulation and stenosis. Accordingly, the armamentarium of medications, which has expanded immensely in recent history, is not without…

Read More
<< Go Back