Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study.

Related Articles Cumulative burden of inflammation predicts colorectal neoplasia risk in ulcerative colitis: a large single-centre study. Gut. 2017 Nov 17;: Authors: Choi CR, Al Bakir I, Ding NJ, Lee GH, Askari A, Warusavitarne J, Moorghen M, Humphries A, Ignjatovic-Wilson A, Thomas-Gibson S, Saunders BP, Rutter MD, Graham TA, Hart AL Abstract OBJECTIVE: Ulcerative colitis (UC) is a dynamic disease with its severity continuously changing over time. We hypothesised that the risk of colorectal neoplasia (CRN) in UC closely follows an actuarial accumulative inflammatory burden, which is inadequately represented by…

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Low eukaryotic viral richness is associated with faecal microbiota transplantation success in patients with UC.

Related Articles Low eukaryotic viral richness is associated with faecal microbiota transplantation success in patients with UC. Gut. 2017 Oct 24;: Authors: Conceição-Neto N, Deboutte W, Dierckx T, Machiels K, Wang J, Yinda KC, Maes P, Van Ranst M, Joossens M, Raes J, Vermeire S, Matthijnssens J PMID: 29066574 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29066574?dopt=Abstract

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Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study.

Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study. Gut. 2017 Oct 05;: Authors: Sandborn WJ, Lee SD, Tarabar D, Louis E, Klopocka M, Klaus J, Reinisch W, Hébuterne X, Park DI, Schreiber S, Nayak S, Ahmad A, Banerjee A, Brown LS, Cataldi F, Gorelick KJ, Cheng JB, Hassan-Zahraee M, Clare R, D’Haens GR Abstract OBJECTIVE: This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds…

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NAD metabolism fuels human and mouse intestinal inflammation.

Related Articles NAD metabolism fuels human and mouse intestinal inflammation. Gut. 2017 Sep 06;: Authors: Gerner RR, Klepsch V, Macheiner S, Arnhard K, Adolph TE, Grander C, Wieser V, Pfister A, Moser P, Hermann-Kleiter N, Baier G, Oberacher H, Tilg H, Moschen AR Abstract OBJECTIVE: Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated in inflammation including IBD and counteracts…

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Early intervention in Crohn’s disease: towards disease modification trials.

Related Articles Early intervention in Crohn’s disease: towards disease modification trials. Gut. 2017 Sep 05;: Authors: Danese S, Fiorino G, Peyrin-Biroulet L Abstract Crohn’s disease (CD) is a chronic progressive destructive inflammatory bowel disease. As in rheumatoid arthritis, there is increasing evidence that early treatment initiation with disease-modifying agents, such as biological drugs, may lead to complete disease control, prevention of disease progression thus protecting against irreversible damage and restoration of normal quality of life. Data from randomised clinical trials with immunosuppressants and biologics suggest that treating patients with a…

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Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.

Related Articles Microbiomarkers in inflammatory bowel diseases: caveats come with caviar. Gut. 2017 Jul 21;: Authors: Sommer F, Rühlemann MC, Bang C, Höppner M, Rehman A, Kaleta C, Schmitt-Kopplin P, Dempfle A, Weidinger S, Ellinghaus E, Krauss-Etschmann S, Schmidt-Arras D, Aden K, Schulte D, Ellinghaus D, Schreiber S, Tholey A, Rupp J, Laudes M, Baines JF, Rosenstiel P, Franke A PMID: 28733278 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/28733278?dopt=Abstract

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Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial.

Related Articles Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial. Gut. 2017 Jul 11;: Authors: Bisschops R, Bessissow T, Joseph JA, Baert F, Ferrante M, Ballet V, Willekens H, Demedts I, Geboes K, De Hertogh G, Vermeire S, Rutgeerts P, Van Assche G Abstract BACKGROUND: Patients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined. OBJECTIVE: To compare the performance…

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Increased risk of acute arterial events in young patients and severely active IBD: a nationwide French cohort study.

Increased risk of acute arterial events in young patients and severely active IBD: a nationwide French cohort study. Gut. 2017 Jun 24;: Authors: Kirchgesner J, Beaugerie L, Carrat F, Andersen NN, Jess T, Schwarzinger M, BERENICE study group Abstract OBJECTIVE: Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. DESIGN: Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years…

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