“Multi-omics analyses to deliver the most effective treatment to every patient with inflammatory bowel disease”.

“Multi-omics analyses to deliver the most effective treatment to every patient with inflammatory bowel disease”. Gastroenterology. 2018 Aug 02;: Authors: Weersma RK, Xavier RJ, IBD Multi-Omics Consortium, Vermeire S, Barrett JC PMID: 30077628 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30077628?dopt=Abstract

Read More

Pulmonary Arterial Hypertension Associated With the Chinese Herb Indigo Naturalis for Ulcerative Colitis: It May Be Reversible.

Related Articles Pulmonary Arterial Hypertension Associated With the Chinese Herb Indigo Naturalis for Ulcerative Colitis: It May Be Reversible. Gastroenterology. 2018 Jul 09;: Authors: Nishio M, Hirooka K, Doi Y PMID: 30001991 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30001991?dopt=Abstract

Read More

Expression of CCR6 and CXCR6 by Gut-derived CD4+/CD8alpha+ T-regulatory Cells Which are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases.

Related Articles Expression of CCR6 and CXCR6 by Gut-derived CD4+/CD8alpha+ T-regulatory Cells Which are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases. Gastroenterology. 2018 Jul 05;: Authors: Godefroy E, Alameddine J, Montassier E, Mathé J, Desfrançois-Noël J, Marec N, Bossard C, Jarry A, Bridonneau C, Le Roy A, Sarrabayrouse G, Kerdreux E, Bourreille A, Sokol H, Jotereau F, Altare F Abstract BACKGROUND & AIMS: Faecalibacterium prausnitzii a member of the Clostridium IV group of the Firmicutes phylum that is abundant in the intestinal microbiota, has anti-inflammatory effects. The…

Read More

Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-label Trial of Patients With Ulcerative Colitis.

Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-label Trial of Patients With Ulcerative Colitis. Gastroenterology. 2018 Jul 04;: Authors: Telesco SE, Brodmerkel C, Zhang H, Kim LL, Johanns J, Mazumder A, Li K, Baribaud F, Curran M, Strauss R, Paxson B, Plevy S, Davison T, Knight L, Dibben S, Schreiber S, Sandborn W, Rutgeerts P, Siegel CA, Reinisch W, Greenbaum L Abstract Golimumab, a tumor necrosis factor (TNF) antagonist, is an effective treatment for patients with moderate-to-severe ulcerative colitis (UC). However, more than 50% of…

Read More

Methotrexate is not superior to placebo in maintaining steroid-free response or remission in ulcerative colitis.

Methotrexate is not superior to placebo in maintaining steroid-free response or remission in ulcerative colitis. Gastroenterology. 2018 Jun 29;: Authors: Herfarth H, Barnes EL, Valentine JF, Hanson J, Higgins PD, Isaacs KL, Jackson S, Osterman MT, Anton K, Ivanova A, Long MD, Martin C, Sandler RS, Abraham B, Cross RK, Dryden G, Fischer M, Harlan W, Levy C, McCabe R, Polyak S, Saha S, Williams E, Yajnik V, Serrano J, Sands BE, Lewis JD, Clinical Research Alliance of the Crohn’s and Colitis Foundation Abstract BACKGROUND & AIMS: Parenteral methotrexate induces…

Read More

Sex-based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-based Studies from Western Countries.

Sex-based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-based Studies from Western Countries. Gastroenterology. 2018 Jun 26;: Authors: Shah SC, Khalili H, Gower-Rousseau C, Olen O, Benchimol EI, Lynge E, Nielsen KR, Brassard P, Vutcovici M, Bitton A, Bernstein CN, Leddin D, Tamim H, Stefansson T, Loftus EV, Moum B, Tang W, Ng SC, Gearry R, Sincic B, Bell S, Sands BE, Lakatos PL, Végh Z, Ott C, Kaplan GG, Burisch J, Colombel JF Abstract BACKGROUND & AIMS: Although the incidence of inflammatory bowel diseases (IBD) varies with…

Read More

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23.

Related Articles Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23. Gastroenterology. 2018 Jun 14;: Authors: Chen L, He Z, Iuga AC, Martins Filho SN, Faith JJ, Clemente JC, Deshpande M, Jayaprakash A, Colombel JF, Lafaille JJ, Sachidanandam R, Furtado GC, Lira SA Abstract BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota,…

Read More
<< Go Back