Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases.

Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases. Gastroenterology. 2018 Apr 12;: Authors: Kirchgesner J, Lemaitre M, Carrat F, Zureik M, Carbonnel MF, Dray-Spira R Abstract BACKGROUND & AIMS: The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of serious and opportunistic infections in patients with IBD treated with thiopurine monotherapy, anti-TNF monotherapy, or combination therapy in a large cohort of patients in France. METHODS: We performed a nationwide population-based study of patients…

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In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration.

In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration. Gastroenterology. 2018 Apr 02;: Authors: Geng H, Bu HF, Liu F, Wu L, Pfeifer K, Chou PM, Wang X, Sun J, Lu L, Pandey A, Bartolomei MS, De Plaen IG, Wang P, Yu J, Qian J, Tan XD Abstract BACKGROUND & AIMS: Inflammation affects regeneration of the intestinal epithelia; long non-coding RNAs (lncRNAs) regulate cell functions such as proliferation, differentiation, and migration. We investigated the mechanisms by which the…

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Association Between Obesity and Weight Change and Risk of Diverticulitis in Women.

Association Between Obesity and Weight Change and Risk of Diverticulitis in Women. Gastroenterology. 2018 Mar 31;: Authors: Ma W, Jovani M, Liu PH, Nguyen LH, Cao Y, Tam I, Wu K, Giovannucci EL, Strate LL, Chan AT Abstract BACKGROUND & AIMS: There is little evidence that adiposity associates with diverticulitis-especially among women. We conducted a comprehensive evaluation of obesity, weight change, and incidence of diverticulitis in a large cohort of women. METHODS: We conducted a prospective cohort study of 46,079 women enrolled in the Nurses’ Health Study, 61-89 years old…

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Identification of Endpoints for Development of Anti-fibrosis Drugs for Treatment of Crohn’s Disease.

Identification of Endpoints for Development of Anti-fibrosis Drugs for Treatment of Crohn’s Disease. Gastroenterology. 2018 Mar 27;: Authors: Danese S, Bonovas S, Lopez A, Fiorino G, Sandborn WJ, Rubin DT, Kamm MA, Colombel JF, Sands BE, Vermeire S, Panes J, Rogler G, D’Haens G, Peyrin-Biroulet L Abstract BACKGROUND & AIMS: Intestinal fibrosis is a challenge to management of patients with Crohn’s disease (CD); there is an urgent need to expedite development of anti-fibrosis drugs for this disease. The International Organization for the Study of Inflammatory Bowel Disease (IOIBD) aimed to…

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Analysis of Genes Associated with Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn’s disease.

Analysis of Genes Associated with Monogenic Primary Immunodeficiency Identifies Rare Variants in XIAP in Patients With Crohn’s disease. Gastroenterology. 2018 Feb 28;: Authors: Amininejad L, Charloteaux B, Theatre E, Liefferinckx C, Dmitrieva J, Hayard P, Muls V, Maisin JM, Schapira M, Ghislain JM, Closset P, Talib M, Abramowicz M, Momozawa Y, Deffontaine V, Crins F, Mni M, Karim L, Cambisano N, Ornemese S, Zucchi A, Minsart C, Deviere J, Hugot JP, De Vos M, Louis E, Vermeire S, Van Gossum A, Coppieters W, Twizere JC, Georges M, Franchimont D, International…

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Methotrexate Reduces DNA Integrity in Sperm From Men with Inflammatory Bowel Disease.

Methotrexate Reduces DNA Integrity in Sperm From Men with Inflammatory Bowel Disease. Gastroenterology. 2018 Feb 23;: Authors: Ley D, Jones J, Parrish J, Salih S, Caldera F, Tirado E, Leader B, Saha S Abstract There are few data on the effects of methotrexate on reproductive capacity in men with inflammatory bowel diseases (IBD). We performed a case-control study to determine the effects of methotrexate on sperm quality and genetic integrity. We compared sperm samples from 7 men with IBD who had been exposed to methotrexate for at least 3 months…

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