Inflammatory Bowel Disease (IBD) in Pregnancy Clinical Care Pathway – A Report from the American Gastroenterological Association IBD Parenthood Project Working Group.

Inflammatory Bowel Disease (IBD) in Pregnancy Clinical Care Pathway – A Report from the American Gastroenterological Association IBD Parenthood Project Working Group. Gastroenterology. 2019 Jan 10;: Authors: Mahadevan U, Robinson C, Bernasko N, Boland B, Chambers C, Dubinsky M, Friedman S, Kane S, Manthey J, Sauerban J, Stone J, Jain R PMID: 30658060 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30658060?dopt=Abstract

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Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-based Data.

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-based Data. Gastroenterology. 2019 Jan 10;: Authors: Coward S, Clement F, Benchimol EI, Bernstein CN, Avina-Zubieta JA, Bitton A, Carroll MW, Hazlewood G, Jacobson K, Jelinski S, Deardon R, Jones JL, Kuenzig ME, Leddin D, McBrien KA, Murthy SK, Nguyen GC, Otley AR, Panaccione R, Rezaie A, Rosenfeld G, Peña-Sánchez JN, Singh H, Targownik LE, Kaplan GG Abstract BACKGROUND AND AIMS: Inflammatory bowel diseases (IBD) exist worldwide, with high prevalence in North America. IBD is complex and costly,…

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Treatment of Active Crohn’s Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition.

Related Articles Treatment of Active Crohn’s Disease With an Ordinary Food-based Diet That Replicates Exclusive Enteral Nutrition. Gastroenterology. 2018 Dec 11;: Authors: Svolos V, Hansen R, Nichols B, Quince C, Ijaz UZ, Papadopoulou RT, Edwards CA, Watson D, Alghamdi A, Brejnrod A, Ansalone C, Duncan H, Gervais L, Tayler R, Salmond J, Bolognini D, Klopfleisch R, Gaya DR, Milling S, Russell RK, Gerasimidis K Abstract BACKGROUND & AIMS: Exclusive enteral nutrition (EEN) is the only established dietary treatment for Crohn’s disease (CD), but its acceptability is limited. There is a…

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American Gastroenterological Association Institute Guideline on the Management of Mild-Moderate Ulcerative Colitis.

Related Articles American Gastroenterological Association Institute Guideline on the Management of Mild-Moderate Ulcerative Colitis. Gastroenterology. 2018 Dec 18;: Authors: Ko CW, Singh S, Feuerstein JD, Falck-Ytter C, Falck-Ytter Y, Cross RK, American Gastroenterological Association Institute Clinical Guidelines Committee PMID: 30576644 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30576644?dopt=Abstract

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American Gastroenterological Association Technical Review on the Management of Mild to Moderate Ulcerative Colitis.

Related Articles American Gastroenterological Association Technical Review on the Management of Mild to Moderate Ulcerative Colitis. Gastroenterology. 2018 Dec 18;: Authors: Singh S, Feuerstein JD, Binion DG, Tremaine WJ Abstract Most patients with ulcerative colitis (UC) have mild to moderate disease activity, with low risk of colectomy, and are managed by primary care physicians or gastroenterologists. Optimal management of these patients decreases the risk of relapse and proximal disease extension, and may prevent disease progression, complications and need for immunosuppressive therapy. With several medications (sulfasalazine, diazo-bonded 5-aminosalicylates [ASA], mesalamines, corticosteroids…

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Modeling Human Digestive Diseases with CRISPR-Cas9-modified Organoids.

Related Articles Modeling Human Digestive Diseases with CRISPR-Cas9-modified Organoids. Gastroenterology. 2018 Nov 23;: Authors: Fujii M, Clevers H, Sato T Abstract Insights into the stem cell niche have allowed researchers to cultivate adult tissue stem cells as organoids that display structural and phenotypic features of healthy and diseased epithelial tissues. Organoids derived from patients’ tissues are used as models of disease and to test drugs. CRISPR-Cas9 technology can be used to genetically engineer organoids for studies of monogenic diseases and cancer. We review the derivation of organoids from human gastrointestinal…

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Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate to Severe Ulcerative Colitis.

Related Articles Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate to Severe Ulcerative Colitis. Gastroenterology. 2018 Nov 22;: Authors: Sandborn WJ, Cyrille M, Hansen MB, Feagan BG, Loftus EV, Rogler G, Vermeire S, Cruz ML, Yang J, Boedigheimer MJ, Abuqayyas L, Evangelista CM, Sullivan BA, Reinisch W Abstract BACKGROUND & AIMS: α4β7 integrin is a validated target in inflammatory bowel disease. This randomized, phase 2b, placebo-controlled, double-blind study evaluated the efficacy and safety of the anti-α4β7 antibody abrilumab in patients with moderate-to-severe ulcerative colitis (UC) despite…

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High Mucosal Plasma Cell Numbers and Low Serum TREM-1 Levels May Predict Nonresponsiveness to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease.

Related Articles High Mucosal Plasma Cell Numbers and Low Serum TREM-1 Levels May Predict Nonresponsiveness to Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease. Gastroenterology. 2019 Jan;156(1):279-281 Authors: Biancheri P, Watson AJM PMID: 30472227 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30472227?dopt=Abstract

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No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.

Related Articles No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2018 Dec 06;: Authors: Mahmoud R, Shah SC, Ten Hove JR, Torres J, Mooiweer E, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH, Dutch initiative on Crohn and Colitis (ICC) Abstract BACKGROUND & AIMS: Patients with inflammatory bowel diseases (IBD) who have post-inflammatory polyps (PIPs) have an increased risk of colorectal neoplasia (CRN). European guidelines propose that patients with PIPs receive more frequent surveillance…

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