Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23.

Related Articles Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23. Gastroenterology. 2018 Jun 14;: Authors: Chen L, He Z, Iuga AC, Martins Filho SN, Faith JJ, Clemente JC, Deshpande M, Jayaprakash A, Colombel JF, Lafaille JJ, Sachidanandam R, Furtado GC, Lira SA Abstract BACKGROUND & AIMS: Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota,…

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Efficacy of Ustekinumab in Inducing Endoscopic Healing in Patients with Crohn’s Disease.

Related Articles Efficacy of Ustekinumab in Inducing Endoscopic Healing in Patients with Crohn’s Disease. Gastroenterology. 2018 Jun 14;: Authors: Rutgeerts P, Gasink C, Chan D, Lang Y, Pollack P, Colombel JF, Wolf DC, Jacobstein D, Johanns J, Szapary P, Adedokun OJ, Feagan BG, Sandborn WJ Abstract BACKGROUND & AIMS: We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn’s disease (CD). METHODS: We performed an endoscopy sub-study of 334 patients with…

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Genomics Identifies XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease: The Clinical and Health Care Impact.

Genomics Identifies XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease: The Clinical and Health Care Impact. Gastroenterology. 2018 Jun 09;: Authors: Quaranta M, Wilson R, Serra EG, Pandey S, Schwerd T, Gilmour K, Klenerman P, Powrie F, Keshav S, Travis SPL, Anderson CA, Uhlig HH PMID: 29894681 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29894681?dopt=Abstract

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Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients with Crohn’s Disease.

Development and Validation of a Scoring System to Predict Outcomes of Vedolizumab Treatment in Patients with Crohn’s Disease. Gastroenterology. 2018 May 29;: Authors: Dulai PS, Boland BS, Singh S, Chaudrey K, Koliani-Pace JL, Kochhar G, Parikh MP, Shmidt E, Hartke J, Chilukuri P, Meserve J, Whitehead D, Hirten R, Winters AC, Katta LG, Peerani F, Narula N, Sultan K, Swaminath A, Bohm M, Lukin D, Hudesman D, Chang JT, Rivera-Nieves J, Jairath V, Zou GY, Feagan BG, Shen B, Siegel CA, Loftus EV, Kane S, Sands BE, Colombel JF, Sandborn…

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Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development.

Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development. Gastroenterology. 2018 May 29;: Authors: Matro R, Martin CF, Wolf D, Shah SA, Mahadevan U Abstract BACKGROUND & AIMS: Exposure to biologic and immunosuppressant agents during breastfeeding is controversial and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBD) and whether breastfeeding while on treatment is associated with infections or developmental delays. METHODS:…

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Plasma N-Glycan Signatures Associate With Features of Inflammatory Bowel Diseases.

Related Articles Plasma N-Glycan Signatures Associate With Features of Inflammatory Bowel Diseases. Gastroenterology. 2018 May 21;: Authors: Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E, IBD-BIOM consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M Abstract BACKGROUND & AIMS: Biomarkers are needed for early detection of Crohn’s disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex post-translational modification of proteins that…

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Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn’s Disease.

Related Articles Abnormal Small Intestinal Epithelial Microvilli in Patients With Crohn’s Disease. Gastroenterology. 2018 May 18;: Authors: VanDussen KL, Stojmirović A, Li K, Liu TC, Kimes PK, Muegge BD, Simpson KF, Ciorba MA, Perrigoue JG, Friedman JR, Towne JE, Head RD, Stappenbeck TS Abstract BACKGROUND & AIMS: Crohn’s disease (CD) presents as chronic and often progressive intestinal inflammation, but the contributing pathogenic mechanisms are unclear. We aimed to identify alterations in intestinal cells that could contribute to the chronic and progressive course of CD. METHODS: We took an unbiased, system-wide…

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Variation in Interleukin 6 Receptor Gene Associates with Risk of Crohn’s Disease and Ulcerative Colitis.

Variation in Interleukin 6 Receptor Gene Associates with Risk of Crohn’s Disease and Ulcerative Colitis. Gastroenterology. 2018 May 15;: Authors: Parisinos CA, Serghiou S, Katsoulis M, George MJ, Patel RS, Hemingway H, Hingorani AD Abstract Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to contribute to development of inflammatory bowel diseases (IBD). The single nucleotide polymorphism rs2228145 in IL6R associates with increased levels of soluble IL6R (s-IL6R), as well as reduced IL6R signaling and risk of inflammatory disorders; its effects are similar to those…

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