CT-Visualized Colonic Mural Stratification Independently Predicts the Need for Medical or Surgical Rescue Therapy in Hospitalized Ulcerative Colitis Patients.

Related Articles CT-Visualized Colonic Mural Stratification Independently Predicts the Need for Medical or Surgical Rescue Therapy in Hospitalized Ulcerative Colitis Patients. Dig Dis Sci. 2019 Feb 22;: Authors: Cushing KC, Kordbacheh H, Gee MS, Kambadakone A, Ananthakrishnan AN Abstract BACKGROUND: Severe ulcerative colitis is associated with significant morbidity. Multidetector computed tomography (MDCT) scans are frequently obtained upon hospital admission, but the ability of radiographic findings to predict steroid failure is unknown. AIM: To identify MDCT features predictive of inpatient rescue in hospitalized UC. METHODS: Patients hospitalized with UC who underwent…

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Receipt of Preventive Care Services Among US Adults with Inflammatory Bowel Disease, 2015-2016.

Related Articles Receipt of Preventive Care Services Among US Adults with Inflammatory Bowel Disease, 2015-2016. Dig Dis Sci. 2019 Feb 12;: Authors: Xu F, Dahlhamer JM, Terlizzi EP, Wheaton AG, Croft JB Abstract BACKGROUND: Previous reports suggest that adults with inflammatory bowel disease (IBD) receive suboptimal preventive care. AIMS: The population-based study compared the receipt of these services by US adults with and without IBD. METHODS: Adults aged ≥ 18 years with IBD (1.2%) and without IBD were identified from the 2015 and 2016 National Health Interview Survey (n = 66,610). Age-standardized prevalence of…

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Personalized Inflammatory Bowel Disease Care Reduced Hospitalizations.

Related Articles Personalized Inflammatory Bowel Disease Care Reduced Hospitalizations. Dig Dis Sci. 2019 Feb 12;: Authors: Liu JJ, Rosson TB, Xie JJ, Harris ZP, McBride RG, Siegel E, Hagedorn C Abstract BACKGROUND AND AIMS: IBD patients with inadequately treated disease often relapse and require hospitalizations for further management. The purpose of this practice review was to determine whether personalized IBD care improved patient outcomes as measured by IBD-related hospitalizations. METHODS: A dedicated IBD clinic was created for personalized patient care in a tertiary veterans health care center in 2014. In…

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Real-World Experience with Tofacitinib in IBD at a Tertiary Center.

Related Articles Real-World Experience with Tofacitinib in IBD at a Tertiary Center. Dig Dis Sci. 2019 Feb 07;: Authors: Weisshof R, Aharoni Golan M, Sossenheimer PH, El Jurdi K, Ollech JE, Pekow J, Cohen RD, Sakuraba A, Dalal S, Rubin DT Abstract BACKGROUND AND AIMS: Many inflammatory bowel disease (IBD) patients do not respond to medical therapy. Tofacitinib is a first-in-class, partially selective inhibitor of Janus kinase, recently approved for treating patients with ulcerative colitis (UC). We describe our experience with the use of tofacitinib for treatment of patients with…

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Early Response to Corticosteroid and Baseline C-Reactive Protein Predicts Outcomes in Children with Moderate to Severe Ulcerative Colitis.

Related Articles Early Response to Corticosteroid and Baseline C-Reactive Protein Predicts Outcomes in Children with Moderate to Severe Ulcerative Colitis. Dig Dis Sci. 2019 Feb 07;: Authors: Deva Rajoo G, Tan L, Lopez A, Lewindon P, Grover Z Abstract BACKGROUND: Initial response to corticosteroids (CS) is recognized as a strong predictor of outcomes in ulcerative colitis (UC). AIM: To compare outcomes of early poor responders (PR) versus good responders (GR) to initial CS at 1, 2, and 3 years from diagnosis. METHODS: In this retrospective study, we report longitudinal outcomes of…

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Off-Label Teduglutide Therapy in Non-intestinal Failure Patients with Chronic Malabsorption.

Related Articles Off-Label Teduglutide Therapy in Non-intestinal Failure Patients with Chronic Malabsorption. Dig Dis Sci. 2019 Feb 07;: Authors: George AT, Li BH, Carroll RE Abstract BACKGROUND: Teduglutide, a glucagon-like peptide 2 analog, has demonstrated efficacy in treating adult patients with short bowel syndrome (SBS) and dependence on parenteral nutrition (PN), but its role in chronic malabsorptive states that do not necessitate PN remains uncertain. AIMS: To evaluate teduglutide use beyond its approved indications and to discuss the results of this adjunctive treatment in patients resistant to established therapy. RESULTS:…

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Impact of Angiotensin II Signaling Blockade on Clinical Outcomes in Patients with Inflammatory Bowel Disease.

Impact of Angiotensin II Signaling Blockade on Clinical Outcomes in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Feb 06;: Authors: Jacobs JD, Wagner T, Gulotta G, Liao C, Li YC, Bissonnette M, Pekow J Abstract BACKGROUND: Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS inhibition on clinical outcomes in inflammatory bowel disease (IBD) patients. AIM: Evaluate the…

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Analysis of Phenotypic Variables and Differentiation Between Untypical Crohn’s Disease and Untypical Intestinal Tuberculosis.

Analysis of Phenotypic Variables and Differentiation Between Untypical Crohn’s Disease and Untypical Intestinal Tuberculosis. Dig Dis Sci. 2019 Feb 06;: Authors: Meng Y, Li Y, Hao R, Li X, Lu F Abstract BACKGROUND: The differentiation between untypical intestinal tuberculosis (UITB) and untypical Crohn’s disease (UCD) is a challenge. AIMS: To analyze phenotypic variables and propose a novel prediction model for differential diagnosis of two conditions. METHODS: A total of 192 patients were prospectively enrolled. The clinical, laboratory, endoscopic, and radiological features were investigated and subjected to univariable and multivariable analyses.…

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