Improving Anemia in Inflammatory Bowel Disease: Impact of the Anemia Care Pathway.

Improving Anemia in Inflammatory Bowel Disease: Impact of the Anemia Care Pathway. Dig Dis Sci. 2019 Mar 16;: Authors: Qureshi T, Peter Nguyen T, Wang R, Willis D, Shah R, Hou JK Abstract BACKGROUND: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn’s and Colitis Foundation developed the Anemia Care Pathway (ACP). AIMS: To implement the ACP in a managed care setting and identify…

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Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease.

Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn’s Disease. Dig Dis Sci. 2019 Mar 14;: Authors: Paredes JM, Moreno N, Latorre P, Ripollés T, Martinez MJ, Vizuete J, Moreno-Osset E Abstract AIM: To assess the clinical benefits of transmural healing (TH) shown on intestinal ultrasound (IUS) after treatment with tumor necrosis factor-alpha antibodies (anti-TNF) in patients with Crohn’s disease. MATERIALS AND METHODS: This prospective study included consecutively 36 patients who underwent IUS in the week prior to start anti-TNF treatment, at 12 weeks, and 1 year…

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Vedolizumab Concentrations Are Associated with Long-Term Endoscopic Remission in Patients with Inflammatory Bowel Diseases.

Vedolizumab Concentrations Are Associated with Long-Term Endoscopic Remission in Patients with Inflammatory Bowel Diseases. Dig Dis Sci. 2019 Mar 05;: Authors: Yarur AJ, Bruss A, Naik S, Beniwal-Patel P, Fox C, Jain A, Berens B, Patel A, Ungaro R, Bahur B, Dubinsky M, Stein DJ Abstract BACKGROUND: The aim of this study was to assess the relationship of serum vedolizumab concentrations (SVC) during induction and endoscopic remission in patients with inflammatory bowel diseases (IBD) after 52 weeks of therapy with vedolizumab. We also sought to assess the incidence of antibody to…

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Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters.

Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters. Dig Dis Sci. 2019 Mar 04;: Authors: Ohashi W, Hara T, Takagishi T, Hase K, Fukada T Abstract Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies…

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Association Between Cannabis Use and Complications Related to Crohn’s Disease: A Retrospective Cohort Study.

Related Articles Association Between Cannabis Use and Complications Related to Crohn’s Disease: A Retrospective Cohort Study. Dig Dis Sci. 2019 Mar 02;: Authors: Mbachi C, Attar B, Wang Y, Paintsil I, Mba B, Fugar S, Agrawal R, Simons-Linares RC, Jaiswal P, Trick W, Kotwal V Abstract BACKGROUND: Crohn’s disease is an idiopathic inflammatory process that is occasionally associated with complications, which cause significant morbidity and mortality. The anti-inflammatory effect of cannabis in intestinal inflammation has been shown in several experimental models; it is unknown whether this correlates with fewer complications…

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Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care.

Related Articles Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care. Dig Dis Sci. 2019 Feb 28;: Authors: Cohen-Mekelburg S, Schneider Y, Gold S, Ghosh G, Rosenblatt R, Hajifathalian K, Scherl E, Schnoll-Sussman F, Katz P, Steinlauf A Abstract BACKGROUND: Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS: To describe the current prevalence of early CRC…

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Thiopurine Therapy for Inflammatory Bowel Disease During Pregnancy Is Not Associated with Anemia in the Infant.

Related Articles Thiopurine Therapy for Inflammatory Bowel Disease During Pregnancy Is Not Associated with Anemia in the Infant. Dig Dis Sci. 2019 Feb 28;: Authors: Koslowsky B, Sadeh C, Grisaru-Granovsky S, Miskin H, Goldin E, Bar-Gil Shitrit A Abstract INTRODUCTION: Thiopurine exposure throughout pregnancy in patients with inflammatory bowel diseases (IBD) is common and teratogenically safe. Late consequences of in utero exposure to thiopurines and its metabolite, 6-thioguanine nucleotides (6-TGN), such as neonatal and infant anemia are still disputed. AIM: To evaluate whether 6-TGN exposure during pregnancy influences anemia in…

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Efficacy of Infliximab in Crohn’s Disease Patients with Prior Primary-Nonresponse to Tumor Necrosis Factor Antagonists.

Related Articles Efficacy of Infliximab in Crohn’s Disease Patients with Prior Primary-Nonresponse to Tumor Necrosis Factor Antagonists. Dig Dis Sci. 2019 Feb 28;: Authors: Clark-Snustad KD, Singla A, Lee SD Abstract BACKGROUND: Tumor necrosis factor antagonists (TNFs) are effective for moderate-severe Crohn’s disease (CD). Approximately one-third of patients have primary-nonresponse to TNFs, which is reported to predict worse response to subsequent TNF therapy. However, this is based on treatment with subcutaneously (SC) administered, fixed-dose TNFs after failure of intravenously (IV) administered, weight-based TNFs. No study has specifically assessed the clinical…

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Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn’s Disease.

Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn’s Disease. Dig Dis Sci. 2019 Feb 26;: Authors: Watanabe Y, Miyoshi N, Fujino S, Takahashi H, Haraguchi N, Hata T, Matsuda C, Yamamoto H, Doki Y, Mori M, Mizushima T Abstract BACKGROUND: Intestinal failure is the most critical complication of Crohn’s disease. Intestinal failure requires home parenteral nutrition, which worsens the quality of life of the patients and sometimes causes life-threatening complications. AIMS: The purpose of this study was to investigate the incidence and risk factors for intestinal…

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