Comparison of Lewis Score and Capsule Endoscopy Crohn’s Disease Activity Index in Patients with Crohn’s Disease.

Related Articles Comparison of Lewis Score and Capsule Endoscopy Crohn’s Disease Activity Index in Patients with Crohn’s Disease. Dig Dis Sci. 2019 Sep 20;: Authors: Omori T, Kambayashi H, Murasugi S, Ito A, Yonezawa M, Nakamura S, Tokushige K Abstract BACKGROUND/AIMS: Small bowel capsule endoscopy (SBCE) is used to visualize mucosal inflammatory changes in the small intestine of patients with Crohn’s disease (CD). The Lewis score (LS) and Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI) are used to evaluate the visualized images. We determined the score disagreement between LS and…

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Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results.

Related Articles Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results. Dig Dis Sci. 2019 Sep 16;: Authors: Chen L, Reynolds C, David R, Peace Brewer A Abstract BACKGROUND: Gut microbiota play an important role in human health. However, the application of gut microbiome in regular clinical practice is limited by interindividual variations and complexity of test results. HYPOTHESIS: It is possible to address interindividual variation by using large data-based exploratory-pattern analysis. METHODS: The current study was conducted using a large data set (n = 173,221) of…

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The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases.

Related Articles The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases. Dig Dis Sci. 2019 Sep 16;: Authors: Ho SSC, Keenan JI, Day AS Abstract The fatty acid-binding proteins play a major role in intracellular transportation of long-chain fatty acids. Nine fatty acid-binding proteins have been identified, with each having individual tissue-specific functions in addition to regulation of fatty acids. This review focuses on the three fatty acid-binding proteins found in the gastrointestinal tract and discusses their role as diagnostic or disease monitoring markers in neonatal necrotizing…

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It’s What’s Up Front That Counts-Part One: Endoscopic Diagnosis and Therapy of Esophageal Crohn’s Disease.

Related Articles It’s What’s Up Front That Counts-Part One: Endoscopic Diagnosis and Therapy of Esophageal Crohn’s Disease. Dig Dis Sci. 2019 Sep 16;: Authors: Alli-Akintade L, Hewitt J, Namiq A, Singh M, Nguyen Y, Keihanian S, Chang JT, Karsan S, Tesfay S, Velayos FS PMID: 31529414 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31529414?dopt=Abstract

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Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients.

Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients. Dig Dis Sci. 2019 Sep 14;: Authors: Jang J, Kwok B, Zhong H, Xia Y, Grucela A, Bernstein M, Remzi F, Hudesman D, Chen J, Axelrad J, Chang S Abstract BACKGROUND: Postoperative ileus (POI) is a temporary delay of coordinated intestinal peristalsis. Alvimopan, an oral peripherally acting mu-opioid receptor antagonist approved for accelerating gastrointestinal recovery, has never been studied specifically in patients with inflammatory bowel disease (IBD). AIM: To investigate the efficacy of alvimopan in preventing POI among…

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Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome.

Related Articles Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome. Dig Dis Sci. 2019 Sep 06;: Authors: Kim SB, Calmet FH, Garrido J, Garcia-Buitrago MT, Moshiree B Abstract BACKGROUND: Patients with irritable bowel syndrome (IBS) frequently have meal-related symptoms and can recognize specific trigger foods. Lactose intolerance is a well-established carbohydrate malabsorption syndrome that causes symptoms similar to IBS such as bloating, abdominal pain, and diarrhea. However, the prevalence of sucrase-isomaltase deficiency (SID) in this population is poorly defined. SID is a condition in which sucrase-isomaltase, an enzyme…

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Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients.

Related Articles Level of UV Exposure, Skin Type, and Age Are More Important than Thiopurine Use for Keratinocyte Carcinoma Development in IBD Patients. Dig Dis Sci. 2019 Sep 06;: Authors: Wu Y, Ghaly S, Kerr S, Jackson B, Hanigan K, Martins D, Krishnaprasad K, Mountifield RE, Whiteman DC, Bampton PA, Gearry RB, Radford-Smith GL, Lawrance IC Abstract BACKGROUND: Retrospective studies observe an increased risk of keratinocyte carcinomas (KCs) in patients with inflammatory bowel disease (IBD) on thiopurine (TP) medication. The role of traditional risk factors such as skin type and…

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Concise Commentary: Second Line Is Not Second Best-Continuing Validity of the Oxford Criteria in the Management of Acute Severe Ulcerative Colitis.

Related Articles Concise Commentary: Second Line Is Not Second Best-Continuing Validity of the Oxford Criteria in the Management of Acute Severe Ulcerative Colitis. Dig Dis Sci. 2019 Sep 05;: Authors: Rivière P, Laharie D, Marteau P PMID: 31489565 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31489565?dopt=Abstract

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Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study.

Related Articles Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn’s Disease: A Nationwide Population-Based Study. Dig Dis Sci. 2019 Sep 04;: Authors: Song EM, Lee HS, Kim YJ, Oh EH, Ham NS, Kim J, Hwang SW, Park SH, Yang DH, Ye BD, Byeon JS, Myung SJ, Lee JL, Yoon YS, Yu CS, Yang SK Abstract BACKGROUND: Little is known about the natural history of perianal fistulas in Asian populations with Crohn’s disease (CD). AIMS: We investigated the incidence and outcomes of perianal CD (pCD) in Korean…

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Current Controversies Concerning Capsule Endoscopy.

Related Articles Current Controversies Concerning Capsule Endoscopy. Dig Dis Sci. 2019 Aug 29;: Authors: Cave DR, Hakimian S, Patel K Abstract Video capsule endoscopy became a reality in 2001. This device enabled us to directly view the mucosa of the small intestine for the first time. The main indications for the video capsule remain the detection of small intestinal bleeding and iron deficiency anemia, diagnosis and management of Crohn’s disease, and detection of tumors. The device is extraordinarily safe and can be used in the very young to the very…

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