Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis.

Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis. Dig Dis Sci. 2019 Nov 13;: Authors: Bossa F, Biscaglia G, Valvano MR, Costantino G, Lauria A, Clemente R, Ferracane C, Shahini E, Mendolaro M, Grossi L, Mazzuoli S, Rispo A, Pranzo G, Sebkova L, Tursi A, Miranda A, Patturelli M, Spagnuolo R, Ricciardelli C, Sgarro C, Paese P, Inserra G, Azzarone A, Nardone O, Fries W, Buccianti N, Privitera AC, Principi MB, Cappello M, Guglielmi FW, Romano M, Riegler G, Fanigliulo L, Melina…

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Managing Patients with Inflammatory Bowel Disease Who Develop Prostate Cancer.

Related Articles Managing Patients with Inflammatory Bowel Disease Who Develop Prostate Cancer. Dig Dis Sci. 2019 Nov 11;: Authors: Kim J, Feagins LA Abstract Prostate cancer is the most common cancer among men in the USA. Interestingly, recent studies suggest that patients with inflammatory bowel disease (IBD) are at increased risk of developing prostate cancer. Importantly, patients with IBD who develop prostate cancer require thoughtful care when using immunosuppressants to treat the IBD in the setting of malignancy. Further, consideration must be given to the proximity of the prostate to…

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Elevating the Technique: Resecting Complex Dysplastic Lesions of the Colon in Patients with Inflammatory Bowel Disease.

Related Articles Elevating the Technique: Resecting Complex Dysplastic Lesions of the Colon in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Nov 09;: Authors: Boparai ES, Velayos FS, Roy A, Li C, Alkoraishi AS, Munroe CA PMID: 31705343 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31705343?dopt=Abstract

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Biologic Use Patterns and Predictors for Non-persistence and Switching of Biologics in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study.

Related Articles Biologic Use Patterns and Predictors for Non-persistence and Switching of Biologics in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Study. Dig Dis Sci. 2019 Nov 01;: Authors: Jung YS, Han M, Park S, Cheon JH Abstract BACKGROUND: Data on real-life patterns of biologic use for inflammatory bowel disease (IBD) are scarce. AIMS: We aimed to examine the patterns of biologic use and the factors associated with non-persistence and switching of biologics in Korean IBD patients. METHODS: Using National Health Insurance claims, we collected data on patients who…

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It’s What’s Up Front That Counts-Part Two: Esophageal Crohn’s Disease Complicated by Recurrent Upper Gastrointestinal Bleeding.

Related Articles It’s What’s Up Front That Counts-Part Two: Esophageal Crohn’s Disease Complicated by Recurrent Upper Gastrointestinal Bleeding. Dig Dis Sci. 2019 Nov 02;: Authors: Levy AN, Ali N, Andrici J, Hamilton MJ PMID: 31677072 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31677072?dopt=Abstract

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UK Patients of Bangladeshi Descent with Crohn’s Disease Respond Less Well to TNF Antagonists Than Caucasian Patients.

Related Articles UK Patients of Bangladeshi Descent with Crohn’s Disease Respond Less Well to TNF Antagonists Than Caucasian Patients. Dig Dis Sci. 2019 Oct 26;: Authors: Gadhok R, Gordon H, Sebepos-Rogers G, Baillie S, Akbar S, Abbott JE, Michael E, Ahmad OF, Cooper B, Lindsay JO Abstract BACKGROUND: Patients with inflammatory bowel disease are currently managed with the assumption that trial data are applicable to all ethnic groups. Previous studies demonstrate differences in disease severity and phenotype of Asian patients with Crohn’s disease (CD), including Bangladeshi Asians within the UK.…

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Pain in Inflammatory Bowel Disease Is Not Improved During Hospitalization: The Impact of Opioids on Pain and Healthcare Utilization.

Related Articles Pain in Inflammatory Bowel Disease Is Not Improved During Hospitalization: The Impact of Opioids on Pain and Healthcare Utilization. Dig Dis Sci. 2019 Oct 25;: Authors: Berry SK, Takakura W, Bresee C, Melmed GY Abstract BACKGROUND: Most patients with IBD experience pain, especially during acute disease exacerbations. Opioid use continues to be more prevalent in IBD than any other chronic gastrointestinal condition, and the majority of IBD patients consume narcotics during hospitalization despite the risks of infection and death. METHODS: We performed a retrospective review of 57 subjects…

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Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis.

Related Articles Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis. Dig Dis Sci. 2019 Oct 23;: Authors: Singh SP, Chand HS, Banerjee S, Agarwal H, Raizada V, Roy S, Sopori M Abstract BACKGROUND: Ulcerative colitis (UC) is a Th2 inflammatory bowel disease characterized by increased IL-5 and IL-13 expression, eosinophilic/neutrophilic infiltration, decreased mucus production, impaired epithelial barrier, and bacterial dysbiosis of the colon. Acetylcholine and nicotine stimulate mucus production and suppress Th2 inflammation through nicotinic receptors in lungs but UC is…

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Tumor Necrosis Factor Inhibitors May Have Limited Efficacy for Complex Perianal Fistulas Without Luminal Crohn’s Disease.

Related Articles Tumor Necrosis Factor Inhibitors May Have Limited Efficacy for Complex Perianal Fistulas Without Luminal Crohn’s Disease. Dig Dis Sci. 2019 Oct 22;: Authors: McCurdy JD, Parlow S, Dawkins Y, Samji K, Rhee GG, Oliveira L, Macdonald B, Sabri E, Murthy S Abstract BACKGROUND: Complex perianal fistulas occurring in the absence of luminal inflammation (isolated perianal disease, IPD) may represent a specific phenotype of Crohn’s disease (CD). AIM: We assessed the effectiveness of tumor necrosis factor (TNF)-antagonists in patients with IPD compared to those with perianal CD (PCD) with…

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