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Histologic scoring indices for evaluation of disease activity in ulcerative colitis.

Related Articles Histologic scoring indices for evaluation of disease activity in ulcerative colitis. Cochrane Database Syst Rev. 2017 May 25;5:CD011256 Authors: Mosli MH, Parker CE, Nelson SA, Baker KA, MacDonald JK, Zou GY, Feagan BG, Khanna R, Levesque BG, Jairath V Abstract BACKGROUND: Disease activity can be determined using clinical, endoscopic or histologic criteria in patients with ulcerative colitis (UC). Persistent disease activity is associated with poor outcomes. Histologic disease activity has been shown to be associated with relapse, colectomy and colorectal cancer. The ability to objectively evaluate microscopic disease…

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Anti-IL-12/23p40 antibodies for induction of remission in Crohn’s disease.

Anti-IL-12/23p40 antibodies for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2016 Nov 25;11:CD007572 Authors: MacDonald JK, Nguyen TM, Khanna R, Timmer A Abstract BACKGROUND: Ustekinumab (CNTO 1275) and briakinumab (ABT-874) are monoclonal antibodies that target the standard p40 subunit of the cytokines interleukin-12 and interleukin-23 (IL-12/23p40), which are involved in the pathogenesis of Crohn’s disease. OBJECTIVES: The objectives of this review were to assess the efficacy and safety of anti-IL-12/23p40 antibodies for induction of remission in Crohn’s disease. SEARCH METHODS: We searched the following databases from inception…

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Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease.

Related Articles Azathioprine or 6-mercaptopurine for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2016 Oct 26;10:CD000545 Authors: Chande N, Townsend CM, Parker CE, MacDonald JK Abstract BACKGROUND: The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treatment of active Crohn’s disease have been conflicting and controversial. An updated meta-analysis was performed to assess the effectiveness of these drugs for the induction of remission in active Crohn’s disease. OBJECTIVES: The primary objective was to determine the efficacy and safety of azathioprine and…

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Vaccines for measles, mumps and rubella in children.

Related Articles Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD004407 Authors: Demicheli V, Jefferson T, Rivetti A, Price D Abstract BACKGROUND: Public debate over the safety of the trivalent measles, mumps and rubella (MMR) vaccine, and the resultant drop in vaccination rates in several countries, persists despite its almost universal use and accepted effectiveness. OBJECTIVES: We carried out a systematic review to assess the evidence of effectiveness and unintended effects associated with MMR. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled…

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Vaccines for measles, mumps and rubella in children.

Related Articles Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD004407 Authors: Demicheli V, Rivetti A, Debalini MG, Di Pietrantonj C Abstract BACKGROUND: Mumps, measles and rubella (MMR) are serious diseases that can lead to potentially fatal illness, disability and death. However, public debate over the safety of the trivalent MMR vaccine and the resultant drop in vaccination coverage in several countries persists, despite its almost universal use and accepted effectiveness. OBJECTIVES: To assess the effectiveness and adverse effects associated with the MMR vaccine…

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The impact of biological interventions for ulcerative colitis on health-related quality of life.

Related Articles The impact of biological interventions for ulcerative colitis on health-related quality of life. Cochrane Database Syst Rev. 2015 Sep 22;(9):CD008655 Authors: LeBlanc K, Mosli MH, Parker CE, MacDonald JK Abstract BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory disorder of the colon that has a relapsing-remitting course. Health related quality of life (HRQL) is significantly lower in patients with UC than the general population due to the negative effects of the disease on physical, psychological and social well-being. Randomized controlled trials (RCTs) evaluating medical interventions for UC have…

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Methotrexate for maintenance of remission in Crohn’s disease.

Related Articles Methotrexate for maintenance of remission in Crohn’s disease. Cochrane Database Syst Rev. 2014 Aug 26;(8):CD006884 Authors: Patel V, Wang Y, MacDonald JK, McDonald JW, Chande N Abstract BACKGROUND: Safe and effective long-term treatments that reduce the need for corticosteroids are needed for Crohn’s disease. Although purine antimetabolites are moderately effective for maintenance of remission patients often relapse despite treatment with these agents. Methotrexate may provide a safe and effective alternative to more expensive maintenance treatment with TNF-α antagonists. This review is an update of a previously published Cochrane…

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Methotrexate for induction of remission in refractory Crohn’s disease.

Related Articles Methotrexate for induction of remission in refractory Crohn’s disease. Cochrane Database Syst Rev. 2014 Aug 06;(8):CD003459 Authors: McDonald JW, Wang Y, Tsoulis DJ, MacDonald JK, Feagan BG Abstract BACKGROUND: Although corticosteroids are effective for induction of remission of Crohn’s disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to its evaluation in patients with refractory Crohn’s disease. Methotrexate has been studied for induction of remission of refractory Crohn’s…

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Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease.

Related Articles Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease. Cochrane Database Syst Rev. 2014 Aug 01;(8):CD010233 Authors: Gordon M, Taylor K, Akobeng AK, Thomas AG Abstract BACKGROUND: Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions. Purine analogues have been used to maintain surgically-induced remission in CD, but the effectiveness of these agents is unclear. OBJECTIVES: The objectives were to evaluate the efficacy and safety of purine analogues for maintenance of surgically-induced remission…

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Methotrexate for induction of remission in ulcerative colitis.

Related Articles Methotrexate for induction of remission in ulcerative colitis. Cochrane Database Syst Rev. 2014 Aug 27;(8):CD006618 Authors: Chande N, Wang Y, MacDonald JK, McDonald JW Abstract BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Methotrexate is a medication that is effective for treating a variety of inflammatory diseases, including Crohn’s disease. This review was performed to determine the effectiveness of methotrexate treatment in UC patients. This review…

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