Interventions for maintenance of surgically induced remission in Crohn’s disease: a network meta-analysis.

Interventions for maintenance of surgically induced remission in Crohn’s disease: a network meta-analysis. Cochrane Database Syst Rev. 2019 Sep 12;9:CD013210 Authors: Iheozor-Ejiofor Z, Gordon M, Clegg A, Freeman SC, Gjuladin-Hellon T, MacDonald JK, Akobeng AK Abstract BACKGROUND: Crohn’s disease (CD) is a chronic disease of the gut. About 75% of people with CD undergo surgery at least once in their lifetime to induce remission. However, as there is no known cure for the disease, patients usually experience a recurrence even after surgery. Different interventions are routinely used in maintaining postsurgical…

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Certolizumab pegol for induction of remission in Crohn’s disease.

Related Articles Certolizumab pegol for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2019 Aug 29;8:CD012893 Authors: Yamazaki H, So R, Matsuoka K, Kobayashi T, Shinzaki S, Matsuura M, Okabayashi S, Kataoka Y, Tsujimoto Y, Furukawa TA, Watanabe N Abstract BACKGROUND: Crohn’s disease (CD) is a chronic inflammatory disease of the gastrointestinal tract, and immune response modulation is the main treatment strategy to induce remission in active CD. Certolizumab pegol (CZP) is a tumor necrosis factor-alfa (TNF-α) inhibitor which regulates impaired immune response. OBJECTIVES: The primary objectives were…

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Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease.

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease. Cochrane Database Syst Rev. 2019 Aug 06;8:CD010233 Authors: Gjuladin-Hellon T, Iheozor-Ejiofor Z, Gordon M, Akobeng AK Abstract BACKGROUND: Crohn’s disease (CD) is a chronic relapsing inflammatory condition and maintenance of remission is a major issue as many patients fail to achieve remission with medical management and require surgical interventions. Purine analogues such as azathioprine (AZA) and 6-mercaptopurine (6-MP) have been used to maintain surgically-induced remission in CD, but the effectiveness, tolerability and safety of these agents remains controversial. OBJECTIVES:…

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The impact of surgical therapies for inflammatory bowel disease on female fertility.

Related Articles The impact of surgical therapies for inflammatory bowel disease on female fertility. Cochrane Database Syst Rev. 2019 Jul 23;7:CD012711 Authors: Lee S, Crowe M, Seow CH, Kotze PG, Kaplan GG, Metcalfe A, Ricciuto A, Benchimol EI, Kuenzig ME Abstract BACKGROUND: Women with inflammatory bowel disease (IBD) may require surgery, which may result in higher risk of infertility. Restorative proctocolectomy with ileal anal pouch anastomosis (IPAA) may increase infertility, but the degree to which IPAA affects infertility remains unclear, and the impact of other surgical interventions on infertility is…

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Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn’s disease.

Oral 5-aminosalicylic acid for maintenance of surgically-induced remission in Crohn’s disease. Cochrane Database Syst Rev. 2019 Jun 20;6:CD008414 Authors: Gjuladin-Hellon T, Gordon M, Iheozor-Ejiofor Z, Akobeng AK Abstract BACKGROUND: Crohn’s disease (CD) is a chronic inflammatory disorder that can involve any part of the gastrointestinal tract. 5-Aminosalicylates (5-ASAs) are locally acting, anti-inflammatory compounds that reduce inflammation of the colonic mucosa with release profiles that vary among various commercially available formulations. This updated Cochrane review summarizes current evidence on the use of 5-ASA formulations for maintenance of surgically-induced remission in CD.…

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Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.

Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. Cochrane Database Syst Rev. 2019 May 28;5:CD001176 Authors: Nguyen N, Zhang B, Holubar SD, Pardi DS, Singh S Abstract BACKGROUND: Pouchitis occurs in approximately 50% of patients following ileal pouch-anal anastomosis (IPAA) for chronic ulcerative colitis (UC). OBJECTIVES: The primary objective was to determine the efficacy and safety of medical therapies for prevention or treatment of acute or chronic pouchitis. SEARCH METHODS: We searched MEDLINE, Embase and CENTRAL from inception to 25 July 2018. We also searched…

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Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation.

Related Articles Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation. Cochrane Database Syst Rev. 2019 Apr 24;4:CD009487 Authors: Hardt J, Meerpohl JJ, Metzendorf MI, Kienle P, Post S, Herrle F Abstract BACKGROUND: A parastomal hernia is defined as an incisional hernia related to a stoma, and belongs to the most common stoma-related complications. Many factors, which are considered to influence the incidence of parastomal herniation, have been investigated. However, it remains unclear whether the enterostomy should be placed through, or lateral to the rectus abdominis muscle, in…

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Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

Related Articles Adjuvant therapy with antidepressants for the management of inflammatory bowel disease. Cochrane Database Syst Rev. 2019 Apr 12;4:CD012680 Authors: Mikocka-Walus A, Prady SL, Pollok J, Esterman AJ, Gordon AL, Knowles S, Andrews JM Abstract BACKGROUND: Symptoms of anxiety and depression are common in inflammatory bowel disease (IBD). Antidepressants are taken by approximately 30% of people with IBD. However, there are no current guidelines on treating co-morbid anxiety and depression in people with IBD with antidepressants, nor are there clear data on the role of antidepressants in managing physical…

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Biomedical risk assessment as an aid for smoking cessation.

Biomedical risk assessment as an aid for smoking cessation. Cochrane Database Syst Rev. 2019 Mar 26;3:CD004705 Authors: Clair C, Mueller Y, Livingstone-Banks J, Burnand B, Camain JY, Cornuz J, Rège-Walther M, Selby K, Bize R Abstract BACKGROUND: A possible strategy for increasing smoking cessation rates could be to provide smokers with feedback on the current or potential future biomedical effects of smoking using, for example, measurement of exhaled carbon monoxide (CO), lung function, or genetic susceptibility to lung cancer or other diseases. OBJECTIVES: The main objective was to determine the…

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Psychological interventions for parents of children and adolescents with chronic illness.

Psychological interventions for parents of children and adolescents with chronic illness. Cochrane Database Syst Rev. 2019 Mar 18;3:CD009660 Authors: Law E, Fisher E, Eccleston C, Palermo TM Abstract BACKGROUND: Psychological therapies for parents of children and adolescents with chronic illness aim to improve parenting behavior and mental health, child functioning (behavior/disability, mental health, and medical symptoms), and family functioning.This is an updated version of the original Cochrane Review (2012) which was first updated in 2015. OBJECTIVES: To evaluate the efficacy and adverse events of psychological therapies for parents of children…

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