Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor.

Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor. Clin Gastroenterol Hepatol. 2019 Aug 20;: Authors: Takenaka K, Fujii T, Suzuki K, Shimizu H, Motobayashi M, Hibiya S, Saito E, Nagahori M, Watanabe M, Ohtsuka K Abstract BACKGROUND & AIMS: It is important to objectively assess Crohn`s disease (CD) activity in patients treated with antibodies against tumor necrosis factor (anti-TNF). Detection of healing by endoscopy (endoscopic healing) associates with patient outcome, based on evidence from studies of ileocolonoscopy. We assessed…

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Stopping 5-Aminosalicylate Therapy in Patients With Crohn’s Disease Starting Biologic Therapy Does Not Increase Risk of Adverse Outcomes.

Stopping 5-Aminosalicylate Therapy in Patients With Crohn’s Disease Starting Biologic Therapy Does Not Increase Risk of Adverse Outcomes. Clin Gastroenterol Hepatol. 2019 Aug 13;: Authors: Ungaro RC, Limketkai BN, Jensen CB, Yzet C, Allin KH, Agrawal M, Ullman T, Burisch J, Jess T, Colombel JF Abstract BACKGROUND & AIMS: Little is known about the effects of discontinuing 5-aminosalycilates (5-ASA) therapy for patients with Crohn’s disease (CD) who initiate therapy with an anti-tumor necrosis factor (anti-TNF) agent. We analyzed data from 2 national population cohorts to compare outcomes of patients with…

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Use of narrative concepts in the EHR to validate genetic determinants of treatment response in a virtual inflammatory bowel disease cohort.

Related Articles Use of narrative concepts in the EHR to validate genetic determinants of treatment response in a virtual inflammatory bowel disease cohort. Clin Gastroenterol Hepatol. 2019 Aug 09;: Authors: Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Savova G, Shaw SY, Churchill S, Burke KE, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ PMID: 31404664 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31404664?dopt=Abstract

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Inflammatory Bowel Disease Increases Risk of Type 2 Diabetes in a Nationwide Cohort Study.

Inflammatory Bowel Disease Increases Risk of Type 2 Diabetes in a Nationwide Cohort Study. Clin Gastroenterol Hepatol. 2019 Aug 05;: Authors: Jess T, Jensen BW, Andersson M, Villumsen M, Allin KH Abstract BACKGROUND & AIMS: The intestine regulates glucose homeostasis, but it is not clear whether chronic intestinal inflammation affects risk for type 2 diabetes. We investigated the long-term risk of type 2 diabetes in patients with inflammatory bowel diseases (IBD) in a nationwide cohort study in Denmark. METHODS: In a nationwide population-based cohort of 6,028,844 persons in Denmark, we…

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Significance of Conducting 2 Types of Fecal Tests in Patients with Ulcerative Colitis.

Significance of Conducting 2 Types of Fecal Tests in Patients with Ulcerative Colitis. Clin Gastroenterol Hepatol. 2019 Aug 05;: Authors: Naganuma M, Kobayashi T, Nasuno M, Motoya S, Kato S, Matsuoka K, Hokari R, Watanabe C, Sakamoto H, Yamamoto H, Sasaki M, Watanabe K, Iijima H, Endo Y, Ichikawa H, Ozeki K, Tanida S, Ueno N, Fujiya M, Sako M, Takeuchi K, Sugimoto S, Abe T, Hibi T, Suzuki Y, Kanai T Abstract BACKGROUND & AIMS: We compared the diagnostic accuracy of the fecal calprotectin (FCP) test vs the fecal…

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Comparison of the EMA and FDA Guidelines on Ulcerative Colitis Drug Development.

Related Articles Comparison of the EMA and FDA Guidelines on Ulcerative Colitis Drug Development. Clin Gastroenterol Hepatol. 2019 Aug;17(9):1673-1679.e1 Authors: Reinisch W, Gottlieb K, Colombel JF, Danese S, Panaccione R, Panes J, Peyrin-Biroulet L, Rubin D, Sands BE, Schreiber S, Vermeire S, Mulberg A, Sandborn B Abstract BACKGROUND & AIMS: In 2016, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) released revised EMA and new FDA draft guidelines related to the development of drugs intended for the treatment of ulcerative colitis. We sought to compare…

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Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients with Crohn’s Disease Not Suspected of Having Perianal Fistulas.

Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients with Crohn’s Disease Not Suspected of Having Perianal Fistulas. Clin Gastroenterol Hepatol. 2019 Jul 25;: Authors: Kim PH, Park SH, Jin K, Ye BD, Yoon YS, Lee JS, Kim HJ, Kim AY, Yu CS, Yang SK Abstract BACKGROUND & AIMS: Few data are available to guide the use of anal imaging for patients with Crohn’s disease (CD) who are not suspected of having perianal fistulas. We aimed to evaluate the role of anal imaging supplementary to magnetic resonance enterography (MRE) in…

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Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases.

Related Articles Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Jul 20;: Authors: Faye AS, Wen T, Ananthakrishnan AN, Lichtiger S, Kaplan GG, Friedman AM, Lawlor G, Wright JD, Attenello FJ, Mack WJ, Lebwohl B Abstract BACKGROUND & AIMS: Patients with inflammatory bowel diseases (IBD) have a high risk of venous thromboembolism (VTE). We assess the timing and risk factors associated with readmission to the hospital for VTE among patients with IBD. METHODS: We collected…

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Rate of Reoperation Decreased Significantly After Year 2002 in Patients with Crohn’s Disease.

Related Articles Rate of Reoperation Decreased Significantly After Year 2002 in Patients with Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Jul 20;: Authors: Shinagawa T, Hata K, Ikeuchi H, Fukushima K, Futami K, Sugita A, Uchino M, Watanabe K, Higashi D, Kimura H, Araki T, Mizushima T, Itabashi M, Ueda T, Koganei K, Oba K, Ishihara S, Suzuki Y Abstract BACKGROUND & AIMS: Patients with Crohn’s disease (CD) can require multiple intestinal operations. We examined time trends and risk factors for reoperation in patients with CD who underwent intestinal surgery, focusing…

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