Primary Sclerosing Cholangitis in Children With Inflammatory Bowel Diseases is Associated with Milder Clinical Activity but More Frequent Subclinical Inflammation and Growth Impairment.

Primary Sclerosing Cholangitis in Children With Inflammatory Bowel Diseases is Associated with Milder Clinical Activity but More Frequent Subclinical Inflammation and Growth Impairment. Clin Gastroenterol Hepatol. 2019 Sep 04;: Authors: Ricciuto A, Hansen BE, Ngo B, Aloi M, Walters TD, Church PC, Mazurek A, Khan M, Carman N, Siddiqui I, Nguyen GC, Kamath BM, Griffiths AM Abstract BACKGROUND & AIMS: Although inflammatory bowel diseases (IBD) associated with primary sclerosing cholangitis (PSC) have been well characterized in adults, there have been few pediatric studies, and these were small and produced conflicting…

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Reliability of Endoscopic Evaluation of Postoperative Recurrent Crohn’s Disease.

Reliability of Endoscopic Evaluation of Postoperative Recurrent Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Aug 29;: Authors: Ma C, Gecse KB, Duijvestein M, Sandborn WJ, Zou G, Shackleton LM, Stitt LW, Parker CE, Bossuyt P, Löwenberg M, Khanna R, Vermeire S, Rutgeerts P, Feagan BG, Jairath V, D’Haens GR PMID: 31473359 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31473359?dopt=Abstract

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Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn’s Disease After Surgery in a Randomized Controlled Trial.

Oral Curcumin No More Effective Than Placebo in Preventing Recurrence of Crohn’s Disease After Surgery in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2019 Aug 27;: Authors: Bommelaer G, Laharie D, Nancey S, Hebuterne X, Roblin X, Nachury M, Peyrin-Biroulet L, Fumery M, Richard D, Pereira B, Goutte M, Buisson A, POPCUR study group Abstract BACKGROUND AND AIMS: Recurrence of Crohn’s disease (CD) after surgery is a major concern. Curcumin has anti-inflammatory properties and induces endoscopic remission in patients with ulcerative colitis. We investigated the efficacy of curcumin vs placebo…

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Rate of, Risk Factors for, and Interventions to Reduce Hospital Readmission in Patients with Inflammatory Bowel Diseases.

Rate of, Risk Factors for, and Interventions to Reduce Hospital Readmission in Patients with Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Aug 27;: Authors: Nguyen NH, Koola J, Dulai PS, Prokop LJ, Sandborn WJ, Singh S Abstract BACKGROUND & AIMS: We investigated 30- and 90-day rates and causes of, risk factors for, and interventions to reduce hospital readmission in patients who received medical treatment for inflammatory bowel diseases (IBD). METHODS: We performed a systematic search of publications through July 1, 2018 for studies of rates of hospital readmission and associated…

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Expression Levels of 4 Genes in Colon Tissue Might be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases.

Related Articles Expression Levels of 4 Genes in Colon Tissue Might be Used to Predict Which Patients Will Enter Endoscopic Remission After Vedolizumab Therapy for Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Aug 22;: Authors: Verstockt B, Verstockt S, Veny M, Dehairs J, Arnauts K, Van Assche G, De Hertogh G, Vermeire S, Salas A, Ferrante M Abstract BACKGROUND & AIMS: We aimed to identify biomarkers that might be used to predict responses of patients with inflammatory bowel diseases (IBD) to vedolizumab therapy. METHODS: We obtained biopsies from inflamed colon…

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Association Between Indefinite Dysplasia and Advanced Neoplasia in Patients With Inflammatory Bowel Diseases Undergoing Surveillance.

Related Articles Association Between Indefinite Dysplasia and Advanced Neoplasia in Patients With Inflammatory Bowel Diseases Undergoing Surveillance. Clin Gastroenterol Hepatol. 2019 Aug 22;: Authors: Mahmoud R, Shah SC, Torres J, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Harpaz N, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH Abstract BACKGROUND AND AIMS: Little is known about the clinical significance of indefinite dysplasia (IND) in patients with inflammatory bowel diseases (IBD) undergoing colonoscopic surveillance for colorectal neoplasia. METHODS: We conducted a retrospective cohort analysis of 492 patients with colonic…

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Comparison of Time to Pregnancy in Women With and Without Inflammatory Bowel Diseases.

Related Articles Comparison of Time to Pregnancy in Women With and Without Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Aug 22;: Authors: Friedman S, Nielsen J, Nøhr EA, Jølving LR, Nørgård BM Abstract BACKGROUND & AIMS: Patients are often diagnosed with inflammatory bowel diseases (IBD) during their peak reproductive years. We investigated how IBD affects fertility in a population study of women in Denmark. METHODS: We collected data from the Danish National Birth Cohort, a nationwide study of 92,274 pregnant women recruited from 1996 through 2002. Women who had been…

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Response to Placebo, Measured by Endoscopic Evaluation of Crohn’s Disease Activity, in a Pooled Analysis of Data from 5 Randomized Controlled Induction Trials.

Response to Placebo, Measured by Endoscopic Evaluation of Crohn’s Disease Activity, in a Pooled Analysis of Data from 5 Randomized Controlled Induction Trials. Clin Gastroenterol Hepatol. 2019 Aug 20;: Authors: Duijvestein M, Jeyarajah J, Guizzetti L, Zou G, Parker CE, van Viegen T, VandeCasteele N, Khanna R, Van Der Aa A, Sandborn WJ, Feagan BG, D’Haens GR, Jairath V Abstract BACKGROUND & AIMS: Endoscopy is used to measure activity of Crohn’s disease (CD) and determine eligibility and outcomes of participants in randomized controlled trials of therapeutic agents. We aimed to…

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