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Asthma is Associated With Subsequent Development of Inflammatory Bowel Disease: a Population-based Case-Control Study.

Related Articles Asthma is Associated With Subsequent Development of Inflammatory Bowel Disease: a Population-based Case-Control Study. Clin Gastroenterol Hepatol. 2017 Mar 23;: Authors: Kuenzig ME, Barnabe C, Seow CH, Eksteen B, Negron ME, Rezaie A, Panaccione R, Benchimol EI, Sadatsafavi M, Aviña-Zubieta JA, Kaplan GG Abstract BACKGROUND & AIMS: Asthma and the inflammatory bowel diseases (IBD) each arise through complex interactions between genetic and environmental factors, and share many environmental risk factors. We examined the association between asthma and Crohn’s disease or ulcerative colitis. METHODS: We performed a population-based case-control…

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Use of Thiopurines During Conception and Pregnancy not Associated With Adverse Pregancy Outcomes or Health of Infants at 1 Year in a Prospective Study.

Related Articles Use of Thiopurines During Conception and Pregnancy not Associated With Adverse Pregancy Outcomes or Health of Infants at 1 Year in a Prospective Study. Clin Gastroenterol Hepatol. 2017 Mar 22;: Authors: Kanis SL, de Lima-Karagiannis A, de Boer NK, van der Woude CJ Abstract BACKGROUND & AIMS: Most data on the safety of thiopurine therapy for inflammatory bowel disease (IBD) during pregnancy come from retrospective studies, making it difficult to adjust for confounding factors. We performed a prospective cohort study to determine whether thiopurine use affects pregnancy outcomes…

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The Impact of Mental and Psychosocial Factors on the Care of Patients with Inflammatory Bowel Disease.

The Impact of Mental and Psychosocial Factors on the Care of Patients with Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2017 Mar 11;: Authors: Szigethy EM, Allen JI, Reiss M, Cohen W, Perera LP, Brillstein L, Cross RK, Schwartz DA, Kosinski LR, Colton JB, LaRusso E, Atreja A, Regueiro MD PMID: 28300693 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/28300693?dopt=Abstract

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Increased intestinal permeability in relatives of patients with Crohn’s Disease is not associated with small bowel ulcerations.

Related Articles Increased intestinal permeability in relatives of patients with Crohn’s Disease is not associated with small bowel ulcerations. Clin Gastroenterol Hepatol. 2017 Mar 07;: Authors: Teshima CW, Goodman KJ, El-Kalla M, Turk S, El-Matary W, Valcheva R, Danchak R, Gordon M, Ho P, Mullins A, Wong D, Kao D, Meddings J, Huynh H, Dieleman LA Abstract BACKGROUND & AIMS: Many first-degree relatives of patients with Crohn’s disease (CD) have increased intestinal permeability. Video capsule endoscopy (VCE) is the most sensitive imaging test to identify small bowel mucosal lesions that…

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Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis.

Related Articles Efficacy of Rectal Tacrolimus for Induction Therapy in Patients With Resistant Ulcerative Proctitis. Clin Gastroenterol Hepatol. 2017 Mar 07;: Authors: Lawrance IC, Baird A, Lightower D, Radford-Smith G, Andrews JM, Connor S Abstract BACKGROUND: Resistant ulcerative proctitis can be extremely difficult to manage. Topically administered tacrolimus, however, may be effective in difficult-to-treat proctitis. AIMS: This was randomized, double-blind, placebo-controlled induction trial of rectal tacrolimus in patients with active ulcerative colitis. METHODS: Eleven patients received rectal tacrolimus (0.5mg/ml), and 10 placebo, for 8 weeks. The primary endpoint was clinical…

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Endoscopic and Histologic Healing in Children With Inflammatory Bowel Diseases Treated With Thalidomide.

Related Articles Endoscopic and Histologic Healing in Children With Inflammatory Bowel Diseases Treated With Thalidomide. Clin Gastroenterol Hepatol. 2017 Mar 07;: Authors: Lazzerini M, Villanacci V, Pellegrin MC, Martelossi S, Magazzù G, Pellegrino S, Lucanto MC, Barabino A, Calvi A, Arrigo S, Lionetti P, Fontana M, Zuin G, Maggiore G, Bramuzzo M, Maschio M, Salemme M, Manenti S, Luisa L, Decorti G, Montico M, Ventura A Abstract BACKGROUND & AIMS: Mucosal healing, determined by endoscopic evaluation, is one of the most important prognostic markers for patients with inflammatory bowel diseases….

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Non-relaxing Pelvic Floor Dysfunction is an Underestimated Complication of Ileal Pouch-Anal Anastomosis.

Non-relaxing Pelvic Floor Dysfunction is an Underestimated Complication of Ileal Pouch-Anal Anastomosis. Clin Gastroenterol Hepatol. 2017 Mar 01;: Authors: Quinn KP, Tse CS, Lightner AL, Pendegraft RS, Enders FT, Raffals LE Abstract BACKGROUND & AIMS: Non-relaxing pelvic floor dysfunction (N-RPFD), or dyssynergic defecation, is the paradoxical contraction and/or impaired relaxation of pelvic floor and anal muscles during defecation. Few studies have evaluated this disorder in patients with an ileal pouch-anal anastomosis (IPAA). We investigated the frequency of N-RPFD in patients with and without chronic pouchitis following IPAA and the effectiveness…

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Temporal Trends in Initiation of Therapy With Tumor Necrosis Factor Antagonists for Patients With Inflammatory Bowel Disease: A Population-based Analysis.

Related Articles Temporal Trends in Initiation of Therapy With Tumor Necrosis Factor Antagonists for Patients With Inflammatory Bowel Disease: A Population-based Analysis. Clin Gastroenterol Hepatol. 2017 Feb 23;: Authors: Targownik LE, Tenakaroon A, Leung S, Lix LM, Singh H, Bernstein CN Abstract BACKGROUND & AIMS: Anti-tumor necrosis factor (anti-TNF) agents are effective treatments for Crohn’s disease (CD) and ulcerative colitis (UC). We aimed to determine their patterns of use and changes in these patterns over time, as well as use of immunomodulators and corticosteroids before anti-TNF therapy for persons with…

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Histologic Normalization Occurs in Ulcerative Colitis and is Associated with Improved Clinical Outcomes.

Related Articles Histologic Normalization Occurs in Ulcerative Colitis and is Associated with Improved Clinical Outcomes. Clin Gastroenterol Hepatol. 2017 Feb 23;: Authors: Christensen B, Hanauer SB, Erlich J, Kassim O, Gibson PR, Turner JR, Hart J, Rubin DT Abstract BACKGROUND & AIMS: Mucosal healing, determined by histologic analysis, is a potential therapeutic target for patients with ulcerative colitis (UC). However, the histologic features of tissue normalization, as an outcome of treatment, have not been well described. We examined the prevalence and predictive values of normalization of the colonic mucosa, based…

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