Management of Inflammatory Bowel Diseases in Special Populations: Obese, Old or Obstetric.

Related Articles Management of Inflammatory Bowel Diseases in Special Populations: Obese, Old or Obstetric. Clin Gastroenterol Hepatol. 2019 Nov 08;: Authors: Singh S, Picardo S, Seow CH Abstract The epidemiology of inflammatory bowel disease (IBD) is progressively evolving impacting the type of patients with IBD we will see in clinical practice. In this review, we discuss specific challenges and solutions in the management of (a) obese, (b) older and (c) obstetric (pregnant) patients with IBD. With the global obesity epidemic, almost one in three patients with IBD are obese. Obesity…

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Risk for Chronic Kidney Disease in Patients with Inflammatory Bowel Diseases Increases with Age but is not Associated with 5-aminosalicylate Use.

Risk for Chronic Kidney Disease in Patients with Inflammatory Bowel Diseases Increases with Age but is not Associated with 5-aminosalicylate Use. Clin Gastroenterol Hepatol. 2019 Nov 01;: Authors: Vajravelu RK, Copelovitch L, Osterman MT, Scott FI, Mamtani R, Lewis JD, Denburg MR Abstract BACKGROUND & AIMS: It is not clear what factors affect risk of chronic kidney disease (CKD) in patients with inflammatory bowel disease (IBD); increased risk has been inconsistently associated with use of 5-aminosalicylates (5-ASAs). We aimed to calculate the relative hazard of CKD among patients with IBD,…

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Positioning Therapies in the Management of Crohn’s Disease.

Related Articles Positioning Therapies in the Management of Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Oct 29;: Authors: Nguyen NH, Singh S, Sandborn WJ Abstract In the last decade, several new therapies with different mechanisms of action have been approved for the management of moderate to severe Crohn’s disease (CD). However, there is limited guidance on optimal positioning of agents as first- or second-line therapies due to the absence of head-to-head trials. Furthermore, given the lack of comparative studies, treatment guidelines provide limited insight. In this review, we will discuss data…

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Risk Factors Associated With Early-onset Colorectal Cancer.

Risk Factors Associated With Early-onset Colorectal Cancer. Clin Gastroenterol Hepatol. 2019 Oct 14;: Authors: Gausman V, Dornblaser D, Anand S, Hayes RB, O’Connell K, Du M, Liang PS Abstract BACKGROUND & AIMS: The incidence of colorectal cancer (CRC) is increasing in individuals younger than 50 years, who do not usually undergo screening if they are of average risk. We sought to identify risk factors for CRC in this population. METHODS: We compared sociodemographic and medical characteristics of patients who received a diagnosis of CRC at an age of 18-49 years…

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No Superiority of Tacrolimus Suppositories vs Beclomethasone Suppositories in a Randomized Trial of Patients With Refractory Ulcerative Proctitis.

No Superiority of Tacrolimus Suppositories vs Beclomethasone Suppositories in a Randomized Trial of Patients With Refractory Ulcerative Proctitis. Clin Gastroenterol Hepatol. 2019 Oct 11;: Authors: Lie MRKL, Kreijne JE, Dijkstra G, Löwenberg M, van Assche G, West RL, van Noord D, van der Meulen-de Jong AE, Oldenburg B, Zaal RJ, Hansen BE, de Vries AC, van der Woude CJ, Dutch Initiative on Crohn and Colitis (ICC) Abstract BACKGROUND & AIMS: Ulcerative proctitis (UP) refractory to 5-aminosalicylic acid (5-ASA) suppositories is a challenge to treat, often requiring step up to immunomodulator…

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Associations between drug exposure and outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease.

Related Articles Associations between drug exposure and outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2019 Oct 05;: Authors: Fung BM, Ali AH, Tabibian JH PMID: 31593771 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31593771?dopt=Abstract

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Levels of Vitamin D are Low After Crohn’s Disease is Established But Not Before.

Levels of Vitamin D are Low After Crohn’s Disease is Established But Not Before. Clin Gastroenterol Hepatol. 2019 Oct 04;: Authors: Limketkai BN, Singla MB, Rodriguez B, Veerappan G, Betteridge JD, Ramos MA, Hutfless SM, Brant SR Abstract BACKGROUND & AIMS: Low serum levels of vitamin D have been associated with Crohn’s disease (CD). However, it is unclear whether low vitamin D levels cause CD or CD reduces serum vitamin D. METHODS: United States military personnel with CD (n=240) and randomly selected individuals without CD (controls, n=240) were matched by…

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Peri-operative and Post-operative Management of Patients with Crohn’s Disease and Ulcerative Colitis.

Peri-operative and Post-operative Management of Patients with Crohn’s Disease and Ulcerative Colitis. Clin Gastroenterol Hepatol. 2019 Oct 04;: Authors: Barnes EL, Lightner AL, Regueiro M Abstract Although the number of available therapies for the treatment of ulcerative colitis (UC) and Crohn’s disease (CD) continues to expand, a significant portion of patients with inflammatory bowel disease (IBD) will require surgical intervention. Surgery remains an integral part of the treatment algorithm for patients with UC and CD, and thus multidisciplinary approaches to the perioperative and postoperative management of patients with IBD are…

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