Functional gastrointestinal symptoms in patients with inflammatory bowel disease: A clinical challenge.

Related Articles Functional gastrointestinal symptoms in patients with inflammatory bowel disease: A clinical challenge. Clin Gastroenterol Hepatol. 2018 Aug 09;: Authors: Colombel JF, Shin A, Gibson PR Abstract DESCRIPTION: The purpose of this clinical practice update review is to describe key principles in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients with inflammatory bowel disease (IBD). METHODS: The evidence and best practices summarized in this manuscript are based on relevant scientific publications, systematic reviews, and expert opinion where applicable. BEST PRACTICE ADVICE 1: A stepwise approach to…

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Early Initiation of Tumor Necrosis Factor Antagonist-based Therapy for Patients with Crohn’s Disease Reduces Costs Compared With Late Initiation.

Early Initiation of Tumor Necrosis Factor Antagonist-based Therapy for Patients with Crohn’s Disease Reduces Costs Compared With Late Initiation. Clin Gastroenterol Hepatol. 2018 Jul 26;: Authors: Beilman CL, Kirwin E, Ma C, McCabe C, Fedorak RN, Halloran B Abstract BACKGROUND & AIMS: Antagonists of tumor necrosis factor (TNF) are effective for induction and maintenance of remission of Crohn’s disease (CD) and are generally prescribed when patients do not respond to conventional, less costly medical therapies. Early initiation of anti-TNF therapy reduced rates of surgery and dose escalation due to loss…

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Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease.

Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease. Clin Gastroenterol Hepatol. 2018 Jul 25;: Authors: Vaughn BP, Rank KM, Khoruts A Abstract Fecal microbiota transplantation was originally introduced as a method to repair intestinal microbiota following failure of multiple treatments of recurrent Clostridium difficile infection with antibiotics. However, it is hypothesized that intestinal dysbiosis may contribute to pathogenesis of many diseases, especially those involving the gastrointestinal tract. Therefore, fecal microbiota transplantation is increasingly being explored as a potential treatment that aims to optimize microbiota composition and…

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Improving Outcomes in Patients with Inflammatory Bowel Disease through Integrated Multi-Disciplinary Care- the Future of IBD Care.

Improving Outcomes in Patients with Inflammatory Bowel Disease through Integrated Multi-Disciplinary Care- the Future of IBD Care. Clin Gastroenterol Hepatol. 2018 Jul 20;: Authors: Christian K, Cross RK PMID: 30036645 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30036645?dopt=Abstract

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Towards a personalized benefit-risk balance for immunosuppressive therapy in inflammatory bowel disease.

Towards a personalized benefit-risk balance for immunosuppressive therapy in inflammatory bowel disease. Clin Gastroenterol Hepatol. 2018 Jul 18;: Authors: Beaugerie L, Kirchgesner J Abstract Infections, cancers and cardiovascular events are the main events that may be attributable to inflammatory bowel disease (IBD) and/or IBD treatment. Immunosuppressive drugs have been shown to promote immunosuppression-related infections and cancers. Via mucosal healing, immunosuppressive drugs should be able to reduce the incidence of infections related to intestinal lesions, malnutrition, intravenous devices and IBD surgery, and to reduce the incidence of cancers attributable to chronic…

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Treatments for Crohn’s Disease-associated Bowel Damage: a Systematic Review.

Related Articles Treatments for Crohn’s Disease-associated Bowel Damage: a Systematic Review. Clin Gastroenterol Hepatol. 2018 Jul 13;: Authors: Pariente B, Hu S, Bettenworth D, Speca S, Desreumaux P, Meuwis MA, Danese S, Rieder F, Louis E Abstract BACKGROUND & AIMS: Despite significant advances in the treatment of Crohn’s disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD patients. METHODS: We searched the PubMed, MBASE, and Cochrane databases from September…

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