Association Between Vulvovaginal Discomfort and Activity of Inflammatory Bowel Diseases.

Association Between Vulvovaginal Discomfort and Activity of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 May 17;: Authors: Ona S, James K, Ananthakrishnan AN, Long MD, Martin C, Chen W, Mitchell CM Abstract BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) affect 200-400 people per 100,000 in the United States, about half of whom are women. We aimed to define the prevalence of vulvovaginal symptoms and association with IBD activity in a large cohort of women. METHODS: Women more than 18 years old with IBD (1250) completed an online survey querying the…

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Efficacy and Speed of Induction of Remission of Infliximab vs Golimumab for Patients With Ulcerative Colitis, Based on Data From Clinical Trials.

Efficacy and Speed of Induction of Remission of Infliximab vs Golimumab for Patients With Ulcerative Colitis, Based on Data From Clinical Trials. Clin Gastroenterol Hepatol. 2019 May 17;: Authors: Singh S, Proudfoot JA, Dulai PS, Xu R, Feagan BG, Sandborn WJ, Jairath V Abstract BACKGROUND & AIMS: With several options available for patients with moderate-severe ulcerative colitis (UC), rapidity of symptom resolution could be an important differentiator. We compared the efficacy and speed of onset of action of infliximab vs golimumab induction therapy using patient-level data from phase 3 trials…

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Effects of Vedolizumab in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases.

Effects of Vedolizumab in Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 May 14;: Authors: Lynch KD, Chapman RW, Keshav S, Montano-Loza AJ, Mason AL, Kremer AE, Vetter M, de Krijger M, Ponsioen CY, Trivedi P, Hirschfield G, Schramm C, Liu CH, Bowlus CL, Estes DJ, Pratt D, Hedin C, Bergquist A, de Vries AC, Janneke van der Woude C, Yu L, Assis DN, Boyer J, Ytting H, Hallibasic E, Trauner M, Marschall HU, Daretti LM, Marzioni M, Yimam KK, Perin N, Floreani A, Beretta-Piccoli…

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Variation Among Patients With Crohn’s Disease in Benefit vs Risk Preferences and Remission Time Equivalents.

Variation Among Patients With Crohn’s Disease in Benefit vs Risk Preferences and Remission Time Equivalents. Clin Gastroenterol Hepatol. 2019 May 14;: Authors: Bewtra M, Reed SD, Johnson FR, Scott FI, Gilroy E, Sandler RS, Chen W, Lewis JD Abstract BACKGROUND & AIMS: Patients with Crohn’s disease (CD) must make decisions about their treatment. We aimed to quantify patients’ preferences for different treatment outcomes and adverse events. We also evaluated the effects of latent-class heterogeneity on these preferences. METHODS: An online stated-preference survey was completed by 812 individuals with CD in…

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Nancy Index Scores of Chronic Inflammatory Bowel Disease Activity Associate With Development of Colorectal Neoplasia.

Related Articles Nancy Index Scores of Chronic Inflammatory Bowel Disease Activity Associate With Development of Colorectal Neoplasia. Clin Gastroenterol Hepatol. 2019 May 11;: Authors: Kirchgesner J, Svrcek M, Le Gall G, Landman C, Dray X, Bourrier A, Nion-Larmurier I, Hoyeau N, Sokol H, Seksik P, Cosnes J, Fléjou JF, Beaugerie L, Saint-Antoine IBD Network Abstract BACKGROUND & AIMS: The degree of histological and endoscopic disease activity has been associated with an increased risk of colorectal neoplasia (CRN) in patients with inflammatory bowel diseases (IBD), but no histological scoring systems have…

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Recommendations for Successful Transition of Adolescents With Inflammatory Bowel Diseases to Adult Care.

Recommendations for Successful Transition of Adolescents With Inflammatory Bowel Diseases to Adult Care. Clin Gastroenterol Hepatol. 2019 May 08;: Authors: Shapiro JM, El-Serag HB, Gandle C, Peacock C, Denson L, Fishman L, Hernaez RL, Hou J Abstract Adolescents and young adults diagnosed with inflammatory bowel diseases (IBD) in pediatric care are vulnerable during their transition to adult care. There are 6 core elements of transition from pediatric to adult IBD care. We identified gaps in this transition and make recommendations for clinical practice and research. There have been few studies…

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Tofacitinib Treatment is Associated with Modest and Reversible Increases in Serum Lipids in Patients with Ulcerative Colitis.

Tofacitinib Treatment is Associated with Modest and Reversible Increases in Serum Lipids in Patients with Ulcerative Colitis. Clin Gastroenterol Hepatol. 2019 May 08;: Authors: Sands BE, Taub PR, Armuzzi A, Friedman GS, Moscariello M, Lawendy N, Pedersen RD, Chan G, Nduaka CI, Quirk D, Salese L, Su C, Feagan BG Abstract BACKGROUND & AIMS: Tofacitinib is an oral, small-molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We analyzed inflammation, lipid concentrations, and incidence rates of major adverse cardiovascular (CV) events (MACEs) in patients who received tofacitinib in…

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Association Between Microscopic Lesions at Ileal Resection Margin and Recurrence After Surgery in Patients With Crohn’s Disease.

Related Articles Association Between Microscopic Lesions at Ileal Resection Margin and Recurrence After Surgery in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Apr 28;: Authors: Hammoudi N, Cazals-Hatem D, Auzolle C, Gardair C, Ngollo M, Bottois H, Nancey S, Pariente B, Buisson A, Treton X, Fumery M, Bezault M, Seksik P, Le Bourhis L, REMIND study group investigators, Flejou JF, Allez M Abstract BACKGROUND AND AIMS: Different types of histologic lesions at the ileal margin, detected by histology, have been associated with increased rates of recurrence after ileocaecal surgery…

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Should We Divide Crohn’s Disease Into Ileum-dominant and Isolated Colonic Diseases?

Should We Divide Crohn’s Disease Into Ileum-dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 Apr 19;: Authors: Dulai PS, Singh S, Casteele NV, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ Abstract Crohn’s disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification…

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