Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease.

Related Articles Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease. Am J Gastroenterol. 2018 Aug 03;: Authors: Axelrad JE, Joelson A, Green PHR, Lawlor G, Lichtiger S, Cadwell K, Lebwohl B Abstract OBJECTIVES: Few studies have examined the role of non-Clostridium difficile enteric infections in flares of inflammatory bowel disease (IBD). Our objective was to investigate enteric infection detected by multiplex PCR stool testing in patients with IBD. METHODS: We performed a cross-sectional analysis of 9403 patients who underwent 13,231 stool tests with a gastrointestinal pathogen…

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Pregnancy Outcomes Reported During the 13-Year TREAT Registry: A Descriptive Report.

Related Articles Pregnancy Outcomes Reported During the 13-Year TREAT Registry: A Descriptive Report. Am J Gastroenterol. 2018 Jul 19;: Authors: Lichtenstein GR, Feagan BG, Mahadevan U, Salzberg BA, Langholff W, Morgan GJ, Safdi M, Nissinen R, Taillard F, Sandborn WJ, Cohen RD Abstract OBJECTIVES: We described pregnancy outcomes in Crohn’s disease (CD) patients enrolled in the TREAT Registry who received infliximab before, or during pregnancy and those not treated with infliximab or any biologic agent. METHODS: In the TREAT Registry (1999-2012), pregnancy outcomes were analyzed from maternal and paternal patients…

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Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn’s Disease Compared to Men Without Inflammatory Bowel Disease: A Nationwide Cohort Study.

Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn’s Disease Compared to Men Without Inflammatory Bowel Disease: A Nationwide Cohort Study. Am J Gastroenterol. 2018 Jul 10;: Authors: Friedman S, Magnussen B, O’Toole A, Fedder J, Larsen MD, Nørgård BM Abstract BACKGROUND: Men with inflammatory bowel disease (IBD) may have decreased sexual function due to factors related to the underlying disease, medication, and/or surgery. We aimed to examine the use of erectile dysfunction (ED) medications in men with IBD. METHODS: This is a nationwide cohort…

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Letter to the Editor Regarding Optimizing Selection of Biologics in Inflammatory Bowel Disease: Development of an Online Patient Decision Aid Using Conjoint Analysis.

Letter to the Editor Regarding Optimizing Selection of Biologics in Inflammatory Bowel Disease: Development of an Online Patient Decision Aid Using Conjoint Analysis. Am J Gastroenterol. 2018 Jul 03;: Authors: Johnson FR, Reed S, Gonzalez JM PMID: 29967477 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29967477?dopt=Abstract

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Continuous Anti-TNF╬▒ Use Throughout Pregnancy: Possible Complications For the Mother But Not for the Fetus. A Retrospective Cohort on the French National Health Insurance Database (EVASION).

Related Articles Continuous Anti-TNFα Use Throughout Pregnancy: Possible Complications For the Mother But Not for the Fetus. A Retrospective Cohort on the French National Health Insurance Database (EVASION). Am J Gastroenterol. 2018 Jul 02;: Authors: Luu M, Benzenine E, Doret M, Michiels C, Barkun A, Degand T, Quantin C, Bardou M Abstract OBJECTIVES: Inflammatory bowel diseases (IBD) need long-term treatment, which can influence pregnancies in young women. Uncontrolled IBD is associated with poor pregnancy outcomes. Despite the labeling of Anti-tumor necrosis factor (TNF) antibodies (anti-TNFα) which indicates that their use…

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Vedolizumab for Ulcerative Colitis: Treatment Outcomes from the VICTORY Consortium.

Related Articles Vedolizumab for Ulcerative Colitis: Treatment Outcomes from the VICTORY Consortium. Am J Gastroenterol. 2018 Jun 27;: Authors: Narula N, Peerani F, Meserve J, Kochhar G, Chaudrey K, Hartke J, Chilukuri P, Koliani-Pace J, Winters A, Katta L, Shmidt E, Hirten R, Faleck D, Parikh MP, Whitehead D, Boland BS, Singh S, Sagi SV, Fischer M, Chang S, Barocas M, Luo M, Lasch K, Bohm M, Lukin D, Sultan K, Swaminath A, Hudesman D, Gupta N, Shen B, Kane S, Loftus EV, Siegel CA, Sands BE, Colombel JF, Sandborn…

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Is There a Role for Thiopurines in IBD?

Related Articles Is There a Role for Thiopurines in IBD? Am J Gastroenterol. 2018 Jun 27;: Authors: Cross RK, Herfarth H Abstract Immunosuppressive therapy (IM) is inexpensive and nearly one-third of patients with inflammatory bowel disease (IBD) experience a benefit from treatment. IM may be ideal for IBD patients at low risk for a disabling disease course or colectomy and/or those patients with inadequate access to biologic therapy. A majority of IBD patients benefit from early biologic therapy with improved short and likely long-term outcomes. Improved methods are needed to…

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No Benefit of Concomitant 5-Aminosalicylates in Patients With Ulcerative Colitis Escalated to Biologic Therapy: Pooled Analysis of Individual Participant Data From Clinical Trials.

Related Articles No Benefit of Concomitant 5-Aminosalicylates in Patients With Ulcerative Colitis Escalated to Biologic Therapy: Pooled Analysis of Individual Participant Data From Clinical Trials. Am J Gastroenterol. 2018 Jun 21;: Authors: Singh S, Proudfoot JA, Dulai PS, Jairath V, Fumery M, Xu R, Feagan BG, Sandborn WJ Abstract OBJECTIVES: 5-aminosalicylates (5-ASA) are frequently continued in patients with moderate-severe ulcerative colitis (UC), even after escalation to biologic agents, without evaluation of the benefit of this approach. We conducted an individual participant data (IPD) pooled analysis of trials of infliximab and…

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Persistence With Immunomodulator Monotherapy Use And Incidence of Therapeutic Ineffectiveness Among Users of Immunomodulator Monotherapy in IBD.

Related Articles Persistence With Immunomodulator Monotherapy Use And Incidence of Therapeutic Ineffectiveness Among Users of Immunomodulator Monotherapy in IBD. Am J Gastroenterol. 2018 Jun 21;: Authors: Targownik LE, Leung S, Lix LM, Singh H, Bernstein CN Abstract OBJECTIVES: Immunomodulator (IM)-based monotherapy with thiopurines or methotrexate is being increasingly supplanted in the management of moderate-to-severe IBD by more efficacious biologic agents. However, given their low cost, IMs may still have a selective role in this setting. METHODS: We used a Canadian population-based dataset of persons with IBD spanning from 1996 until…

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