Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease.

Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease. Aliment Pharmacol Ther. 2019 Sep 13;: Authors: Ashton JJ, Latham K, Beattie RM, Ennis S Abstract BACKGROUND: The human leucocyte antigen (HLA) complex, located at chromosome 6p21.3 is a highly polymorphic region containing the classical class I and II HLA genes. The region is highly associated with inflammatory bowel disease (IBD), largely through genome-wide association studies (GWAS). AIMS: To review the role of HLA in immune function, summarise data on risk/protective HLA genotypes for IBD, discuss…

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Systematic review with network meta-analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease.

Related Articles Systematic review with network meta-analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease. Aliment Pharmacol Ther. 2019 Sep 09;: Authors: Iannone A, Ruospo M, Palmer SC, Principi M, Barone M, Di Leo A, Strippoli GFM Abstract BACKGROUND: International guidelines recommend dysplasia surveillance in IBD. AIM: To compare endoscopic techniques for dysplasia surveillance METHODS: We searched MEDLINE, Embase, CENTRAL for randomised trials through May 2019. We estimated odds ratios (ORs) for binary and mean differences (MDs) for continuous outcomes, using frequentist random-effects network meta-analysis. We assessed study risk…

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Systematic review with meta-analysis: association between vedolizumab trough concentration and clinical outcomes in patients with inflammatory bowel diseases.

Related Articles Systematic review with meta-analysis: association between vedolizumab trough concentration and clinical outcomes in patients with inflammatory bowel diseases. Aliment Pharmacol Ther. 2019 Sep 04;: Authors: Singh S, Dulai PS, Vande Casteele N, Battat R, Fumery M, Boland BS, Sandborn WJ Abstract BACKGROUND: There has been limited evaluation of the association between vedolizumab trough concentration and clinical outcomes in patients with inflammatory bowel diseases (IBD). AIM: To perform a systematic review and meta-analysis to evaluate the potential role of therapeutic drug monitoring (TDM) for vedolizumab. METHODS: Through a systematic…

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Infliximab induction regimens in steroid-refractory acute severe colitis: a multicentre retrospective cohort study with propensity score analysis.

Related Articles Infliximab induction regimens in steroid-refractory acute severe colitis: a multicentre retrospective cohort study with propensity score analysis. Aliment Pharmacol Ther. 2019 Sep;50(6):675-683 Authors: Sebastian S, Myers S, Argyriou K, Martin G, Los L, Fiske J, Ranjan R, Cooper B, Goodoory V, Ching HL, Jayasooriya N, Brooks J, Dhar A, Shenoy AH, Limdi JK, Butterworth J, Allen PB, Samuel S, Moran GW, Shenderey R, Parkes G, Lobo A, Kennedy NA, Subramanian S, Raine T Abstract BACKGROUND: Accelerated induction regimens of infliximab have been proposed to improve response rates in…

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Letter: previous exposure to corticosteroids increases the risk of post-discharge venous thromboembolic events in patients with inflammatory bowel disease.

Related Articles Letter: previous exposure to corticosteroids increases the risk of post-discharge venous thromboembolic events in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2019 Sep;50(6):712-713 Authors: Zeng J, Gan HT PMID: 31456298 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31456298?dopt=Abstract

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Letter: previous exposure to corticosteroids increases the risk of post-discharge venous thromboembolic events in patients with inflammatory bowel disease-author’s reply.

Related Articles Letter: previous exposure to corticosteroids increases the risk of post-discharge venous thromboembolic events in patients with inflammatory bowel disease-author’s reply. Aliment Pharmacol Ther. 2019 Sep;50(6):714-715 Authors: McCurdy JD PMID: 31456301 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31456301?dopt=Abstract

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Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD.

Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD. Aliment Pharmacol Ther. 2019 Aug 16;: Authors: Mogilevski T, Burgell R, Aziz Q, Gibson PR Abstract BACKGROUND: There is a growing body of evidence implicating a role for the brain-gut axis in the pathogenesis of inflammation in patients with IBD. AIMS: To perform a narrative review of published literature regarding the association of the autonomic nervous system and intestinal inflammation and to describe the rationale for and emerging use of autonomic manipulation as a…

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Editorial: real-world short-term effectiveness of ustekinumab in 305 patients with Crohn’s disease-results from the ENEIDA registry. Authors’ reply.

Related Articles Editorial: real-world short-term effectiveness of ustekinumab in 305 patients with Crohn’s disease-results from the ENEIDA registry. Authors’ reply. Aliment Pharmacol Ther. 2019 Sep;50(5):600-601 Authors: Iborra M, Beltrán B, Nos P PMID: 31414541 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31414541?dopt=Abstract

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