Review article: novel oral-targeted therapies in inflammatory bowel disease.

Related Articles Review article: novel oral-targeted therapies in inflammatory bowel disease. Aliment Pharmacol Ther. 2018 Apr 19;: Authors: White JR, Phillips F, Monaghan T, Fateen W, Samuel S, Ghosh S, Moran GW Abstract BACKGROUND: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of medications that target specific genetic pathways found to be relevant in other immune mediated diseases. AIMS: To provide an overview of recent clinical…

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Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition.

Related Articles Fibrostenotic Phenotype of Myofibroblasts in Crohn’s Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition. J Crohns Colitis. 2018 Apr 16;: Authors: de Bruyn JR, van den Brink GR, Steenkamer J, Buskens CJ, Bemelman WA, Meisner S, Muncan V, Te Velde AA, D’Haens GR, Wildenberg ME Abstract Background and Aims: Crohn’s disease is a chronic inflammatory disorder of the intestine and often leads to fibrosis, characterized by excess extracellular matrix [ECM] deposition, increased tissue stiffness, and stricture formation. Here we evaluated the contribution of myofibroblast-ECM interactions…

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Clinical differences between elderly-onset and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan.

Clinical differences between elderly-onset and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan. J Gastroenterol Hepatol. 2018 Apr 18;: Authors: Komoto S, Higashiyama M, Watanabe C, Suzuki Y, Watanabe M, Hibi T, Takebayashi T, Asakura K, Nishiwaki Y, Miura S, Hokari R Abstract OBJECTIVE: Studies on the characteristics of elderly-onset ulcerative colitis (EOUC) and non-elderly-onset UC (NEOUC) have reported conflicting findings. The aim of this study was to compare disease characteristics of EOUC and NEOUC by analyzing the database of the Japanese nationwide inflammatory bowel disease (IBD) registry. STUDY…

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Improved Medical Treatment and Surgical Surveillance of Children and Adolescents with Ulcerative Colitis in the United Kingdom.

Improved Medical Treatment and Surgical Surveillance of Children and Adolescents with Ulcerative Colitis in the United Kingdom. Inflamm Bowel Dis. 2018 Apr 13;: Authors: Auth MK, Bunn SK, Protheroe AL, Williams LJ, Fell JM, Muhammed R, Croft NM, Beattie RM, Willmott A, Spray C, Vadamalayan B, Rodrigues A, Puntis J, Pigott AJ, Wilson DC, Mitton S, Furman M, Charlton C, Chong SKF, BSPGHAN IBD working group, BSPGHAN IBD site leads, Russell RK Abstract Background: Pediatric ulcerative colitis (UC) presents at an earlier age and increasing prevalence. Our aim was to…

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What Is the Risk of Progressive Multifocal Leukoencephalopathy in Patients With Ulcerative Colitis or Crohn’s Disease Treated With Vedolizumab?

What Is the Risk of Progressive Multifocal Leukoencephalopathy in Patients With Ulcerative Colitis or Crohn’s Disease Treated With Vedolizumab? Inflamm Bowel Dis. 2018 Apr 13;: Authors: Card T, Xu J, Liang H, Bhayat F Abstract Background: Progressive multifocal leukoencephalopathy is a serious condition linked to certain diseases and immunosuppressant therapies, including the α4 integrin antagonist natalizumab. No cases have been reported to date with vedolizumab, a selective antagonist of the α4β7 integrin expressed on gut-homing lymphocytes. This analysis aimed to describe the current and future expected occurrence of progressive multifocal…

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Outcomes of Endoscopic Resections of Large Laterally Spreading Colorectal Lesions in Inflammatory Bowel Disease: a Single United Kingdom Center Experience.

Outcomes of Endoscopic Resections of Large Laterally Spreading Colorectal Lesions in Inflammatory Bowel Disease: a Single United Kingdom Center Experience. Inflamm Bowel Dis. 2018 Apr 13;: Authors: Gulati S, Emmanuel A, Burt M, Dubois P, Hayee B, Haji A Abstract Background: The SCENIC consensus statement recommends endoscopic resection of all visible dysplasia in inflammatory bowel disease, but patients with large or complex lesions may still be advised to have colectomy. This article presents outcomes for large nonpolypoid resections associated with colitis at our institution. Methods: Data including demographics, clinical history,…

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The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter.

The Onset and Progression of Chronic Colitis Parallels Increased Mucosal Serotonin Release via Enterochromaffin Cell Hyperplasia and Downregulation of the Serotonin Reuptake Transporter. Inflamm Bowel Dis. 2018 Apr 13;: Authors: Stavely R, Fraser S, Sharma S, Rahman AA, Stojanovska V, Sakkal S, Apostolopoulos V, Bertrand P, Nurgali K Abstract Background: Serotonin (5-hydroxytryptamine, 5-HT) has been linked with several inflammation-associated intestinal diseases, including ulcerative colitis (UC). The largest pool of 5-HT in the body is in enterochromaffin (EC) cells located throughout the intestinal tract. EC cells are mechanosensitive and detect noxious…

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No Significant Association Between the Fecal Microbiome and the Presence of Irritable Bowel Syndrome-type Symptoms in Patients with Quiescent Inflammatory Bowel Disease.

No Significant Association Between the Fecal Microbiome and the Presence of Irritable Bowel Syndrome-type Symptoms in Patients with Quiescent Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Apr 13;: Authors: Shutkever O, Gracie DJ, Young C, Wood HM, Taylor M, John Hamlin P, Ford AC, Quirke P Abstract Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD patients is uncertain. We aimed to resolve this issue using…

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