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Asthma is Associated With Subsequent Development of Inflammatory Bowel Disease: a Population-based Case-Control Study.

Related Articles Asthma is Associated With Subsequent Development of Inflammatory Bowel Disease: a Population-based Case-Control Study. Clin Gastroenterol Hepatol. 2017 Mar 23;: Authors: Kuenzig ME, Barnabe C, Seow CH, Eksteen B, Negron ME, Rezaie A, Panaccione R, Benchimol EI, Sadatsafavi M, Aviña-Zubieta JA, Kaplan GG Abstract BACKGROUND & AIMS: Asthma and the inflammatory bowel diseases (IBD) each arise through complex interactions between genetic and environmental factors, and share many environmental risk factors. We examined the association between asthma and Crohn’s disease or ulcerative colitis. METHODS: We performed a population-based case-control…

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Use of Thiopurines During Conception and Pregnancy not Associated With Adverse Pregancy Outcomes or Health of Infants at 1 Year in a Prospective Study.

Related Articles Use of Thiopurines During Conception and Pregnancy not Associated With Adverse Pregancy Outcomes or Health of Infants at 1 Year in a Prospective Study. Clin Gastroenterol Hepatol. 2017 Mar 22;: Authors: Kanis SL, de Lima-Karagiannis A, de Boer NK, van der Woude CJ Abstract BACKGROUND & AIMS: Most data on the safety of thiopurine therapy for inflammatory bowel disease (IBD) during pregnancy come from retrospective studies, making it difficult to adjust for confounding factors. We performed a prospective cohort study to determine whether thiopurine use affects pregnancy outcomes…

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Activation of Epithelial STAT1 by Interleukin 28 Controls Mucosal Healing in Mice with Colitis and is Increased in Mucosa of Patients With Inflammatory Bowel Disease.

Related Articles Activation of Epithelial STAT1 by Interleukin 28 Controls Mucosal Healing in Mice with Colitis and is Increased in Mucosa of Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 Mar 22;: Authors: Chiriac MT, Buchen B, Wandersee A, Hundorfean G, Günther C, Bourjau Y, Doyle SE, Frey B, Ekici AB, Büttner C, Weigmann B, Atreya R, Wirtz S, Becker C, Siebler J, Neurath MF Abstract BACKGROUND & AIMS: We investigated the roles of interleukin 28A (also called IL28A or interferon lambda 2) in intestinal epithelial cell (IEC) activation, studying its…

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The Effect of Disease Activity on Birth Outcomes in a Nationwide Cohort of Women with Moderate to Severe Inflammatory Bowel Disease.

The Effect of Disease Activity on Birth Outcomes in a Nationwide Cohort of Women with Moderate to Severe Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Mar 24;: Authors: Kammerlander H, Nielsen J, Kjeldsen J, Knudsen T, Friedman S, Nørgård B Abstract BACKGROUND: Active inflammatory bowel disease (IBD) during conception and pregnancy may increase the risk of adverse birth outcomes. Former studies have examined heterogeneous groups of women with varying degrees of IBD severity. We aimed to examine the effect of active IBD on birth outcomes in a more homogeneous group…

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Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study.

Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. Inflamm Bowel Dis. 2017 Mar 24;: Authors: Hata K, Ishii H, Anzai H, Ishihara S, Nozawa H, Kawai K, Kiyomatsu T, Watanabe T Abstract BACKGROUND: Pouchitis is a major problem after ileal pouch-anal anastomosis in patients with ulcerative colitis. Chronic pouchitis is particularly troublesome. This study aimed to identify risk factors for the development of chronic pouchitis in a Japanese population. METHODS: We retrospectively reviewed 100 patients who underwent pouchoscopy…

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Inadequate Gestational Weight Gain Predicts Adverse Pregnancy Outcomes in Mothers with Inflammatory Bowel Disease: Results from a Prospective US Pregnancy Cohort.

Related Articles Inadequate Gestational Weight Gain Predicts Adverse Pregnancy Outcomes in Mothers with Inflammatory Bowel Disease: Results from a Prospective US Pregnancy Cohort. Dig Dis Sci. 2017 Mar 22;: Authors: Bengtson MB, Martin CF, Aamodt G, Vatn MH, Mahadevan U Abstract BACKGROUND: Malnutrition and weight loss are common features of patients with inflammatory bowel disease (IBD). AIM: To explore the impact of inadequate gestational weight gain (GWG) on adverse outcomes among IBD mothers in the prospective US pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes (PIANO) cohort. METHODS: The PIANO…

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Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines.

Machine Learning Algorithms for Objective Remission and Clinical Outcomes with Thiopurines. J Crohns Colitis. 2017 Mar 14;: Authors: Waljee AK, Sauder K, Patel A, Segar S, Liu B, Zhang Y, Zhu J, Stidham RW, Balis U, Higgins PD Abstract Background and Aims: Big data analytics leverage patterns in data to harvest valuable information, but are rarely implemented in clinical care. Optimising thiopurine therapy for inflammatory bowel disease [IBD] has proved difficult. Current methods using 6-thioguanine nucleotide [6-TGN] metabolites have failed in randomized controlled trials [RCTs], and have not been used…

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Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.

Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease. J Crohns Colitis. 2017 Feb 17;: Authors: Taxonera C, Ponferrada Á, Bermejo F, Riestra S, Saro C, Martín-Arranz MD, Cabriada JL, Barreiro-de Acosta M, de Castro ML, López-Serrano P, Barrio J, Suarez C, Iglesias E, Argüelles-Arias F, Ferrer I, Marín-Jiménez I, Hernández-Camba A, Bastida G, Van Domselaar M, Martínez-Montiel P, Olivares D, Alba C, Gisbert JP, SEGURTB study group from GETECCU Abstract Background and Aim: Sensitivity of tuberculin skin test [TST] during screening…

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Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn’s Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study.

Eldelumab [anti-interferon-γ-inducible protein-10 antibody] Induction Therapy for Active Crohn’s Disease: a Randomised, Double-blind, Placebo-controlled Phase IIa Study. J Crohns Colitis. 2017 Feb 22;: Authors: Sandborn WJ, Rutgeerts P, Colombel JF, Ghosh S, Petryka R, Sands BE, Mitra P, Luo A Abstract Background and Aims: This 11-week Phase IIa induction study evaluated the efficacy and safety of eldelumab in patients with active Crohn’s disease. Methods: Adults with Crohn’s Disease Activity Index 220-450 were randomised 1:1:1 to placebo or eldelumab 10 or 20 mg/kg intravenously on Days 1 and 8, and alternate…

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X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans.

X chromosome-wide association study identifies a susceptibility locus for inflammatory bowel disease in Koreans. J Crohns Colitis. 2017 Feb 22;: Authors: Lee HS, Oh H, Baek J, Jung S, Hong M, Kim KM, Shin HD, Kim KJ, Park SH, Ye BD, Han B, Yang SK, Song K Abstract Background and Aims: Genome-wide association studies of inflammatory bowel disease identified >200 susceptibility loci only in autosomes. This study aimed to identify inflammatory bowel disease susceptibility loci on the X chromosome. Methods: We performed an X chromosome-wide association study in Korean patients…

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