Fecal Calprotectin in Assessing Endoscopic and Histological Remission in Patients with Ulcerative Colitis.

Related Articles Fecal Calprotectin in Assessing Endoscopic and Histological Remission in Patients with Ulcerative Colitis. Dig Dis Sci. 2018 Feb 22;: Authors: Mak WY, Buisson A, Andersen MJ, Lei D, Pekow J, Cohen RD, Kahn SA, Pereira B, Rubin DT Abstract BACKGROUND: Persistent active endoscopic and histological inflammation is associated with poorer outcomes in ulcerative colitis (UC). Fecal calprotectin is a surrogate marker of endoscopic and histological remission. AIMS: To confirm the correlation between fecal calprotectin and endoscopic or histological disease activity and to define the optimal cutoff value to…

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Efficacy of vedolizumab in fistulising Crohn’s disease: Exploratory analyses of data from GEMINI 2.

Efficacy of vedolizumab in fistulising Crohn’s disease: Exploratory analyses of data from GEMINI 2. J Crohns Colitis. 2018 Feb 17;: Authors: Feagan BG, Schwartz D, Danese S, Rubin DT, Lissoos TW, Xu J, Lasch K Abstract Background and Aims: Medical management of fistulising Crohn’s disease (CD) is constrained by the limited number of available therapies. We evaluated the efficacy of vedolizumab, a gut-selective α4β7 integrin antagonist approved for treating moderately to severely active CD, in a subpopulation of patients with fistulising CD who participated in the GEMINI 2 trial (NCT00783692).…

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A Case of Panenteritis With Massive IgG4-Positive Plasma Cell Infiltration Developed 26 Years After Total Proctocolectomy for Ulcerative Colitis.

Related Articles A Case of Panenteritis With Massive IgG4-Positive Plasma Cell Infiltration Developed 26 Years After Total Proctocolectomy for Ulcerative Colitis. Am J Gastroenterol. 2018 Feb;113(2):173 Authors: Tominaga K, Tsuchiya A, Honda Y, Abe T, Yokoyama J, Umezu H, Terai S PMID: 29467530 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29467530?dopt=Abstract

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Glucose transporter expression in the human colon.

Related Articles Glucose transporter expression in the human colon. World J Gastroenterol. 2018 Feb 21;24(7):775-793 Authors: Merigo F, Brandolese A, Facchin S, Missaggia S, Bernardi P, Boschi F, D’Incà R, Savarino EV, Sbarbati A, Sturniolo GC Abstract AIM: To investigate by immunostaining glucose transporter expression in human colorectal mucosa in controls and patients with inflammatory bowel disease (IBD). METHODS: Colorectal samples were obtained from patients undergoing lower endoscopic colonoscopy or recto-sigmoidoscopy. Patients diagnosed with ulcerative colitis (n = 18) or Crohn’s disease (n = 10) and scheduled for diagnostic colonoscopy…

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Correction for “Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis” (World J Gastroenterol 2015; 21: 12667-12675).

Related Articles Correction for “Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis” (World J Gastroenterol 2015; 21: 12667-12675). World J Gastroenterol. 2018 Feb 21;24(7):876 Authors: Hokama A Abstract [This corrects the article on p. 12667 in vol. 21, PMID: 26640344.]. PMID: 29467558 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29467558?dopt=Abstract

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Editorial: Increasing Incidence of Pediatric Inflammatory Bowel Disease in France: Implications for Etiology, Diagnosis, Prognosis, and Treatment.

Related Articles Editorial: Increasing Incidence of Pediatric Inflammatory Bowel Disease in France: Implications for Etiology, Diagnosis, Prognosis, and Treatment. Am J Gastroenterol. 2018 Feb;113(2):273-275 Authors: Barnes EL, Kappelman MD Abstract The significant increase in pediatric-onset inflammatory bowel disease in recent decades appears to be a global phenomenon, with studies from multiple geographic areas noting an increase in Crohn’s disease (CD) and ulcerative colitis (UC). In this large, population-based cohort from northern France, the rapid increase in pediatric CD and UC from 1988-2011 may be due to multiple potential etiologies including…

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A comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.

A comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis. J Gastroenterol Hepatol. 2018 Feb 20;: Authors: Hirano A, Umeno J, Okamoto Y, Shibata H, Ogura Y, Moriyama T, Torisu T, Fujioka S, Fuyuno Y, Kawarabayasi Y, Matsumoto T, Kitazono T, Esaki M Abstract BACKGROUND AND AIM: The gut microbiota is suggested to play an important role in the pathogenesis of ulcerative colitis (UC). However, inter-individual and spatial variations hamper the identification of UC-related changes. We thus investigated paired mucosa-associated microbiota obtained from…

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Increased Rate of Venous Thromboembolism in Hospitalized Inflammatory Bowel Disease Patients With Clostridium difficile Infection.

Increased Rate of Venous Thromboembolism in Hospitalized Inflammatory Bowel Disease Patients With Clostridium difficile Infection. Inflamm Bowel Dis. 2018 Feb 15;24(3):661 Authors: Bhandari S, Saeian K, Stein D PMID: 29462393 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29462393?dopt=Abstract

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Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX.

Nondysplastic Ulcerative Colitis Has High Levels of the Homologous Recombination Repair Protein NUCKS1 and Low Levels of the DNA Damage Marker Gamma-H2AX. Inflamm Bowel Dis. 2018 Feb 15;24(3):593-600 Authors: De Angelis PM, Schjølberg AR, Hughes JB, Huitfeldt HS, Norheim Andersen S, Østvold AC Abstract Background: The colon and rectum are continuously exposed to oxidative stress that generates reactive oxygen species, which are a major cause of DNA double-strand breaks (DSB). Furthermore, chronic inflammatory diseases such as ulcerative colitis (UC) are characterized by an excess of reactive nitrogen species that can…

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