Transcriptomic analysis and High dimensional phenotypic mapping of mononuclear phagocytes in mesenteric lymph nodes reveal differences between ulcerative colitis and Crohn’s disease.

Related Articles Transcriptomic analysis and High dimensional phenotypic mapping of mononuclear phagocytes in mesenteric lymph nodes reveal differences between ulcerative colitis and Crohn’s disease. J Crohns Colitis. 2019 Sep 21;: Authors: Chapuy L, Bsat M, Rubio M, Harvey F, Motta V, Schwenter F, Wassef R, Richard C, Deslandres C, Nguyen BN, Soucy G, Hacohen N, Fritz J, Villani AC, Mehta H, Sarfati M Abstract BACKGROUND & AIM: Crohn’s disease (CD) and ulcerative colitis (UC) are distinct forms of inflammatory bowel diseases. Heterogeneity of HLA-DR+SIRPα+ mononuclear phagocytes (MNPs), including macrophages (MΦ),…

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The role of immunomodulators and biologics in the medical management of stricturing Crohn’s disease.

Related Articles The role of immunomodulators and biologics in the medical management of stricturing Crohn’s disease. J Crohns Colitis. 2019 Sep 21;: Authors: Rodríguez-Lago I, Gisbert JP Abstract Crohn’s disease is a progressive and disabling inflammatory disease involving the gastrointestinal tract. It usually produces inflammatory lesions in the ileocolonic region, but up to half of patients will also develop complications such as strictures in the long term. Indeed, a proportion of patients have progression of the disease with the development of stricturing lesions because there are no drugs that effectively…

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Small Bowel Adenocarcinoma: Is there a difference in survival for Crohn’s versus Sporadic cases?

Related Articles Small Bowel Adenocarcinoma: Is there a difference in survival for Crohn’s versus Sporadic cases? J Crohns Colitis. 2019 Sep 21;: Authors: Fields AC, Hu FY, Lu P, Irani J, Bleday R, Goldberg JE, Melnitchouk N Abstract BACKGROUND AND AIMS: It is well known that Crohn’s disease is a risk factor for the development of small bowel adenocarcinoma. However, the association between Crohn’s disease-associated small bowel adenocarcinoma and survival is less understood. The goal of this study is to determine the impact of Crohn’s disease on survival in small…

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Comparison of Lewis Score and Capsule Endoscopy Crohn’s Disease Activity Index in Patients with Crohn’s Disease.

Related Articles Comparison of Lewis Score and Capsule Endoscopy Crohn’s Disease Activity Index in Patients with Crohn’s Disease. Dig Dis Sci. 2019 Sep 20;: Authors: Omori T, Kambayashi H, Murasugi S, Ito A, Yonezawa M, Nakamura S, Tokushige K Abstract BACKGROUND/AIMS: Small bowel capsule endoscopy (SBCE) is used to visualize mucosal inflammatory changes in the small intestine of patients with Crohn’s disease (CD). The Lewis score (LS) and Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI) are used to evaluate the visualized images. We determined the score disagreement between LS and…

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Eosinophilic esophagitis: Current concepts in diagnosis and treatment.

Related Articles Eosinophilic esophagitis: Current concepts in diagnosis and treatment. World J Gastroenterol. 2019 Aug 28;25(32):4598-4613 Authors: Gómez-Aldana A, Jaramillo-Santos M, Delgado A, Jaramillo C, Lúquez-Mindiola A Abstract Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology (genetic and environmental) that affects both pediatric and adult patients. Its symptoms, which include heartburn, regurgitation, and esophageal stenosis (with dysphagia being more frequent in eosinophilic esophagitis in young adults and children), are similar to those of gastroesophageal reflux disease, causing delays in diagnosis and treatment. Although endoscopic findings such as furrows, esophageal…

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CANADIAN ASSOCIATION OF GASTROENTEROLOGY CLINICAL PRACTICE GUIDELINE ON THE MANAGEMENT OF BILE ACID DIARRHEA.

Related Articles CANADIAN ASSOCIATION OF GASTROENTEROLOGY CLINICAL PRACTICE GUIDELINE ON THE MANAGEMENT OF BILE ACID DIARRHEA. Clin Gastroenterol Hepatol. 2019 Sep 14;: Authors: Sadowski DC, Camilleri M, Chey WD, Leontiadis GI, Marshall JK, Shaffer EA, Tse F, Walters JRF Abstract BACKGROUND & AIMS: Chronic diarrhea affects about 5% of the population overall. Altered bile acid metabolism is a common but frequently undiagnosed cause. METHODS: We performed a systematic search of publication databases for studies of assessment and management of bile acid diarrhea (BAD). The certainty (quality) of evidence and strength…

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Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results.

Related Articles Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results. Dig Dis Sci. 2019 Sep 16;: Authors: Chen L, Reynolds C, David R, Peace Brewer A Abstract BACKGROUND: Gut microbiota play an important role in human health. However, the application of gut microbiome in regular clinical practice is limited by interindividual variations and complexity of test results. HYPOTHESIS: It is possible to address interindividual variation by using large data-based exploratory-pattern analysis. METHODS: The current study was conducted using a large data set (n = 173,221) of…

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Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study.

Related Articles Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study. J Gastroenterol. 2019 Sep 16;: Authors: Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T, INDIGO Study Group Abstract BACKGROUND: We recently reported the efficacy of indigo naturalis (IN) in patients with active ulcerative colitis (UC)…

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The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases.

Related Articles The Role of Gastrointestinal-Related Fatty Acid-Binding Proteins as Biomarkers in Gastrointestinal Diseases. Dig Dis Sci. 2019 Sep 16;: Authors: Ho SSC, Keenan JI, Day AS Abstract The fatty acid-binding proteins play a major role in intracellular transportation of long-chain fatty acids. Nine fatty acid-binding proteins have been identified, with each having individual tissue-specific functions in addition to regulation of fatty acids. This review focuses on the three fatty acid-binding proteins found in the gastrointestinal tract and discusses their role as diagnostic or disease monitoring markers in neonatal necrotizing…

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