Vaccine-Preventable Diseases in Hospitalized Patients With Inflammatory Bowel Disease: A Nationwide Cohort Analysis.

Vaccine-Preventable Diseases in Hospitalized Patients With Inflammatory Bowel Disease: A Nationwide Cohort Analysis. Inflamm Bowel Dis. 2019 May 08;: Authors: Guerrero Vinsard D, Wakefield D, Vaziri H, Karagozian R Abstract BACKGROUND: Inflammatory bowel disease (IBD) entails a higher risk of infections, including those that could be prevented with immunizations. Current Advisory Committee on Immunization Practices and American College of Gastroenterology vaccine recommendations for patients with IBD are based on low levels of evidence. METHODS: We conducted a population-based descriptive cohort study using the US National Inpatient Sample ICD-9 codes from…

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Improved Antibody Response to Three Additional Hepatitis B Vaccine Doses Following Primary Vaccination Failure in Patients with Inflammatory Bowel Disease.

Related Articles Improved Antibody Response to Three Additional Hepatitis B Vaccine Doses Following Primary Vaccination Failure in Patients with Inflammatory Bowel Disease. Dig Dis Sci. 2019 Apr 03;: Authors: Pratt PK, Nunes D, Long MT, Farraye FA Abstract BACKGROUND: Studies have shown the efficacy of hepatitis B (HBV) vaccination in patients with inflammatory bowel disease (IBD) is impaired, but few data exist regarding the effectiveness of revaccination strategies following primary vaccination failure. Our aim was to analyze the association between administration of additional vaccine doses and hepatitis B surface antibody…

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Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Related Articles Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Dec 14;: Authors: deBruyn JCC, Soon IS, Fonseca K, Feng S, Purtzki M, Goedhart C, Kuhn S, Vanderkooi OG, Wrobel I Abstract Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD. Methods: In a cross-sectional study, demographic data, IBD…

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Efficacy of Live Attenuated Herpes Zoster Vaccine in Patients with Inflammatory Bowel Diseases.

Efficacy of Live Attenuated Herpes Zoster Vaccine in Patients with Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2018 Oct 13;: Authors: Khan N, Trivedi C, Kavani H, Medvedeva E, Lewis J, Yang YX Abstract BACKGROUND & AIMS: The risk of herpes zoster virus infection is increased among patients with inflammatory bowel diseases (IBD). The herpes zoster vaccine (HZV) is therefore recommended for these patients, but little is known about its effectiveness, resulting in low use. METHODS: We conducted a retrospective cohort study using data from the national veterans Affairs Healthcare System…

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Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice.

Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice. Inflamm Bowel Dis. 2018 May 17;: Authors: Guan Q, Weiss CR, Wang S, Qing G, Yang X, Warrington RJ, Bernstein CN, Peng Z Abstract Interleukin (IL)-12 and IL-23 that share subunit p40 are important cytokines in the pathogenesis of inflammatory bowel disease. We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Here, we evaluated whether administration of the vaccine…

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Immunogenicity of Quadrivalent Influenza Vaccine for Patients with Inflammatory Bowel Disease Undergoing Immunosuppressive Therapy.

Immunogenicity of Quadrivalent Influenza Vaccine for Patients with Inflammatory Bowel Disease Undergoing Immunosuppressive Therapy. Inflamm Bowel Dis. 2018 Mar 09;: Authors: Shirai S, Hara M, Sakata Y, Tsuruoka N, Yamamoto K, Shimoda R, Gomi Y, Yoshii H, Fujimoto K, Iwakiri R Abstract Background and Aims: No reports have described the immunogenicity and boosting effect of the quadrivalent inactivated influenza vaccine (QIV) in adults with inflammatory bowel disease. Methods: Adults with Crohn’s disease or ulcerative colitis were randomly assigned to a single vaccination group or booster group, and a QIV was…

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Antibody Response to Hepatitis B Virus Vaccine is Impaired in Patients With Inflammatory Bowel Disease on Infliximab Therapy.

Antibody Response to Hepatitis B Virus Vaccine is Impaired in Patients With Inflammatory Bowel Disease on Infliximab Therapy. Inflamm Bowel Dis. 2018 Jan 18;24(2):380-386 Authors: Pratt PK, David N, Weber HC, Little FF, Kourkoumpetis T, Patts GJ, Weinberg J, Farraye FA Abstract Background: Studies have demonstrated an association between anti-TNF/immunomodulator agents used in inflammatory bowel disease (IBD) and impaired hepatitis B virus (HBV) vaccine immunogenicity, but little data exist on whether specific medication types affect protective HBsAb titers. Our aim was to analyze this association. Methods: This is a retrospective…

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Use of Biologic Therapy by Pregnant Women with Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines.

Related Articles Use of Biologic Therapy by Pregnant Women with Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines. Clin Gastroenterol Hepatol. 2017 Sep 01;: Authors: Beaulieu DB, Ananthakrishnan AN, Martin C, Cohen RD, Kane SV, Mahadevan U Abstract BACKGROUND & AIMS: In women with inflammatory bowel diseases (IBD), exposure to immunomodulator or biologic therapy has not been associated with adverse events during pregnancy or outcomes of newborns. We investigated whether exposure of patients to these agents during pregnancy affects serologic responses to vaccines in newborns. METHODS: We collected…

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Risk of Attenuated Live Vaccine-Induced Infection in Infants of Mothers Receiving Anti-Tumor Necrosis Factor Agents for Inflammatory Bowel Disease.

Related Articles Risk of Attenuated Live Vaccine-Induced Infection in Infants of Mothers Receiving Anti-Tumor Necrosis Factor Agents for Inflammatory Bowel Disease. Gastroenterology. 2016 Oct 31;: Authors: El-Matary W PMID: 27810374 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/27810374?dopt=Abstract

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Oral BCG vaccine in Crohn’s disease.

Related Articles Oral BCG vaccine in Crohn’s disease. Gut. 1979 Mar;20(3):229-33 Authors: Burnham WR, Lennard-Jones JE, Hecketsweiler P, Colin R, Geffroy Y Abstract In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn’s disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking…

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