Use of Biologic Therapy by Pregnant Women with Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines.

Related Articles Use of Biologic Therapy by Pregnant Women with Inflammatory Bowel Disease Does Not Affect Infant Response to Vaccines. Clin Gastroenterol Hepatol. 2017 Sep 01;: Authors: Beaulieu DB, Ananthakrishnan AN, Martin C, Cohen RD, Kane SV, Mahadevan U Abstract BACKGROUND & AIMS: In women with inflammatory bowel diseases (IBD), exposure to immunomodulator or biologic therapy has not been associated with adverse events during pregnancy or outcomes of newborns. We investigated whether exposure of patients to these agents during pregnancy affects serologic responses to vaccines in newborns. METHODS: We collected…

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Risk of Attenuated Live Vaccine-Induced Infection in Infants of Mothers Receiving Anti-Tumor Necrosis Factor Agents for Inflammatory Bowel Disease.

Related Articles Risk of Attenuated Live Vaccine-Induced Infection in Infants of Mothers Receiving Anti-Tumor Necrosis Factor Agents for Inflammatory Bowel Disease. Gastroenterology. 2016 Oct 31;: Authors: El-Matary W PMID: 27810374 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/27810374?dopt=Abstract

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Oral BCG vaccine in Crohn’s disease.

Related Articles Oral BCG vaccine in Crohn’s disease. Gut. 1979 Mar;20(3):229-33 Authors: Burnham WR, Lennard-Jones JE, Hecketsweiler P, Colin R, Geffroy Y Abstract In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn’s disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking…

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Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease.

Related Articles Immune response to influenza vaccine in pediatric patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2007 Jul;5(7):851-6 Authors: Mamula P, Markowitz JE, Piccoli DA, Klimov A, Cohen L, Baldassano RN Abstract BACKGROUND & AIMS: The aim of this study was to compare response to inactivated influenza vaccine in healthy children and pediatric patients with inflammatory bowel disease (IBD). METHODS: A prospective, open-label, controlled clinical trial during influenza seasons of 2002-2004 was performed. Single-dose inactive trivalent influenza vaccine was administered. Immune response to vaccination was measured by pre-immunization and…

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Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses.

Related Articles Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. Am J Gastroenterol. 2006 Aug;101(8):1834-40 Authors: Melmed GY, Ippoliti AF, Papadakis KA, Tran TT, Birt JL, Lee SK, Frenck RW, Targan SR, Vasiliauskas EA Abstract BACKGROUND: Patients with chronic, immune-mediated conditions such as inflammatory bowel disease (IBD) are often treated with long-term immunosuppressive therapies, potentially increasing their risk of developing an infection. Empiric data suggest that vaccines are underutilized in immunocompromised patients, despite published guidelines recommending their use. We aimed to assess exposure risk and immunization status…

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Vaccines for measles, mumps and rubella in children.

Related Articles Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD004407 Authors: Demicheli V, Jefferson T, Rivetti A, Price D Abstract BACKGROUND: Public debate over the safety of the trivalent measles, mumps and rubella (MMR) vaccine, and the resultant drop in vaccination rates in several countries, persists despite its almost universal use and accepted effectiveness. OBJECTIVES: We carried out a systematic review to assess the evidence of effectiveness and unintended effects associated with MMR. SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled…

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Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis.

Related Articles Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis. Inflamm Bowel Dis. 2010 Jun;16(6):1040-50 Authors: Ma Y, Guan Q, Bai A, Weiss CR, Hillman CL, Ma A, Zhou G, Qing G, Peng Z Abstract BACKGROUND: Intestinal fibrosis and stricture formation are major complications of inflammatory bowel disease (IBD), for which there are currently few effective treatments. We sought to investigate whether targeting transforming growth factor-beta1 (TGF-beta1), a key profibrotic mediator, with a peptide-based virus-like particle vaccine would be effective in suppressing intestinal…

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Immune response to influenza vaccine in children with inflammatory bowel disease.

Related Articles Immune response to influenza vaccine in children with inflammatory bowel disease. Am J Gastroenterol. 2009 Feb;104(2):444-53 Authors: Lu Y, Jacobson DL, Ashworth LA, Grand RJ, Meyer AL, McNeal MM, Gregas MC, Burchett SK, Bousvaros A Abstract OBJECTIVES: Patients with inflammatory bowel disease (IBD) frequently receive immunosuppressive therapy. The immune response in these patients to vaccines has not been well studied. We conducted a prospective, open label study to evaluate the serologic response to influenza vaccine in children with IBD. METHODS: Serum was obtained from 146 children and young…

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