Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases.

Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases. Gastroenterology. 2018 Apr 12;: Authors: Kirchgesner J, Lemaitre M, Carrat F, Zureik M, Carbonnel MF, Dray-Spira R Abstract BACKGROUND & AIMS: The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of serious and opportunistic infections in patients with IBD treated with thiopurine monotherapy, anti-TNF monotherapy, or combination therapy in a large cohort of patients in France. METHODS: We performed a nationwide population-based study of patients…

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Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection.

Systemic Inflammatory Responses in Ulcerative Colitis Patients and Clostridium difficile Infection. Dig Dis Sci. 2018 Apr 12;: Authors: Limsrivilai J, Rao K, Stidham RW, Govani SM, Waljee AK, Reinink A, Johnson L, Briggs E, Higgins PDR Abstract BACKGROUND/AIMS: Finding differences in systemic inflammatory response in ulcerative colitis (UC), UC with Clostridium difficile infection (CDI), and CDI could lead to a better ability to differentiate between UC with symptomatic CDI and UC with C. difficile colonization, and could identify specific inflammatory pathways for UC or CDI, which could be therapeutic targets.…

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Immunogenicity of Quadrivalent Influenza Vaccine for Patients with Inflammatory Bowel Disease Undergoing Immunosuppressive Therapy.

Immunogenicity of Quadrivalent Influenza Vaccine for Patients with Inflammatory Bowel Disease Undergoing Immunosuppressive Therapy. Inflamm Bowel Dis. 2018 Mar 09;: Authors: Shirai S, Hara M, Sakata Y, Tsuruoka N, Yamamoto K, Shimoda R, Gomi Y, Yoshii H, Fujimoto K, Iwakiri R Abstract Background and Aims: No reports have described the immunogenicity and boosting effect of the quadrivalent inactivated influenza vaccine (QIV) in adults with inflammatory bowel disease. Methods: Adults with Crohn’s disease or ulcerative colitis were randomly assigned to a single vaccination group or booster group, and a QIV was…

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Effect of Faecal Microbiota Transplantation for Treatment of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Cohort Studies.

Effect of Faecal Microbiota Transplantation for Treatment of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Cohort Studies. J Crohns Colitis. 2018 Mar 08;: Authors: Chen T, Zhou Q, Zhang D, Jiang F, Wu J, Zhou JY, Zheng X, Chen YG Abstract Background: Evidence concerning the effect of faecal microbiota transplantation (FMT) in Clostridium difficile infection (CDI) patients with inflammatory bowel disease (IBD) has not been firmly established. Therefore, we performed a systematic review and meta-analysis to evaluate FMT treatment outcomes in patients…

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Correction for “Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis” (World J Gastroenterol 2015; 21: 12667-12675).

Related Articles Correction for “Evaluation of a multiplex PCR assay for detection of cytomegalovirus in stool samples from patients with ulcerative colitis” (World J Gastroenterol 2015; 21: 12667-12675). World J Gastroenterol. 2018 Feb 21;24(7):876 Authors: Hokama A Abstract [This corrects the article on p. 12667 in vol. 21, PMID: 26640344.]. PMID: 29467558 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29467558?dopt=Abstract

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Increased Rate of Venous Thromboembolism in Hospitalized Inflammatory Bowel Disease Patients With Clostridium difficile Infection.

Increased Rate of Venous Thromboembolism in Hospitalized Inflammatory Bowel Disease Patients With Clostridium difficile Infection. Inflamm Bowel Dis. 2018 Feb 15;24(3):661 Authors: Bhandari S, Saeian K, Stein D PMID: 29462393 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29462393?dopt=Abstract

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Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes.

Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes. Inflamm Bowel Dis. 2018 Feb 15;24(3):573-582 Authors: Zhou F, Hamza T, Fleur AS, Zhang Y, Yu H, Chen K, Heath JE, Chen Y, Huang H, Feng H Abstract Background: Over the past several decades, there has been a significant increase in the incidence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD). However, a wild-type animal model is not available to study these comorbid diseases. Methods: We evaluated the susceptibility to…

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Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study.

Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study. Dig Dis Sci. 2018 Feb 08;: Authors: Micic D, Yarur A, Gonsalves A, Rao VL, Broadaway S, Cohen R, Dalal S, Gaetano JN, Glick LR, Hirsch A, Pekow J, Sakuraba A, Walk ST, Rubin DT Abstract INTRODUCTION: Clostridium difficile is the most commonly isolated stool pathogen in inflammatory bowel disease (IBD). Traditional risk factors for C. difficile may not exist in patients with IBD, and no prior studies have assessed the risk factors for the isolation of…

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