Methotrexate is not superior to placebo in maintaining steroid-free response or remission in ulcerative colitis.

Methotrexate is not superior to placebo in maintaining steroid-free response or remission in ulcerative colitis. Gastroenterology. 2018 Jun 29;: Authors: Herfarth H, Barnes EL, Valentine JF, Hanson J, Higgins PD, Isaacs KL, Jackson S, Osterman MT, Anton K, Ivanova A, Long MD, Martin C, Sandler RS, Abraham B, Cross RK, Dryden G, Fischer M, Harlan W, Levy C, McCabe R, Polyak S, Saha S, Williams E, Yajnik V, Serrano J, Sands BE, Lewis JD, Clinical Research Alliance of the Crohn’s and Colitis Foundation Abstract BACKGROUND & AIMS: Parenteral methotrexate induces…

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Is There a Role for Thiopurines in IBD?

Related Articles Is There a Role for Thiopurines in IBD? Am J Gastroenterol. 2018 Jun 27;: Authors: Cross RK, Herfarth H Abstract Immunosuppressive therapy (IM) is inexpensive and nearly one-third of patients with inflammatory bowel disease (IBD) experience a benefit from treatment. IM may be ideal for IBD patients at low risk for a disabling disease course or colectomy and/or those patients with inadequate access to biologic therapy. A majority of IBD patients benefit from early biologic therapy with improved short and likely long-term outcomes. Improved methods are needed to…

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NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.

Related Articles NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study. J Gastroenterol. 2018 Jun 19;: Authors: Kakuta Y, Kawai Y, Okamoto D, Takagawa T, Ikeya K, Sakuraba H, Nishida A, Nakagawa S, Miura M, Toyonaga T, Onodera K, Shinozaki M, Ishiguro Y, Mizuno S, Takahara M, Yanai S, Hokari R, Nakagawa T, Araki H, Motoya S, Naito T, Moroi R, Shiga H, Endo K, Kobayashi T, Naganuma M, Hiraoka S, Matsumoto T, Nakamura S,…

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Sperm DNA Integrity is Unaffected by Thiopurine Treatment in Men with Inflammatory Bowel Disease.

Related Articles Sperm DNA Integrity is Unaffected by Thiopurine Treatment in Men with Inflammatory Bowel Disease. J Crohns Colitis. 2018 Jun 16;: Authors: Grosen A, Nersting J, Bungum M, Christensen LA, Schmiegelow K, Spanò M, Julsgaard M, Cordelli E, Leter G, Larsen PB, Hvas CL, Kelsen J Abstract Background & Aims: Sperm DNA integrity, concentration and motility are suspected to be altered by thiopurines (azathioprine (AZA) and 6-mercaptopurine (6-MP)). We investigated the impact of thiopurines on semen quality in men with inflammatory bowel disease (IBD) by a comprehensive panel of…

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Editorial: an argument for low-dose thiopurine allopurinol combination use as first-line therapy in inflammatory bowel disease-authors’ reply.

Editorial: an argument for low-dose thiopurine allopurinol combination use as first-line therapy in inflammatory bowel disease-authors’ reply. Aliment Pharmacol Ther. 2018 Jul;48(1):98-99 Authors: Friedman AB, Sparrow MP PMID: 29882984 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29882984?dopt=Abstract

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Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.

Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 May 16;: Authors: Roberts RL, Wallace MC, Seinen ML, van Bodegraven AA, Krishnaprasad K, Jones GT, van Rij AM, Baird A, Lawrance IC, Prosser R, Bampton P, Grafton R, Simms LA, Studd C, Bell SJ, Kennedy MA, Halliwell J, Gearry RB, Radford-Smith G, Andrews JM, McHugh PC, Barclay ML Abstract Background : Up to 20% of patients with inflammatory bowel disease (IBD) who are refractory…

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Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients.

Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients. Clin Gastroenterol Hepatol. 2018 May 15;: Authors: Simsek M, Meijer B, Ramsoekh D, Bouma G, van der Wouden EJ, den Hartog B, de Vries AC, Hoentjen F, Dijkstra G, de Boer SY, Jansen JM, van der Meulen AE, Beukers R, Brink MA, Steinhauser T, Oldenburg B, Gilissen LP, Naber TH, Verhagen MA, de Boer NKH, Mulder CJJ, Dutch Initiative on Crohn and Colitis (ICC) PMID: 29775790 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29775790?dopt=Abstract

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Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease.

Related Articles Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn’s disease. World J Gastroenterol. 2018 May 14;24(18):2036-2046 Authors: Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS Abstract AIM: To determine the distribution of anthropometric parameter (AP)-z-scores and characterize associations between medications/serum biomarkers and AP-z-scores in pediatric Crohn’s disease (CD). METHODS: CD patients [< chronological age (CA) 21 years] were enrolled in a cross-sectional study. Descriptive statistics were generated for participants’ demographic characteristics and key variables of interest. Paired t-tests were used to compare AP-z-scores…

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Methotrexate for the Treatment of Pediatric Crohn’s Disease: A Systematic Review and Meta-analysis.

Related Articles Methotrexate for the Treatment of Pediatric Crohn’s Disease: A Systematic Review and Meta-analysis. Inflamm Bowel Dis. 2018 Apr 23;: Authors: Colman RJ, Lawton RC, Dubinsky MC, Rubin DT Abstract Background: Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature. Methods: A systematic literature search was performed using MEDLINE…

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