Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics.

Related Articles Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics. Dig Dis Sci. 2017 May 02;: Authors: Singh SB, Wilson M, Ritz N, Lin HC Abstract BACKGROUND: Defective autophagic machinery, such as that in Crohn’s disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investigated the effect of antibiotic-induced disruption of the gut microbiome (dysbiosis) on autophagy gene…

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Maternal Infections That Would Warrant Antibiotic Use Antepartum or Peripartum Are Not a Risk Factor for the Development of IBD: A Population-Based Analysis.

Maternal Infections That Would Warrant Antibiotic Use Antepartum or Peripartum Are Not a Risk Factor for the Development of IBD: A Population-Based Analysis. Inflamm Bowel Dis. 2017 Feb 10;: Authors: Bernstein CN, Burchill C, Targownik LE, Singh H, Ghia JE, Roos LL Abstract BACKGROUND: We aimed to determine whether maternal antenatal or perinatal infections (and thereby use of antibiotics) increase the risk of developing inflammatory bowel disease (IBD) in their offspring. METHODS: The University of Manitoba IBD Epidemiology Database contains records of all Manitobans diagnosed with IBD from 1984 to…

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Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis.

Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis. Inflamm Bowel Dis. 2016 Nov 22; Authors: Ishikawa D, Sasaki T, Osada T, Kuwahara-Arai K, Haga K, Shibuya T, Hiramatsu K, Watanabe S Abstract BACKGROUND: Fecal microbiota transplantation (FMT) is a potential therapeutic approach to restore normal intestinal microbiota in patients with ulcerative colitis (UC), which is associated with dysbiosis; however, treatment efficacy remains unclear. Hence, we studied the impact of antibiotic pretreatment with amoxicillin, fosfomycin, and metronidazole (AFM therapy) and FMT versus AFM…

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Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis.

Related Articles Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis. J Crohns Colitis. 2016 Nov;10(11):1324-1335 Authors: Hernández-Chirlaque C, Aranda CJ, Ocón B, Capitán-Cañadas F, Ortega-González M, Carrero JJ, Suárez MD, Zarzuelo A, Sánchez de Medina F, Martínez-Augustin O Abstract BACKGROUND AND AIMS: Intestinal microbiota is required to maintain immune homeostasis and intestinal barrier function. At the same time, intraluminal bacteria are considered to be involved in inflammatory bowel disease and are required for colitis induction in animal models, with the possible exception of dextran sulphate…

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Double blind, placebo controlled trial of metronidazole in Crohn’s disease.

Related Articles Double blind, placebo controlled trial of metronidazole in Crohn’s disease. Gut. 1991 Sep;32(9):1071-5 Authors: Sutherland L, Singleton J, Sessions J, Hanauer S, Krawitt E, Rankin G, Summers R, Mekhjian H, Greenberger N, Kelly M Abstract A double blind study compared the efficacy of metronidazole in two doses (20 mg/kg, 10 mg/kg) with placebo in patients with Crohn’s disease. One hundred and five patients participated but only 56 completed the 16 week study -21 were withdrawn for deterioration of symptoms, 17 for adverse experiences, and 11 for protocol violation….

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Treatment of Crohn’s disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.

Related Articles Treatment of Crohn’s disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. Aliment Pharmacol Ther. 1992 Aug;6(4):495-502 Authors: Langholz E, Brynskov J, Bendtzen K, Vilien M, Binder V Abstract Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn’s disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients. Eight Crohn’s disease patients were included. Fusidic acid…

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Is there a role for antibiotics as primary therapy in Crohn’s ileitis?

Related Articles Is there a role for antibiotics as primary therapy in Crohn’s ileitis? J Clin Gastroenterol. 1993 Oct;17(3):235-7 Authors: Peppercorn MA Abstract Although their use has been deemed plausible by previous investigators, the role of antibiotics as primary therapy in active Crohn’s ileitis is still unclear. Here we detail the response of four patients with active ileitis to ciprofloxacin, a quinolone antibiotic. Each patient had a dramatic improvement in abdominal pain and diarrhea coincident with the institution of ciprofloxacin, despite the absence of any obvious enteric infection. It is…

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Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis.

Related Articles Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis. Am J Gastroenterol. 1994 Jan;89(1):43-6 Authors: Mantzaris GJ, Hatzis A, Kontogiannis P, Triadaphyllou G Abstract OBJECTIVES: The aim of this study was to evaluate the role of metronidazole and tobramycin as an adjunct to corticosteroids in acute, severe ulcerative colitis. METHODS: Thirty-nine consecutive patients with severe ulcerative colitis were randomized on admission to the hospital to receive intravenously either metronidazole (0.5g tid) and tobramycin (4 mg/kg tid) (n = 19), or placebo (n =…

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Are antibiotics useful in the management of nontoxic severe ulcerative colitis?

Related Articles Are antibiotics useful in the management of nontoxic severe ulcerative colitis? J Clin Gastroenterol. 1993 Jul;17(1):14-7 Authors: Peppercorn MA Abstract Severely ill patients with ulcerative colitis are usually treated with parenteral corticoids. Those with signs of systemic toxicity usually receive antibiotics as well. However, the role of antibiotics in patients without high fever, profound leukocytosis, peritoneal signs or megacolon is not clear. Since 1985, seven patients who were admitted to the hospital with severe ulcerative colitis but without signs of toxicity have received broad spectrum antibiotics. The patients…

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