An association between Helicobacter pylori infection and serum vitamin B12 levels in healthy adults.

Related Articles An association between Helicobacter pylori infection and serum vitamin B12 levels in healthy adults. J Clin Gastroenterol. 2003 Feb;36(2):130-3 Authors: Shuval-Sudai O, Granot E Abstract GOALS: To determine whether serum vitamin B12 levels in non-vitamin B12 deficient healthy adults correlate with serological evidence of H. pylori infection. BACKGROUND: An association between H. pylori infection and vitamin B12 deficiency has been recently reported. STUDY: 133 adults, presenting to a community based primary care clinic who met the following exclusion criteria; history of H. pylori eradication or antacid use, liver…

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Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants.

Related Articles Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am J Gastroenterol. 2003 Jan;98(1):112-7 Authors: Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, de Franchis R Abstract OBJECTIVES: Individuals with inflammatory bowel disease (IBD) are at increased risk for thrombosis and vitamin deficiencies. Low plasma levels of vitamin B(6) are an independent risk factor for thrombosis and may cause hyperhomocysteinemia, another recognized risk factor for thrombosis.…

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Increased levels of homocysteine in patients with Crohn’s disease are related to folate levels.

Related Articles Increased levels of homocysteine in patients with Crohn’s disease are related to folate levels. Am J Gastroenterol. 2000 Dec;95(12):3498-502 Authors: Chowers Y, Sela BA, Holland R, Fidder H, Simoni FB, Bar-Meir S Abstract OBJECTIVES: The risk for thrombotic events is increased in inflammatory bowel disease. The factors responsible for such a risk are poorly defined. Recently, an elevated homocysteine level is emerging as a risk factor for thrombosis. The aim of this study was to determine the levels of homocysteine in a well-characterized population of patients with Crohn’s…

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Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation.

Related Articles Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation. Am J Gastroenterol. 1998 Nov;93(11):2060-4 Authors: Cravo ML, Albuquerque CM, Salazar de Sousa L, Glória LM, Chaves P, Dias Pereira A, Nobre Leitão C, Quina MG, Costa Mira F Abstract OBJECTIVE: Microsatellite instability (MSI) detected in non-neoplastic mucosa of patients with ulcerative colitis has been ascribed to an excess of DNA damage associated with chronic inflammation. Folate deficiency, commonly found in patients with long-standing disease, could further contribute to this defect because folate is…

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Influence of sulfasalazine and olsalamine on colonic epithelial cell folate content in patients with ulcerative colitis.

Related Articles Influence of sulfasalazine and olsalamine on colonic epithelial cell folate content in patients with ulcerative colitis. Inflamm Bowel Dis. 1996;2(3):163-7 Authors: Meenan J, Oʼhallinan E, Scott J, Weir DG Abstract : Inflammatory bowel disease is associated with a reduction in serum and red blood cell folate levels that may contribute to colonic carcinogenesis. Sulfasalazine may exacerbate such deficiencies. Indirect evidence suggests that folate supplements reduce the risk of colonic neoplasia in those using this agent, although a direct effect on colonic epithelial cells has not been shown. The…

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Hyperhomocysteinemia in ulcerative colitis is related to folate levels.

Related Articles Hyperhomocysteinemia in ulcerative colitis is related to folate levels. World J Gastroenterol. 2005 Oct 14;11(38):6038-42 Authors: Zezos P, Papaioannou G, Nikolaidis N, Vasiliadis T, Giouleme O, Evgenidis N Abstract AIM: To study the prevalence and clinical significance of hyperhomocysteinemia (hHcys), an independent factor for arterial and venous thrombosis, in a group of patients with ulcerative colitis (UC). METHODS: Fasting homocysteine (Hcys), folate, and vitamin B(12) serum levels were measured in 40 UC patients and 50 healthy controls. Clinical data regarding UC were gathered. RESULTS: Median serum Hcys levels…

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Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases.

Related Articles Increased folate intake with no changes in serum homocysteine and decreased levels of C-reactive protein in patients with inflammatory bowel diseases. Dig Dis Sci. 2009 Mar;54(3):627-33 Authors: Chiarello PG, Penaforte FR, Japur CC, Souza CD, Vannucchi H, Troncon LE Abstract In order to increase dietary folic acid intake and to improve nutritional status regarding folate by controlling homocysteine concentrations, ten patients with inflammatory bowel diseases (Crohn’s disease in the colon and ulcerative colitis) received individualized nutritional guidance and were followed up as outpatients for 2 months. The following…

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Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications.

Related Articles Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications. J Clin Gastroenterol. 2008 May-Jun;42(5):481-6 Authors: Erzin Y, Uzun H, Celik AF, Aydin S, Dirican A, Uzunismail H Abstract OBJECTIVE: Homocysteine is a sulfur-containing amino acid formed during the demethylation of methionine and high levels of this amino acid is a known risk factor for both arterial and also venous thromboembolic complications. Deficiencies of cobalamin, folate, and pyridoxine may predispose subjects to hyperhomocysteinemia,…

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Association of hyperhomocysteinemia and folate deficiency with colon tumors in patients with inflammatory bowel disease.

Related Articles Association of hyperhomocysteinemia and folate deficiency with colon tumors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2008 Feb;14(2):242-8 Authors: Phelip JM, Ducros V, Faucheron JL, Flourie B, Roblin X Abstract BACKGROUND: Folate deficiency associated with hyperhomocysteinemia might increase the risk of developing colorectal cancer. The aim of this study was to evaluate factors associated with colonic carcinogenesis, in particular, folate and homocysteinemia levels, in a cross-sectional study of patients with inflammatory bowel disease (IBD). METHODS: IBD patients with carcinogenic lesions discovered during colonoscopy [dysplasia-associated lesion or…

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Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease.

Related Articles Prevalence of and risk factors for vitamin B(12) deficiency in patients with Crohn’s disease. Inflamm Bowel Dis. 2008 Feb;14(2):217-23 Authors: Headstrom PD, Rulyak SJ, Lee SD Abstract BACKGROUND: Crohn’s disease (CD) can commonly involve the terminal ileum, which is the site of B(12) absorption. The aim of this study was to define the prevalence of vitamin B(12) abnormalities in a population with CD and to identify risk factors associated with B(12) abnormalities in CD. METHODS: The medical records of 201 patients with CD evaluated at a tertiary care…

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