Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?

Related Articles Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects? JAMA. 1986 Mar 28;255(12):1605-6 Authors: Schilling RF Abstract Two women developed significant neurologic dysfunction, consistent with subacute combined degeneration of the spinal cord, within eight weeks of being anesthetized with nitrous oxide. Investigation revealed that each had preclinical or masked vitamin B12 deficiency. The first patient had two previous ileal resections for Crohn’s disease and the other had pernicious anemia. It is postulated that nitrous oxide anesthesia may precipitate neurologic disease in people with unrecognized deficiency of vitamin…

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Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis.

Related Articles Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis. Gut. 1981 Jun;22(6):456-61 Authors: Swinson CM, Perry J, Lumb M, Levi AJ Abstract Only two (2.5%) of 80 outpatients with histologically proven ulcerative colitis had folate deficiency associated with anaemia or macrocytosis. Mean folate absorption, measured using micrograms/kg body weight of a tritium-labelled physiological folate derivative, 5-methyltetrahydroteroylglutamic acid, in six newly diagnosed patients was 76.7% (normal greater than 95%) but fell to 69.4% after three months’ treatment with sulphasalazine. Mean difference in individual patients was 7.5%…

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Acid microclimate in coeliac and Crohn’s disease: a model for folate malabsorption.

Related Articles Acid microclimate in coeliac and Crohn’s disease: a model for folate malabsorption. Gut. 1978 Aug;19(8):735-42 Authors: Lucas ML, Cooper BT, Lei FH, Johnson IT, Holmes GK, Blair JA, Cooke WT Abstract The surface pH of human proximal jejunum was measured in biopsy samples and found to be more acid than the phosphate buffer in which they were incubated. The in vitro jejunal surface pH was 5.93 +/- 0.05 in control subjects and 6.19 +/- 0.09 in treated coeliac patients. A group of untreated coeliac patients with a surface…

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The ileum is the major site of absorption of vitamin B12 analogues.

Related Articles The ileum is the major site of absorption of vitamin B12 analogues. Am J Gastroenterol. 1989 Jan;84(1):22-6 Authors: Shaw S, Jayatilleke E, Meyers S, Colman N, Herzlich B, Herbert V Abstract Non-cobalamin vitamin B12 analogues constitute a significant percentage of total corrinoids in human serum. The source and means of absorption of analogues and their significance are largely unknown. We studied the sites of production and absorption of B12 analogues by measuring serum vitamin B12 and analogues in 93 patients with various gastrointestinal diseases: pernicious anemia (PA), ileal…

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Crohn’s disease and vitamin B12 metabolism.

Related Articles Crohn’s disease and vitamin B12 metabolism. Dig Dis Sci. 1996 Jul;41(7):1417-22 Authors: Lambert D, Benhayoun S, Adjalla C, Gelot MA, Renkes P, Felden F, Gerard P, Belleville F, Gaucher P, Guéant JL, Nicolas JP Abstract The concentrations of vitamin B12, its analogs, and the haptocorrin and transcobalamin carriers in 21 patients suffering from Crohn’s disease and a group of controls (20 adults) were measured. There were no significant differences in the mean values for vitamin B12, total corrinoids (vitamin B12 + analogs), or vitamin B12 or total corrinoids…

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Peripheral neuropathy and folate deficiency as the first sign of Crohn’s disease.

Related Articles Peripheral neuropathy and folate deficiency as the first sign of Crohn’s disease. J Clin Gastroenterol. 1991 Aug;13(4):442-4 Authors: Lossos A, Argov Z, Ackerman Z, Abramsky O Abstract A 33-year-old man developed severe sensory peripheral neuropathy associated with low serum folate levels. No systemic disease was identified on the initial evaluation, but 21/2 years later he developed clinical and radiological features of Crohn’s disease, confirmed by intestinal biopsy. Thus, sensory polyneuropathy may occur as the first manifestation of Crohn’s disease. PMID: 1655863 [PubMed – indexed for MEDLINE] PubMed Link:…

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Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study.

Related Articles Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study. Gastroenterology. 1989 Aug;97(2):255-9 Authors: Lashner BA, Heidenreich PA, Su GL, Kane SV, Hanauer SB Abstract Folate deficiency has been associated with dysplasia in human cancer models. Patients with ulcerative colitis commonly have decreased folate levels, which are partially due to sulfasalazine, a competitive inhibitor of folate absorption. To study the effect of folate supplementation on the risk of dysplasia or cancer (neoplasia) in ulcerative colitis, records from 99 patients with…

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