Impaired Inactivation of Digestive Proteases in Lower Gut Due to Inhibition of Gut Bacteria by Food Additives Such as Saccharin and Sucralose as Main Cause of Inflammatory Bowel Disease: A Two-Decades-Long Hypothesis Warrants Testing.

Impaired Inactivation of Digestive Proteases in Lower Gut Due to Inhibition of Gut Bacteria by Food Additives Such as Saccharin and Sucralose as Main Cause of Inflammatory Bowel Disease: A Two-Decades-Long Hypothesis Warrants Testing. Inflamm Bowel Dis. 2019 Aug 24;: Authors: Qin X PMID: 31504530 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31504530?dopt=Abstract

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Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo.

Related Articles Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models in vivo. World J Gastroenterol. 2019 Aug 14;25(30):4181-4198 Authors: Vargas-Robles H, Castro-Ochoa KF, Citalán-Madrid AF, Schnoor M Abstract Acute and chronic colitis affect a huge proportion of the population world-wide. The etiology of colitis cases can be manifold, and diet can significantly affect onset and outcome of colitis. While many forms of acute colitis are easily treatable, chronic forms of colitis such as ulcerative colitis and Crohn’s disease (summarized as inflammatory bowel diseases) are…

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Intake of Dietary Fiber, Fruits, and Vegetables and Risk of Diverticulitis.

Intake of Dietary Fiber, Fruits, and Vegetables and Risk of Diverticulitis. Am J Gastroenterol. 2019 Aug 07;: Authors: Ma W, Nguyen LH, Song M, Jovani M, Liu PH, Cao Y, Tam I, Wu K, Giovannucci EL, Strate LL, Chan AT Abstract OBJECTIVES: Although low fiber intake has been considered a risk factor for diverticulitis, prospective evidence is limited in women despite having a disproportionate burden of disease, with little known about variation in the protective effects according to food sources. We assessed the associations of intakes of fiber and major…

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Oral Nano Vitamin D Supplementation Reduces Disease Activity in Ulcerative Colitis: A Double-Blind Randomized Parallel Group Placebo-controlled Trial.

Oral Nano Vitamin D Supplementation Reduces Disease Activity in Ulcerative Colitis: A Double-Blind Randomized Parallel Group Placebo-controlled Trial. J Clin Gastroenterol. 2019 Jul 26;: Authors: Ahamed Z R, Dutta U, Sharma V, Prasad KK, Popli P, Kalsi D, Vaishnavi C, Arora S, Kochhar R Abstract INTRODUCTION: Vitamin D possesses anti-inflammatory properties and could be beneficial in ulcerative colitis (UC). METHODS: We studied the effect of oral nano vitamin D3 supplementation on disease activity in active UC [ulcerative colitis disease activity index (UCDAI)≥3]. Patients with active UC and vitamin D <40 ng/mL…

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Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients with Crohn’s Disease Not Suspected of Having Perianal Fistulas.

Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients with Crohn’s Disease Not Suspected of Having Perianal Fistulas. Clin Gastroenterol Hepatol. 2019 Jul 25;: Authors: Kim PH, Park SH, Jin K, Ye BD, Yoon YS, Lee JS, Kim HJ, Kim AY, Yu CS, Yang SK Abstract BACKGROUND & AIMS: Few data are available to guide the use of anal imaging for patients with Crohn’s disease (CD) who are not suspected of having perianal fistulas. We aimed to evaluate the role of anal imaging supplementary to magnetic resonance enterography (MRE) in…

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The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction.

Related Articles The reduction of faecal calprotectin during exclusive enteral nutrition is lost rapidly after food re-introduction. Aliment Pharmacol Ther. 2019 Jul 25;: Authors: Logan M, Clark CM, Ijaz UZ, Gervais L, Duncan H, Garrick V, Curtis L, Buchanan E, Cardigan T, Armstrong L, Delahunty C, Flynn DM, Barclay AR, Tayler R, McDonald E, Milling S, Hansen RK, Gerasimidis K, Russell RK Abstract BACKGROUND: Faecal calprotectin decreases during exclusive enteral nutrition in children with active Crohn’s disease. It is unknown how faecal calprotectin changes during food re-introduction and the influence…

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Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial.

Related Articles Crohn’s Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial. Gastroenterology. 2019 Jun 03;: Authors: Levine A, Wine E, Assa A, Sigall Boneh R, Shaoul R, Kori M, Cohen S, Peleg S, Shamali H, On A, Millman P, Abramas L, Ziv-Baran T, Grant S, Abitbol G, Dunn KA, Bielawski JP, Van Limbergen J Abstract BACKGROUND & AIMS: Exclusive enteral nutrition (EEN) is recommended for children with mild-to-moderate Crohn’s disease (CD) but implementation is challenging. We compared EEN to the CD exclusion-diet (CDED),…

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Vitamin D inhibits pro-inflammatory T cell function in patients with inflammatory bowel disease.

Related Articles Vitamin D inhibits pro-inflammatory T cell function in patients with inflammatory bowel disease. J Crohns Colitis. 2019 May 04;: Authors: Schardey J, Globig AM, Janssen C, Hofmann M, Manegold P, Thimme R, Hasselblatt P Abstract BACKGROUND AND AIMS: Dysregulated T cell responses contribute to the pathogenesis of inflammatory bowel disease (IBD). Since vitamin D (vitD) deficiency is a risk factor for adverse disease outcomes, we aimed to characterize the impact of vitD on intestinal and peripheral T cell profiles. METHODS: T cells were isolated from peripheral blood and…

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