Ultrasound vs Endoscopy, Surgery, or Pathology for the Diagnosis of Small Bowel Crohn’s Disease and its Complications.

Ultrasound vs Endoscopy, Surgery, or Pathology for the Diagnosis of Small Bowel Crohn’s Disease and its Complications. Inflamm Bowel Dis. 2019 Mar 19;: Authors: Bollegala N, Griller N, Bannerman H, Habal M, Nguyen GC Abstract BACKGROUND: In patients with inflammatory bowel disease, we strive to achieve mucosal healing, as this has been shown to decrease the risk of disease flares, hospitalization, and surgery. For this reason, we must use objective measures of mucosal healing to inform our clinical decision-making and can no longer rely on patient symptoms alone. Assessment of…

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Ileal Gene Expression Data from Crohn’s Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups.

Related Articles Ileal Gene Expression Data from Crohn’s Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups. J Crohns Colitis. 2019 Mar 16;: Authors: Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J Abstract BACKGROUND AND AIMS: Heterogeneity in Crohn’s disease (CD) provides a challenge for development of effective therapies. Our goal was to define a unique molecular signature for severe, refractory CD to enable precision therapy approaches to disease treatment and facilitate earlier intervention in complicated disease.…

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Shall Patients With a History of Inflammatory Bowel Disease-Related Surgery Be Excluded in the Assessment of Sexual Function?

Shall Patients With a History of Inflammatory Bowel Disease-Related Surgery Be Excluded in the Assessment of Sexual Function? Inflamm Bowel Dis. 2019 Mar 15;: Authors: Li Y, Liu X Abstract Surgical treatment is not rare for patients with IBD. Currently, surgery seems to have a protective effect on sexual function. Thus, exclusion of those treated with IBD related surgery may affect conclusions. PMID: 30874291 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30874291?dopt=Abstract

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Low-dose metronidazole is associated with a decreased rate of endoscopic recurrence of Crohn’s disease after ileal resection: a retrospective cohort study.

Related Articles Low-dose metronidazole is associated with a decreased rate of endoscopic recurrence of Crohn’s disease after ileal resection: a retrospective cohort study. J Crohns Colitis. 2019 Feb 27;: Authors: Glick LR, Sossenheimer PH, Ollech JE, Cohen RD, Hyman NH, Hurst RD, Rubin DT Abstract BACKGROUND & AIMS: Recurrence of Crohn’s disease after surgical resection and primary anastomosis is an important clinical challenge. Previous studies have demonstrated the benefit of imidazole antibiotics, but have been limited by adverse events and medication intolerance. We evaluated whether administration of low-dose metronidazole (250mg…

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Management of Biological Therapy Before Elective Inflammatory Bowel Disease Surgeries.

Management of Biological Therapy Before Elective Inflammatory Bowel Disease Surgeries. Inflamm Bowel Dis. 2019 Feb 22;: Authors: Hansen TM, Targownik LE, Karimuddin A, Leung Y Abstract Increasing uptake of biologic therapy has contributed to declining surgical rates for inflammatory bowel disease (IBD). However, a significant number of patients on biologic therapy will go on to require surgery. The literature is conflicted with regard to the preoperative management of biologic therapy before urgent or elective IBD surgery. This article reviews the available data on postoperative complications following preoperative treatment with anti-tumor…

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The Influence of Preoperative Medications on Postoperative Complications in Patients After Intestinal Surgery for Crohn’s Disease.

The Influence of Preoperative Medications on Postoperative Complications in Patients After Intestinal Surgery for Crohn’s Disease. Inflamm Bowel Dis. 2019 Feb 08;: Authors: Yu CS, Jung SW, Lee JL, Lim SB, Park IJ, Yoon YS, Kim CW, Ynag SK, Ye BD, Park SH, Han M, Kim JC Abstract Background: Many patients with Crohn’s disease (CD) are treated with medications, including steroids, immunomodulators, and anti-tumor necrosis factor alpha (anti-TNF-α) agents, at the time of surgery. This study evaluated the effects of these medications on postoperative complications in CD patients. Methods: This…

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Early Postoperative Anti-TNF Therapy Does Not Increase Complications Following Abdominal Surgery in Crohn’s Disease.

Related Articles Early Postoperative Anti-TNF Therapy Does Not Increase Complications Following Abdominal Surgery in Crohn’s Disease. Dig Dis Sci. 2019 Jan 25;: Authors: Schad CA, Haac BE, Cross RK, Syed A, Lonsako S, Bafford AC Abstract BACKGROUND: The impact of postoperative anti-TNF therapy on infectious complications following Crohn’s disease surgery remains controversial. Use of anti-TNF therapy 2-4 weeks postoperatively appears safe, but safety of use within 2 weeks is unknown. AIMS: We sought to evaluate the effect of anti-TNF therapy initiated within 2 weeks of abdominal surgery in patients with Crohn’s disease. METHODS:…

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Increased prevalence of anti-TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood.

Related Articles Increased prevalence of anti-TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood. Aliment Pharmacol Ther. 2019 Jan 09;: Authors: Ashton JJ, Borca F, Mossotto E, Coelho T, Batra A, Afzal NA, Phan HTT, Stanton M, Ennis S, Beattie RM Abstract BACKGROUND: Anti-tumour necrosis factor-α (anti-TNF) therapy use has risen in paediatric-onset inflammatory bowel disease (PIBD). Whether this has translated into preventing/delaying childhood surgery is uncertain. The Wessex PIBD cohort was analysed for trends in anti-TNF-therapy and surgery. DESIGN: All patients…

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Decreasing Risk of First and Subsequent Surgeries in Patients With Crohn’s Disease in England From 1994 through 2013.

Related Articles Decreasing Risk of First and Subsequent Surgeries in Patients With Crohn’s Disease in England From 1994 through 2013. Clin Gastroenterol Hepatol. 2018 Dec 21;: Authors: Burr NE, Lord R, Hull MA, Subramanian V Abstract BACKGROUND & AIMS: Gastrointestinal (GI) surgery is an important part of the treatment algorithm for patients with Crohn’s disease (CD) that is complicated or does not respond to medical therapy. Cohort studies from Denmark and Canada have shown that the risk of primary surgery is decreasing but there is a lack of contemporary data…

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