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Anti-TNFα Treatment After Surgical Resection for Crohn’s Disease Is Effective Despite Previous Pharmacodynamic Failure.

Anti-TNFα Treatment After Surgical Resection for Crohn’s Disease Is Effective Despite Previous Pharmacodynamic Failure. Inflamm Bowel Dis. 2017 Feb 22;: Authors: Assa A, Bronsky J, Kolho KL, Zarubova K, de Meij T, Ledder O, Sladek M, van Biervliet S, Strisciuglio C, Shamir R Abstract BACKGROUND: The outcome of patients with Crohn’s disease who failed anti-tumor necrosis factor alpha (anti-TNFα) therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric patients who underwent intestinal resection and were re-treated with the same anti-TNFα agent postoperatively. METHODS:…

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Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease.

Related Articles Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease. World J Gastroenterol. 2017 Jan 21;23(3):472-477 Authors: Kristo I, Riss S, Argeny S, Maschke S, Chitsabesan P, Stift A Abstract AIM: To evaluate frequency and clinical course of incidental adenocarcinoma in patients with stricturing Crohn’s disease (CD). METHODS: In this study, consecutive patients, who were operated on for stricturing CD between 1997-2012, were included at an academic tertiary referral center. Demographic data and clinical course were obtained by an institutional database and individual chart review. Besides baseline characteristics,…

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Third European Evidence-Based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders.

Related Articles Third European Evidence-Based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis. 2017 Feb 02;: Authors: Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Barreiro-de Acosta M, Burisch J, Gecse KB, Hart AL, Hindryckx P, Langner C, Limdi JK, Pellino G, Zagórowicz E, Raine T, Harbord M, Rieder F, European Crohn’s and Colitis Organisation (ECCO) PMID: 28158501 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/28158501?dopt=Abstract

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Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study.

Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study. Inflamm Bowel Dis. 2017 Feb 01;: Authors: Alexakis C, Saxena S, Chhaya V, Cecil E, Curcin V, Pollok R Abstract BACKGROUND: Evidence that thiopurines impact on the risk of surgery in elderly onset inflammatory bowel disease (EO-IBD) is lacking. We aimed to compare the rates of surgery in EO-IBD (>60 years at diagnosis) with adult-onset IBD (18-59 yrs), and examine the impact of thiopurines on surgical risk in EO-IBD. METHODS: Using…

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Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn’s disease.

Related Articles Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn’s disease. Aliment Pharmacol Ther. 2017 Jan 20;: Authors: Heerasing N, Thompson B, Hendy P, Heap GA, Walker G, Bethune R, Mansfield S, Calvert C, Kennedy NA, Ahmad T, Goodhand JR Abstract BACKGROUND: Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting. AIMS: To test the hypothesis that exclusive enteral nutrition provides a safe and effective bridge to surgery and reduces post-operative complications, in adult patients with…

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Impact of Early Surgery and Immunosuppression on Crohn’s Disease Disabling Outcomes.

Impact of Early Surgery and Immunosuppression on Crohn’s Disease Disabling Outcomes. Inflamm Bowel Dis. 2017 Feb;23(2):289-297 Authors: Magro F, Dias CC, Coelho R, Santos PM, Fernandes S, Caetano C, Rodrigues Â, Portela F, Oliveira A, Ministro P, Cancela E, Vieira AI, Barosa R, Cotter J, Carvalho P, Cremers I, Trabulo D, Caldeira P, Antunes A, Rosa I, Moleiro J, Peixe P, Herculano R, Gonçalves R, Gonçalves B, Tavares Sousa H, Contente L, Morna H, Lopes S Abstract BACKGROUND AND AIMS: The definition of early therapeutic strategies to control Crohn’s disease…

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Granulomas in mesenteric lymph nodes in Crohn’s disease patients with ileocolic resection are areassociated with younger age and transmural inflammation.

Granulomas in mesenteric lymph nodes in Crohn’s disease patients with ileocolic resection are areassociated with younger age and transmural inflammation. J Gastroenterol Hepatol. 2017 Jan 14;: Authors: Sun X, Yuan L, Li Y, Shen B, Xie H, Liu X Abstract BACKGROUND & AIMS: Mesenteric lymph nodes were usually removed during bowel resection surgery for Crohn’s disease (CD). Mesenteric lymph node (MLN) granuloma predicted postoperative disease recurrence in patients with CD after ileocolic resection (ICR). This study was aimed to identify factors associated with MLN granulomas in a cohort of CD…

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Complications and Disease Recurrence After Primary Ileocecal Resection in Pediatric Crohn’s Disease: A Multicenter Cohort Analysis.

Complications and Disease Recurrence After Primary Ileocecal Resection in Pediatric Crohn’s Disease: A Multicenter Cohort Analysis. Inflamm Bowel Dis. 2017 Jan 06;: Authors: Diederen K, de Ridder L, van Rheenen P, Wolters VM, Mearin ML, Damen GM, de Meij TG, van Wering H, Tseng LA, Oomen MW, de Jong JR, Sloots CE, Benninga MA, Kindermann A Abstract BACKGROUND: Studies on the outcome of ileocecal resection in pediatric Crohn’s disease (CD) have a limited follow-up and fail to assign predictors of adverse outcomes. Therefore, we aimed to investigate (I) the complication…

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Factors associated with surgery in patients with intra-abdominal fistulizing Crohn’s disease.

Related Articles Factors associated with surgery in patients with intra-abdominal fistulizing Crohn’s disease. World J Gastroenterol. 2016 Dec 21;22(47):10380-10387 Authors: Yaari S, Benson A, Aviran E, Lev Cohain N, Oren R, Sosna J, Israeli E Abstract AIM: To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn’s disease (CD) patients with intra-abdominal fistulae. METHODS: From a cohort of 1244 CD patients seen over an eight year period (2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was…

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