Increased enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn’s disease.

Increased enteric glial cells in proximal margin of resection is associated with postoperative recurrence of Crohn’s disease. J Gastroenterol Hepatol. 2017 Sep 05;: Authors: Li Y, Ge Y, Zhu W, Gong J, Cao L, Guo Z, Gu L, Li J Abstract BACKGROUND AND AIM: The enteric nervous system can amplify or modulate intestinal inflammation through secretion of neuropeptides, and enteric glial cells has been implicated in the pathophysiology of Crohn’s disease. The goal of the study was to search for an association between the density of neurons, neuropeptides, as well…

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Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: a randomised controlled, open-label, multicentre trial.

Related Articles Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: a randomised controlled, open-label, multicentre trial. Lancet Gastroenterol Hepatol. 2017 Aug 21;: Authors: Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, Warusavitarne J, Buskens CJ, van Bodegraven AA, Brink MA, Consten ECJ, van Wagensveld BA, Rijk MCM, Crolla RMPH, Noomen CG, Houdijk APJ, Mallant RC, Boom M, Marsman WA, Stockmann HB, Mol B, de Groof AJ, Stokkers PC, D’Haens GR, Bemelman WA, LIR!C study group Abstract BACKGROUND: Treatment of patients with ileocaecal…

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Findings of Retrograde Contrast Study Through Double-balloon Enteroscopy Predict the Risk of Bowel Resections in Patients with Crohn’s Disease with Small Bowel Stenosis.

Findings of Retrograde Contrast Study Through Double-balloon Enteroscopy Predict the Risk of Bowel Resections in Patients with Crohn’s Disease with Small Bowel Stenosis. Inflamm Bowel Dis. 2017 Aug 22;: Authors: Okazaki N, Inokuchi T, Hiraoka S, Ohmori M, Takashima S, Takei D, Sugihara Y, Takahara M, Harada K, Kawano S, Okada H, Kato J Abstract BACKGROUND: Patients with Crohn’s disease (CD) with small bowel strictures are at risk of surgery. Double-balloon enteroscopy (DBE) can evaluate the status of the small intestine, and retrograde contrast through the scope enables the surgeon…

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Thiopurines prevented surgical recurrence in patients with Crohn’s disease after intestinal resection: strategy based on risk stratification.

Related Articles Thiopurines prevented surgical recurrence in patients with Crohn’s disease after intestinal resection: strategy based on risk stratification. J Gastroenterol Hepatol. 2017 Aug 14;: Authors: Guo J, Chen BL, Chen ZH, Luo XP, Qiu Y, Zhang SH, Feng R, He Y, Zeng ZR, Song XM, Ben-Horin S, Mao R, Chen MH Abstract BACKGROUND: Thiopurines (TPs) are effective in reducing risk of clinical and endoscopic recurrence in postoperative patients with Crohn’s disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. AIM: To explore whether TPs could prevent…

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Anti-TNF treatment in Crohn’s disease and risk of bowel resection-a population based cohort study.

Related Articles Anti-TNF treatment in Crohn’s disease and risk of bowel resection-a population based cohort study. Aliment Pharmacol Ther. 2017 Jul 28;: Authors: Eberhardson M, Söderling JK, Neovius M, Cars T, Myrelid P, Ludvigsson JF, Askling J, Ekbom A, Olén O Abstract BACKGROUND: TNF inhibitors (TNFi) have been shown to reduce the need for surgery in Crohn’s disease, but few studies have examined their effect beyond the first year of treatment. AIM: To conduct a register-based observational cohort study in Sweden 2006-2014 to investigate the risk of bowel resection in…

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Evolution of Clinical Behavior in Crohn’s Disease: Factors Associated with Complicated Disease and Surgery.

Related Articles Evolution of Clinical Behavior in Crohn’s Disease: Factors Associated with Complicated Disease and Surgery. Dig Dis Sci. 2017 Jul 26;: Authors: de Barros KSC, Flores C, Harlacher L, Francesconi CFM Abstract BACKGROUND: The phenotypic expression of Crohn’s disease may vary over time. Establishment of Crohn’s disease phenotypes is important for definition of patient care strategies. AIMS: The aim of the study was to evaluate the long-term evolution of patients based on disease phenotypes and the main factors associated with this evolution. METHODS: Data from 179 patients were collected…

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A Systematic Review of Internet Decision-Making Resources for Patients Considering Surgery for Ulcerative Colitis.

A Systematic Review of Internet Decision-Making Resources for Patients Considering Surgery for Ulcerative Colitis. Inflamm Bowel Dis. 2017 Jul 12;: Authors: Baker DM, Marshall JH, Lee MJ, Jones GL, Brown SR, Lobo AJ Abstract BACKGROUND: Guidance from the Royal College of Surgeons advocates patient use of on-line resources to assist in decision making. Our aim was to assess the quality of on-line resources to facilitate decision making for patients considering surgery for ulcerative colitis (UC). METHODS: We undertook a systematic review based on PRISMA guidelines. This was registered on the…

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Endoscopic Balloon Dilation Size and Avoidance of Surgery in Stricturing Crohn’s Disease.

Endoscopic Balloon Dilation Size and Avoidance of Surgery in Stricturing Crohn’s Disease. Inflamm Bowel Dis. 2017 Jul 06;: Authors: Reutemann BA, Turkeltaub JA, Al-Hawary M, Waljee AK, Higgins PDR, Stidham RW Abstract BACKGROUND: Endoscopic balloon dilation (EBD) is an effective method for treating stricture-related obstruction in Crohn’s disease. We aimed to identify factors predictive of successful avoidance of surgery, including endoscopic features, in patients undergoing balloon dilation. METHODS: We performed a retrospective review of patients with symptomatic Crohn’s disease-related intestinal strictures undergoing EBD. Clinical, medication use, laboratory, and dilation data,…

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Treatment with Biologic Agents has not Reduced Surgeries among Patients with Crohn’s Disease with Short Bowel Syndrome.

Treatment with Biologic Agents has not Reduced Surgeries among Patients with Crohn’s Disease with Short Bowel Syndrome. Clin Gastroenterol Hepatol. 2017 Jun 27;: Authors: Limketkai BN, Parian AM, Chen PH, Colombel JF Abstract BACKGROUND & AIMS: Little is known about the effects of biologic agents used to treat Crohn’s disease (CD) on its long-term complications, such as short bowel syndrome and intestinal failure (SBS-IF). We evaluated trends in small bowel resections and health care utilization among patients with CD with and without SBS-IF. METHODS: We collected data on the National…

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