Real-Time Shear Wave Ultrasound Elastography Differentiates Fibrotic from Inflammatory Strictures in Patients with Crohn’s Disease.

Related Articles Real-Time Shear Wave Ultrasound Elastography Differentiates Fibrotic from Inflammatory Strictures in Patients with Crohn’s Disease. Inflamm Bowel Dis. 2018 Apr 28;: Authors: Chen YJ, Mao R, Md XL, Cao QH, Chen ZH, Liu BX, Chen SL, Chen BL, He Y, Zeng ZR, Ben-Horin S, Rimola J, Rieder F, Xie XY, Chen MH Abstract Background and aim: The distinction of intestinal fibrosis from inflammation in Crohn’s disease (CD) associated strictures has important therapeutic implications. Ultrasound elastography is useful in evaluating the degree of fibrosis in liver, but there is…

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Outcomes of Endoscopic Therapy for Luminal Strictures in Crohn’s Disease.

Related Articles Outcomes of Endoscopic Therapy for Luminal Strictures in Crohn’s Disease. Inflamm Bowel Dis. 2018 Apr 26;: Authors: Shivashankar R, Edakkanambeth Varayil J, Scott Harmsen W, Faubion WA, Wong Kee Song LM, Bruining DH, Schroeder KW, Kisiel J, Loftus EV, Coelho Prabhu N Abstract Backgrounds: We sought to describe the outcomes of endoscopic therapy of luminal strictures in patients with Crohn’s disease (CD) at a large tertiary referral center. Methods: All patients who had undergone endoscopic dilation of CD strictures between January 1, 1990 and November 30, 2013 were…

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Efficacy and Safety of Endoscopic Balloon Dilatation of Ileoanal Pouch Strictures.

Related Articles Efficacy and Safety of Endoscopic Balloon Dilatation of Ileoanal Pouch Strictures. Inflamm Bowel Dis. 2018 Apr 25;: Authors: Fumery M, Patel NS, Boland BS, Dulai PS, Singh S, Sandborn WJ Abstract Background and aims: Colectomy with ileoanal pouch is the standard of care for most patients with ulcerative colitis (UC) who require surgery. However, 5%-38% of patients with ileoanal pouch develop pouch strictures that can severely impact the functional results. We retrospectively evaluated the efficacy and safety of endoscopic balloon dilation of ileoanal pouch strictures in patients with…

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Endoscopic Stricturotomy Versus Balloon Dilation in the Treatment of Anastomotic Strictures in Crohn’s Disease.

Endoscopic Stricturotomy Versus Balloon Dilation in the Treatment of Anastomotic Strictures in Crohn’s Disease. Inflamm Bowel Dis. 2018 Mar 12;: Authors: Lan N, Shen B Abstract Background: Current treatment modalities for anastomotic stricture in Crohn’s disease (CD) include endoscopic balloon dilation (EBD) and surgery. We recently published a case series of inflammatory bowel disease patients treated with the novel endoscopic stricturotomy (ES). The aim of this case-control study was to compare the efficacy and safety of ES versus conventional EBD in the treatment of anastomotic strictures in CD patients. Methods:…

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Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients with Crohn’s Disease.

Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients with Crohn’s Disease. Clin Gastroenterol Hepatol. 2018 Mar 02;: Authors: Lan N, Stocchi L, Ashburn JH, Hull TL, Steele SR, Delaney CP, Shen B Abstract BACKGROUND & AIMS: Few studies have compared endoscopic balloon dilation (EBD) with ileocolic resection (ICR) in the treatment of primary ileocolic strictures in patients with Crohn’s disease (CD). METHODS: We performed a retrospective study to compare post-procedure morbidity and surgery-free survival among 258 patients with primary stricturing ileo (colic) CD (B2,…

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Crohn’s Disease associated Strictures.

Crohn’s Disease associated Strictures. J Gastroenterol Hepatol. 2018 Feb 10;: Authors: Wo WCP, Mourad F, Leong RWL Abstract Crohn’s disease (CD) is a chronic relapsing and remitting disease that can affect any segments of the gastrointestinal (GI) tract. More than 50% of patients with CD develop stricturing or penetrating complications within the first 10 years after diagnosis. Strictures can lead to intestinal obstruction, which is a common indication for surgery. Despite significant advances in the understanding of the pathogenesis of intestinal fibrostenosis, imaging and therapeutic armamentarium of CD, the risk…

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Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo.

Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo. Inflamm Bowel Dis. 2018 Jan 18;24(2):332-345 Authors: Truffi M, Sorrentino L, Monieri M, Fociani P, Mazzucchelli S, Bonzini M, Zerbi P, Sampietro GM, Di Sabatino A, Corsi F Abstract Background: Crohn’s disease (CD) is a chronic bowel inflammation that ultimately leads to fibrosis, for which medical therapy is currently unavailable. Fibrotic strictures in CD are characterized by excessive extracellular matrix (ECM) deposition, altered balance between matrix metalloproteinases (MMPs) and their tissue…

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Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review.

Related Articles Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review. World J Gastroenterol. 2017 Dec 07;23(45):8073-8081 Authors: Baars JE, Theyventhiran R, Aepli P, Saxena P, Kaffes AJ Abstract AIM: To evaluate the therapeutic role of double-balloon enteroscopy (DBE) in small bowel strictures and to propose a standard approach to small bowel strictures. METHODS: Systematic review of studies involving DBE in patients with small bowel strictures. Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded. RESULTS: In total 13 studies…

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Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn’s disease: A nationwide, multi-center, open-label, prospective cohort study.

Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn’s disease: A nationwide, multi-center, open-label, prospective cohort study. J Crohns Colitis. 2017 Nov 29;: Authors: Hirai F, Andoh A, Ueno F, Watanabe K, Ohmiya N, Nakase H, Kato S, Esaki M, Endo Y, Yamamoto H, Matsui T, Iida M, Hibi T, Watanabe M, Suzuki Y, Matsumoto T Abstract Background and Aims: Endoscopic balloon dilation (EBD) is an alternative to surgery for Crohn’s strictures. However, there have been no prospective studies of EBD for small bowel strictures in…

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