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Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures.

Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures. Inflamm Bowel Dis. 2017 Jan 26;: Authors: Lu C, Gui X, Chen W, Fung T, Novak K, Wilson SR Abstract BACKGROUND: Inflammation, fibrosis, and muscular hypertrophy lead to thickened bowel in Crohn’s disease forming strictures. Ultrasound shear wave elastography (SWE) measures bowel wall stiffness. Contrast-enhanced ultrasound (CEUS) uniquely detects bowel wall inflammation. We aim to correlate SWE of ileal Crohn’s disease in vivo to CEUS peak enhancement and pathology grades of inflammation, fibrosis, and muscular hypertrophy. METHODS:…

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Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study.

Related Articles Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study. Gut. 2017 Jan 24;: Authors: Bouhnik Y, Carbonnel F, Laharie D, Stefanescu C, Hébuterne X, Abitbol V, Nachury M, Brixi H, Bourreille A, Picon L, Bourrier A, Allez M, Peyrin-Biroulet L, Moreau J, Savoye G, Fumery M, Nancey S, Roblin X, Altwegg R, Bouguen G, Bommelaer G, Danese S, Louis E, Zappa M, Mary JY, GETAID CREOLE Study Group Abstract OBJECTIVE: The efficacy of anti-tumour necrosis factors (anti-TNFs)…

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Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis.

Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis. Dig Dis Sci. 2016 Dec 09; Authors: Wannhoff A, Rupp C, Friedrich K, Knierim J, Flechtenmacher C, Weiss KH, Stremmel W, Gotthardt DN Abstract BACKGROUND: Carcinoembryonic antigen (CEA) can be used to screen for biliary tract cancer in patients with primary sclerosing cholangitis (PSC). AIM: To study the influence of benign dominant strictures (DS), superimposed bacterial cholangitis (SBC), smoking status, and inflammatory bowel disease on CEA serum levels. METHODS: A retrospective analysis of CEA…

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Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy.

Related Articles Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy. J Gastroenterol. 2016 Nov 15; Authors: Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M Abstract BACKGROUND: Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. METHODS: Two hundred Crohn’s disease patients…

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Comparison of Endoscopic Dilation vs Surgery for Anastomotic Stricture in Patients With Crohn’s Disease Following Ileocolonic Resection.

Related Articles Comparison of Endoscopic Dilation vs Surgery for Anastomotic Stricture in Patients With Crohn’s Disease Following Ileocolonic Resection. Clin Gastroenterol Hepatol. 2016 Nov 2;: Authors: Lian L, Stocchi L, Remzi FH, Shen B Abstract BACKGROUND & AIMS: It is not clear whether endoscopic balloon dilation (EBD) or surgery are more effective treatments for ileocolonic anastomosis (ICA) stricture in patients with Crohn’s disease (CD). We aimed to compare long-term outcomes of patients who underwent EBD vs surgery for ICA stricture. METHODS: We performed a retrospective study of adult patients with…

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Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum.

Related Articles Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum. J Gastroenterol Hepatol. 1999 Nov;14(11):1132-4 Authors: Barwood N, Platell C Abstract Patients with Crohn’s disease affecting the small intestine appear to have an increased risk of developing adenocarcinoma. However, it remains an uncommon complication of an uncommon disease. The diagnosis is difficult to make both pre- and intra-operatively, and is most commonly made postoperatively on histopathology. Hence, at laparotomy, consideration should be given to performing a frozen section on all small bowel strictures due to Crohn’s disease…

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Pancreatitis in ulcerative colitis: a case report of improved stricture of the main pancreatic duct.

Related Articles Pancreatitis in ulcerative colitis: a case report of improved stricture of the main pancreatic duct. J Clin Gastroenterol. 1999 Jan;28(1):74-6 Authors: Takizawa H, Natsui M, Aoyagi Y, Asakura H Abstract We present one case with pancreatitis that synchronized with manifestations of ulcerative colitis, in which an improvement of stricture of the main pancreatic duct was observed. A 27-year-old man, having a history of nonalcoholic acute pancreatitis, complained of anal bleeding and pain in the epigastric region. The treatment for pancreatitis relieved the pain and decreased the serum levels…

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Markedly elevated serum CA 19-9 levels in association with a benign biliary stricture due to primary sclerosing cholangitis.

Related Articles Markedly elevated serum CA 19-9 levels in association with a benign biliary stricture due to primary sclerosing cholangitis. J Clin Gastroenterol. 2007 Jan;41(1):115-7 Authors: Murray MD, Burton FR, Di Bisceglie AM Abstract We report on the case of a 55-year-old man with long-standing ulcerative colitis who developed jaundice. This led to a diagnosis of primary sclerosing cholangitis being made, with a dominant stricture in the common bile duct. Serum CA 19-9 was initially markedly raised at 26,321 U/mL but fell promptly into the normal range after stenting of…

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