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Endoscopic Stricturotomy with Needle Knife in the Treatment of Strictures from Inflammatory Bowel Disease.

Endoscopic Stricturotomy with Needle Knife in the Treatment of Strictures from Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Apr;23(4):502-513 Authors: Lan N, Shen B Abstract BACKGROUND: Fibrotic strictures in patients with inflammatory bowel disease (IBD) are often not amenable to medical therapy. Therapy with endoscopic balloon dilation usually requires frequent repeat treatments. Therefore, we developed the novel needle knife stricturotomy (NKSt) for the treatment of strictures in the patients with IBD. The aim of this study was to evaluate the efficacy and safety of NKSt. METHODS: Data of patients with…

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A Fixed Stricture on Routine Cross-sectional Imaging Predicts Disease-Related Complications and Adverse Outcomes in Patients with Crohn’s Disease.

A Fixed Stricture on Routine Cross-sectional Imaging Predicts Disease-Related Complications and Adverse Outcomes in Patients with Crohn’s Disease. Inflamm Bowel Dis. 2017 Mar 06;: Authors: Chaudhry NA, Riverso M, Grajo JR, Moser PP, Zou F, Homsi M, Punglia DR, Zimmermann EM Abstract BACKGROUND: Patients with Crohn’s disease (CD) typically undergo multiple cross-sectional imaging exams including computed tomography and magnetic resonance enterography during the course of their disease. The aim was to identify imaging findings that predict future disease-related poor outcomes. METHODS: This was a retrospective, case control study at a…

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Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures.

Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures. Inflamm Bowel Dis. 2017 Jan 26;: Authors: Lu C, Gui X, Chen W, Fung T, Novak K, Wilson SR Abstract BACKGROUND: Inflammation, fibrosis, and muscular hypertrophy lead to thickened bowel in Crohn’s disease forming strictures. Ultrasound shear wave elastography (SWE) measures bowel wall stiffness. Contrast-enhanced ultrasound (CEUS) uniquely detects bowel wall inflammation. We aim to correlate SWE of ileal Crohn’s disease in vivo to CEUS peak enhancement and pathology grades of inflammation, fibrosis, and muscular hypertrophy. METHODS:…

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Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study.

Related Articles Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study. Gut. 2017 Jan 24;: Authors: Bouhnik Y, Carbonnel F, Laharie D, Stefanescu C, Hébuterne X, Abitbol V, Nachury M, Brixi H, Bourreille A, Picon L, Bourrier A, Allez M, Peyrin-Biroulet L, Moreau J, Savoye G, Fumery M, Nancey S, Roblin X, Altwegg R, Bouguen G, Bommelaer G, Danese S, Louis E, Zappa M, Mary JY, GETAID CREOLE Study Group Abstract OBJECTIVE: The efficacy of anti-tumour necrosis factors (anti-TNFs)…

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Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis.

Carcinoembryonic Antigen Level in Primary Sclerosing Cholangitis Is Not Influenced by Dominant Strictures or Bacterial Cholangitis. Dig Dis Sci. 2016 Dec 09; Authors: Wannhoff A, Rupp C, Friedrich K, Knierim J, Flechtenmacher C, Weiss KH, Stremmel W, Gotthardt DN Abstract BACKGROUND: Carcinoembryonic antigen (CEA) can be used to screen for biliary tract cancer in patients with primary sclerosing cholangitis (PSC). AIM: To study the influence of benign dominant strictures (DS), superimposed bacterial cholangitis (SBC), smoking status, and inflammatory bowel disease on CEA serum levels. METHODS: A retrospective analysis of CEA…

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Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy.

Related Articles Magnetic resonance evaluation for small bowel strictures in Crohn’s disease: comparison with balloon enteroscopy. J Gastroenterol. 2016 Nov 15; Authors: Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Fujioka T, Araki A, Watanabe M Abstract BACKGROUND: Magnetic resonance (MR) imaging is the recommended technique for detection of small bowel lesions in Crohn’s disease. We aimed to evaluate the impact of stricture findings obtained by MR imaging on patient outcomes using balloon-assisted enteroscopy (BAE) as a reference. METHODS: Two hundred Crohn’s disease patients…

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Comparison of Endoscopic Dilation vs Surgery for Anastomotic Stricture in Patients With Crohn’s Disease Following Ileocolonic Resection.

Related Articles Comparison of Endoscopic Dilation vs Surgery for Anastomotic Stricture in Patients With Crohn’s Disease Following Ileocolonic Resection. Clin Gastroenterol Hepatol. 2016 Nov 2;: Authors: Lian L, Stocchi L, Remzi FH, Shen B Abstract BACKGROUND & AIMS: It is not clear whether endoscopic balloon dilation (EBD) or surgery are more effective treatments for ileocolonic anastomosis (ICA) stricture in patients with Crohn’s disease (CD). We aimed to compare long-term outcomes of patients who underwent EBD vs surgery for ICA stricture. METHODS: We performed a retrospective study of adult patients with…

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Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum.

Related Articles Case report: adenocarcinoma arising in a Crohn’s stricture of the jejunum. J Gastroenterol Hepatol. 1999 Nov;14(11):1132-4 Authors: Barwood N, Platell C Abstract Patients with Crohn’s disease affecting the small intestine appear to have an increased risk of developing adenocarcinoma. However, it remains an uncommon complication of an uncommon disease. The diagnosis is difficult to make both pre- and intra-operatively, and is most commonly made postoperatively on histopathology. Hence, at laparotomy, consideration should be given to performing a frozen section on all small bowel strictures due to Crohn’s disease…

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Pancreatitis in ulcerative colitis: a case report of improved stricture of the main pancreatic duct.

Related Articles Pancreatitis in ulcerative colitis: a case report of improved stricture of the main pancreatic duct. J Clin Gastroenterol. 1999 Jan;28(1):74-6 Authors: Takizawa H, Natsui M, Aoyagi Y, Asakura H Abstract We present one case with pancreatitis that synchronized with manifestations of ulcerative colitis, in which an improvement of stricture of the main pancreatic duct was observed. A 27-year-old man, having a history of nonalcoholic acute pancreatitis, complained of anal bleeding and pain in the epigastric region. The treatment for pancreatitis relieved the pain and decreased the serum levels…

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