Endoscopic Stricturotomy Versus Balloon Dilation in the Treatment of Anastomotic Strictures in Crohn’s Disease.

Endoscopic Stricturotomy Versus Balloon Dilation in the Treatment of Anastomotic Strictures in Crohn’s Disease. Inflamm Bowel Dis. 2018 Mar 12;: Authors: Lan N, Shen B Abstract Background: Current treatment modalities for anastomotic stricture in Crohn’s disease (CD) include endoscopic balloon dilation (EBD) and surgery. We recently published a case series of inflammatory bowel disease patients treated with the novel endoscopic stricturotomy (ES). The aim of this case-control study was to compare the efficacy and safety of ES versus conventional EBD in the treatment of anastomotic strictures in CD patients. Methods:…

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Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients with Crohn’s Disease.

Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients with Crohn’s Disease. Clin Gastroenterol Hepatol. 2018 Mar 02;: Authors: Lan N, Stocchi L, Ashburn JH, Hull TL, Steele SR, Delaney CP, Shen B Abstract BACKGROUND & AIMS: Few studies have compared endoscopic balloon dilation (EBD) with ileocolic resection (ICR) in the treatment of primary ileocolic strictures in patients with Crohn’s disease (CD). METHODS: We performed a retrospective study to compare post-procedure morbidity and surgery-free survival among 258 patients with primary stricturing ileo (colic) CD (B2,…

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Crohn’s Disease associated Strictures.

Crohn’s Disease associated Strictures. J Gastroenterol Hepatol. 2018 Feb 10;: Authors: Wo WCP, Mourad F, Leong RWL Abstract Crohn’s disease (CD) is a chronic relapsing and remitting disease that can affect any segments of the gastrointestinal (GI) tract. More than 50% of patients with CD develop stricturing or penetrating complications within the first 10 years after diagnosis. Strictures can lead to intestinal obstruction, which is a common indication for surgery. Despite significant advances in the understanding of the pathogenesis of intestinal fibrostenosis, imaging and therapeutic armamentarium of CD, the risk…

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Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo.

Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo. Inflamm Bowel Dis. 2018 Jan 18;24(2):332-345 Authors: Truffi M, Sorrentino L, Monieri M, Fociani P, Mazzucchelli S, Bonzini M, Zerbi P, Sampietro GM, Di Sabatino A, Corsi F Abstract Background: Crohn’s disease (CD) is a chronic bowel inflammation that ultimately leads to fibrosis, for which medical therapy is currently unavailable. Fibrotic strictures in CD are characterized by excessive extracellular matrix (ECM) deposition, altered balance between matrix metalloproteinases (MMPs) and their tissue…

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Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review.

Related Articles Double-balloon enteroscopy-assisted dilatation avoids surgery for small bowel strictures: A systematic review. World J Gastroenterol. 2017 Dec 07;23(45):8073-8081 Authors: Baars JE, Theyventhiran R, Aepli P, Saxena P, Kaffes AJ Abstract AIM: To evaluate the therapeutic role of double-balloon enteroscopy (DBE) in small bowel strictures and to propose a standard approach to small bowel strictures. METHODS: Systematic review of studies involving DBE in patients with small bowel strictures. Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded. RESULTS: In total 13 studies…

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Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn’s disease: A nationwide, multi-center, open-label, prospective cohort study.

Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn’s disease: A nationwide, multi-center, open-label, prospective cohort study. J Crohns Colitis. 2017 Nov 29;: Authors: Hirai F, Andoh A, Ueno F, Watanabe K, Ohmiya N, Nakase H, Kato S, Esaki M, Endo Y, Yamamoto H, Matsui T, Iida M, Hibi T, Watanabe M, Suzuki Y, Matsumoto T Abstract Background and Aims: Endoscopic balloon dilation (EBD) is an alternative to surgery for Crohn’s strictures. However, there have been no prospective studies of EBD for small bowel strictures in…

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A systematic review: The management and outcomes of ileal pouch strictures.

A systematic review: The management and outcomes of ileal pouch strictures. J Crohns Colitis. 2017 Nov 16;: Authors: Segal JP, Worley G, Adegbola SO, Sahnan K, Tozer P, Lung PFC, Faiz OD, Clark SK, Hart AL Abstract Background: Restorative proctocolectomy with ileal pouch-anal anastomosis removes the diseased tissue in ulcerative colitis but also allows gastrointestinal continuity and stoma-free living. Pouch strictures are a complication with a reported incidence of 5-38%. The three areas where pouch strictures occur are in the pouch inlet, mid-pouch and pouch-anal anastomosis. Aim: To undertake a…

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Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact.

Related Articles Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact. World J Gastroenterol. 2017 Nov 07;23(41):7397-7406 Authors: Lopes S, Rodrigues-Pinto E, Andrade P, Afonso J, Baron TH, Magro F, Macedo G Abstract AIM: To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn’s disease (CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation (EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS: Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015 including…

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Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn’s disease patients with anastomotic strictures.

Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn’s disease patients with anastomotic strictures. World J Gastroenterol. 2017 Sep 21;23(35):6482-6490 Authors: Lopes S, Andrade P, Rodrigues-Pinto E, Afonso J, Macedo G, Magro F Abstract AIM: To evaluate the accuracy and best cut-off value of fecal calprotectin (FC) and fecal lactoferrin (FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures. METHODS: This was a longitudinal single tertiary center study based on prospectively collected data (recorded in a clinical database created for this purpose) performed…

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