Tenascin-C Produced by Intestinal Myofibroblasts Promotes Colitis-associated Cancer Development Through Angiogenesis.

Related Articles Tenascin-C Produced by Intestinal Myofibroblasts Promotes Colitis-associated Cancer Development Through Angiogenesis. Inflamm Bowel Dis. 2018 Dec 04;: Authors: Kawamura T, Yamamoto M, Suzuki K, Suzuki Y, Kamishima M, Sakata M, Kurachi K, Setoh M, Konno H, Takeuchi H Abstract Background: Colitis-associated cancer (CAC) is one of the prognostic factors in inflammatory bowel disease (IBD), and prevention of CAC is a critical concern for patients with IBD. Component cells of the microenvironment, especially myofibroblasts, are known to affect tumor development, but the role of intestinal myofibroblasts (IMFs) in CAC…

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Decreasing Risk of First and Subsequent Surgeries in Patients With Crohn’s Disease in England From 1994 through 2013.

Related Articles Decreasing Risk of First and Subsequent Surgeries in Patients With Crohn’s Disease in England From 1994 through 2013. Clin Gastroenterol Hepatol. 2018 Dec 21;: Authors: Burr NE, Lord R, Hull MA, Subramanian V Abstract BACKGROUND & AIMS: Gastrointestinal (GI) surgery is an important part of the treatment algorithm for patients with Crohn’s disease (CD) that is complicated or does not respond to medical therapy. Cohort studies from Denmark and Canada have shown that the risk of primary surgery is decreasing but there is a lack of contemporary data…

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Risk of Skin Cancers in Thiopurines-treated and Untreated patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

Related Articles Risk of Skin Cancers in Thiopurines-treated and Untreated patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. J Gastroenterol Hepatol. 2018 Nov 04;: Authors: Huang SZ, Liu ZC, Liao WX, Wei JX, Huang XW, Yang C, Xia YH, Li L, Ye C, Dai SX Abstract BACKGROUND AND AIM: The thiopurines are effective in the management of patients with inflammatory bowel disease (IBD), but the association between thiopurines use and the risk of skin cancer (including nonmelanoma skin cancer [NMSC] and melanoma skin cancer [MSC]) has already been…

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Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling.

Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling. J Gastroenterol Hepatol. 2018 Oct 30;: Authors: Kim YH, Kim JH, Kim BG, Lee KL, Kim JW, Koh SJ Abstract BACKGROUND AND AIM: Inflammatory bowel diseases (IBD) is associated with an increased risk for the development of colorectal cancer. However, the mechanism of immune signaling pathways linked to colitis-associated cancer (CAC) has not been fully elucidated. Tauroursodeoxycholic acid (TUDCA) exhibits anti-inflammatory and anti-cancer activities. The aim of this study is to investigate the role of TUDCA in the…

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Editorial: predicting recurrence of Crohn’s disease after surgical resection-Close to a crystal ball. Authors’ reply.

Editorial: predicting recurrence of Crohn’s disease after surgical resection-Close to a crystal ball. Authors’ reply. Aliment Pharmacol Ther. 2018 Nov;48(10):1157-1158 Authors: Allez M, Auzolle C, Le Bourhis L, Seksik P PMID: 30375683 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30375683?dopt=Abstract

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Strategies for Detecting Colorectal Cancer in Patients with Inflammatory Bowel Disease: A Cochrane Systematic Review and Meta-Analysis.

Related Articles Strategies for Detecting Colorectal Cancer in Patients with Inflammatory Bowel Disease: A Cochrane Systematic Review and Meta-Analysis. Am J Gastroenterol. 2018 Oct 23;: Authors: Bye WA, Ma C, Nguyen TM, Parker CE, Jairath V, East JE Abstract OBJECTIVES: Patients with longstanding ulcerative colitis (UC) and colonic Crohn’s disease (CD) have an increased risk of colorectal cancer (CRC). We assess the effectiveness of endoscopic surveillance in patients with inflammatory bowel disease (IBD) for diagnosing CRC and reducing CRC-related mortality. METHODS: MEDLINE, EMBASE, and CENTRAL were searched from inception to…

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The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn’s Disease.

The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn’s Disease. Inflamm Bowel Dis. 2018 Oct 19;: Authors: Mao R, Kurada S, Gordon IO, Baker ME, Gandhi N, McDonald C, Calvin Coffey J, Rieder F Abstract Adipose tissue is present in close proximity to various organs in the human body. One prominent example is fat contained in the mesentery that is contiguous with all abdominal digestive organs including the intestine. Despite the fact that mesenteric fat-wrapping around the inflamed gut (so called “creeping fat”) was described…

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The risk of colectomy and colorectal cancer after appendectomy in patients with ulcerative colitis: a systematic review and meta-analysis.

Related Articles The risk of colectomy and colorectal cancer after appendectomy in patients with ulcerative colitis: a systematic review and meta-analysis. J Crohns Colitis. 2018 Oct 18;: Authors: Stellingwerf ME, de Koning MA, Pinkney T, Bemelman WA, D’Haens GR, Buskens CJ Abstract Background: Appendectomy decreases the risk of developing ulcerative colitis (UC), and is suggested to have a beneficial effect on the clinical course of established UC. However, recent studies showed no significantly decreased colectomy rate, and moreover an apparently increased risk of colorectal cancer (CRC). We aimed to investigate…

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