Discordance between the degree of osteopenia and the prevalence of spontaneous vertebral fractures in Crohn’s disease.

Related Articles Discordance between the degree of osteopenia and the prevalence of spontaneous vertebral fractures in Crohn’s disease. Aliment Pharmacol Ther. 2002 Aug;16(8):1519-27 Authors: Stockbrügger RW, Schoon EJ, Bollani S, Mills PR, Israeli E, Landgraf L, Felsenberg D, Ljunghall S, Nygard G, Persson T, Graffner H, Bianchi Porro G, Ferguson A Abstract BACKGROUND: A high prevalence of osteoporosis has been noted in Crohn’s disease, but data about fractures are scarce. METHODS: The relationship between low bone mineral density and the prevalence of vertebral fractures was studied in 271 patients with…

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Corticosteroid-induced osteoporosis: does it occur in patients with Crohn’s disease?

Related Articles Corticosteroid-induced osteoporosis: does it occur in patients with Crohn’s disease? Am J Gastroenterol. 2002 Aug;97(8):2011-5 Authors: de Jong DJ, Corstens FH, Mannaerts L, van Rossum LG, Naber AH Abstract OBJECTIVE: In Crohn’s disease, osteoporosis is frequently found. However, the etiology of osteoporosis remains unclear. The aim of this study was to determine disease-related variables predictive for impaired bone mineral density (BMD). METHODS: A total of 91 patients with Crohn’s disease who were admitted for BMD assessment were enrolled in the study. BMD was measured at the femoral neck…

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Quantitative ultrasound of the proximal phalanges and dual-energy X-ray absorptiometry in Crohn’s disease patients with osteopenia.

Related Articles Quantitative ultrasound of the proximal phalanges and dual-energy X-ray absorptiometry in Crohn’s disease patients with osteopenia. J Gastroenterol. 2003;38(3):238-43 Authors: von Tirpitz C, Klaus J, Steinkamp M, Mason R, Kratzer W, Adler G, Rieber A, Reinshagen M Abstract BACKGROUND: Osteopenia and osteoporosis are frequent complications in Crohn’s disease, and these features are associated with an increased risk of vertebral and appendicular fractures. Bone mineral density (BMD) measurements are widely accepted to assess the fracture risk in postmenopausal osteoporosis. In recent years, quantitative ultrasound (QUS) has become attractive for…

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Review article: Osteoporosis and inflammatory bowel disease.

Related Articles Review article: Osteoporosis and inflammatory bowel disease. Aliment Pharmacol Ther. 2004 May 1;19(9):941-52 Authors: Bernstein CN, Leslie WD Abstract Studies using dual-energy X-ray absorptiometry have suggested a high prevalence of osteoporosis in inflammatory bowel disease. However, population-based data on fracture incidence suggest only a small increased risk of fracture amongst patients with inflammatory bowel disease compared with the general population. Therefore, it would be helpful to identify patients with inflammatory bowel disease at particularly high risk for fracture so that these risks might be modified or interventions might…

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Therapy of osteoporosis in patients with Crohn’s disease: a randomized study comparing sodium fluoride and ibandronate.

Related Articles Therapy of osteoporosis in patients with Crohn’s disease: a randomized study comparing sodium fluoride and ibandronate. Aliment Pharmacol Ther. 2003 Mar 15;17(6):807-16 Authors: von Tirpitz C, Klaus J, Steinkamp M, Hofbauer LC, Kratzer W, Mason R, Boehm BO, Adler G, Reinshagen M Abstract BACKGROUND: Osteoporosis is a frequent complication in Crohn’s disease. Although the efficacy of both sodium fluoride and aminobisphosphonates in postmenopausal osteoporosis has been investigated in long-term therapy studies, no long-term results are available regarding the effect of these agents in the management of osteoporosis in…

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Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones.

Related Articles Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Gastroenterology. 2004 Sep;127(3):792-801 Authors: Dresner-Pollak R, Gelb N, Rachmilewitz D, Karmeli F, Weinreb M Abstract BACKGROUND & AIMS: Bone loss is a common complication of human inflammatory bowel disease (IBD), but its mechanisms are not understood completely. We investigated bone metabolism in interleukin-10-deficient ( IL-10-/- ) mice, an animal model with IBD features. METHODS: IL-10-/- male mice (8- and 12-weeks-old) and their age-matched wild-type counterparts (C57BL/6J) were studied. Bone mass of the femur was…

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CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin.

Related Articles CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. Gut. 2005 Jan;54(1):78-86 Authors: Byrne FR, Morony S, Warmington K, Geng Z, Brown HL, Flores SA, Fiorino M, Yin SL, Hill D, Porkess V, Duryea D, Pretorius JK, Adamu S, Manoukian R, Manuokian R, Danilenko DM, Sarosi I, Lacey DL, Kostenuik PJ, Senaldi G Abstract BACKGROUND AND AIMS: Transfer of CD4+CD45RBHi T cells into semi syngeneic immunodeficient mice represents a model of inflammatory bowel disease (IBD). As patients with…

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Guidelines do help change behavior in the management of osteoporosis by gastroenterologists.

Related Articles Guidelines do help change behavior in the management of osteoporosis by gastroenterologists. Am J Gastroenterol. 2006 Aug;101(8):1841-4 Authors: Kane S, Reddy D Abstract BACKGROUND AND AIMS: The American College of Gastroenterology supported the development of evidence-based guidelines for the management of osteoporosis in inflammatory bowel disease. Our aim was to determine the short-term impact of the guidelines on practice patterns. METHODS: Two hundred clinicians were surveyed prior to and 3 and 6 months after the guidelines were disseminated. The number of bone density scans ordered by these physicians…

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