Risk of malignant cancers in inflammatory bowel disease.

Risk of malignant cancers in inflammatory bowel disease. J Crohns Colitis. 2019 Mar 15;: Authors: Loo SY, Vutcovici M, Bitton A, Lakatos PL, Azoulay L, Suissa S, Brassard P Abstract OBJECTIVES: To explore the trends and the predictors of incident malignant cancer among patients with inflammatory bowel disease (IBD). METHODS: We identified a cohort of all patients with incident IBD in Quebec, Canada, from 1998 to 2015, using provincial administrative healthcare databases (RAMQ and Med-Echo). Annual incidence rates (IRs) of cancer were calculated using Poisson regression and were compared to…

Read More

Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines.

Related Articles Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. Clin Gastroenterol Hepatol. 2019 Mar 07;: Authors: Khan N, Lee H, Trivedi C, Kavani H, Medvedeva E, Xie D, Lewis JD, Yang YX Abstract BACKGROUND & AIMS: Treatment with thiopurines is associated with an increased risk of squamous cell carcinoma of the skin (SCC) in patients with inflammatory bowel diseases (IBD). We studied outcomes of patients with IBD who developed SCC while receiving thiopurine therapy. METHODS: We conducted a retrospective…

Read More

Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care.

Related Articles Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care. Dig Dis Sci. 2019 Feb 28;: Authors: Cohen-Mekelburg S, Schneider Y, Gold S, Ghosh G, Rosenblatt R, Hajifathalian K, Scherl E, Schnoll-Sussman F, Katz P, Steinlauf A Abstract BACKGROUND: Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS: To describe the current prevalence of early CRC…

Read More

Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients.

Related Articles Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients. Gut. 2019 Feb 26;: Authors: Cheung KS, Chen L, Chan EW, Seto WK, Wong ICK, Leung WK Abstract BACKGROUND AND AIMS: Postcolonoscopy colorectal cancer (PCCRC) accounts for up to 9% of all CRCs. Statins have been shown to be associated with a lower CRC risk. We aimed to investigate whether PCCRC risk was also lower among statin users. METHODS: This is a retrospective cohort study using a territory-wide electronic healthcare database…

Read More

Whole Exome Sequencing of Ulcerative Colitis-associated Colorectal Cancer Based on Novel Somatic Mutations Identified in Chinese Patients.

Whole Exome Sequencing of Ulcerative Colitis-associated Colorectal Cancer Based on Novel Somatic Mutations Identified in Chinese Patients. Inflamm Bowel Dis. 2019 Feb 22;: Authors: Yan P, Wang Y, Meng X, Yang H, Liu Z, Qian J, Zhou W, Li J Abstract BACKGROUND: Carcinogenesis is a severe consequence of chronic ulcerative colitis. We investigated the somatic mutations and pathway alterations in ulcerative colitis-associated colorectal cancer (CRC) in Chinese patients compared with sporadic CRCs to reveal potential therapeutic targets in ulcerative colitis-associated CRC. METHODS: Whole exome sequencing was performed on archival tumor…

Read More

Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies.

Related Articles Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies. World J Gastroenterol. 2019 Feb 14;25(6):659-671 Authors: Fung BM, Lindor KD, Tabibian JH Abstract Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by progressive fibroinflammatory destruction of the intra- and/or extrahepatic biliary ducts. While its features and disease course can be variable, most patients with PSC have concurrent inflammatory bowel disease and will eventually develop liver cirrhosis and end-stage liver disease, with liver transplantation representing the only potentially curative option. Importantly, PSC is associated…

Read More

Risk Factors and Clinical Outcomes of Head and Neck Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study.

Risk Factors and Clinical Outcomes of Head and Neck Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study. Inflamm Bowel Dis. 2018 Aug 16;24(9):2015-2026 Authors: Nissen LHC, Derikx LAAP, Jacobs AME, van Herpen CM, Kievit W, Verhoeven R, van den Broek E, Bekers E, van den Heuvel T, Pierik M, Rahamat-Langendoen J, Takes RP, Melchers WJG, Nagtegaal ID, Hoentjen F, Dutch Initiative on Crohn and Colitis (ICC) , Dutch Head and Neck Society, PALGA group, IBD/HNC group Abstract Background: Immunosuppressed inflammatory bowel disease (IBD) patients are at increased risk to…

Read More

Surveillance Colonoscopy for Ulcerative Colitis-Associated Colorectal Cancer Offers Better Overall Survival in Real-World Surgically Resected Cases.

Surveillance Colonoscopy for Ulcerative Colitis-Associated Colorectal Cancer Offers Better Overall Survival in Real-World Surgically Resected Cases. Am J Gastroenterol. 2019 Feb 08;: Authors: Hata K, Anzai H, Ikeuchi H, Futami K, Fukushima K, Sugita A, Uchino M, Higashi D, Itabashi M, Watanabe K, Koganei K, Araki T, Kimura H, Mizushima T, Ueda T, Ishihara S, Suzuki Y, Research Group for Intractable Inflammatory Bowel Disease of the Ministry of Health, Labour and Welfare of Japan (RGIBD) Abstract OBJECTIVES: To determine the effectiveness of surveillance colonoscopy (SC) and optimize its use by…

Read More

IBD-associated colon cancers differ in DNA methylation and gene expression profiles compared to sporadic colon cancers.

IBD-associated colon cancers differ in DNA methylation and gene expression profiles compared to sporadic colon cancers. J Crohns Colitis. 2019 Feb 11;: Authors: Pekow J, Hernandez K, Meckel K, Deng Z, Haider HI, Khalil A, Zhang C, Talisila N, Siva S, Jasmine F, Li YC, Rubin DT, Hyman N, Bissonnette M, Weber C, Kibriya MG Abstract Background and Aims: As ulcerative colitis (UC)-associated colorectal cancer (CRC) and sporadic CRC differ in presentation and molecular features, we sought to evaluate differences in the impact of DNA methylation on gene expression. Methods…

Read More

CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p.

CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p. Inflamm Bowel Dis. 2019 Jan 04;: Authors: Ma D, Cao Y, Wang Z, He J, Chen H, Xiong H, Ren L, Shen C, Zhang X, Yan Y, Yan T, Guo F, Xuan B, Cui Z, Ye G, Fang JY, Chen H, Hong J Abstract Background: The long noncoding RNA (lncRNA) colon cancer-associated transcript-1 (CCAT1) has been reported to play a vital role in the development of cancer. Although the link between inflammation and cancer initiation is…

Read More
<< Go Back