You are here

Anti-TNFα Treatment After Surgical Resection for Crohn’s Disease Is Effective Despite Previous Pharmacodynamic Failure.

Anti-TNFα Treatment After Surgical Resection for Crohn’s Disease Is Effective Despite Previous Pharmacodynamic Failure. Inflamm Bowel Dis. 2017 Feb 22;: Authors: Assa A, Bronsky J, Kolho KL, Zarubova K, de Meij T, Ledder O, Sladek M, van Biervliet S, Strisciuglio C, Shamir R Abstract BACKGROUND: The outcome of patients with Crohn’s disease who failed anti-tumor necrosis factor alpha (anti-TNFα) therapy despite adequate serum drug levels (pharmacodynamic failure) is unclear. We aimed to assess such pediatric patients who underwent intestinal resection and were re-treated with the same anti-TNFα agent postoperatively. METHODS:…

Read More

Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease.

Related Articles Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn’s disease. World J Gastroenterol. 2017 Jan 21;23(3):472-477 Authors: Kristo I, Riss S, Argeny S, Maschke S, Chitsabesan P, Stift A Abstract AIM: To evaluate frequency and clinical course of incidental adenocarcinoma in patients with stricturing Crohn’s disease (CD). METHODS: In this study, consecutive patients, who were operated on for stricturing CD between 1997-2012, were included at an academic tertiary referral center. Demographic data and clinical course were obtained by an institutional database and individual chart review. Besides baseline characteristics,…

Read More

MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1.

MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology. 2017 Feb 10;: Authors: He C, Yu T, Shi Y, Ma C, Yang W, Fang L, Sun M, Wu W, Xiao F, Guo F, Chen M, Yang H, Qian J, Cong Y, Liu Z Abstract BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A), compared to tissues from patients without IBD. We studied the mechanisms of MIR301A in progression of IBD in human tissues and…

Read More

Infliximab not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease.

Infliximab not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 Feb 10;: Authors: Hyams JS, Dubinsky MC, Baldassano RN, Colletti RB, Cucchiara S, Escher J, Faubion W, Fell J, Gold BD, Griffiths A, Koletzko S, Kugathasan S, Markowitz J, Ruemmele FM, Veereman G, Winter H, Masel N, Shin CR, Tang KL, Thayu M Abstract BACKGROUND AND AIMS: Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis…

Read More

Third European Evidence-Based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders.

Related Articles Third European Evidence-Based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. J Crohns Colitis. 2017 Feb 02;: Authors: Magro F, Gionchetti P, Eliakim R, Ardizzone S, Armuzzi A, Barreiro-de Acosta M, Burisch J, Gecse KB, Hart AL, Hindryckx P, Langner C, Limdi JK, Pellino G, Zagórowicz E, Raine T, Harbord M, Rieder F, European Crohn’s and Colitis Organisation (ECCO) PMID: 28158501 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/28158501?dopt=Abstract

Read More

Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study.

Do Thiopurines Reduce the Risk of Surgery in Elderly Onset Inflammatory Bowel Disease? A 20-Year National Population-Based Cohort Study. Inflamm Bowel Dis. 2017 Feb 01;: Authors: Alexakis C, Saxena S, Chhaya V, Cecil E, Curcin V, Pollok R Abstract BACKGROUND: Evidence that thiopurines impact on the risk of surgery in elderly onset inflammatory bowel disease (EO-IBD) is lacking. We aimed to compare the rates of surgery in EO-IBD (>60 years at diagnosis) with adult-onset IBD (18-59 yrs), and examine the impact of thiopurines on surgical risk in EO-IBD. METHODS: Using…

Read More

Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures.

Ultrasound Shear Wave Elastography and Contrast Enhancement: Effective Biomarkers in Crohn’s Disease Strictures. Inflamm Bowel Dis. 2017 Jan 26;: Authors: Lu C, Gui X, Chen W, Fung T, Novak K, Wilson SR Abstract BACKGROUND: Inflammation, fibrosis, and muscular hypertrophy lead to thickened bowel in Crohn’s disease forming strictures. Ultrasound shear wave elastography (SWE) measures bowel wall stiffness. Contrast-enhanced ultrasound (CEUS) uniquely detects bowel wall inflammation. We aim to correlate SWE of ileal Crohn’s disease in vivo to CEUS peak enhancement and pathology grades of inflammation, fibrosis, and muscular hypertrophy. METHODS:…

Read More

Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study.

Related Articles Efficacy of adalimumab in patients with Crohn’s disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study. Gut. 2017 Jan 24;: Authors: Bouhnik Y, Carbonnel F, Laharie D, Stefanescu C, Hébuterne X, Abitbol V, Nachury M, Brixi H, Bourreille A, Picon L, Bourrier A, Allez M, Peyrin-Biroulet L, Moreau J, Savoye G, Fumery M, Nancey S, Roblin X, Altwegg R, Bouguen G, Bommelaer G, Danese S, Louis E, Zappa M, Mary JY, GETAID CREOLE Study Group Abstract OBJECTIVE: The efficacy of anti-tumour necrosis factors (anti-TNFs)…

Read More

Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn’s disease.

Related Articles Exclusive enteral nutrition provides an effective bridge to safer interval elective surgery for adults with Crohn’s disease. Aliment Pharmacol Ther. 2017 Jan 20;: Authors: Heerasing N, Thompson B, Hendy P, Heap GA, Walker G, Bethune R, Mansfield S, Calvert C, Kennedy NA, Ahmad T, Goodhand JR Abstract BACKGROUND: Few studies have reported the systematic use of exclusive enteral nutrition in the perioperative setting. AIMS: To test the hypothesis that exclusive enteral nutrition provides a safe and effective bridge to surgery and reduces post-operative complications, in adult patients with…

Read More

Impact of Early Surgery and Immunosuppression on Crohn’s Disease Disabling Outcomes.

Impact of Early Surgery and Immunosuppression on Crohn’s Disease Disabling Outcomes. Inflamm Bowel Dis. 2017 Feb;23(2):289-297 Authors: Magro F, Dias CC, Coelho R, Santos PM, Fernandes S, Caetano C, Rodrigues Â, Portela F, Oliveira A, Ministro P, Cancela E, Vieira AI, Barosa R, Cotter J, Carvalho P, Cremers I, Trabulo D, Caldeira P, Antunes A, Rosa I, Moleiro J, Peixe P, Herculano R, Gonçalves R, Gonçalves B, Tavares Sousa H, Contente L, Morna H, Lopes S Abstract BACKGROUND AND AIMS: The definition of early therapeutic strategies to control Crohn’s disease…

Read More
<< Go Back