A systematic review: The management and outcomes of ileal pouch strictures.

A systematic review: The management and outcomes of ileal pouch strictures. J Crohns Colitis. 2017 Nov 16;: Authors: Segal JP, Worley G, Adegbola SO, Sahnan K, Tozer P, Lung PFC, Faiz OD, Clark SK, Hart AL Abstract Background: Restorative proctocolectomy with ileal pouch-anal anastomosis removes the diseased tissue in ulcerative colitis but also allows gastrointestinal continuity and stoma-free living. Pouch strictures are a complication with a reported incidence of 5-38%. The three areas where pouch strictures occur are in the pouch inlet, mid-pouch and pouch-anal anastomosis. Aim: To undertake a…

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Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact.

Related Articles Endoscopic balloon dilation of Crohn’s disease strictures-safety, efficacy and clinical impact. World J Gastroenterol. 2017 Nov 07;23(41):7397-7406 Authors: Lopes S, Rodrigues-Pinto E, Andrade P, Afonso J, Baron TH, Magro F, Macedo G Abstract AIM: To evaluate the incidence of anastomotic strictures after intestinal resection in Crohn’s disease (CD), demonstrate long-term efficacy and safety of endoscopic balloon dilation (EBD) in CD strictures and its impact on the diagnosis of subclinical postoperative endoscopic recurrence. METHODS: Retrospective single tertiary center study based on prospectively collected data between 2010 and 2015 including…

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Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease.

Related Articles Association Between Use of Thiopurines or Tumor Necrosis Factor Antagonists Alone or in Combination and Risk of Lymphoma in Patients With Inflammatory Bowel Disease. JAMA. 2017 Nov 07;318(17):1679-1686 Authors: Lemaitre M, Kirchgesner J, Rudnichi A, Carrat F, Zureik M, Carbonnel F, Dray-Spira R Abstract Importance: An increased risk of lymphoma has been reported among patients receiving thiopurines for inflammatory bowel disease (IBD). The risk of lymphoma associated with anti-tumor necrosis factor (TNF) agents either alone or in combination with thiopurines is uncertain. Objective: To assess the risk of…

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The risk of non-melanoma skin cancer in New Zealand in Inflammatory Bowel Disease patients treated with thiopurines.

Related Articles The risk of non-melanoma skin cancer in New Zealand in Inflammatory Bowel Disease patients treated with thiopurines. J Gastroenterol Hepatol. 2017 Nov 04;: Authors: Bahi M, Walmsley RS, Gray AR, Young D, Hobbs CE, Aluzaite K, Schultz M Abstract BACKGROUND AND AIM: New Zealand (NZ) has one of the highest rates of non-melanoma skin cancers (NMSC) in the world. Thiopurine use in Inflammatory Bowel Disease (IBD) patients has been shown to increase NMSC risk. This study aimed to investigate the possible increase of NMSC risk in thiopurine-treated IBD…

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Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn’s disease.

Related Articles Risk factors for postoperative recurrence after primary bowel resection in patients with Crohn’s disease. World J Gastroenterol. 2017 Oct 14;23(38):7016-7024 Authors: Yang KM, Yu CS, Lee JL, Kim CW, Yoon YS, Park IJ, Lim SB, Park SH, Ye BD, Yang SK, Kim JC Abstract AIM: To evaluate the risk factors for postoperative recurrence after primary bowel resection in a cohort of Korean Crohn’s disease (CD) patients. METHODS: This study included 260 patients with no history of previous bowel surgery who underwent primary surgery for CD between January 2000…

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Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery.

Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery. World J Gastroenterol. 2017 Sep 21;23(35):6474-6481 Authors: Lee DW, Koo JS, Choe JW, Suh SJ, Kim SY, Hyun JJ, Jung SW, Jung YK, Yim HJ, Lee SW Abstract AIM: To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease (IBD). METHODS: We retrospectively studied 165 patients with Crohn’s disease (CD) and 130 patients with ulcerative colitis (UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan…

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Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn’s disease patients with anastomotic strictures.

Fecal marker levels as predictors of need for endoscopic balloon dilation in Crohn’s disease patients with anastomotic strictures. World J Gastroenterol. 2017 Sep 21;23(35):6482-6490 Authors: Lopes S, Andrade P, Rodrigues-Pinto E, Afonso J, Macedo G, Magro F Abstract AIM: To evaluate the accuracy and best cut-off value of fecal calprotectin (FC) and fecal lactoferrin (FL) to predict disease recurrence in asymptomatic patients presenting with anastomotic strictures. METHODS: This was a longitudinal single tertiary center study based on prospectively collected data (recorded in a clinical database created for this purpose) performed…

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Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn’s disease.

Related Articles Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn’s disease. Aliment Pharmacol Ther. 2017 Oct 20;: Authors: Lang BM, Biedermann L, van Haaften WT, de Vallière C, Schuurmans M, Begré S, Zeitz J, Scharl M, Turina M, Greuter T, Schreiner P, Heinrich H, Kuntzen T, Vavricka SR, Rogler G, Beerenwinkel N, Misselwitz B, Swiss IBD Cohort Study Group Abstract BACKGROUND: Smoking is a strong environmental factor leading to adverse outcomes in Crohn’s disease, but a more benign course in ulcerative colitis. Several…

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Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease.

Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease. J Crohns Colitis. 2017 Sep 19;: Authors: Guizzetti L, Zou G, Khanna R, Dulai PS, Sandborn WJ, Jairath V, Feagan BG Abstract Background and Aims: Crohn’s disease-related complications account for a substantial proportion of inflammatory bowel disease-associated healthcare expenditure. Identifying patients at risk for complications may allow for targeted use of early therapeutic interventions to off-set this natural course. We aimed to develop risk prediction models for Crohn’s disease-related surgery and complications. Methods: Using data from the Randomized…

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