It’s What’s Up Front That Counts-Part One: Endoscopic Diagnosis and Therapy of Esophageal Crohn’s Disease.

Related Articles It’s What’s Up Front That Counts-Part One: Endoscopic Diagnosis and Therapy of Esophageal Crohn’s Disease. Dig Dis Sci. 2019 Sep 16;: Authors: Alli-Akintade L, Hewitt J, Namiq A, Singh M, Nguyen Y, Keihanian S, Chang JT, Karsan S, Tesfay S, Velayos FS PMID: 31529414 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31529414?dopt=Abstract

Read More

The Cost-effectiveness of Initial Immunomodulators or Infliximab Using Modern Optimization Strategies for Crohn’s Disease in the Biosimilar Era.

Related Articles The Cost-effectiveness of Initial Immunomodulators or Infliximab Using Modern Optimization Strategies for Crohn’s Disease in the Biosimilar Era. Inflamm Bowel Dis. 2019 Sep 18;: Authors: Vasudevan A, Ip F, Liew D, Van Langenberg DR Abstract BACKGROUND: Treatment cost, efficacy, and safety are integral considerations when optimizing management of Crohn’s disease (CD). This study assessed the cost-effectiveness of initial immunomodulator and anti-tumor necrosis factor (anti-TNF) agents for the treatment of CD from a US third-party perspective, incorporating current treatment algorithms, optimization strategies, and reduced costs availed by biosimilars. METHOD:…

Read More

Letter: increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNFα agents, particularly etanercept, for autoimmune diseases other than IBD.

Related Articles Letter: increased risk of developing Crohn’s disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNFα agents, particularly etanercept, for autoimmune diseases other than IBD. Aliment Pharmacol Ther. 2019 Oct;50(7):834-835 Authors: Dai C, Jiang M, Sun MJ PMID: 31532556 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31532556?dopt=Abstract

Read More

Clinical Significance of Granulomas in Crohn’s Disease: A Systematic Review and Meta-analysis.

Clinical Significance of Granulomas in Crohn’s Disease: A Systematic Review and Meta-analysis. J Gastroenterol Hepatol. 2019 Sep 14;: Authors: Hong SW, Yoon H, Shin CM, Park YS, Kim N, Lee DH, Kim JS Abstract BACKGROUND AND AIM: Epithelioid granuloma is one hallmark used to histologically diagnose Crohn’s disease (CD). However, the clinical significance of granulomas in CD is unclear. Therefore, we performed a meta-analysis to compare the clinical features with CD according to the presence of granulomas. METHODS: A literature search in PubMed, EMBASE, and Cochrane databases was performed on…

Read More

Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients.

Alvimopan for the Prevention of Postoperative Ileus in Inflammatory Bowel Disease Patients. Dig Dis Sci. 2019 Sep 14;: Authors: Jang J, Kwok B, Zhong H, Xia Y, Grucela A, Bernstein M, Remzi F, Hudesman D, Chen J, Axelrad J, Chang S Abstract BACKGROUND: Postoperative ileus (POI) is a temporary delay of coordinated intestinal peristalsis. Alvimopan, an oral peripherally acting mu-opioid receptor antagonist approved for accelerating gastrointestinal recovery, has never been studied specifically in patients with inflammatory bowel disease (IBD). AIM: To investigate the efficacy of alvimopan in preventing POI among…

Read More

Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease.

Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease. Aliment Pharmacol Ther. 2019 Sep 13;: Authors: Ashton JJ, Latham K, Beattie RM, Ennis S Abstract BACKGROUND: The human leucocyte antigen (HLA) complex, located at chromosome 6p21.3 is a highly polymorphic region containing the classical class I and II HLA genes. The region is highly associated with inflammatory bowel disease (IBD), largely through genome-wide association studies (GWAS). AIMS: To review the role of HLA in immune function, summarise data on risk/protective HLA genotypes for IBD, discuss…

Read More

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

Related Articles Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Sep 11;: Authors: Newton K, Wickliffe KE, Dugger DL, Maltzman A, Roose-Girma M, Dohse M, Kőműves L, Webster JD, Dixit VM Abstract The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a RIPK3- and MLKL-dependent manner during embryogenesis1-3. In humans, caspase-8 deficiency is associated with immunodeficiency4 or very early onset inflammatory bowel disease5. The substrates that are cleaved by caspase-8 to prevent necroptosis…

Read More

Interventions for maintenance of surgically induced remission in Crohn’s disease: a network meta-analysis.

Interventions for maintenance of surgically induced remission in Crohn’s disease: a network meta-analysis. Cochrane Database Syst Rev. 2019 Sep 12;9:CD013210 Authors: Iheozor-Ejiofor Z, Gordon M, Clegg A, Freeman SC, Gjuladin-Hellon T, MacDonald JK, Akobeng AK Abstract BACKGROUND: Crohn’s disease (CD) is a chronic disease of the gut. About 75% of people with CD undergo surgery at least once in their lifetime to induce remission. However, as there is no known cure for the disease, patients usually experience a recurrence even after surgery. Different interventions are routinely used in maintaining postsurgical…

Read More
<< Go Back