Prognostic value of the burden of cytomegalovirus colonic reactivation evaluated by immunohistochemical staining in patients with active ulcerative colitis.

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Prognostic value of the burden of cytomegalovirus colonic reactivation evaluated by immunohistochemical staining in patients with active ulcerative colitis. J Crohns Colitis. 2018 Oct 20;: Authors: Clos-Parals A, Rodríguez-Martínez P, Cañete F, Mañosa M, Ruiz-Cerulla A, Paúles MJ, Llaó J, Gordillo J, Fumagalli C, Garcia-Planella E, Ojanguren I, Cabré E, Guardiola J, Domènech E Abstract Background: Colonic cytomegalovirus (CMV) reactivation has been involved in steroid refractoriness in patients with active ulcerative colitis (UC). The benefits of antiviral therapy in this clinical setting are still under debate, but the burden of…

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Appropriateness of Biologics in the Management of Crohn’s Disease Using RAND/UCLA Appropriateness Methodology.

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Appropriateness of Biologics in the Management of Crohn’s Disease Using RAND/UCLA Appropriateness Methodology. Inflamm Bowel Dis. 2018 Oct 19;: Authors: Weizman AV, Nguyen GC, Seow CH, Targownik L, Murthy SK, Boland K, Afzal NM, Khanna R, Jones J, Afif W, Halder S, Reinglas J, Fowler S, Huang V, Kaplan GG, Melmed GY Abstract Background: 3 classes of biologics are now available for the treatment of Crohn’s disease. The availability of multiple treatment options has led to questions regarding the appropriateness of each agent for a given patient. We aimed to…

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Update on the Natural Course of Fistulizing Perianal Crohn’s Disease in a Population-Based Cohort.

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Update on the Natural Course of Fistulizing Perianal Crohn’s Disease in a Population-Based Cohort. Inflamm Bowel Dis. 2018 Oct 19;: Authors: Park SH, Aniwan S, Scott Harmsen W, Tremaine WJ, Lightner AL, Faubion WA, Loftus EV Abstract Background: This study sought to re-estimate the cumulative incidence of perianal or rectovaginal fistulas and the associated proctectomy rate in the prebiologic era vs the biologic era using a population-based cohort of Crohn’s disease (CD) patients. Methods: The medical records of 414 residents of Olmsted County, Minnesota, who were diagnosed with CD between…

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Gut Microbial Signatures Underline Complicated Crohn’s Disease but Vary Between Cohorts; An In Silico Approach.

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Gut Microbial Signatures Underline Complicated Crohn’s Disease but Vary Between Cohorts; An In Silico Approach. Inflamm Bowel Dis. 2018 Oct 19;: Authors: Dovrolis N, Drygiannakis I, Filidou E, Kandilogiannakis L, Arvanitidis K, Tentes I, Kolios G, Valatas V Abstract Microflora dysbiosis is implicated in the pathophysiology of Crohn’s disease. This work analyzes differences in microbial communities and relevant metabolic pathways among the nonstricturing nonpenetrating (B1), stricturing (B2), and penetrating (B3) subphenotypes of Crohn’s disease vs healthy controls. We conducted a bioinformatics analysis using the QIIME pipeline and the Calypso, linear…

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The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn’s Disease.

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The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn’s Disease. Inflamm Bowel Dis. 2018 Oct 19;: Authors: Mao R, Kurada S, Gordon IO, Baker ME, Gandhi N, McDonald C, Calvin Coffey J, Rieder F Abstract Adipose tissue is present in close proximity to various organs in the human body. One prominent example is fat contained in the mesentery that is contiguous with all abdominal digestive organs including the intestine. Despite the fact that mesenteric fat-wrapping around the inflamed gut (so called “creeping fat”) was described…

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Persistent damage on magnetic resonance enterography in patients with Crohn’s disease in endoscopic remission.

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Related Articles Persistent damage on magnetic resonance enterography in patients with Crohn’s disease in endoscopic remission. Aliment Pharmacol Ther. 2018 Oct 22;: Authors: Rimola J, Alfaro I, Fernández-Clotet A, Castro-Poceiro J, Vas D, Rodríguez S, Masamunt MC, Ordás I, Ricart E, Panés J Abstract BACKGROUND: In Crohn’s disease, it is essential to distinguish between persistent damage and abnormalities that can heal with anti-inflammatory therapy. AIM: To magnetic resonance enterography (MRE) lesions that persist in patients in long-standing endoscopic remission, analyse their relationship with baseline characteristics, and determine their prognostic implications.…

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Circadian rhythms in the pathogenesis of gastrointestinal diseases.

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Related Articles Circadian rhythms in the pathogenesis of gastrointestinal diseases. World J Gastroenterol. 2018 Oct 14;24(38):4297-4303 Authors: Codoñer-Franch P, Gombert M Abstract The etiology of digestive pathologies such as irritable bowel syndrome (IBS), inflammatory bowel diseases (IBD) and cancer is not yet fully understood. In recent years, several studies have evidenced circadian variations in mechanisms involved in digestive health. In situations of disturbed circadian rhythms (chronodisruption) where the central clock and the peripheral clocks receive incoherent signals, the synchronicity is lost producing implications for health. This lack of coordination could…

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Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis.

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Related Articles Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis. World J Gastroenterol. 2018 Oct 14;24(38):4341-4355 Authors: Nunes NS, Kim S, Sundby M, Chandran P, Burks SR, Paz AH, Frank JA Abstract AIM: To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium (DSS)-induced acute colitis. METHODS: Acute colitis was induced in C57Bl/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and…

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Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis.

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Related Articles Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis. World J Gastroenterol. 2018 Oct 14;24(38):4384-4392 Authors: Urushikubo J, Yanai S, Nakamura S, Kawasaki K, Akasaka R, Sato K, Toya Y, Asakura K, Gonai T, Sugai T, Matsumoto T Abstract AIM: To determine appropriate fecal calprotectin cut-off values for the prediction of endoscopic and histologic remission in Japanese patients with ulcerative colitis (UC). METHODS: We performed a cross-sectional observational study of 131 Japanese patients with UC and measured fecal calprotectin levels by fluorescence enzyme immunoassay. The clinical…

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