Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.

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Related Articles Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations. World J Gastroenterol. 2019 Apr 14;25(14):1753-1763 Authors: Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T Abstract BACKGROUND: We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with…

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Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease.

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Related Articles Endoscopic response to tumor necrosis factor inhibitors predicts long term benefits in Crohn’s disease. World J Gastroenterol. 2019 Apr 14;25(14):1764-1774 Authors: Alfaro I, Masamunt MC, Planell N, López-García A, Castro J, Gallego M, Barastegui R, Giner A, Vara A, Salas A, Ricart E, Panés J, Ordás I Abstract BACKGROUND: Identifying predictors of therapeutic response is the cornerstone of personalized medicine. AIM: To identify predictors of long-term mucosal healing (MH) in patients with Crohn’s disease (CD) treated with tumor necrosis factor α (TNF-α) inhibitors. METHODS: Prospective single center study.…

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Race/Ethnicity-specific Disparities in In-Hospital Mortality and Hospital Charges Among Inflammatory Bowel Disease-related Hospitalizations in the United States.

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Race/Ethnicity-specific Disparities in In-Hospital Mortality and Hospital Charges Among Inflammatory Bowel Disease-related Hospitalizations in the United States. J Clin Gastroenterol. 2019 Apr 17;: Authors: Galoosian A, Rezapour M, Liu B, Bhuket T, Wong RJ Abstract GOAL: The goal of this study was to evaluate disparities in hospital outcomes among inflammatory bowel disease (IBD) related hospitalizations in the United States with a focus on ethnicity-specific disparities. BACKGROUND: IBD-related hospitalizations contribute to significant morbidity and health care economic burden. METHODS: IBD-related hospitalizations (identified with ICD-9) among US adults were evaluated using 2007…

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Should We Divide Crohn’s Disease Into Ileum-dominant and Isolated Colonic Diseases?

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Should We Divide Crohn’s Disease Into Ileum-dominant and Isolated Colonic Diseases? Clin Gastroenterol Hepatol. 2019 Apr 19;: Authors: Dulai PS, Singh S, Casteele NV, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ Abstract Crohn’s disease (CD) is an inflammatory bowel disease, which can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification…

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Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.

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Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children. Clin Gastroenterol Hepatol. 2019 Apr 19;: Authors: Nicholson MR, Mitchell PD, Alexander E, Ballal S, Bartlett M, Becker P, Davidovics Z, Docktor M, Dole M, Felix G, Gisser J, Hourigan SK, Jensen MK, Kaplan JL, Kelsen J, Kennedy M, Khanna S, Knackstedt E, Leier M, Lewis J, Lodarek A, Michail S, Oliva-Hemker M, Patton T, Queliza K, Russell GH, Singh N, Solomon A, Suskind DL, Werlin S, Kellermayer R, Kahn SA Abstract BACKGROUND & AIMS: Fecal microbiota transplantation (FMT)…

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Risk Factors of Colectomy in Patients With Refractory Ulcerative Colitis Under Calcineurin Inhibitors Combined With Vedolizumab.

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Related Articles Risk Factors of Colectomy in Patients With Refractory Ulcerative Colitis Under Calcineurin Inhibitors Combined With Vedolizumab. Clin Gastroenterol Hepatol. 2019 May;17(6):1213-1214 Authors: Fragaki M, Demetriou G, Koutroubakis IE PMID: 31003696 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31003696?dopt=Abstract

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Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis.

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Related Articles Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis. Gut. 2019 Apr 19;: Authors: Lemoinne S, Kemgang A, Ben Belkacem K, Straube M, Jegou S, Corpechot C, Saint-Antoine IBD Network, Chazouillères O, Housset C, Sokol H Abstract OBJECTIVE: Patients with primary sclerosing cholangitis (PSC) were previously shown to display a bacterial gut dysbiosis but fungal microbiota has never been examined in these patients. The aim of this study was to assess the fungal gut microbiota in patients with PSC. DESIGN: We analysed the…

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Differential miRNA expression in ileal and colonic tissues reveals an altered immunoregulatory molecular profile in individuals with Crohn’s disease versus healthy subjects.

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Related Articles Differential miRNA expression in ileal and colonic tissues reveals an altered immunoregulatory molecular profile in individuals with Crohn’s disease versus healthy subjects. J Crohns Colitis. 2019 Apr 19;: Authors: Mohammadi A, Kelly OB, Smith MI, Kabakchiev B, Silverberg MS Abstract MicroRNAs (miRNAs) are key modulators of gene expression in Crohn’s disease (CD) and may drive tissue-specific molecular alterations underlying CD susceptibility. In this study we analysed differential miRNA expression between CD and healthy subjects across ileal and colonic tissues. A cohort of CD and healthy control (HC) subjects…

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