Immunological Mechanisms of Adsorptive Cytapheresis in Inflammatory Bowel Disease.

Related Articles Immunological Mechanisms of Adsorptive Cytapheresis in Inflammatory Bowel Disease. Dig Dis Sci. 2017 Apr 21;: Authors: Sáez-González E, Moret I, Alvarez-Sotomayor D, Díaz-Jaime FC, Cerrillo E, Iborra M, Nos P, Beltrán B Abstract Ulcerative colitis and Crohn’s disease are the two main forms of inflammatory bowel disease (IBD). The study of immunological pathways involved in the onset of IBD is of fundamental importance to identify potential biological markers of disease activity and specific targets for therapy. Removing excess and activated circulating leukocytes with adsorptive cytapheresis has been shown…

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Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner.

Related Articles Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. Gut. 2017 Apr 20;: Authors: Trivedi PJ, Tickle J, Vesterhus MN, Eddowes PJ, Bruns T, Vainio J, Parker R, Smith D, Liaskou E, Thorbjørnsen LW, Hirschfield GM, Auvinen K, Hubscher SG, Salmi M, Adams DH, Weston CJ Abstract OBJECTIVE: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. This clinical association is linked pathologically to the recruitment of mucosal T…

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A 20 year temporal change analysis in incidence, presenting phenotype and mortality in the Dutch IBDSL cohort – Can diagnostic factors explain the increase in IBD incidence?

A 20 year temporal change analysis in incidence, presenting phenotype and mortality in the Dutch IBDSL cohort – Can diagnostic factors explain the increase in IBD incidence? J Crohns Colitis. 2017 Apr 20;: Authors: van den Heuvel TRA, Jeuring SFG, Zeegers MP, van Dongen DHE, Wolters A, Masclee AAM, Hameeteman WH, Romberg-Camps MJL, Oostenbrug LE, Pierik MJ, Jonkers DM Abstract Background: The aim was to study temporal changes in incidence, disease phenotype at diagnosis, and mortality of adult inflammatory bowel disease (IBD) patients in South Limburg, the Netherlands, diagnosed between…

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Development and validation of diagnostic criteria for IBD subtypes with an emphasis on IBD-Unclassified in children: a multicenter study from the Pediatric IBD Porto group of ESPGHAN.

Development and validation of diagnostic criteria for IBD subtypes with an emphasis on IBD-Unclassified in children: a multicenter study from the Pediatric IBD Porto group of ESPGHAN. J Crohns Colitis. 2017 Apr 18;: Authors: Birimberg-Schwartz L, Zucker DM, Akriv A, Cucchiara S, Cameron FL, Wilson DC, Lazowska I, Yianni L, Paul SP, Romano C, Kolacek S, Buderus S, Pærregaard A, Russell RK, Escher JC, Turner D, Pediatric IBD Porto group of ESPGHAN Abstract Background: The revised Porto criteria identify subtypes of pediatric inflammatory bowel diseases: ulcerative colitis (UC), atypical UC,…

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Quality of Care and Outcomes Among Hospitalized Inflammatory Bowel Disease Patients: A Multicenter Retrospective Study.

Quality of Care and Outcomes Among Hospitalized Inflammatory Bowel Disease Patients: A Multicenter Retrospective Study. Inflamm Bowel Dis. 2017 May;23(5):695-701 Authors: Nguyen GC, Murthy SK, Bressler B, Lam MCW, Alali A, Toumi A, Reinglas J, Rampersad A, Weizman AV, Afif W, CINERGI group Abstract BACKGROUND: Half of patients with inflammatory bowel disease (IBD) require hospitalization. We sought to characterize inpatient quality indicators of care and outcomes during IBD-related hospitalizations at 4 major IBD referral centers in Canada. METHODS: We conducted a multicenter retrospective cohort study of patients with IBD admitted…

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Defining the Most Appropriate Delivery Mode in Women with Inflammatory Bowel Disease: A Systematic Review.

Defining the Most Appropriate Delivery Mode in Women with Inflammatory Bowel Disease: A Systematic Review. Inflamm Bowel Dis. 2017 May;23(5):712-720 Authors: Foulon A, Dupas JL, Sabbagh C, Chevreau J, Rebibo L, Brazier F, Bouguen G, Gondry J, Fumery M Abstract INTRODUCTION: High cesarean section (CS) rates are observed in patients with inflammatory bowel disease (IBD), but limited data are available to support this decision. We conducted a comprehensive review to evaluate the most appropriate mode of delivery in women with IBD according to disease phenotype and activity, as well as…

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Indications for Mode of Delivery in Pregnant Women with Inflammatory Bowel Disease.

Indications for Mode of Delivery in Pregnant Women with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 May;23(5):721-726 Authors: Burke KE, Haviland MJ, Hacker MR, Shainker SA, Cheifetz AS Abstract BACKGROUND: Reasons for the increased incidence of cesarean delivery among women with inflammatory bowel disease remain unclear. We assessed cesarean delivery incidence and factors influencing mode of delivery in women with inflammatory bowel disease. METHODS: We performed a 10-year retrospective cohort study of nulliparous women who delivered a singleton infant at our institution. We compared the risk of each mode of…

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Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines.

Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines. Inflamm Bowel Dis. 2017 May;23(5):728-738 Authors: Tani S, Takano R, Tamura S, Oishi S, Iwaizumi M, Hamaya Y, Takagaki K, Nagata T, Seto S, Horii T, Kosugi I, Iwashita T, Osawa S, Furuta T, Miyajima H, Sugimoto K Abstract BACKGROUND: Digoxin, a cardiac glycoside used for the treatment of heart failure, was reported to inhibit the retinoid-related orphan receptor gamma t (RORγt) and attenuate the severity of experimental autoimmune encephalomyelitis and arthritis in mice. However, the effects of digoxin in a…

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Expression and Localization of miR-21 and miR-126 in Mucosal Tissue from Patients with Inflammatory Bowel Disease.

Expression and Localization of miR-21 and miR-126 in Mucosal Tissue from Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 May;23(5):739-752 Authors: Thorlacius-Ussing G, Schnack Nielsen B, Andersen V, Holmstrøm K, Pedersen AE Abstract BACKGROUND: microRNAs (miRNAs) are small noncoding RNAs that guide degradation of mRNA and regulate protein expression. miRNA based diagnostic biomarkers for ulcerative colitis (UC) and Crohn’s disease (CD) are emerging but information about the cellular localization of many miRNAs is limited and more detailed histologic evaluation of miRNA expression patterns is needed to understand their immunobiological…

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Race Differences in Initial Presentation, Early Treatment, and 1-year Outcomes of Pediatric Crohn’s Disease: Results from the ImproveCareNow Network.

Race Differences in Initial Presentation, Early Treatment, and 1-year Outcomes of Pediatric Crohn’s Disease: Results from the ImproveCareNow Network. Inflamm Bowel Dis. 2017 May;23(5):767-774 Authors: Dotson JL, Cho M, Bricker J, Kappelman MD, Chisolm DJ, Tomer G, Crandall WV, ImproveCareNow Pediatric IBD Learning Health System Abstract BACKGROUND: Racially disparate care has been shown to contribute to suboptimal health care outcomes for minorities. Using the ImproveCareNow network, we investigated differences in management and outcomes of pediatric patients with Crohn’s disease at diagnosis and 1-year postdiagnosis. METHODS: ImproveCareNow is a learning health…

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