Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management.

Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management. Aliment Pharmacol Ther. 2017 Oct 16;: Authors: McIlroy J, Ianiro G, Mukhopadhya I, Hansen R, Hold GL Abstract BACKGROUND: The concept of an altered collective gut microbiota rather than identification of a single culprit is possibly the most significant development in inflammatory bowel disease research. We have entered the “omics” era, which now allows us to undertake large-scale/high-throughput microbiota analysis which may well define how we approach diagnosis and treatment of inflammatory bowel disease (IBD) in the future,…

Read More

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

Related Articles DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology. 2017 Oct 11;: Authors: Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M Abstract BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about…

Read More

Surgical treatment in childhood-onset inflammatory bowel disease -A nationwide register-based study of 4,695 incident patients in Sweden 2002-2014.

Surgical treatment in childhood-onset inflammatory bowel disease -A nationwide register-based study of 4,695 incident patients in Sweden 2002-2014. J Crohns Colitis. 2017 Sep 27;: Authors: Nordenvall C, Rosvall O, Bottai M, Everhov ÅH, Malmborg P, Smedby KE, Ekbom A, Askling J, Ludvigsson JF, Myrelid P, Olén O Abstract Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and…

Read More

Biopsy-derived intestinal epithelial cell cultures for pathway based stratification of patients with inflammatory bowel disease.

Biopsy-derived intestinal epithelial cell cultures for pathway based stratification of patients with inflammatory bowel disease. J Crohns Colitis. 2017 Sep 23;: Authors: Vanhove W, Nys K, Arijs I, Cleynen I, Noben M, De Schepper S, Van Assche G, Ferrante M, Vermeire S Abstract Background: Endoplasmic reticulum stress was shown to be pivotal in the pathogenesis of inflammatory bowel disease. Despite progress in IBD drug development, not more than one third of patients achieve steroid-free remission and mucosal healing with current therapies. Furthermore, patient stratification tools for therapy selection are lacking….

Read More

Genital granulomatosis in male and female patients with Crohn`s disease: clinical presentation and treatment outcomes.

Genital granulomatosis in male and female patients with Crohn`s disease: clinical presentation and treatment outcomes. J Crohns Colitis. 2017 Sep 27;: Authors: Dederichs F, Iesalnieks I, Sladek M, Tzivinikos C, Hansen R, Muñoz C, Pavli P, Cavicchi MN, Abitbol V, Rahier JF, Vavricka SR, Katsanos K, Domènech E, ECCO-CONFER investigators Abstract Background: Genital granulomatosis (GG) is a metastatic form of Crohn’s Disease (CD), characterized by granulomatous inflammation of the genital skin without contact to the gastrointestinal tract. Little is known about GG as most publications are case reports or small…

Read More

Antibiotic use and new-onset inflammatory bowel disease in Olmsted County, Minnesota: a population-based case-control study.

Antibiotic use and new-onset inflammatory bowel disease in Olmsted County, Minnesota: a population-based case-control study. J Crohns Colitis. 2017 Sep 28;: Authors: Aniwan S, Tremaine WJ, Raffals LE, Kane SV, Loftus EV Abstract Background and Aims: Several studies have suggested significant associations between environmental factors and the risk of developing inflammatory bowel disease (IBD). However, data supporting the role of antibiotics are conflicting. The aim of this study was to evaluate the association between antibiotic use and new-onset IBD. Methods: We conducted a population-based case-control study using the Rochester Epidemiology…

Read More

Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomized Controlled Induction and Maintenance Studies.

Tofacitinib in Patients with Ulcerative Colitis: Health-Related Quality of Life in Phase 3 Randomized Controlled Induction and Maintenance Studies. J Crohns Colitis. 2017 Sep 27;: Authors: Panés J, Vermeire S, Lindsay JO, Sands BE, Su C, Friedman G, Zhang H, Yarlas A, Bayliss M, Maher S, Cappelleri JC, Bushmakin AG, Rubin DT Abstract Background and Aims: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for UC. We evaluated healthrelated quality of life [HRQoL] in tofacitinib UC Phase 3 studies. Methods: Patients ≥18 years old in OCTAVE Induction…

Read More

Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease.

Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease. J Crohns Colitis. 2017 Sep 19;: Authors: Guizzetti L, Zou G, Khanna R, Dulai PS, Sandborn WJ, Jairath V, Feagan BG Abstract Background and Aims: Crohn’s disease-related complications account for a substantial proportion of inflammatory bowel disease-associated healthcare expenditure. Identifying patients at risk for complications may allow for targeted use of early therapeutic interventions to off-set this natural course. We aimed to develop risk prediction models for Crohn’s disease-related surgery and complications. Methods: Using data from the Randomized…

Read More

Review article: consensus statements on therapeutic drug monitoring of anti-tumour necrosis factor therapy in inflammatory bowel diseases.

Related Articles Review article: consensus statements on therapeutic drug monitoring of anti-tumour necrosis factor therapy in inflammatory bowel diseases. Aliment Pharmacol Ther. 2017 Oct 13;: Authors: Mitrev N, Vande Casteele N, Seow CH, Andrews JM, Connor SJ, Moore GT, Barclay M, Begun J, Bryant R, Chan W, Corte C, Ghaly S, Lemberg DA, Kariyawasam V, Lewindon P, Martin J, Mountifield R, Radford-Smith G, Slobodian P, Sparrow M, Toong C, van Langenberg D, Ward MG, Leong RW, IBD Sydney Organisation and the Australian Inflammatory Bowel Diseases Consensus Working Group Abstract BACKGROUND:…

Read More

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study.

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study. J Gastroenterol. 2017 Oct 13;: Authors: Naganuma M, Aoyama N, Tada T, Kobayashi K, Hirai F, Watanabe K, Watanabe M, Hibi T Abstract In Fig. 2(c) of this article, the length of the “95% CI difference bars” under the items labelled “Left-sided and Pancolitis” and “Left-sided” under the heading “Disease type” was corrected. The correct figure is shown in the following page. PMID:…

Read More
<< Go Back