De-escalation of immunomodulator and biological therapy in inflammatory bowel disease.

Related Articles De-escalation of immunomodulator and biological therapy in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2020 Jan;5(1):63-79 Authors: Chapman TP, Gomes CF, Louis E, Colombel JF, Satsangi J Abstract Treatment strategies for inflammatory bowel disease (IBD) focus on the induction and long-term maintenance of deep remission to avoid complications of active disease and improve long-term outcomes. Medical therapies for IBD, notably the increasingly widespread use of biological therapy, are often effective at controlling disease, but these drugs are associated with substantial adverse events, which together with other factors-including increasing treatment…

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Personalised medicine in Crohn’s disease.

Related Articles Personalised medicine in Crohn’s disease. Lancet Gastroenterol Hepatol. 2020 Jan;5(1):80-92 Authors: Noor NM, Verstockt B, Parkes M, Lee JC Abstract Similar to many immune-mediated diseases, Crohn’s disease follows a relapsing-remitting pattern, with a variable disease course and heterogeneous clinical outcomes. Frequency of flare-ups, development of complications, and response to treatment collectively determine the effect on a patient’s quality of life, which can vary from minimal disruption to profound disability or death. Despite recent advances in the understanding of complex disease pathogenesis, including for Crohn’s disease, management decisions are…

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Diet Therapy for Inflammatory Bowel Diseases: A Call to the Dining Table.

Related Articles Diet Therapy for Inflammatory Bowel Diseases: A Call to the Dining Table. Inflamm Bowel Dis. 2019 Dec 10;: Authors: Limketkai BN, Gordon M, Mutlu EA, De Silva PS, Lewis JD Abstract There is vigorous interest among patients, caregivers, clinicians, and scientists to identify useful dietary interventions for inflammatory bowel diseases (IBD). Through the Cochrane Collaboration, we recently performed a systematic review and meta-analysis of dietary interventions for the induction or maintenance of remission in Crohn’s disease (CD) and ulcerative colitis (UC) to assess the latest state of research.…

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Poor Sleep Quality in Crohn’s Disease Is Associated With Disease Activity and Risk for Hospitalization or Surgery.

Poor Sleep Quality in Crohn’s Disease Is Associated With Disease Activity and Risk for Hospitalization or Surgery. Inflamm Bowel Dis. 2019 Dec 10;: Authors: Sofia MA, Lipowska AM, Zmeter N, Perez E, Kavitt R, Rubin DT Abstract BACKGROUND AND AIMS: Poor sleep quality in Crohn’s disease (CD) is associated with histologic activity and clinical relapse. We sought to characterize sleep dysfunction and determine the effect of poor sleep quality on risk for hospitalization and surgery. METHODS: Clinical data were collected for CD subjects including the Pittsburgh Sleep Quality Index (PSQI)…

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Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in Inflammatory Bowel Disease.

Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 Dec 09;: Authors: Tariq R, Disbrow MB, Dibaise JK, Orenstein R, Saha S, Solanky D, Loftus EV, Pardi DS, Khanna S Abstract BACKGROUND: Clostridioides difficile infection (CDI) is associated with poor outcomes in inflammatory bowel disease (IBD) patients. Data are scarce on efficacy of fecal microbiota transplant (FMT) for recurrent CDI in IBD patients. METHODS: We reviewed health records of IBD patients (18 years of age or older) with recurrent CDI who…

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Intestinal Microbiota Transplantation for Patients With Inflammatory Bowel Disease Prevents Recurrence of C. difficile Infections but Not Recurrence of Gastrointestinal Symptoms.

Intestinal Microbiota Transplantation for Patients With Inflammatory Bowel Disease Prevents Recurrence of C. difficile Infections but Not Recurrence of Gastrointestinal Symptoms. Inflamm Bowel Dis. 2019 Dec 10;: Authors: Chen LA PMID: 31821445 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31821445?dopt=Abstract

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Systematic review with meta-analysis: mortality in acute severe ulcerative colitis.

Systematic review with meta-analysis: mortality in acute severe ulcerative colitis. Aliment Pharmacol Ther. 2019 Dec 10;: Authors: Dong C, Metzger M, Holsbø E, Perduca V, Carbonnel F Abstract BACKGROUND: Acute severe ulcerative colitis (ASUC) is a life-threatening condition. Mortality in ASUC decreased in published series but there is uncertainty as to whether this also applies to the real-life setting. AIM: To perform a systematic review and meta-analysis of mortality in ASUC in studies from referral centres and in population-based studies, separately and combined. A second aim was to identify risk…

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Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: a Systematic Review.

Related Articles Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: a Systematic Review. Gastroenterology. 2019 Dec 05;: Authors: Pittayanon R, Lau JT, Leontiadis GI, Tse F, Yuan Y, Surette M, Moayyedi P Abstract BACKGROUND & AIMS: Altering the intestinal microbiota has been proposed as a treatment for inflammatory bowel diseases (IBD), but there are no established associations between specific microbes and IBD. We performed a systematic review to identify frequent associations. METHODS: We searched the MEDLINE, EMBASE, Cochrane CDSR, and CENTRAL databases, through April 2, 2018…

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Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn’s Disease than Endoscopic Healing.

Related Articles Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn’s Disease than Endoscopic Healing. Clin Gastroenterol Hepatol. 2019 Dec 05;: Authors: Christensen B, Erlich J, Gibson PR, Turner JR, Hart J, Rubin DT Abstract BACKGROUND & AIMS: Deep remission, based on clinical remission and evidence of healing during endoscopic evaluation, are goals of medical treatments for Crohn’s disease (CD). We investigated whether histologic healing is associated with outcomes of patients with CD ileitis. METHODS: We performed a retrospective study of 101 patients with CD (52% male)…

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Diet in treatment of Inflammatory Bowel Diseases.

Related Articles Diet in treatment of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2019 Dec 05;: Authors: Sasson AN, Ananthakrishnan AN, Raman M Abstract There has been an alarming increase in the incidence of inflammatory bowel diseases (IBD) worldwide over the past several decades. The pathogenesis of IBD involves genetic and environmental factors. Diet is a potentially modifiable environmental risk factor for IBD onset and severity. Diet can promote intestinal inflammation by dysregulating the immune system, altering intestinal permeability and the mucous layer, contributing to microbial dysbiosis, and other mechanisms. Dietary…

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