Plasma N-Glycan Signatures Associate With Features of Inflammatory Bowel Diseases.

Related Articles Plasma N-Glycan Signatures Associate With Features of Inflammatory Bowel Diseases. Gastroenterology. 2018 May 21;: Authors: Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E, IBD-BIOM consortium, Targan SR, Barron G, Manetti N, Latiano A, McGovern DPB, Annese V, Lauc G, Wuhrer M Abstract BACKGROUND & AIMS: Biomarkers are needed for early detection of Crohn’s disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex post-translational modification of proteins that…

Read More

Long-term course of inflammatory bowel disease after the Great East Japan Earthquake.

Related Articles Long-term course of inflammatory bowel disease after the Great East Japan Earthquake. J Gastroenterol Hepatol. 2018 May 23;: Authors: Miyazawa T, Shiga H, Kinouchi Y, Takahashi S, Tominaga G, Takahashi H, Takagi S, Obana N, Kikuchi T, Omori S, Sato Y, Takahashi S, Umemura K, Endo K, Kakuta Y, Matsuura M, Kimura T, Kuroha M, Shimosegawa T Abstract BACKGROUND AND AIM: This study analyzed inflammatory bowel disease activity for two years after the Great East Japan Earthquake. METHODS: We compared the relapse rates of patients with ulcerative colitis…

Read More

Umbilical Cord Blood Transplantation Corrects Very Early-Onset Inflammatory Bowel Disease in Chinese Patients With IL10RA-Associated Immune Deficiency.

Umbilical Cord Blood Transplantation Corrects Very Early-Onset Inflammatory Bowel Disease in Chinese Patients With IL10RA-Associated Immune Deficiency. Inflamm Bowel Dis. 2018 May 18;: Authors: Peng K, Qian X, Huang Z, Lu J, Wang Y, Zhou Y, Wang H, Wu B, Wang Y, Chen L, Zhai X, Huang Y Abstract Background: Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood transplantation in patients with interleukin-10 receptor-A deficiency.…

Read More

Pregnancy-Onset Inflammatory Bowel Disease: A Subtle Diagnosis.

Pregnancy-Onset Inflammatory Bowel Disease: A Subtle Diagnosis. Inflamm Bowel Dis. 2018 May 17;: Authors: Koslowsky B, Grisaru-Granovsky S, Livovsky DM, Milgrom Y, Goldin E, Bar-Gil Shitrit A Abstract Background: Inflammatory bowel diseases (IBDs) are commonly diagnosed during the reproductive years. IBD first manifested during pregnancy (pregnancy-onset IBD [POIBD]) is still an undescribed entity. The aim of the study was to evaluate the characteristics and maternal and neonatal outcomes of patients with POIBD. Methods: Data of all pregnant women with IBD within a single multidisciplinary referral clinic, IBD-MOM, between 2011-2016, were…

Read More

Effectiveness and Safety of Vedolizumab in Anti-TNF-Naïve Patients With Inflammatory Bowel Disease-A Multicenter Retrospective European Study.

Effectiveness and Safety of Vedolizumab in Anti-TNF-Naïve Patients With Inflammatory Bowel Disease-A Multicenter Retrospective European Study. Inflamm Bowel Dis. 2018 May 18;: Authors: Kopylov U, Verstockt B, Biedermann L, Sebastian S, Pugliese D, Sonnenberg E, Steinhagen P, Arebi N, Ron Y, Kucharzik T, Roblin X, Ungar B, Shitrit AB, Ardizzone S, Molander P, Coletta M, Peyrin-Biroulet L, Bossuyt P, Avni-Biron I, Tsoukali E, Allocca M, Katsanos K, Raine T, Sipponen T, Fiorino G, Ben-Horin S, Eliakim R, Armuzzi A, Siegmund B, Baumgart DC, Kamperidis N, Maharshak N, Maaser C, Mantzaris…

Read More

Development and Psychometric Properties of the Inflammatory Bowel Disease Distress Scale (IBD-DS): A New Tool to Measure Disease-Specific Distress.

Development and Psychometric Properties of the Inflammatory Bowel Disease Distress Scale (IBD-DS): A New Tool to Measure Disease-Specific Distress. Inflamm Bowel Dis. 2018 May 18;: Authors: Dibley L, Czuber-Dochan W, Woodward S, Wade T, Bassett P, Sturt J, Norton C, IBD-DS Patient and Public Involvement Team Abstract Background: Inflammatory bowel disease (IBD) imposes a heavy psychosocial burden, with many patients reporting anxiety, depression, and distress. In diseases such as diabetes, disease-specific distress is associated with concordance with treatments and disease control. IBD distress, distinct from anxiety and depression, is evident…

Read More

Microbial Signatures as a Predictive Tool in IBD-Pearls and Pitfalls.

Microbial Signatures as a Predictive Tool in IBD-Pearls and Pitfalls. Inflamm Bowel Dis. 2018 May 18;24(6):1123-1132 Authors: Waldschmitt N, Metwaly A, Fischer S, Haller D Abstract Studies of microbial signatures have improved our understanding of the role of dysbiosis in gut microbiota for the pathogenesis of inflammatory bowel disease (IBD). New technological advances such as next-generation sequencing facilitate investigations on large patient cohorts, but require methodological considerations regarding study design, sample processing, data analysis, and integration. Here, we summarize recent study approaches in microbial ecology with respect to IBD research…

Read More

Clinical Pharmacology in Adult and Pediatric Inflammatory Bowel Disease.

Clinical Pharmacology in Adult and Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 May 17;: Authors: Hemperly A, Sandborn WJ, Vande Casteele N Abstract This review describes the clinical pharmacology of the major drugs used for the treatment of patients with inflammatory bowel disease (IBD). Pharmacokinetics, drug metabolism, mechanism of action, efficacy, and safety profile are discussed. Some small molecules were developed to act systemically (eg, ozanimod) or locally (eg, aminosalicylates) and thus have disparate pharmacokinetic properties. In addition, locally acting compounds have been optimized to mitigate systemic exposure-eg, budesonide,…

Read More

CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis.

CD1a-Expressing Monocytes as Mediators of Inflammation in Ulcerative Colitis. Inflamm Bowel Dis. 2018 May 17;: Authors: Al-Amodi O, Jodeleit H, Beigel F, Wolf E, Siebeck M, Gropp R Abstract Background: CD1a-expressing CD14+ monocytes have been identified as inducers of autoreactive T cells. In this study, the link between inflammatory and metabolic signals and CD1a-expressing monocytes in vitro and in vivo was examined, and CD1a was evaluated as a potential therapeutic target for treatment of ulcerative colitis (UC). Methods: Peripheral blood mononuclear cells (PBMCs) from UC patients and non-UC donors were…

Read More

Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study.

Food Exclusion Based on IgG Antibodies Alleviates Symptoms in Ulcerative Colitis: A Prospective Study. Inflamm Bowel Dis. 2018 May 16;: Authors: Jian L, Anqi H, Gang L, Litian W, Yanyan X, Mengdi W, Tong L Abstract Background: Most patients with ulcerative colitis (UC) rely predominantly on medication for disease control. Diet interventions can reduce pharmaceutical expenditures and prolong remission. We designed a prospective study to evaluate whether an immunoglobulin G (IgG)-guided exclusion diet would improve symptoms and quality of life (QoL) in patients with UC. Methods: The 6-month diet intervention…

Read More
<< Go Back