Male gender, active smoking and previous intestinal resection are risk factors of post-operative endoscopic recurrence in Crohn’s disease: results from a prospective cohort study.

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Male gender, active smoking and previous intestinal resection are risk factors of post-operative endoscopic recurrence in Crohn’s disease: results from a prospective cohort study. Aliment Pharmacol Ther. 2018 Aug 20;: Authors: Auzolle C, Nancey S, Tran-Minh ML, Buisson A, Pariente B, Stefanescu C, Fumery M, Marteau P, Treton X, Hammoudi N, REMIND Study Group Investigators, Jouven X, Seksik P, Allez M Abstract BACKGROUND: After ileocaecal resection for Crohn’s disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo-terminal ileum. AIM: To identify predictors of early post-operative endoscopic…

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A Comprehensive Approach to Pouch Disorders.

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A Comprehensive Approach to Pouch Disorders. Inflamm Bowel Dis. 2018 Aug 16;: Authors: Quinn KP, Lightner AL, Faubion WA, Raffals LE Abstract Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for patients with medically refractory ulcerative colitis (UC) or indeterminate colitis, UC with colonic dysplasia or neoplasia, and familial adenomatous polyposis. In general, patients experience good function outcomes and quality of life with an IPAA. Although pouchitis is the most well-recognized and frequent complication after IPAA, a number of additional inflammatory, postsurgical, structural, neoplastic, and…

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Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease.

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Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn’s Disease. Inflamm Bowel Dis. 2018 Aug 13;: Authors: Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Alexander Valencia C, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan…

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A comparison of the risk of postoperative recurrence between African-American and Caucasian patients with Crohn’s disease.

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A comparison of the risk of postoperative recurrence between African-American and Caucasian patients with Crohn’s disease. Aliment Pharmacol Ther. 2018 Aug 20;: Authors: Anyane-Yeboa A, Yamada A, Haider H, Wang Y, Komaki Y, Komaki F, Pekow J, Dalal S, Cohen RD, Cannon L, Umanskiy K, Smith R, Hurst R, Hyman N, Rubin DT, Sakuraba A Abstract BACKGROUND: Many patients with Crohn’s disease will develop complications that require surgery. Recurrence after surgery is common. AIM: To assess racial differences in postoperative recurrence between African-Americans and Caucasians. METHODS: Medical records of Crohn’s…

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Response to the Letter to the Editor from Dai et al, Regarding “Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch Anal Anastomosis”.

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Response to the Letter to the Editor from Dai et al, Regarding “Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch Anal Anastomosis”. Inflamm Bowel Dis. 2018 Aug 13;: Authors: Gorrepati VS, Stuart A, Deiling S, Koltun W, Tinsley A, Williams ED, Coates MD PMID: 30124832 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30124832?dopt=Abstract

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Comparative efficacy and tolerability of pharmacological agents for management of mild to moderate ulcerative colitis: a systematic review and network meta-analyses.

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Related Articles Comparative efficacy and tolerability of pharmacological agents for management of mild to moderate ulcerative colitis: a systematic review and network meta-analyses. Lancet Gastroenterol Hepatol. 2018 Aug 16;: Authors: Nguyen NH, Fumery M, Dulai PS, Prokop LJ, Sandborn WJ, Murad MH, Singh S Abstract BACKGROUND: The majority of patients with ulcerative colitis have mildly to moderately active disease. To inform the management of patients with left-sided or extensive mildly to moderately active ulcerative colitis, we assessed the comparative efficacy and tolerability of different therapies. METHODS: In this systematic review…

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Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats.

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Related Articles Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats. World J Gastroenterol. 2018 Aug 14;24(30):3384-3397 Authors: Zhang D, Ren YB, Wei K, Hong J, Yang YT, Wu LJ, Zhang J, Shi Z, Wu HG, Ma XP Abstract AIM: To observe the effect of herb-partitioned moxibustion (HPM) on expression of colonic cytokines in ulcerative colitis (UC) rats. METHODS: A UC rat model was established by protein immunization in combination with topical chemical stimulation. Rats in the HPM group (n = 8) received HPM at bilateral Tianshu (ST25) points. The…

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Total flavone of Abelmoschus manihot suppresses epithelial-mesenchymal transition via interfering transforming growth factor-β1 signaling in Crohn’s disease intestinal fibrosis.

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Related Articles Total flavone of Abelmoschus manihot suppresses epithelial-mesenchymal transition via interfering transforming growth factor-β1 signaling in Crohn’s disease intestinal fibrosis. World J Gastroenterol. 2018 Aug 14;24(30):3414-3425 Authors: Yang BL, Zhu P, Li YR, Xu MM, Wang H, Qiao LC, Xu HX, Chen HJ Abstract AIM: To explore the role and mechanism of total flavone of Abelmoschus manihot (TFA) on epithelial-mesenchymal transition (EMT) progress of Crohn’s disease (CD) intestinal fibrosis. METHODS: First, CCK-8 assay was performed to assess TFA on the viability of intestinal epithelial (IEC-6) cells and select the…

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The Microbial Composition of Bacteroidetes Species in Ulcerative Colitis Is Effectively Improved by Combination Therapy With Fecal Microbiota Transplantation and Antibiotics.

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The Microbial Composition of Bacteroidetes Species in Ulcerative Colitis Is Effectively Improved by Combination Therapy With Fecal Microbiota Transplantation and Antibiotics. Inflamm Bowel Dis. 2018 Aug 14;: Authors: Ishikawa D, Sasaki T, Takahashi M, Kuwahara-Arai K, Haga K, Ito S, Okahara K, Nakajima A, Shibuya T, Osada T, Hiramatsu K, Watanabe S, Nagahara A Abstract Background: We previously reported that fresh fecal microbiota transplantation (FMT) after triple-antibiotic therapy (amoxicillin, fosfomycin, and metronidazole [AFM]; A-FMT) synergistically contributed to the recovery of phylum Bacteroidetes composition associated with the endoscopic severity and treatment…

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