Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn’s disease of inflammatory type.

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Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn’s disease of inflammatory type. J Gastroenterol. 2018 Sep 22;: Authors: Nagata Y, Esaki M, Moriyama T, Hirano A, Umeno J, Maehata Y, Torisu T, Matsumoto T, Kitazono T Abstract BACKGROUND: Anti-tumor necrosis factor (TNF) therapy induces and maintains clinical remission in patients with Crohn’s disease (CD). However, the effect of anti-TNF therapy on the natural course of CD remains controversial. We aimed to investigate the effect of anti-TNF therapy on the initial intestinal surgery for…

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Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn’s Disease.

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Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1682-1683 Authors: Li JD, Xu XF, Xing H PMID: 30243356 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30243356?dopt=Abstract

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Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation.

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Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation. Inflamm Bowel Dis. 2018 Sep 20;: Authors: Duricova D, Dvorakova E, Hradsky O, Mitrova K, Durilova M, Kozeluhova J, Kohout P, Zarubova K, Bronsky J, Hradska N, Bronska E, Adamcova M, Machkova N, Hruba V, Bortlik M, Lukas M, Malickova K, Lukas M Abstract Background: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero…

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The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis.

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The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis. J Crohns Colitis. 2018 Sep 15;: Authors: Kiernan MG, Coffey JC, McDermott K, Cotter PD, Cabrera-Rubio R, Kiely PA, Dunne CP Abstract Background and Aims: Mesenteric lymph nodes are sites in which translocated bacteria incite and progress immunological responses. For this reason, understanding the microbiome of mesenteric lymph nodes in inflammatory bowel disease is important. The bacterial profile of Crohn’s disease mesenteric lymph nodes has been analysed using culture-independent methods in only one previous study. This study…

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A (glyco)biomarker that predicts failure to standard therapy in Ulcerative Colitis patients.

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A (glyco)biomarker that predicts failure to standard therapy in Ulcerative Colitis patients. J Crohns Colitis. 2018 Sep 20;: Authors: Pereira MS, Maia L, Azevedo LF, Campos S, Carvalho S, Dias AM, Albergaria A, Lima J, Marcos-Pinto R, Lago P, Pinho SS Abstract Background and Aims: There is a clinical need to identify biomarkers able to select patients who are most likely to develop aggressive/complicated disease and early select them for appropriate therapy. Changes in the glycosylation profile of intestinal lymphocytic infiltrate was previously demonstrated to regulate T cell activity being…

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Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease.

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Higher Infliximab Trough Levels Are Associated With Better Outcome in Paediatric Patients With Inflammatory Bowel Disease. J Crohns Colitis. 2018 Sep 19;: Authors: van Hoeve K, Dreesen E, Hoffman I, Van Assche G, Ferrante M, Gils A, Vermeire S Abstract Background: The role of therapeutic drug monitoring for infliximab [IFX] therapy in children with inflammatory bowel disease [IBD] is poorly investigated. We determined if IFX exposure correlates with long-term remission in children. Methods: In this retrospective study, all children with Crohn’s disease [CD] and ulcerative colitis [UC], receiving maintenance IFX…

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