Modern management of perianal fistulas in Crohn’s disease: future directions.

Modern management of perianal fistulas in Crohn’s disease: future directions. Gut. 2018 Jan 13;: Authors: Kotze PG, Shen B, Lightner A, Yamamoto T, Spinelli A, Ghosh S, Panaccione R Abstract Perianal fistulae in patients with Crohn’s disease (CD) can be associated with significant morbidity resulting in negative impact on quality of life. The last two decades have seen significant advancements in the management of perianal fistulas in CD, which has evolved into a multidisciplinary approach that includes gastroenterologists, colorectal surgeons, endoscopists and radiologists. Despite the introduction of new medical therapies…

Read More

Early changes in the pharmacokinetic profile of vedolizumab-treated patients with IBD may predict response after dose optimisation.

Early changes in the pharmacokinetic profile of vedolizumab-treated patients with IBD may predict response after dose optimisation. Gut. 2018 Jan 13;: Authors: Gouynou C, Pouillon L, Rousseau H, Zallot C, Baumann C, Peyrin-Biroulet L PMID: 29331941 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29331941?dopt=Abstract

Read More

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease.

Related Articles Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease. Gastroenterology. 2017 Dec 30;: Authors: Bruining DH, Zimmermann EM, Loftus EV, Sandborn WJ, Sauer CG, Strong SA, Society of Abdominal Radiology Crohn’s Disease-Focused Panel Abstract Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn’s disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will…

Read More

Autologous haematopoietic stem cell transplantation (AHSCT) in severe Crohn’s Disease: a review on behalf of ECCO and EBMT.

Related Articles Autologous haematopoietic stem cell transplantation (AHSCT) in severe Crohn’s Disease: a review on behalf of ECCO and EBMT. J Crohns Colitis. 2018 Jan 08;: Authors: Snowden JA, Panés J, Alexander T, Allez M, Ardizzone S, Dierickx D, Finke J, Hasselblatt P, Hawkey C, Kazmi M, Lindsay JO, Onida F, Salas A, Saccardi R, Vermeire S, Rovira M, Ricart E, European Crohn’s and Colitis Organisation (ECCO), European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for…

Read More

Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study.

Related Articles Fetal and early life antibiotics exposure and very early onset inflammatory bowel disease: a population-based study. Gut. 2018 Jan 10;: Authors: Örtqvist AK, Lundholm C, Halfvarson J, Ludvigsson JF, Almqvist C Abstract OBJECTIVE: Earlier studies on antibiotics exposure and development of IBD (Crohn’s disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. We aimed to estimate the association between antibiotics during pregnancy or infantile age and very early onset (VEO) IBD. DESIGN: In this cohort study of 827 239 children born in…

Read More

Corticosteroid Sparing in Inflammatory Bowel Disease is More Often Achieved in the Immunomodulator and Biological Era-Results from the Dutch Population-Based IBDSL Cohort.

Corticosteroid Sparing in Inflammatory Bowel Disease is More Often Achieved in the Immunomodulator and Biological Era-Results from the Dutch Population-Based IBDSL Cohort. Am J Gastroenterol. 2018 Jan 09;: Authors: Jeuring SFG, Biemans VBC, van den Heuvel TRA, Zeegers MP, Hameeteman WH, Romberg-Camps MJL, Oostenbrug LE, Masclee AAM, Jonkers DMAE, Pierik MJ Abstract OBJECTIVES: Corticosteroid-free remission is an emerging treatment goal in the management of inflammatory bowel disease (IBD). In the population-based Inflammatory Bowel Disease South Limburg cohort, we studied temporal changes in corticosteroid use and assessed the corticosteroid-sparing effects of…

Read More

Increasing Infliximab Dose Based on Symptoms, Biomarkers, and Serum Drug Concentrations Does Not Increase Clinical, Endoscopic, or Corticosteroid-Free Remission in Patients With Active Luminal Crohn’s Disease.

Increasing Infliximab Dose Based on Symptoms, Biomarkers, and Serum Drug Concentrations Does Not Increase Clinical, Endoscopic, or Corticosteroid-Free Remission in Patients With Active Luminal Crohn’s Disease. Gastroenterology. 2018 Jan 06;: Authors: D’Haens G, Vermeire S, Lambrecht G, Baert F, Bossuyt P, Pariente B, Buisson A, Bouhnik Y, Filippi J, Vander Woude J, Van Hootegem P, Moreau J, Louis E, Franchimont D, De Vos M, Mana F, Peyrin-Biroulet L, Brixi H, Allez M, Caenepeel P, Aubourg A, Oldenburg B, Pierik M, Gils A, Chevret S, Laharie D, GETAID Abstract BACKGROUND &…

Read More

Long-term efficacy and safety of ustekinumab in 122 refractory Crohn’s disease patients: a multicentre experience.

Long-term efficacy and safety of ustekinumab in 122 refractory Crohn’s disease patients: a multicentre experience. Aliment Pharmacol Ther. 2018 Jan 08;: Authors: Wils P, Bouhnik Y, Michetti P, Flourie B, Brixi H, Bourrier A, Allez M, Duclos B, Serrero M, Buisson A, Amiot A, Fumery M, Roblin X, Peyrin-Biroulet L, Filippi J, Bouguen G, Abitbol V, Coffin B, Simon M, Laharie D, Pariente B, Groupe d’Etude Thérapeutique des Affections Inflammatoires du Tube Digestif (GETAID) Abstract BACKGROUND: Long-term outcome of ustekinumab in Crohn’s disease (CD) has not been evaluated. AIM: To…

Read More

Letter: the safety of herpes zoster vaccination for patients with inflammatory bowel disease being treated with anti-TNF medications.

Letter: the safety of herpes zoster vaccination for patients with inflammatory bowel disease being treated with anti-TNF medications. Aliment Pharmacol Ther. 2018 Feb;47(3):446-447 Authors: Côté-Daigneault J, Luong ML, Colombel JF, Peerani F PMID: 29314127 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29314127?dopt=Abstract

Read More

Letter: therapeutic drug monitoring and inflammatory bowel disease-a call for an urgent standardization of the results.

Letter: therapeutic drug monitoring and inflammatory bowel disease-a call for an urgent standardization of the results. Aliment Pharmacol Ther. 2018 Feb;47(3):448-449 Authors: Ribaldone DG, Saracco GM, Astegiano M, Pellicano R PMID: 29314133 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/29314133?dopt=Abstract

Read More
<< Go Back