Bacterial related events and the immunological response of onset and relapse adult Crohn’s disease patients.

Bacterial related events and the immunological response of onset and relapse adult Crohn’s disease patients. J Crohns Colitis. 2018 Sep 22;: Authors: Cantó E, Zamora C, Garcia-Planella E, Gordillo J, Ortiz MA, Perea L, Vidal S Abstract Background and Aims: Crohn’s disease (CD) is a chronic, systemic inflammatory disease characterized by periods of remission and flare-ups. It has been associated with a disturbed gastrointestinal barrier function, an increase in the transport of luminal contents into the tissue and lower immune tolerance. Methods: Peripheral blood samples were collected from healthy controls…

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Risk factors associated with Clostridium difficile infection in inflammatory bowel disease: a systematic review and meta-analysis.

Risk factors associated with Clostridium difficile infection in inflammatory bowel disease: a systematic review and meta-analysis. J Crohns Colitis. 2018 Sep 21;: Authors: Balram B, Battat R, Al-Khoury A, D’Aoust J, Afif W, Bitton A, Lakatos PL, Bessissow T Abstract Background: Clostridium difficile Infection (CDI) is a significant concern in Inflammatory Bowel Disease (IBD). Risk factors and consequences associated with CDI in Inflammatory Bowel Disease (IBD) patients are important to characterize. Aim: To perform a systematic review and meta-analysis to assess risk factors and outcomes associated with CDI in IBD…

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Index Severity Score and Early Readmission Predicts Increased Mortality in Ulcerative Colitis Patients.

Index Severity Score and Early Readmission Predicts Increased Mortality in Ulcerative Colitis Patients. Inflamm Bowel Dis. 2018 Sep 20;: Authors: Kruger AJ, Hinton A, Afzali A Abstract Background: Readmissions are common after hospitalization related to ulcerative colitis (UC). A risk score to stratify the severity of UC hospitalizations and risk of colectomy has been previously reported. Our aim was to predict hospital-related outcomes after hospitalizations for UC utilizing this severity score. Methods: We utilized the Nationwide Readmissions Database (2010-2014) for hospitalized patients with UC and differentiated patients by index severity…

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Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn’s disease of inflammatory type.

Anti-tumor necrosis factor therapy decreases the risk of initial intestinal surgery after diagnosis of Crohn’s disease of inflammatory type. J Gastroenterol. 2018 Sep 22;: Authors: Nagata Y, Esaki M, Moriyama T, Hirano A, Umeno J, Maehata Y, Torisu T, Matsumoto T, Kitazono T Abstract BACKGROUND: Anti-tumor necrosis factor (TNF) therapy induces and maintains clinical remission in patients with Crohn’s disease (CD). However, the effect of anti-TNF therapy on the natural course of CD remains controversial. We aimed to investigate the effect of anti-TNF therapy on the initial intestinal surgery for…

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Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn’s Disease.

Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1682-1683 Authors: Li JD, Xu XF, Xing H PMID: 30243356 [PubMed – in process] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30243356?dopt=Abstract

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Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation.

Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation. Inflamm Bowel Dis. 2018 Sep 20;: Authors: Duricova D, Dvorakova E, Hradsky O, Mitrova K, Durilova M, Kozeluhova J, Kohout P, Zarubova K, Bronsky J, Hradska N, Bronska E, Adamcova M, Machkova N, Hruba V, Bortlik M, Lukas M, Malickova K, Lukas M Abstract Background: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero…

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The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis.

The human mesenteric lymph node microbiome differentiates between Crohn’s disease and ulcerative colitis. J Crohns Colitis. 2018 Sep 15;: Authors: Kiernan MG, Coffey JC, McDermott K, Cotter PD, Cabrera-Rubio R, Kiely PA, Dunne CP Abstract Background and Aims: Mesenteric lymph nodes are sites in which translocated bacteria incite and progress immunological responses. For this reason, understanding the microbiome of mesenteric lymph nodes in inflammatory bowel disease is important. The bacterial profile of Crohn’s disease mesenteric lymph nodes has been analysed using culture-independent methods in only one previous study. This study…

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