Ion Transport Basis of Diarrhea in a Mouse Model of Adoptive T Cell Transfer Colitis.

Related Articles Ion Transport Basis of Diarrhea in a Mouse Model of Adoptive T Cell Transfer Colitis. Dig Dis Sci. 2019 Nov 18;: Authors: Jayawardena D, Tyagi S, Nazmi A, Olivares-Villagómez D, Dudeja PK Abstract BACKGROUND: Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn’s disease. Although mice with T cell transfer colitis demonstrate diarrhea,…

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ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment.

ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment. J Crohns Colitis. 2019 Nov 19;: Authors: Adamina M, Bonovas S, Raine T, Spinelli A, Warusavitarne J, Armuzzi A, Bachmann O, Bager P, Biancone L, Bokemeyer B, Bossuyt P, Burisch J, Collins P, Doherty G, El-Hussuna A, Ellul P, Fiorino G, Frei-Lanter C, Furfaro F, Gingert C, Gionchetti P, Gisbert JP, Gomollon F, Lorenzo MG, Gordon H, Hlavaty T, Juillerat P, Katsanos K, Kopylov U, Krustins E, Kucharzik T, Lytras T, Maaser C, Magro F, Marshall JK, Myrelid P, Pellino G,…

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Adalimumab for induction of remission in Crohn’s disease.

Adalimumab for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2019 Nov 14;2019(11): Authors: Abbass M, Cepek J, Parker CE, Nguyen TM, MacDonald JK, Feagan BG, Khanna R, Jairath V Abstract BACKGROUND: Adalimumab is an IgG1 monoclonal antibody that targets and blocks tumor necrosis factor-alpha, a pro-inflammatory cytokine involved in the pathogenesis of Crohn’s disease (CD). A significant proportion of people with CD fail conventional therapy or therapy with biologics or develop significant adverse events. Adalimumab may be an effective alternative for these individuals. OBJECTIVES: The objectives of…

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Complete Endoscopic Healing Associated With Better Outcomes Than Partial Endoscopic Healing in Patients With Crohn’s Disease.

Complete Endoscopic Healing Associated With Better Outcomes Than Partial Endoscopic Healing in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2019 Nov 16;: Authors: Yzet C, Diouf M, Le Mouel JP, Brazier F, Turpin J, Loreau J, Dupas JL, Peyrin-Biroulet L, Fumery M Abstract BACKGROUND & AIMS: Mucosal healing (MH) has been associated with a good outcomes of patients with Crohn’s disease (CD). It is not clear what levels of endoscopic healing, based on CD endoscopic index score (CDEIS), associate with different courses of disease progression. We assessed long-term outcomes of…

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Endoscopic alterations in Peyer’s patches in patients with ulcerative colitis: A prospective, multicenter study.

Endoscopic alterations in Peyer’s patches in patients with ulcerative colitis: A prospective, multicenter study. J Gastroenterol Hepatol. 2019 Nov 16;: Authors: Hiyama S, Iijima H, Sakakibara Y, Yamada T, Mukai A, Otake Y, Yamaguchi T, Araki M, Kawai S, Tsujii Y, Inoue T, Hayashi Y, Shinzaki S, Takehara T Abstract BACKGROUND AND AIM: Peyer’s patches (PPs) play a major role in intestinal mucosal immunity; however, their role in ulcerative colitis (UC) is not well investigated. We evaluated endoscopic features of PPs on narrow-band imaging with magnifying endoscopy (NBI-ME) and investigated…

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Cost-effectiveness and Clinical Outcomes of Early Anti-Tumor Necrosis Factor-α Intervention in Pediatric Crohn’s Disease.

Related Articles Cost-effectiveness and Clinical Outcomes of Early Anti-Tumor Necrosis Factor-α Intervention in Pediatric Crohn’s Disease. Inflamm Bowel Dis. 2019 Nov 15;: Authors: Bashir NS, Walters TD, Griffiths AM, Ito S, Ungar WJ Abstract BACKGROUND: Anti-tumor necrosis factor-α (anti-TNF-α) treatments are increasingly used to treat pediatric Crohn’s disease, even without a prior trial of immunomodulators, but the cost-effectiveness of such treatment algorithms has not been formally examined. Drug plan decision-makers require evidence of cost-effectiveness to inform funding decisions. The objective was to assess the incremental cost-effectiveness of early intervention with…

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The Incidence and Prevalence of Anxiety, Depression, and Post-traumatic Stress Disorder in a National Cohort of US Veterans With Inflammatory Bowel Disease.

Related Articles The Incidence and Prevalence of Anxiety, Depression, and Post-traumatic Stress Disorder in a National Cohort of US Veterans With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2019 Nov 15;: Authors: Thakur ER, Sansgiry S, Kramer JR, Waljee AK, Gaidos JK, Feagins LA, Govani SM, Dindo L, El-Serag HB, Hou JK Abstract BACKGROUND: Patients with inflammatory bowel disease (IBD) are more susceptible to mental health problems than the general population; however, temporal trends in psychiatric diagnoses’ incidence or prevalence in the United States are lacking. We sought to identify these…

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Reply – Associations between drug exposure and outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease.

Reply – Associations between drug exposure and outcomes in patients with primary sclerosing cholangitis and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2019 Nov 12;: Authors: Bergquist A, Stokkeland K, Bottai M, Söderberg-Löfdal K PMID: 31730911 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31730911?dopt=Abstract

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