Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis.

Related Articles Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis. World J Gastroenterol. 2017 Jun 14;23(22):4039-4046 Authors: Matusiewicz M, Neubauer K, Bednarz-Misa I, Gorska S, Krzystek-Korpacka M Abstract AIM: To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker. METHODS: Serum IL9 as well as other cytokines (IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn’s disease (CD) and 74 with ulcerative colitis (UC) and in 122 apparently…

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Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015.

Related Articles Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015. World J Gastroenterol. 2017 Jun 14;23(22):4090-4101 Authors: Schwarz J, Sýkora J, Cvalínová D, Pomahačová R, Klečková J, Kryl M, Včelák P Abstract AIM: To examine the incidence and trends in pediatric inflammatory bowel diseases (IBDs) over 2000-2015 and project the incidence to 2018. METHODS: A 16-year prospective study of IBD patients < 19 years of age was conducted in the Czech Republic (the Pilsen region). All incident IBD cases within a well-defined geographical area were retrieved…

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Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study.

Related Articles Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study. World J Gastroenterol. 2017 Jun 14;23(22):4102-4111 Authors: Koller T, Galambosova M, Filakovska S, Kubincova M, Hlavaty T, Toth J, Krajcovicova A, Payer J Abstract AIM: To analyze 1-year liver injury burden in inflammatory bowel disease (IBD) patients. METHODS: During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase (AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase (GGT)…

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Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study.

Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study. Am J Gastroenterol. 2017 Jun 27;: Authors: Myrelid P, Landerholm K, Nordenvall C, Pinkney TD, Andersson RE Abstract OBJECTIVES: Ulcerative colitis (UC) is a chronic inflammatory disease usually responding well to anti-inflammatory drugs but many patients will still need colectomy. Appendectomy is associated with a lower risk of later developing UC. We aimed to assess the longitudinal relationship between appendectomy, appendicitis, and disease course in UC patients. METHODS: A national cohort of UC patients with a diagnosis…

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Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease.

Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther. 2017 Jun 27;: Authors: Derwa Y, Gracie DJ, Hamlin PJ, Ford AC Abstract BACKGROUND: Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBD). Evidence implicates disturbances of the gastrointestinal microbiota in their pathogenesis. AIM: To perform a systematic review and meta-analysis to examine the efficacy of probiotics in IBD. METHODS: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register were searched (until November 2016). Eligible randomised controlled trials (RCTs) recruited adults with UC…

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The development of a magnetic resonance imaging index for fistulising Crohn’s disease.

The development of a magnetic resonance imaging index for fistulising Crohn’s disease. Aliment Pharmacol Ther. 2017 Jun 27;: Authors: Samaan MA, Puylaert CAJ, Levesque BG, Zou GY, Stitt L, Taylor SA, Shackelton LM, Vandervoort MK, Khanna R, Santillan C, Rimola J, Hindryckx P, Nio CY, Sandborn WJ, D’Haens G, Feagan BG, Jairath V, Stoker J Abstract BACKGROUND: Magnetic resonance imaging (MRI) is the gold standard for assessment of perianal fistulising Crohn’s disease (CD). The Van Assche index is the most commonly used MRI fistula index. AIMS: To assess the reliability…

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Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn’s Disease.

Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn’s Disease. J Clin Gastroenterol. 2017 Jun 26;: Authors: Galata C, Hirsch D, Reindl W, Post S, Kienle P, Boutros M, Gaiser T, Horisberger K Abstract GOALS: The aim of this study was to assess the histopathologic characteristics of colorectal carcinomas (CRC) in patients with Crohn’s disease (CD). BACKGROUND: A higher frequency of microsatellite instability (MSI) is seen in mucinous compared with nonmucinous CRC which suggests that its pathogenesis involves distinct molecular pathways. Several publications reported a higher percentage of mucinous adenocarcinoma…

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Increased risk of acute arterial events in young patients and severely active IBD: a nationwide French cohort study.

Increased risk of acute arterial events in young patients and severely active IBD: a nationwide French cohort study. Gut. 2017 Jun 24;: Authors: Kirchgesner J, Beaugerie L, Carrat F, Andersen NN, Jess T, Schwarzinger M, BERENICE study group Abstract OBJECTIVE: Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. DESIGN: Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years…

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Mesenchymal stem cell therapy for acute and chronic pancreatitis.

Related Articles Mesenchymal stem cell therapy for acute and chronic pancreatitis. J Gastroenterol. 2017 Jun 23;: Authors: Kawakubo K, Ohnishi S, Kuwatani M, Sakamoto N Abstract Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis…

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