Efficacy of Induction Therapy with High-intensity Tofacitinib in 4 Patients with Acute Severe Ulcerative Colitis.

Efficacy of Induction Therapy with High-intensity Tofacitinib in 4 Patients with Acute Severe Ulcerative Colitis. Clin Gastroenterol Hepatol. 2018 Nov 17;: Authors: Berinstein JA, Steiner CA, Regal RE, Allen JI, Kinnucan JAR, Stidham RW, Waljee AK, Bishu S, Aldrich LB, Higgins PDR PMID: 30458248 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/30458248?dopt=Abstract

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Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation.

Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation. Gastroenterology. 2018 Nov 16;: Authors: Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C Abstract BACKGROUND & AIMS: Intestinal fibrosis is a long-term complication in inflammatory bowel diseases (IBD) frequently resulting in functional damage, bowel obstruction, and surgery.…

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Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis.

Elevation in Cell Cycle and Protein Metabolism Gene Transcription in Inactive Colonic Tissue From Icelandic Patients With Ulcerative Colitis. Inflamm Bowel Dis. 2018 Nov 19;: Authors: Vinayaga-Pavan M, Frampton M, Pontikos N, Levine AP, Smith PJ, Jonasson JG, Björnsson ES, Segal AW, Smith AM Abstract Background: A combination of genetic and environmental factors is thought to be involved in the pathogenesis of ulcerative colitis (UC). In Iceland, the incidence of UC is one of the highest in the world. The aim of this study was to characterize patients with UC…

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Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases.

Acceptance and Commitment Therapy Reduces Psychological Stress in Patients With Inflammatory Bowel Diseases. Gastroenterology. 2018 Nov 16;: Authors: Wynne B, McHugh L, Gao W, Keegan D, Byrne K, Rowan C, Hartery K, Kirschbaum C, Doherty G, Cullen G, Dooley B, Mulcahy HE Abstract BACKGROUND & AIMS: Patients with Crohn’s disease or ulcerative colitis patients have relatively high levels of stress and psychological dysfunction. Acceptance and commitment therapy (ACT) is a psychological intervention that comprises acceptance and mindfulness procedures along with commitment and behavior change strategies to increase psychological flexibility and…

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Gut-Directed Pelvic Floor Behavioral Treatment for Fecal Incontinence and Constipation in Patients with Inflammatory Bowel Disease.

Gut-Directed Pelvic Floor Behavioral Treatment for Fecal Incontinence and Constipation in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Nov 19;: Authors: Khera AJ, Chase JW, Salzberg M, Thompson AJV, Kamm MA Abstract Background: Patients with inflammatory bowel disease (IBD) often experience functional bowel symptoms despite achieving disease remission. Although behavioral treatment (bowel and pelvic floor muscle retraining) is effective for managing constipation or fecal incontinence in non-IBD patients, there is limited evidence for its efficacy in patients with quiescent inflammatory bowel disease. The aim of this study was…

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Diverting Stoma for Refractory Ano-perineal Crohn’s Disease, Is It Really Useful in the Anti-TNF Era? A multivariate analysis in 74 consecutive patients.

Diverting Stoma for Refractory Ano-perineal Crohn’s Disease, Is It Really Useful in the Anti-TNF Era? A multivariate analysis in 74 consecutive patients. J Crohns Colitis. 2018 Nov 19;: Authors: Hain E, Maggiori L, Orville M, Tréton X, Bouhnik Y, Panis Y Abstract Background & Aims: Faecal diversion (FD) can be proposed in patients with refractory anoperineal Crohn’s disease (APCD). This study aimed to assess long-term results of this strategy, following the advent of the anti-TNF era. Methods: All patients who underwent FD for refractory APCD between 2005 and 2017 were…

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Response to treatment is more important than disease severity at diagnosis for prediction of early relapse in new-onset paediatric Crohn’s disease.

Related Articles Response to treatment is more important than disease severity at diagnosis for prediction of early relapse in new-onset paediatric Crohn’s disease. Aliment Pharmacol Ther. 2018 Nov 18;: Authors: Ziv-Baran T, Hussey S, Sladek M, Amil Dias J, Martin de Carpi J, Miele E, Veres G, Lionetti P, Koletzko S, Nuti F, Paerregaard A, Kolho KL, Russell RK, Shaoul R, Weiner D, Sigall Boneh R, Escher J, Finnby L, Turner D, Levine A Abstract BACKGROUND: Paediatric Crohn’s disease is characteried by frequently relapsing disease which may lead to hospitalisations…

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Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease.

Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease. J Crohns Colitis. 2018 Nov 19;: Authors: Kang B, Choi SY, Choi YO, Lee SY, Baek SY, Sohn I, Choe BH, Lee HJ, Choe YH Abstract Background and Aims: Mucosal healing is an important treatment goal in Crohn’s disease. We investigated the association between serum infliximab trough levels and mucosal healing, and the infliximab cut-off levels required for mucosal healing in paediatric patients. Methods: In this multicentre, retrospective, cross-sectional study, medical records and…

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Faecal calprotectin and MRI Enterography in ileal Crohn’s disease: correlations between disease activity and long term follow up.

Faecal calprotectin and MRI Enterography in ileal Crohn’s disease: correlations between disease activity and long term follow up. J Crohns Colitis. 2018 Nov 19;: Authors: Jones GR, Fascì-Spurio F, Kennedy NA, Plevris N, Jenkinson P, Lyons M, Wong L, MacLean P, Glancy S, Lees CW Abstract Background and Aims: Magnetic resonance enterography (MRE) is the gold standard for assessing ileal inflammation in Crohn’s disease. The aim of the present study was to correlate faecal calprotectin (FC) to MRE via a simple score in an exclusive ileal cohort with long term…

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