Ustekinumab drug levels in maternal and cord blood in a woman with Crohn’s disease treated until 33 weeks gestation.

Ustekinumab drug levels in maternal and cord blood in a woman with Crohn’s disease treated until 33 weeks gestation. J Crohns Colitis. 2017 Oct 16;: Authors: Rowan CR, Cullen G, Mulcahy HE, Keegan D, Byrne K, Murphy DJ, Sheridan J, Doherty GA Abstract A 35-year old woman with ileocolonic, perianal and vulval Crohn’s disease was treated with subcutaneous ustekinuamb (USK) throughout pregnancy. Dose intervals were shortened from 6-weekly to 4-weekly to maintain clinical remission. The last dose of USK was administered at 33 weeks gestation and a healthy baby boy…

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Incidence and Outcomes of Central Venous Catheter-related Blood Stream Infection in Patients with Inflammatory Bowel Disease in Routine Clinical Practice Setting.

Incidence and Outcomes of Central Venous Catheter-related Blood Stream Infection in Patients with Inflammatory Bowel Disease in Routine Clinical Practice Setting. Inflamm Bowel Dis. 2017 Nov;23(11):2042-2047 Authors: Shibata W, Sohara M, Wu R, Kobayashi K, Yagi S, Yaguchi K, Iizuka Y, Iwasa M, Nakahata H, Yamaguchi T, Matsumoto H, Okada M, Taniguchi K, Hayashi A, Inazawa S, Inagaki N, Sasaki T, Koh R, Kinoshita H, Nishio M, Ogashiwa T, Ookawara A, Miyajima E, Oba M, Ohge H, Maeda S, Kimura H, Kunisaki R Abstract BACKGROUND: Patients with inflammatory bowel disease…

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Non-Clostridium difficile Bacterial Infections Are Rare in Patients With Flares of Inflammatory Bowel Disease.

Related Articles Non-Clostridium difficile Bacterial Infections Are Rare in Patients With Flares of Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2017 Oct 13;: Authors: Hanada Y, Khanna S, Loftus EV, Raffals LE, Pardi DS Abstract BACKGROUND & AIMS: Clostridium difficile infection (CDI) causes flares in patients with inflammatory bowel disease (IBD). We investigated the frequency and outcomes of non-CDI bacterial enteric infections in symptomatic patients with IBD. METHODS: We performed a retrospective study of patients with ulcerative colitis (UC) or Crohn’s disease (CD) from whom stool samples were collected and analyzed…

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Transcriptomic Landscape of Treatment – Na├»ve Ulcerative Colitis.

Related Articles Transcriptomic Landscape of Treatment – Naïve Ulcerative Colitis. J Crohns Colitis. 2017 Oct 10;: Authors: Taman H, Fenton CG, Hensel IV, Anderssen E, Florholmen J, Paulssen RH Abstract Background and Aims: Ulcerative colitis (UC) is a chronic inflammatory disease that effects the gastrointestinal tract and is considered one of the most prominent and common forms of inflammatory bowel disease (IBD). This study aimed to define and describe the entire transcriptomic landscape in a well-stratified, treatment-naïve UC patient population compared to control patients by using next-generation technology, RNA-Seq. Methods:…

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Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management.

Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management. Aliment Pharmacol Ther. 2017 Oct 16;: Authors: McIlroy J, Ianiro G, Mukhopadhya I, Hansen R, Hold GL Abstract BACKGROUND: The concept of an altered collective gut microbiota rather than identification of a single culprit is possibly the most significant development in inflammatory bowel disease research. We have entered the “omics” era, which now allows us to undertake large-scale/high-throughput microbiota analysis which may well define how we approach diagnosis and treatment of inflammatory bowel disease (IBD) in the future,…

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DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

Related Articles DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome. Gastroenterology. 2017 Oct 11;: Authors: Howell KJ, Kraiczy J, Nayak KM, Gasparetto M, Ross A, Lee C, Mak TN, Koo BK, Kumar N, Lawley T, Sinha A, Rosenstiel P, Heuschkel R, Stegle O, Zilbauer M Abstract BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel diseases (IBD) to learn more about…

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Surgical treatment in childhood-onset inflammatory bowel disease -A nationwide register-based study of 4,695 incident patients in Sweden 2002-2014.

Surgical treatment in childhood-onset inflammatory bowel disease -A nationwide register-based study of 4,695 incident patients in Sweden 2002-2014. J Crohns Colitis. 2017 Sep 27;: Authors: Nordenvall C, Rosvall O, Bottai M, Everhov ÅH, Malmborg P, Smedby KE, Ekbom A, Askling J, Ludvigsson JF, Myrelid P, Olén O Abstract Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and…

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Biopsy-derived intestinal epithelial cell cultures for pathway based stratification of patients with inflammatory bowel disease.

Biopsy-derived intestinal epithelial cell cultures for pathway based stratification of patients with inflammatory bowel disease. J Crohns Colitis. 2017 Sep 23;: Authors: Vanhove W, Nys K, Arijs I, Cleynen I, Noben M, De Schepper S, Van Assche G, Ferrante M, Vermeire S Abstract Background: Endoplasmic reticulum stress was shown to be pivotal in the pathogenesis of inflammatory bowel disease. Despite progress in IBD drug development, not more than one third of patients achieve steroid-free remission and mucosal healing with current therapies. Furthermore, patient stratification tools for therapy selection are lacking….

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