Case-matched comparison of postoperative outcomes following surgery for inflammatory bowel disease after exposure to vedolizumab vs. other biologics.

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Related Articles Case-matched comparison of postoperative outcomes following surgery for inflammatory bowel disease after exposure to vedolizumab vs. other biologics. J Crohns Colitis. 2019 Jul 20;: Authors: Novello M, Stocchi L, Steele SR, Holubar SD, Duraes LC, Kessler H, Shawki S, Hull LT Abstract BACKGROUND AND AIM: The effects of vedolizumab (VEDO) exposure on perioperative outcomes following surgery for inflammatory bowel disease (IBD) remain controversial. The aim of our study was to compare postoperative morbidity of IBD surgery following treatment with VEDO vs. other biologics or no biologics. METHODS: An…

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Corrigendum to Predicting Risk of Postoperative Disease Recurrence in Crohn’s Disease: Patients With Indolent Crohn’s Disease Have Distinct Whole Transcriptome Profiles at the Time of First Surgery.

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Corrigendum to Predicting Risk of Postoperative Disease Recurrence in Crohn’s Disease: Patients With Indolent Crohn’s Disease Have Distinct Whole Transcriptome Profiles at the Time of First Surgery. Inflamm Bowel Dis. 2019 Jul 22;: Authors: PMID: 31329224 [PubMed – as supplied by publisher] PubMed Link: https://www.ncbi.nlm.nih.gov/pubmed/31329224?dopt=Abstract

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High-Risk Ileocolic Anastomoses for Crohn’s Disease: When Is Diversion Indicated?

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High-Risk Ileocolic Anastomoses for Crohn’s Disease: When Is Diversion Indicated? J Crohns Colitis. 2019 Apr 24;: Authors: Neary PM, Aiello AC, Stocchi L, Shawki S, Hull T, Steele SR, Delaney CP, Holubar SD Abstract BACKGROUND AND AIMS: Patients with Crohn’s disease undergoing ileocolectomy and primary anastomosis are often at increased risk of anastomotic leak. We aimed to determine whether diverting ileostomy was protective against anastomotic leak after ileocolic resection for Crohn’s disease using a large international registry. METHODS: We analysed the National Surgical Quality Improvement Program Colectomy Module from 2012…

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Diagnostic Accuracy of Transabdominal Ultrasound in detecting intestinal inflammation in paediatric IBD patients- a systematic review.

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Diagnostic Accuracy of Transabdominal Ultrasound in detecting intestinal inflammation in paediatric IBD patients- a systematic review. J Crohns Colitis. 2019 Apr 23;: Authors: van Wassenaer EA, de Voogd FAE, van Rijn RR, van der Lee JH, Tabbers MM, van Etten-Jamaludin FS, Gecse KB, Kindermann A, de Meij TGJ, D’Haens GR, Benninga MA, Koot BGP Abstract BACKGROUND & AIMS: Currently used non-invasive tools for monitoring children with inflammatory bowel disease (IBD), such as faecal calprotectin, do not accurately reflect the degree of intestinal inflammation and do not provide information on disease…

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Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.

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Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases. Gastroenterology. 2019 Jul 18;: Authors: Aden K, Rehman A, Waschina S, Pan WH, Walker A, Lucio M, Nunez AM, Bharti R, Zimmerman J, Bethge J, Schulte B, Schulte D, Franke A, Nikolaus S, Schroeder JO, Vandeputte D, Raes J, Szymczak S, Waetzig GH, Zeuner R, Schmitt-Kopplin P, Kaleta C, Schreiber S, Rosenstiel P Abstract BACKGROUND & AIMS: Altered interactions between the mucosal immune system and intestinal microbiota contribute to pathogenesis of…

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Lifetime Economic Burden of Crohn’s Disease and Ulcerative Colitis by Age at Diagnosis.

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Lifetime Economic Burden of Crohn’s Disease and Ulcerative Colitis by Age at Diagnosis. Clin Gastroenterol Hepatol. 2019 Jul 18;: Authors: Lichtenstein GR, Shahabi A, Seabury SA, Lakdawalla DN, Espinosa OD, Green S, Brauer M, Baldassano RN Abstract BACKGROUND & AIMS: Understanding the burden of Crohn’s disease (CD) and ulcerative colitis (UC) is important for measuring treatment value. We estimated lifetime healthcare costs incurred by patients with CD or UC by age at diagnosis. METHODS: We collected data from 78,620 patients with CD, 85,755 with UC, and propensity score-matched controls from…

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Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease.

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Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease. J Crohns Colitis. 2019 Jul 20;: Authors: Li T, Wang C, Liu Y, Li B, Zhang W, Wang L, Yu M, Zhao X, Du J, Zhang J, Dong Z, Jiang T, Xie R, Ma R, Fang S, Zhou J, Shi J Abstract BACKGROUND AND AIMS: Despite the presence of neutrophil extracellular traps (NETs) in inflamed colon has been confirmed, the role of NETs, especially the circulating NETs, in the progression and thrombotic tendency of inflammatory bowel disease…

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Epithelial IDO1 Modulates AHR and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota.

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Epithelial IDO1 Modulates AHR and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota. Gastroenterology. 2019 Jul 13;: Authors: Alvarado DM, Chen B, Iticovici M, Thaker AI, Dai N, VanDussen KL, Shaikh N, Lim CK, Guillemin GJ, Tarr PI, Ciorba MA Abstract BACKGROUND & AIMS: Inflammation, injury, and infection upregulate expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in the intestinal epithelium. We studied the effects of cell-specific IDO1 expression in the epithelium at baseline and during intestinal inflammation in mice. METHODS: We generated transgenic…

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Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn’s Disease.

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Related Articles Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn’s Disease. Gastroenterology. 2019 May 14;: Authors: Mack DR, Benchimol EI, Critch J, Jennifer deBruyn, Tse F, Moayyedi P, Church P, Deslandres C, El-Matary W, Huynh H, Jantchou P, Lawrence S, Otley A, Sherlock M, Walters T, Kappelman MD, Sadowski D, Marshall JK, Griffiths A Abstract BACKGROUND & AIMS: We aim to provide guidance for medical treatment of luminal Crohn’s disease in children. METHODS: We performed a systematic search of publication databases to identify…

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Trends of Utilization of Tumor Necrosis Factor Antagonists in Children With Inflammatory Bowel Disease: A Canadian Population-Based Study.

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Trends of Utilization of Tumor Necrosis Factor Antagonists in Children With Inflammatory Bowel Disease: A Canadian Population-Based Study. Inflamm Bowel Dis. 2019 Jul 19;: Authors: El-Matary W, Leung S, Tennakoon A, Benchimol EI, Bernstein CN, Targownik LE Abstract BACKGROUND: Population-based studies examining the prevalence of anti-tumor necrosis factor (anti-TNF) antagonist utilization in children and young adults with inflammatory bowel disease (IBD) are lacking. We aimed to describe the trend of anti-TNF utilization in pediatric IBD over time. METHODS: Survival analyses were performed for all patients diagnosed with IBD before age…

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